Amino acid dipepetide frequency for Dysgonamonadaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.972AlaAla: 4.972 ± 0.112	0.76AlaCys: 0.76 ± 0.031	3.945AlaAsp: 3.945 ± 0.076	4.462AlaGlu: 4.462 ± 0.079	3.238AlaPhe: 3.238 ± 0.058	4.555AlaGly: 4.555 ± 0.096	1.128AlaHis: 1.128 ± 0.039	5.153AlaIle: 5.153 ± 0.089	4.178AlaLys: 4.178 ± 0.072	6.251AlaLeu: 6.251 ± 0.093	1.696AlaMet: 1.696 ± 0.051	3.259AlaAsn: 3.259 ± 0.072	2.071AlaPro: 2.071 ± 0.056	2.639AlaGln: 2.639 ± 0.064	2.838AlaArg: 2.838 ± 0.066	4.061AlaSer: 4.061 ± 0.068	3.409AlaThr: 3.409 ± 0.073	4.185AlaVal: 4.185 ± 0.073	0.695AlaTrp: 0.695 ± 0.029	2.674AlaTyr: 2.674 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.553CysAla: 0.553 ± 0.027	0.145CysCys: 0.145 ± 0.015	0.497CysAsp: 0.497 ± 0.026	0.568CysGlu: 0.568 ± 0.028	0.459CysPhe: 0.459 ± 0.024	0.82CysGly: 0.82 ± 0.04	0.228CysHis: 0.228 ± 0.014	0.701CysIle: 0.701 ± 0.033	0.525CysLys: 0.525 ± 0.023	0.806CysLeu: 0.806 ± 0.034	0.213CysMet: 0.213 ± 0.017	0.474CysAsn: 0.474 ± 0.025	0.46CysPro: 0.46 ± 0.026	0.262CysGln: 0.262 ± 0.018	0.508CysArg: 0.508 ± 0.024	0.601CysSer: 0.601 ± 0.03	0.479CysThr: 0.479 ± 0.027	0.568CysVal: 0.568 ± 0.029	0.11CysTrp: 0.11 ± 0.013	0.367CysTyr: 0.367 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.75AspAla: 3.75 ± 0.068	0.507AspCys: 0.507 ± 0.026	2.98AspAsp: 2.98 ± 0.059	4.521AspGlu: 4.521 ± 0.079	3.453AspPhe: 3.453 ± 0.062	3.619AspGly: 3.619 ± 0.074	0.972AspHis: 0.972 ± 0.035	4.46AspIle: 4.46 ± 0.07	4.147AspLys: 4.147 ± 0.079	5.058AspLeu: 5.058 ± 0.072	1.322AspMet: 1.322 ± 0.033	2.858AspAsn: 2.858 ± 0.077	2.295AspPro: 2.295 ± 0.055	1.646AspGln: 1.646 ± 0.046	2.657AspArg: 2.657 ± 0.06	3.103AspSer: 3.103 ± 0.064	2.573AspThr: 2.573 ± 0.056	3.515AspVal: 3.515 ± 0.072	0.826AspTrp: 0.826 ± 0.033	2.705AspTyr: 2.705 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	4.356GluAla: 4.356 ± 0.084	0.49GluCys: 0.49 ± 0.026	3.09GluAsp: 3.09 ± 0.066	4.715GluGlu: 4.715 ± 0.091	2.698GluPhe: 2.698 ± 0.064	3.745GluGly: 3.745 ± 0.068	1.066GluHis: 1.066 ± 0.038	5.76GluIle: 5.76 ± 0.079	6.331GluLys: 6.331 ± 0.095	5.858GluLeu: 5.858 ± 0.101	2.008GluMet: 2.008 ± 0.051	4.389GluAsn: 4.389 ± 0.077	1.876GluPro: 1.876 ± 0.048	2.528GluGln: 2.528 ± 0.06	3.03GluArg: 3.03 ± 0.075	3.478GluSer: 3.478 ± 0.063	3.605GluThr: 3.605 ± 0.067	3.745GluVal: 3.745 ± 0.063	0.859GluTrp: 0.859 ± 0.037	2.628GluTyr: 2.628 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.388PheAla: 3.388 ± 0.072	0.557PheCys: 0.557 ± 0.028	3.494PheAsp: 3.494 ± 0.069	3.122PheGlu: 3.122 ± 0.061	2.594PhePhe: 2.594 ± 0.069	3.591PheGly: 3.591 ± 0.063	0.913PheHis: 0.913 ± 0.033	3.383PheIle: 3.383 ± 0.067	2.408PheLys: 2.408 ± 0.057	4.324PheLeu: 4.324 ± 0.086	1.233PheMet: 1.233 ± 0.04	2.423PheAsn: 2.423 ± 0.053	1.853PhePro: 1.853 ± 0.051	1.424PheGln: 1.424 ± 0.042	2.339PheArg: 2.339 ± 0.057	3.887PheSer: 3.887 ± 0.08	2.618PheThr: 2.618 ± 0.068	3.487PheVal: 3.487 ± 0.067	0.599PheTrp: 0.599 ± 0.027	1.964PheTyr: 1.964 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.983GlyAla: 3.983 ± 0.088	0.711GlyCys: 0.711 ± 0.034	3.334GlyAsp: 3.334 ± 0.077	3.825GlyGlu: 3.825 ± 0.086	3.449GlyPhe: 3.449 ± 0.061	4.512GlyGly: 4.512 ± 0.097	1.168GlyHis: 1.168 ± 0.037	5.715GlyIle: 5.715 ± 0.086	5.282GlyLys: 5.282 ± 0.074	5.511GlyLeu: 5.511 ± 0.089	1.944GlyMet: 1.944 ± 0.054	3.584GlyAsn: 3.584 ± 0.072	1.396GlyPro: 1.396 ± 0.043	2.025GlyGln: 2.025 ± 0.055	2.743GlyArg: 2.743 ± 0.069	3.957GlySer: 3.957 ± 0.086	3.685GlyThr: 3.685 ± 0.065	4.257GlyVal: 4.257 ± 0.081	0.922GlyTrp: 0.922 ± 0.041	3.001GlyTyr: 3.001 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.178HisAla: 1.178 ± 0.041	0.222HisCys: 0.222 ± 0.016	0.92HisAsp: 0.92 ± 0.033	1.067HisGlu: 1.067 ± 0.04	1.114HisPhe: 1.114 ± 0.037	1.109HisGly: 1.109 ± 0.033	0.45HisHis: 0.45 ± 0.026	1.431HisIle: 1.431 ± 0.038	1.018HisLys: 1.018 ± 0.042	1.788HisLeu: 1.788 ± 0.05	0.306HisMet: 0.306 ± 0.02	0.98HisAsn: 0.98 ± 0.033	1.131HisPro: 1.131 ± 0.037	0.699HisGln: 0.699 ± 0.031	0.926HisArg: 0.926 ± 0.033	1.157HisSer: 1.157 ± 0.033	0.971HisThr: 0.971 ± 0.036	0.962HisVal: 0.962 ± 0.038	0.241HisTrp: 0.241 ± 0.018	0.821HisTyr: 0.821 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.685IleAla: 5.685 ± 0.095	0.806IleCys: 0.806 ± 0.037	5.477IleAsp: 5.477 ± 0.098	5.518IleGlu: 5.518 ± 0.094	3.661IlePhe: 3.661 ± 0.073	5.153IleGly: 5.153 ± 0.09	1.509IleHis: 1.509 ± 0.038	5.216IleIle: 5.216 ± 0.092	4.393IleLys: 4.393 ± 0.078	6.847IleLeu: 6.847 ± 0.105	1.512IleMet: 1.512 ± 0.045	3.574IleAsn: 3.574 ± 0.066	3.575IlePro: 3.575 ± 0.072	2.276IleGln: 2.276 ± 0.057	3.855IleArg: 3.855 ± 0.07	5.155IleSer: 5.155 ± 0.09	4.074IleThr: 4.074 ± 0.082	5.199IleVal: 5.199 ± 0.1	0.723IleTrp: 0.723 ± 0.032	2.929IleTyr: 2.929 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.351LysAla: 4.351 ± 0.084	0.442LysCys: 0.442 ± 0.023	3.741LysAsp: 3.741 ± 0.074	5.073LysGlu: 5.073 ± 0.089	2.523LysPhe: 2.523 ± 0.06	4.237LysGly: 4.237 ± 0.075	1.137LysHis: 1.137 ± 0.036	5.642LysIle: 5.642 ± 0.086	5.435LysLys: 5.435 ± 0.096	5.697LysLeu: 5.697 ± 0.091	2.068LysMet: 2.068 ± 0.048	4.556LysAsn: 4.556 ± 0.082	2.381LysPro: 2.381 ± 0.05	2.818LysGln: 2.818 ± 0.067	2.99LysArg: 2.99 ± 0.071	4.16LysSer: 4.16 ± 0.08	4.058LysThr: 4.058 ± 0.069	4.008LysVal: 4.008 ± 0.067	0.785LysTrp: 0.785 ± 0.033	3.025LysTyr: 3.025 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.761LeuAla: 5.761 ± 0.079	0.885LeuCys: 0.885 ± 0.038	4.672LeuAsp: 4.672 ± 0.085	5.11LeuGlu: 5.11 ± 0.087	4.582LeuPhe: 4.582 ± 0.084	5.367LeuGly: 5.367 ± 0.1	1.758LeuHis: 1.758 ± 0.052	6.505LeuIle: 6.505 ± 0.104	6.551LeuLys: 6.551 ± 0.097	8.376LeuLeu: 8.376 ± 0.116	2.275LeuMet: 2.275 ± 0.058	4.953LeuAsn: 4.953 ± 0.1	4.013LeuPro: 4.013 ± 0.072	3.487LeuGln: 3.487 ± 0.077	4.233LeuArg: 4.233 ± 0.074	7.119LeuSer: 7.119 ± 0.128	4.984LeuThr: 4.984 ± 0.077	4.977LeuVal: 4.977 ± 0.084	0.927LeuTrp: 0.927 ± 0.035	3.357LeuTyr: 3.357 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.849MetAla: 1.849 ± 0.055	0.172MetCys: 0.172 ± 0.014	1.37MetAsp: 1.37 ± 0.042	1.592MetGlu: 1.592 ± 0.044	0.94MetPhe: 0.94 ± 0.039	1.715MetGly: 1.715 ± 0.05	0.462MetHis: 0.462 ± 0.022	1.851MetIle: 1.851 ± 0.048	2.276MetLys: 2.276 ± 0.051	2.272MetLeu: 2.272 ± 0.062	0.734MetMet: 0.734 ± 0.029	1.631MetAsn: 1.631 ± 0.045	1.114MetPro: 1.114 ± 0.04	1.073MetGln: 1.073 ± 0.033	1.128MetArg: 1.128 ± 0.041	1.537MetSer: 1.537 ± 0.041	1.244MetThr: 1.244 ± 0.034	1.344MetVal: 1.344 ± 0.039	0.223MetTrp: 0.223 ± 0.016	0.84MetTyr: 0.84 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.52AsnAla: 3.52 ± 0.071	0.45AsnCys: 0.45 ± 0.024	3.049AsnAsp: 3.049 ± 0.071	3.57AsnGlu: 3.57 ± 0.073	2.662AsnPhe: 2.662 ± 0.056	3.66AsnGly: 3.66 ± 0.082	1.002AsnHis: 1.002 ± 0.037	4.416AsnIle: 4.416 ± 0.098	3.354AsnLys: 3.354 ± 0.074	4.748AsnLeu: 4.748 ± 0.082	1.294AsnMet: 1.294 ± 0.038	2.946AsnAsn: 2.946 ± 0.073	2.925AsnPro: 2.925 ± 0.056	1.774AsnGln: 1.774 ± 0.049	2.762AsnArg: 2.762 ± 0.052	3.342AsnSer: 3.342 ± 0.066	2.69AsnThr: 2.69 ± 0.056	3.162AsnVal: 3.162 ± 0.056	0.659AsnTrp: 0.659 ± 0.029	2.478AsnTyr: 2.478 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.553ProAla: 2.553 ± 0.055	0.275ProCys: 0.275 ± 0.023	2.893ProAsp: 2.893 ± 0.064	3.333ProGlu: 3.333 ± 0.066	2.083ProPhe: 2.083 ± 0.055	2.377ProGly: 2.377 ± 0.058	0.733ProHis: 0.733 ± 0.032	2.717ProIle: 2.717 ± 0.053	2.231ProLys: 2.231 ± 0.055	3.353ProLeu: 3.353 ± 0.066	0.918ProMet: 0.918 ± 0.032	1.979ProAsn: 1.979 ± 0.059	1.089ProPro: 1.089 ± 0.044	1.52ProGln: 1.52 ± 0.041	1.348ProArg: 1.348 ± 0.036	2.451ProSer: 2.451 ± 0.058	1.938ProThr: 1.938 ± 0.05	2.856ProVal: 2.856 ± 0.056	0.459ProTrp: 0.459 ± 0.026	1.723ProTyr: 1.723 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.205GlnAla: 2.205 ± 0.053	0.237GlnCys: 0.237 ± 0.017	1.45GlnAsp: 1.45 ± 0.042	2.014GlnGlu: 2.014 ± 0.053	1.596GlnPhe: 1.596 ± 0.047	1.934GlnGly: 1.934 ± 0.045	0.686GlnHis: 0.686 ± 0.029	3.037GlnIle: 3.037 ± 0.064	2.809GlnLys: 2.809 ± 0.078	3.493GlnLeu: 3.493 ± 0.065	1.077GlnMet: 1.077 ± 0.033	2.271GlnAsn: 2.271 ± 0.058	1.32GlnPro: 1.32 ± 0.041	1.732GlnGln: 1.732 ± 0.057	1.696GlnArg: 1.696 ± 0.048	2.272GlnSer: 2.272 ± 0.051	2.06GlnThr: 2.06 ± 0.055	1.945GlnVal: 1.945 ± 0.049	0.421GlnTrp: 0.421 ± 0.024	1.374GlnTyr: 1.374 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.67ArgAla: 2.67 ± 0.069	0.337ArgCys: 0.337 ± 0.021	2.245ArgAsp: 2.245 ± 0.053	3.181ArgGlu: 3.181 ± 0.069	2.397ArgPhe: 2.397 ± 0.054	2.491ArgGly: 2.491 ± 0.059	0.884ArgHis: 0.884 ± 0.032	3.765ArgIle: 3.765 ± 0.068	3.679ArgLys: 3.679 ± 0.074	4.321ArgLeu: 4.321 ± 0.084	1.406ArgMet: 1.406 ± 0.044	2.728ArgAsn: 2.728 ± 0.058	1.571ArgPro: 1.571 ± 0.041	1.943ArgGln: 1.943 ± 0.053	2.227ArgArg: 2.227 ± 0.069	2.603ArgSer: 2.603 ± 0.061	2.234ArgThr: 2.234 ± 0.051	2.536ArgVal: 2.536 ± 0.06	0.616ArgTrp: 0.616 ± 0.029	2.165ArgTyr: 2.165 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.173SerAla: 4.173 ± 0.075	0.644SerCys: 0.644 ± 0.03	3.82SerAsp: 3.82 ± 0.083	4.259SerGlu: 4.259 ± 0.074	3.498SerPhe: 3.498 ± 0.066	4.631SerGly: 4.631 ± 0.083	1.154SerHis: 1.154 ± 0.035	4.967SerIle: 4.967 ± 0.084	3.931SerLys: 3.931 ± 0.075	5.922SerLeu: 5.922 ± 0.088	1.476SerMet: 1.476 ± 0.049	3.113SerAsn: 3.113 ± 0.088	2.601SerPro: 2.601 ± 0.061	2.2SerGln: 2.2 ± 0.049	2.811SerArg: 2.811 ± 0.059	4.167SerSer: 4.167 ± 0.101	3.208SerThr: 3.208 ± 0.069	4.2SerVal: 4.2 ± 0.079	0.765SerTrp: 0.765 ± 0.032	2.586SerTyr: 2.586 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	3.551ThrAla: 3.551 ± 0.065	0.427ThrCys: 0.427 ± 0.025	3.273ThrAsp: 3.273 ± 0.067	3.152ThrGlu: 3.152 ± 0.071	2.655ThrPhe: 2.655 ± 0.062	3.957ThrGly: 3.957 ± 0.078	1.008ThrHis: 1.008 ± 0.033	4.218ThrIle: 4.218 ± 0.071	3.047ThrLys: 3.047 ± 0.067	5.02ThrLeu: 5.02 ± 0.088	1.076ThrMet: 1.076 ± 0.038	2.521ThrAsn: 2.521 ± 0.064	2.548ThrPro: 2.548 ± 0.059	1.773ThrGln: 1.773 ± 0.045	2.01ThrArg: 2.01 ± 0.054	3.288ThrSer: 3.288 ± 0.063	2.93ThrThr: 2.93 ± 0.07	3.515ThrVal: 3.515 ± 0.071	0.535ThrTrp: 0.535 ± 0.024	2.164ThrTyr: 2.164 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.303ValAla: 4.303 ± 0.08	0.726ValCys: 0.726 ± 0.033	3.559ValAsp: 3.559 ± 0.066	4.038ValGlu: 4.038 ± 0.075	3.142ValPhe: 3.142 ± 0.066	3.907ValGly: 3.907 ± 0.078	1.089ValHis: 1.089 ± 0.041	4.622ValIle: 4.622 ± 0.089	4.199ValLys: 4.199 ± 0.075	5.308ValLeu: 5.308 ± 0.084	1.53ValMet: 1.53 ± 0.045	3.263ValAsn: 3.263 ± 0.074	2.491ValPro: 2.491 ± 0.064	1.822ValGln: 1.822 ± 0.044	2.878ValArg: 2.878 ± 0.059	4.442ValSer: 4.442 ± 0.075	3.225ValThr: 3.225 ± 0.064	4.18ValVal: 4.18 ± 0.087	0.721ValTrp: 0.721 ± 0.034	2.316ValTyr: 2.316 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.032	0.11TrpCys: 0.11 ± 0.012	0.691TrpAsp: 0.691 ± 0.032	0.774TrpGlu: 0.774 ± 0.034	0.553TrpPhe: 0.553 ± 0.029	0.795TrpGly: 0.795 ± 0.035	0.268TrpHis: 0.268 ± 0.017	0.936TrpIle: 0.936 ± 0.037	0.88TrpLys: 0.88 ± 0.035	1.027TrpLeu: 1.027 ± 0.036	0.388TrpMet: 0.388 ± 0.023	0.719TrpAsn: 0.719 ± 0.028	0.287TrpPro: 0.287 ± 0.021	0.542TrpGln: 0.542 ± 0.025	0.565TrpArg: 0.565 ± 0.028	0.638TrpSer: 0.638 ± 0.029	0.603TrpThr: 0.603 ± 0.029	0.675TrpVal: 0.675 ± 0.029	0.146TrpTrp: 0.146 ± 0.014	0.45TrpTyr: 0.45 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.059	0.443TyrCys: 0.443 ± 0.025	2.467TyrAsp: 2.467 ± 0.065	2.358TyrGlu: 2.358 ± 0.051	2.304TyrPhe: 2.304 ± 0.061	2.831TyrGly: 2.831 ± 0.067	0.875TyrHis: 0.875 ± 0.034	2.643TyrIle: 2.643 ± 0.059	2.451TyrLys: 2.451 ± 0.058	3.912TyrLeu: 3.912 ± 0.076	0.891TyrMet: 0.891 ± 0.035	2.244TyrAsn: 2.244 ± 0.06	1.831TyrPro: 1.831 ± 0.046	1.448TyrGln: 1.448 ± 0.045	2.457TyrArg: 2.457 ± 0.055	2.707TyrSer: 2.707 ± 0.063	2.081TyrThr: 2.081 ± 0.052	2.446TyrVal: 2.446 ± 0.05	0.517TyrTrp: 0.517 ± 0.032	1.844TyrTyr: 1.844 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2317 proteins (801358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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