Amino acid dipepetide frequency for Moorella humiferrea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.058AlaAla: 14.058 ± 0.2
1.202AlaCys: 1.202 ± 0.043
4.155AlaAsp: 4.155 ± 0.075
6.398AlaGlu: 6.398 ± 0.105
3.406AlaPhe: 3.406 ± 0.065
10.091AlaGly: 10.091 ± 0.123
1.457AlaHis: 1.457 ± 0.047
5.731AlaIle: 5.731 ± 0.09
3.455AlaLys: 3.455 ± 0.072
11.129AlaLeu: 11.129 ± 0.145
2.532AlaMet: 2.532 ± 0.058
2.438AlaAsn: 2.438 ± 0.06
3.433AlaPro: 3.433 ± 0.064
2.473AlaGln: 2.473 ± 0.063
7.731AlaArg: 7.731 ± 0.107
4.145AlaSer: 4.145 ± 0.078
4.533AlaThr: 4.533 ± 0.082
9.192AlaVal: 9.192 ± 0.117
1.119AlaTrp: 1.119 ± 0.039
2.703AlaTyr: 2.703 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.032
0.214CysCys: 0.214 ± 0.02
0.434CysAsp: 0.434 ± 0.023
0.489CysGlu: 0.489 ± 0.024
0.319CysPhe: 0.319 ± 0.019
1.379CysGly: 1.379 ± 0.051
0.287CysHis: 0.287 ± 0.02
0.533CysIle: 0.533 ± 0.026
0.32CysLys: 0.32 ± 0.021
1.254CysLeu: 1.254 ± 0.041
0.222CysMet: 0.222 ± 0.017
0.344CysAsn: 0.344 ± 0.022
0.908CysPro: 0.908 ± 0.04
0.417CysGln: 0.417 ± 0.026
1.115CysArg: 1.115 ± 0.047
0.569CysSer: 0.569 ± 0.03
0.551CysThr: 0.551 ± 0.031
0.627CysVal: 0.627 ± 0.03
0.12CysTrp: 0.12 ± 0.013
0.371CysTyr: 0.371 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.848AspAla: 3.848 ± 0.078
0.49AspCys: 0.49 ± 0.024
1.829AspAsp: 1.829 ± 0.055
2.98AspGlu: 2.98 ± 0.069
2.044AspPhe: 2.044 ± 0.051
3.68AspGly: 3.68 ± 0.068
0.745AspHis: 0.745 ± 0.03
3.278AspIle: 3.278 ± 0.073
2.072AspLys: 2.072 ± 0.057
5.489AspLeu: 5.489 ± 0.079
1.044AspMet: 1.044 ± 0.035
1.374AspAsn: 1.374 ± 0.04
2.603AspPro: 2.603 ± 0.063
1.103AspGln: 1.103 ± 0.033
2.811AspArg: 2.811 ± 0.06
1.447AspSer: 1.447 ± 0.043
2.012AspThr: 2.012 ± 0.054
3.435AspVal: 3.435 ± 0.072
0.627AspTrp: 0.627 ± 0.031
1.697AspTyr: 1.697 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
7.452GluAla: 7.452 ± 0.114
0.52GluCys: 0.52 ± 0.028
2.988GluAsp: 2.988 ± 0.058
6.635GluGlu: 6.635 ± 0.126
2.034GluPhe: 2.034 ± 0.055
5.611GluGly: 5.611 ± 0.089
1.215GluHis: 1.215 ± 0.039
5.207GluIle: 5.207 ± 0.109
4.728GluLys: 4.728 ± 0.089
7.516GluLeu: 7.516 ± 0.108
1.929GluMet: 1.929 ± 0.054
2.306GluAsn: 2.306 ± 0.051
2.566GluPro: 2.566 ± 0.058
2.354GluGln: 2.354 ± 0.06
4.861GluArg: 4.861 ± 0.086
1.858GluSer: 1.858 ± 0.044
3.014GluThr: 3.014 ± 0.069
5.953GluVal: 5.953 ± 0.105
0.653GluTrp: 0.653 ± 0.033
1.826GluTyr: 1.826 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.961PheAla: 2.961 ± 0.054
0.497PheCys: 0.497 ± 0.026
1.615PheAsp: 1.615 ± 0.047
1.52PheGlu: 1.52 ± 0.045
1.754PhePhe: 1.754 ± 0.057
2.771PheGly: 2.771 ± 0.063
0.75PheHis: 0.75 ± 0.029
2.569PheIle: 2.569 ± 0.072
1.61PheLys: 1.61 ± 0.054
4.423PheLeu: 4.423 ± 0.092
0.825PheMet: 0.825 ± 0.032
1.443PheAsn: 1.443 ± 0.053
1.744PhePro: 1.744 ± 0.05
1.124PheGln: 1.124 ± 0.041
1.977PheArg: 1.977 ± 0.052
1.971PheSer: 1.971 ± 0.051
2.191PheThr: 2.191 ± 0.049
2.053PheVal: 2.053 ± 0.047
0.508PheTrp: 0.508 ± 0.028
1.387PheTyr: 1.387 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
7.194GlyAla: 7.194 ± 0.11
1.181GlyCys: 1.181 ± 0.042
3.574GlyAsp: 3.574 ± 0.075
5.829GlyGlu: 5.829 ± 0.092
2.973GlyPhe: 2.973 ± 0.065
6.849GlyGly: 6.849 ± 0.108
1.528GlyHis: 1.528 ± 0.046
5.774GlyIle: 5.774 ± 0.106
4.458GlyLys: 4.458 ± 0.077
9.15GlyLeu: 9.15 ± 0.127
2.208GlyMet: 2.208 ± 0.055
2.571GlyAsn: 2.571 ± 0.055
3.209GlyPro: 3.209 ± 0.075
2.737GlyGln: 2.737 ± 0.061
6.34GlyArg: 6.34 ± 0.102
4.047GlySer: 4.047 ± 0.081
4.327GlyThr: 4.327 ± 0.076
6.261GlyVal: 6.261 ± 0.094
1.108GlyTrp: 1.108 ± 0.041
2.909GlyTyr: 2.909 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.297HisAla: 1.297 ± 0.047
0.302HisCys: 0.302 ± 0.017
0.731HisAsp: 0.731 ± 0.031
0.928HisGlu: 0.928 ± 0.034
0.738HisPhe: 0.738 ± 0.031
1.537HisGly: 1.537 ± 0.043
0.48HisHis: 0.48 ± 0.028
1.018HisIle: 1.018 ± 0.037
0.597HisLys: 0.597 ± 0.028
2.219HisLeu: 2.219 ± 0.057
0.36HisMet: 0.36 ± 0.023
0.594HisAsn: 0.594 ± 0.031
1.275HisPro: 1.275 ± 0.047
0.621HisGln: 0.621 ± 0.023
1.192HisArg: 1.192 ± 0.04
0.749HisSer: 0.749 ± 0.031
0.894HisThr: 0.894 ± 0.029
1.076HisVal: 1.076 ± 0.038
0.191HisTrp: 0.191 ± 0.015
0.62HisTyr: 0.62 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.158IleAla: 6.158 ± 0.093
0.724IleCys: 0.724 ± 0.029
3.127IleAsp: 3.127 ± 0.068
3.724IleGlu: 3.724 ± 0.07
2.428IlePhe: 2.428 ± 0.062
4.673IleGly: 4.673 ± 0.095
1.022IleHis: 1.022 ± 0.038
4.733IleIle: 4.733 ± 0.087
3.57IleLys: 3.57 ± 0.079
6.706IleLeu: 6.706 ± 0.103
1.479IleMet: 1.479 ± 0.045
2.504IleAsn: 2.504 ± 0.061
3.194IlePro: 3.194 ± 0.062
1.67IleGln: 1.67 ± 0.051
3.372IleArg: 3.372 ± 0.08
3.052IleSer: 3.052 ± 0.075
3.747IleThr: 3.747 ± 0.081
4.382IleVal: 4.382 ± 0.075
0.612IleTrp: 0.612 ± 0.032
1.953IleTyr: 1.953 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.486LysAla: 4.486 ± 0.072
0.361LysCys: 0.361 ± 0.027
2.368LysAsp: 2.368 ± 0.066
4.45LysGlu: 4.45 ± 0.09
1.213LysPhe: 1.213 ± 0.036
3.99LysGly: 3.99 ± 0.079
0.675LysHis: 0.675 ± 0.025
3.474LysIle: 3.474 ± 0.073
2.945LysLys: 2.945 ± 0.07
4.074LysLeu: 4.074 ± 0.077
1.288LysMet: 1.288 ± 0.042
1.72LysAsn: 1.72 ± 0.054
1.994LysPro: 1.994 ± 0.052
1.336LysGln: 1.336 ± 0.045
2.565LysArg: 2.565 ± 0.058
1.861LysSer: 1.861 ± 0.049
2.292LysThr: 2.292 ± 0.055
4.067LysVal: 4.067 ± 0.075
0.434LysTrp: 0.434 ± 0.022
1.406LysTyr: 1.406 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
13.158LeuAla: 13.158 ± 0.158
0.967LeuCys: 0.967 ± 0.034
5.016LeuAsp: 5.016 ± 0.078
8.221LeuGlu: 8.221 ± 0.134
3.615LeuPhe: 3.615 ± 0.071
8.641LeuGly: 8.641 ± 0.106
1.748LeuHis: 1.748 ± 0.049
6.102LeuIle: 6.102 ± 0.105
6.293LeuLys: 6.293 ± 0.095
11.605LeuLeu: 11.605 ± 0.156
2.374LeuMet: 2.374 ± 0.061
3.587LeuAsn: 3.587 ± 0.075
6.081LeuPro: 6.081 ± 0.089
3.899LeuGln: 3.899 ± 0.086
6.242LeuArg: 6.242 ± 0.103
4.984LeuSer: 4.984 ± 0.094
5.756LeuThr: 5.756 ± 0.091
8.11LeuVal: 8.11 ± 0.101
1.068LeuTrp: 1.068 ± 0.034
3.006LeuTyr: 3.006 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
3.072MetAla: 3.072 ± 0.066
0.161MetCys: 0.161 ± 0.013
1.129MetAsp: 1.129 ± 0.036
1.826MetGlu: 1.826 ± 0.055
0.648MetPhe: 0.648 ± 0.032
2.127MetGly: 2.127 ± 0.057
0.362MetHis: 0.362 ± 0.021
1.234MetIle: 1.234 ± 0.038
1.048MetLys: 1.048 ± 0.035
2.291MetLeu: 2.291 ± 0.063
0.48MetMet: 0.48 ± 0.026
0.675MetAsn: 0.675 ± 0.028
1.172MetPro: 1.172 ± 0.039
0.771MetGln: 0.771 ± 0.034
1.234MetArg: 1.234 ± 0.039
1.007MetSer: 1.007 ± 0.039
1.237MetThr: 1.237 ± 0.041
2.128MetVal: 2.128 ± 0.048
0.179MetTrp: 0.179 ± 0.016
0.456MetTyr: 0.456 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.416AsnAla: 2.416 ± 0.061
0.415AsnCys: 0.415 ± 0.024
1.304AsnAsp: 1.304 ± 0.042
1.77AsnGlu: 1.77 ± 0.046
1.315AsnPhe: 1.315 ± 0.045
2.329AsnGly: 2.329 ± 0.051
0.54AsnHis: 0.54 ± 0.026
2.282AsnIle: 2.282 ± 0.062
1.393AsnLys: 1.393 ± 0.039
3.907AsnLeu: 3.907 ± 0.072
0.752AsnMet: 0.752 ± 0.028
1.156AsnAsn: 1.156 ± 0.042
2.082AsnPro: 2.082 ± 0.061
0.893AsnGln: 0.893 ± 0.033
2.04AsnArg: 2.04 ± 0.053
1.341AsnSer: 1.341 ± 0.049
1.471AsnThr: 1.471 ± 0.049
2.04AsnVal: 2.04 ± 0.052
0.419AsnTrp: 0.419 ± 0.025
1.15AsnTyr: 1.15 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
5.081ProAla: 5.081 ± 0.09
0.53ProCys: 0.53 ± 0.027
2.605ProAsp: 2.605 ± 0.065
4.551ProGlu: 4.551 ± 0.086
1.838ProPhe: 1.838 ± 0.047
5.01ProGly: 5.01 ± 0.096
0.896ProHis: 0.896 ± 0.034
2.05ProIle: 2.05 ± 0.052
1.425ProLys: 1.425 ± 0.047
4.919ProLeu: 4.919 ± 0.096
0.866ProMet: 0.866 ± 0.036
1.196ProAsn: 1.196 ± 0.042
2.52ProPro: 2.52 ± 0.063
1.575ProGln: 1.575 ± 0.048
2.944ProArg: 2.944 ± 0.066
2.064ProSer: 2.064 ± 0.053
1.926ProThr: 1.926 ± 0.051
4.467ProVal: 4.467 ± 0.089
0.649ProTrp: 0.649 ± 0.03
1.631ProTyr: 1.631 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.712GlnAla: 3.712 ± 0.075
0.283GlnCys: 0.283 ± 0.018
1.388GlnAsp: 1.388 ± 0.043
3.185GlnGlu: 3.185 ± 0.062
0.88GlnPhe: 0.88 ± 0.03
2.643GlnGly: 2.643 ± 0.066
0.499GlnHis: 0.499 ± 0.027
1.913GlnIle: 1.913 ± 0.049
1.803GlnLys: 1.803 ± 0.053
3.072GlnLeu: 3.072 ± 0.067
0.818GlnMet: 0.818 ± 0.033
0.878GlnAsn: 0.878 ± 0.034
1.464GlnPro: 1.464 ± 0.044
1.455GlnGln: 1.455 ± 0.05
1.99GlnArg: 1.99 ± 0.057
1.078GlnSer: 1.078 ± 0.033
1.251GlnThr: 1.251 ± 0.036
3.153GlnVal: 3.153 ± 0.059
0.319GlnTrp: 0.319 ± 0.023
0.817GlnTyr: 0.817 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.611ArgAla: 5.611 ± 0.097
0.772ArgCys: 0.772 ± 0.035
2.792ArgAsp: 2.792 ± 0.051
6.188ArgGlu: 6.188 ± 0.107
2.249ArgPhe: 2.249 ± 0.051
4.599ArgGly: 4.599 ± 0.093
1.36ArgHis: 1.36 ± 0.037
3.515ArgIle: 3.515 ± 0.076
2.591ArgLys: 2.591 ± 0.059
8.164ArgLeu: 8.164 ± 0.108
1.48ArgMet: 1.48 ± 0.043
1.692ArgAsn: 1.692 ± 0.046
3.354ArgPro: 3.354 ± 0.068
3.351ArgGln: 3.351 ± 0.066
6.147ArgArg: 6.147 ± 0.113
2.425ArgSer: 2.425 ± 0.051
2.575ArgThr: 2.575 ± 0.057
5.033ArgVal: 5.033 ± 0.086
0.809ArgTrp: 0.809 ± 0.032
2.294ArgTyr: 2.294 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
3.086SerAla: 3.086 ± 0.067
0.61SerCys: 0.61 ± 0.026
1.701SerAsp: 1.701 ± 0.043
2.057SerGlu: 2.057 ± 0.058
1.955SerPhe: 1.955 ± 0.05
4.131SerGly: 4.131 ± 0.074
0.835SerHis: 0.835 ± 0.032
2.641SerIle: 2.641 ± 0.068
1.437SerLys: 1.437 ± 0.05
5.595SerLeu: 5.595 ± 0.096
1.018SerMet: 1.018 ± 0.034
1.177SerAsn: 1.177 ± 0.045
2.331SerPro: 2.331 ± 0.052
1.352SerGln: 1.352 ± 0.041
3.353SerArg: 3.353 ± 0.063
2.131SerSer: 2.131 ± 0.061
2.124SerThr: 2.124 ± 0.054
2.561SerVal: 2.561 ± 0.05
0.672SerTrp: 0.672 ± 0.027
1.436SerTyr: 1.436 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.371ThrAla: 5.371 ± 0.089
0.645ThrCys: 0.645 ± 0.029
1.923ThrAsp: 1.923 ± 0.048
2.475ThrGlu: 2.475 ± 0.059
1.905ThrPhe: 1.905 ± 0.052
5.144ThrGly: 5.144 ± 0.084
0.813ThrHis: 0.813 ± 0.033
3.21ThrIle: 3.21 ± 0.07
1.689ThrLys: 1.689 ± 0.042
5.394ThrLeu: 5.394 ± 0.093
1.042ThrMet: 1.042 ± 0.04
1.368ThrAsn: 1.368 ± 0.046
2.892ThrPro: 2.892 ± 0.075
1.086ThrGln: 1.086 ± 0.038
2.929ThrArg: 2.929 ± 0.06
2.295ThrSer: 2.295 ± 0.052
2.667ThrThr: 2.667 ± 0.062
4.216ThrVal: 4.216 ± 0.084
0.574ThrTrp: 0.574 ± 0.029
1.489ThrTyr: 1.489 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
8.425ValAla: 8.425 ± 0.125
0.786ValCys: 0.786 ± 0.036
3.949ValAsp: 3.949 ± 0.071
5.466ValGlu: 5.466 ± 0.094
2.701ValPhe: 2.701 ± 0.059
5.496ValGly: 5.496 ± 0.093
1.213ValHis: 1.213 ± 0.04
5.181ValIle: 5.181 ± 0.086
4.057ValLys: 4.057 ± 0.073
8.21ValLeu: 8.21 ± 0.103
1.77ValMet: 1.77 ± 0.047
2.596ValAsn: 2.596 ± 0.063
3.766ValPro: 3.766 ± 0.075
2.229ValGln: 2.229 ± 0.057
4.597ValArg: 4.597 ± 0.084
3.286ValSer: 3.286 ± 0.061
4.528ValThr: 4.528 ± 0.086
6.522ValVal: 6.522 ± 0.125
0.663ValTrp: 0.663 ± 0.029
2.246ValTyr: 2.246 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.872TrpAla: 0.872 ± 0.042
0.113TrpCys: 0.113 ± 0.011
0.531TrpAsp: 0.531 ± 0.028
0.863TrpGlu: 0.863 ± 0.032
0.35TrpPhe: 0.35 ± 0.022
0.873TrpGly: 0.873 ± 0.035
0.261TrpHis: 0.261 ± 0.019
0.524TrpIle: 0.524 ± 0.024
0.396TrpLys: 0.396 ± 0.021
1.456TrpLeu: 1.456 ± 0.044
0.247TrpMet: 0.247 ± 0.017
0.311TrpAsn: 0.311 ± 0.022
0.569TrpPro: 0.569 ± 0.028
0.849TrpGln: 0.849 ± 0.036
0.977TrpArg: 0.977 ± 0.039
0.508TrpSer: 0.508 ± 0.028
0.438TrpThr: 0.438 ± 0.025
0.666TrpVal: 0.666 ± 0.029
0.216TrpTrp: 0.216 ± 0.015
0.338TrpTyr: 0.338 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.378TyrAla: 2.378 ± 0.058
0.447TyrCys: 0.447 ± 0.024
1.448TyrAsp: 1.448 ± 0.05
1.671TyrGlu: 1.671 ± 0.051
1.329TyrPhe: 1.329 ± 0.042
2.651TyrGly: 2.651 ± 0.058
0.731TyrHis: 0.731 ± 0.029
1.859TyrIle: 1.859 ± 0.053
1.113TyrLys: 1.113 ± 0.044
3.902TyrLeu: 3.902 ± 0.085
0.505TyrMet: 0.505 ± 0.027
1.085TyrAsn: 1.085 ± 0.046
1.587TyrPro: 1.587 ± 0.051
1.307TyrGln: 1.307 ± 0.039
2.583TyrArg: 2.583 ± 0.063
1.384TyrSer: 1.384 ± 0.041
1.592TyrThr: 1.592 ± 0.048
1.747TyrVal: 1.747 ± 0.055
0.416TyrTrp: 0.416 ± 0.025
1.213TyrTyr: 1.213 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2665 proteins (780899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski