Amino acid dipepetide frequency for Lysinibacillus manganicus DSM 26584

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.956AlaAla: 4.956 ± 0.097	0.556AlaCys: 0.556 ± 0.024	3.043AlaAsp: 3.043 ± 0.063	4.269AlaGlu: 4.269 ± 0.075	3.153AlaPhe: 3.153 ± 0.054	4.716AlaGly: 4.716 ± 0.081	1.204AlaHis: 1.204 ± 0.04	6.354AlaIle: 6.354 ± 0.08	4.671AlaLys: 4.671 ± 0.075	6.767AlaLeu: 6.767 ± 0.096	1.829AlaMet: 1.829 ± 0.045	2.992AlaAsn: 2.992 ± 0.054	1.879AlaPro: 1.879 ± 0.048	2.201AlaGln: 2.201 ± 0.045	2.473AlaArg: 2.473 ± 0.057	3.803AlaSer: 3.803 ± 0.071	3.753AlaThr: 3.753 ± 0.068	4.915AlaVal: 4.915 ± 0.074	0.522AlaTrp: 0.522 ± 0.026	2.094AlaTyr: 2.094 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.438CysAla: 0.438 ± 0.023	0.098CysCys: 0.098 ± 0.01	0.374CysAsp: 0.374 ± 0.02	0.439CysGlu: 0.439 ± 0.02	0.288CysPhe: 0.288 ± 0.016	0.7CysGly: 0.7 ± 0.029	0.184CysHis: 0.184 ± 0.019	0.612CysIle: 0.612 ± 0.024	0.371CysLys: 0.371 ± 0.029	0.62CysLeu: 0.62 ± 0.024	0.149CysMet: 0.149 ± 0.011	0.346CysAsn: 0.346 ± 0.02	0.329CysPro: 0.329 ± 0.019	0.198CysGln: 0.198 ± 0.015	0.257CysArg: 0.257 ± 0.015	0.486CysSer: 0.486 ± 0.025	0.366CysThr: 0.366 ± 0.018	0.396CysVal: 0.396 ± 0.017	0.071CysTrp: 0.071 ± 0.008	0.226CysTyr: 0.226 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.303AspAla: 3.303 ± 0.057	0.374AspCys: 0.374 ± 0.02	2.405AspAsp: 2.405 ± 0.052	4.744AspGlu: 4.744 ± 0.08	2.523AspPhe: 2.523 ± 0.049	3.44AspGly: 3.44 ± 0.065	1.084AspHis: 1.084 ± 0.035	4.134AspIle: 4.134 ± 0.07	2.907AspLys: 2.907 ± 0.053	4.886AspLeu: 4.886 ± 0.072	1.239AspMet: 1.239 ± 0.034	1.882AspAsn: 1.882 ± 0.042	1.846AspPro: 1.846 ± 0.041	1.874AspGln: 1.874 ± 0.045	1.989AspArg: 1.989 ± 0.047	2.701AspSer: 2.701 ± 0.051	2.399AspThr: 2.399 ± 0.047	3.78AspVal: 3.78 ± 0.06	0.548AspTrp: 0.548 ± 0.022	2.189AspTyr: 2.189 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.933GluAla: 4.933 ± 0.08	0.373GluCys: 0.373 ± 0.018	4.013GluAsp: 4.013 ± 0.064	6.599GluGlu: 6.599 ± 0.1	2.979GluPhe: 2.979 ± 0.055	4.299GluGly: 4.299 ± 0.064	1.516GluHis: 1.516 ± 0.044	6.353GluIle: 6.353 ± 0.083	6.365GluLys: 6.365 ± 0.09	7.403GluLeu: 7.403 ± 0.092	2.248GluMet: 2.248 ± 0.05	4.036GluAsn: 4.036 ± 0.056	1.912GluPro: 1.912 ± 0.043	3.537GluGln: 3.537 ± 0.059	3.22GluArg: 3.22 ± 0.058	3.685GluSer: 3.685 ± 0.062	3.838GluThr: 3.838 ± 0.063	5.435GluVal: 5.435 ± 0.072	0.783GluTrp: 0.783 ± 0.028	2.286GluTyr: 2.286 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.14PheAla: 3.14 ± 0.06	0.371PheCys: 0.371 ± 0.023	2.528PheAsp: 2.528 ± 0.049	3.298PheGlu: 3.298 ± 0.054	2.385PhePhe: 2.385 ± 0.066	3.45PheGly: 3.45 ± 0.069	0.931PheHis: 0.931 ± 0.03	4.432PheIle: 4.432 ± 0.087	2.613PheLys: 2.613 ± 0.049	4.501PheLeu: 4.501 ± 0.08	1.203PheMet: 1.203 ± 0.036	2.292PheAsn: 2.292 ± 0.046	1.584PhePro: 1.584 ± 0.041	1.553PheGln: 1.553 ± 0.035	1.456PheArg: 1.456 ± 0.037	3.237PheSer: 3.237 ± 0.061	2.887PheThr: 2.887 ± 0.057	3.467PheVal: 3.467 ± 0.07	0.484PheTrp: 0.484 ± 0.023	1.746PheTyr: 1.746 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.556GlyAla: 4.556 ± 0.078	0.554GlyCys: 0.554 ± 0.024	3.088GlyAsp: 3.088 ± 0.066	4.508GlyGlu: 4.508 ± 0.067	3.392GlyPhe: 3.392 ± 0.06	4.571GlyGly: 4.571 ± 0.085	1.368GlyHis: 1.368 ± 0.04	6.113GlyIle: 6.113 ± 0.094	4.652GlyLys: 4.652 ± 0.062	6.269GlyLeu: 6.269 ± 0.088	1.883GlyMet: 1.883 ± 0.044	2.836GlyAsn: 2.836 ± 0.063	1.546GlyPro: 1.546 ± 0.045	2.173GlyGln: 2.173 ± 0.053	2.422GlyArg: 2.422 ± 0.055	3.837GlySer: 3.837 ± 0.065	3.979GlyThr: 3.979 ± 0.07	4.931GlyVal: 4.931 ± 0.073	0.732GlyTrp: 0.732 ± 0.027	2.732GlyTyr: 2.732 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.205HisAla: 1.205 ± 0.033	0.187HisCys: 0.187 ± 0.013	0.956HisAsp: 0.956 ± 0.038	1.455HisGlu: 1.455 ± 0.044	1.045HisPhe: 1.045 ± 0.035	1.313HisGly: 1.313 ± 0.037	0.66HisHis: 0.66 ± 0.042	1.609HisIle: 1.609 ± 0.042	1.061HisLys: 1.061 ± 0.036	2.02HisLeu: 2.02 ± 0.04	0.426HisMet: 0.426 ± 0.02	0.853HisAsn: 0.853 ± 0.031	1.048HisPro: 1.048 ± 0.03	0.813HisGln: 0.813 ± 0.031	0.743HisArg: 0.743 ± 0.03	1.232HisSer: 1.232 ± 0.042	1.01HisThr: 1.01 ± 0.035	1.345HisVal: 1.345 ± 0.039	0.208HisTrp: 0.208 ± 0.015	0.846HisTyr: 0.846 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.361IleAla: 6.361 ± 0.091	0.655IleCys: 0.655 ± 0.024	4.791IleAsp: 4.791 ± 0.072	6.679IleGlu: 6.679 ± 0.083	3.835IlePhe: 3.835 ± 0.078	6.108IleGly: 6.108 ± 0.093	1.666IleHis: 1.666 ± 0.044	7.107IleIle: 7.107 ± 0.11	4.582IleLys: 4.582 ± 0.085	8.033IleLeu: 8.033 ± 0.105	1.833IleMet: 1.833 ± 0.045	3.769IleAsn: 3.769 ± 0.075	3.457IlePro: 3.457 ± 0.065	3.164IleGln: 3.164 ± 0.064	3.181IleArg: 3.181 ± 0.061	5.581IleSer: 5.581 ± 0.086	4.849IleThr: 4.849 ± 0.075	6.397IleVal: 6.397 ± 0.093	0.682IleTrp: 0.682 ± 0.026	2.766IleTyr: 2.766 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.008LysAla: 4.008 ± 0.067	0.38LysCys: 0.38 ± 0.026	3.61LysAsp: 3.61 ± 0.059	6.4LysGlu: 6.4 ± 0.083	2.337LysPhe: 2.337 ± 0.048	4.106LysGly: 4.106 ± 0.06	1.311LysHis: 1.311 ± 0.042	5.053LysIle: 5.053 ± 0.074	5.301LysLys: 5.301 ± 0.096	6.146LysLeu: 6.146 ± 0.077	2.207LysMet: 2.207 ± 0.041	3.607LysAsn: 3.607 ± 0.068	2.11LysPro: 2.11 ± 0.042	2.813LysGln: 2.813 ± 0.057	2.947LysArg: 2.947 ± 0.052	3.817LysSer: 3.817 ± 0.062	3.658LysThr: 3.658 ± 0.061	4.782LysVal: 4.782 ± 0.076	0.772LysTrp: 0.772 ± 0.029	2.382LysTyr: 2.382 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.952LeuAla: 6.952 ± 0.09	0.659LeuCys: 0.659 ± 0.028	4.726LeuAsp: 4.726 ± 0.066	6.717LeuGlu: 6.717 ± 0.092	4.946LeuPhe: 4.946 ± 0.085	6.186LeuGly: 6.186 ± 0.091	1.844LeuHis: 1.844 ± 0.043	7.764LeuIle: 7.764 ± 0.128	6.691LeuLys: 6.691 ± 0.088	9.938LeuLeu: 9.938 ± 0.124	2.443LeuMet: 2.443 ± 0.054	4.767LeuAsn: 4.767 ± 0.078	3.723LeuPro: 3.723 ± 0.056	3.593LeuGln: 3.593 ± 0.063	3.45LeuArg: 3.45 ± 0.064	6.627LeuSer: 6.627 ± 0.084	5.671LeuThr: 5.671 ± 0.081	6.666LeuVal: 6.666 ± 0.092	0.754LeuTrp: 0.754 ± 0.03	3.135LeuTyr: 3.135 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.709MetAla: 1.709 ± 0.042	0.141MetCys: 0.141 ± 0.01	1.355MetAsp: 1.355 ± 0.038	1.836MetGlu: 1.836 ± 0.042	1.11MetPhe: 1.11 ± 0.035	1.67MetGly: 1.67 ± 0.047	0.468MetHis: 0.468 ± 0.024	2.162MetIle: 2.162 ± 0.051	2.328MetLys: 2.328 ± 0.044	2.365MetLeu: 2.365 ± 0.054	0.794MetMet: 0.794 ± 0.027	1.545MetAsn: 1.545 ± 0.036	0.983MetPro: 0.983 ± 0.036	0.881MetGln: 0.881 ± 0.031	1.069MetArg: 1.069 ± 0.035	1.65MetSer: 1.65 ± 0.039	1.583MetThr: 1.583 ± 0.043	1.569MetVal: 1.569 ± 0.034	0.18MetTrp: 0.18 ± 0.011	0.768MetTyr: 0.768 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.972AsnAla: 2.972 ± 0.056	0.316AsnCys: 0.316 ± 0.018	2.446AsnAsp: 2.446 ± 0.047	4.239AsnGlu: 4.239 ± 0.07	2.016AsnPhe: 2.016 ± 0.049	3.455AsnGly: 3.455 ± 0.069	1.063AsnHis: 1.063 ± 0.036	3.928AsnIle: 3.928 ± 0.076	3.11AsnLys: 3.11 ± 0.058	4.432AsnLeu: 4.432 ± 0.067	1.252AsnMet: 1.252 ± 0.037	2.56AsnAsn: 2.56 ± 0.068	2.204AsnPro: 2.204 ± 0.055	1.856AsnGln: 1.856 ± 0.056	2.147AsnArg: 2.147 ± 0.048	2.773AsnSer: 2.773 ± 0.053	2.454AsnThr: 2.454 ± 0.053	3.349AsnVal: 3.349 ± 0.053	0.542AsnTrp: 0.542 ± 0.021	1.892AsnTyr: 1.892 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	1.89ProAla: 1.89 ± 0.04	0.195ProCys: 0.195 ± 0.014	1.7ProAsp: 1.7 ± 0.041	2.753ProGlu: 2.753 ± 0.055	1.973ProPhe: 1.973 ± 0.048	2.064ProGly: 2.064 ± 0.048	0.757ProHis: 0.757 ± 0.023	3.186ProIle: 3.186 ± 0.061	2.259ProLys: 2.259 ± 0.05	3.169ProLeu: 3.169 ± 0.054	0.798ProMet: 0.798 ± 0.033	1.887ProAsn: 1.887 ± 0.044	0.898ProPro: 0.898 ± 0.028	1.096ProGln: 1.096 ± 0.036	0.965ProArg: 0.965 ± 0.032	2.21ProSer: 2.21 ± 0.044	2.223ProThr: 2.223 ± 0.05	2.634ProVal: 2.634 ± 0.059	0.328ProTrp: 0.328 ± 0.021	1.398ProTyr: 1.398 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.438GlnAla: 2.438 ± 0.054	0.18GlnCys: 0.18 ± 0.013	1.588GlnAsp: 1.588 ± 0.04	2.555GlnGlu: 2.555 ± 0.057	1.874GlnPhe: 1.874 ± 0.043	1.9GlnGly: 1.9 ± 0.043	0.793GlnHis: 0.793 ± 0.027	2.911GlnIle: 2.911 ± 0.052	2.549GlnLys: 2.549 ± 0.051	4.145GlnLeu: 4.145 ± 0.077	1.091GlnMet: 1.091 ± 0.038	1.904GlnAsn: 1.904 ± 0.048	1.168GlnPro: 1.168 ± 0.041	1.72GlnGln: 1.72 ± 0.053	1.334GlnArg: 1.334 ± 0.038	2.224GlnSer: 2.224 ± 0.046	2.001GlnThr: 2.001 ± 0.042	2.363GlnVal: 2.363 ± 0.052	0.347GlnTrp: 0.347 ± 0.019	1.478GlnTyr: 1.478 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.338ArgAla: 2.338 ± 0.05	0.232ArgCys: 0.232 ± 0.017	1.934ArgAsp: 1.934 ± 0.044	2.995ArgGlu: 2.995 ± 0.054	1.884ArgPhe: 1.884 ± 0.043	2.294ArgGly: 2.294 ± 0.048	0.728ArgHis: 0.728 ± 0.029	3.06ArgIle: 3.06 ± 0.054	2.966ArgLys: 2.966 ± 0.063	3.609ArgLeu: 3.609 ± 0.069	1.087ArgMet: 1.087 ± 0.032	2.006ArgAsn: 2.006 ± 0.048	1.215ArgPro: 1.215 ± 0.037	1.389ArgGln: 1.389 ± 0.04	1.597ArgArg: 1.597 ± 0.046	2.057ArgSer: 2.057 ± 0.045	1.971ArgThr: 1.971 ± 0.047	2.589ArgVal: 2.589 ± 0.054	0.343ArgTrp: 0.343 ± 0.018	1.39ArgTyr: 1.39 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.473SerAla: 3.473 ± 0.059	0.364SerCys: 0.364 ± 0.019	2.705SerAsp: 2.705 ± 0.048	4.133SerGlu: 4.133 ± 0.074	3.386SerPhe: 3.386 ± 0.058	4.149SerGly: 4.149 ± 0.077	1.161SerHis: 1.161 ± 0.033	5.783SerIle: 5.783 ± 0.084	4.218SerLys: 4.218 ± 0.077	6.068SerLeu: 6.068 ± 0.083	1.59SerMet: 1.59 ± 0.039	3.118SerAsn: 3.118 ± 0.059	1.978SerPro: 1.978 ± 0.047	1.978SerGln: 1.978 ± 0.046	2.184SerArg: 2.184 ± 0.058	3.921SerSer: 3.921 ± 0.077	3.314SerThr: 3.314 ± 0.051	4.043SerVal: 4.043 ± 0.067	0.572SerTrp: 0.572 ± 0.022	2.338SerTyr: 2.338 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.688ThrAla: 3.688 ± 0.072	0.344ThrCys: 0.344 ± 0.021	2.73ThrAsp: 2.73 ± 0.056	3.662ThrGlu: 3.662 ± 0.065	2.75ThrPhe: 2.75 ± 0.05	3.919ThrGly: 3.919 ± 0.064	1.027ThrHis: 1.027 ± 0.03	5.263ThrIle: 5.263 ± 0.073	3.629ThrLys: 3.629 ± 0.065	5.326ThrLeu: 5.326 ± 0.07	1.283ThrMet: 1.283 ± 0.034	2.951ThrAsn: 2.951 ± 0.057	2.269ThrPro: 2.269 ± 0.047	1.547ThrGln: 1.547 ± 0.04	1.794ThrArg: 1.794 ± 0.035	3.435ThrSer: 3.435 ± 0.058	3.324ThrThr: 3.324 ± 0.065	4.291ThrVal: 4.291 ± 0.07	0.484ThrTrp: 0.484 ± 0.023	2.034ThrTyr: 2.034 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	5.126ValAla: 5.126 ± 0.094	0.569ValCys: 0.569 ± 0.024	3.735ValAsp: 3.735 ± 0.06	5.239ValGlu: 5.239 ± 0.075	3.247ValPhe: 3.247 ± 0.062	4.763ValGly: 4.763 ± 0.072	1.343ValHis: 1.343 ± 0.042	5.988ValIle: 5.988 ± 0.08	4.68ValLys: 4.68 ± 0.072	6.904ValLeu: 6.904 ± 0.097	1.72ValMet: 1.72 ± 0.04	3.43ValAsn: 3.43 ± 0.067	2.621ValPro: 2.621 ± 0.052	2.468ValGln: 2.468 ± 0.052	2.626ValArg: 2.626 ± 0.05	4.452ValSer: 4.452 ± 0.065	4.132ValThr: 4.132 ± 0.072	5.44ValVal: 5.44 ± 0.081	0.58ValTrp: 0.58 ± 0.025	2.313ValTyr: 2.313 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.54TrpAla: 0.54 ± 0.025	0.068TrpCys: 0.068 ± 0.008	0.502TrpAsp: 0.502 ± 0.019	0.585TrpGlu: 0.585 ± 0.024	0.502TrpPhe: 0.502 ± 0.024	0.63TrpGly: 0.63 ± 0.027	0.191TrpHis: 0.191 ± 0.015	0.877TrpIle: 0.877 ± 0.032	0.635TrpLys: 0.635 ± 0.028	1.015TrpLeu: 1.015 ± 0.034	0.285TrpMet: 0.285 ± 0.017	0.549TrpAsn: 0.549 ± 0.025	0.241TrpPro: 0.241 ± 0.017	0.351TrpGln: 0.351 ± 0.02	0.324TrpArg: 0.324 ± 0.017	0.541TrpSer: 0.541 ± 0.02	0.499TrpThr: 0.499 ± 0.022	0.651TrpVal: 0.651 ± 0.024	0.122TrpTrp: 0.122 ± 0.012	0.306TrpTyr: 0.306 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.124TyrAla: 2.124 ± 0.044	0.333TyrCys: 0.333 ± 0.018	2.017TyrAsp: 2.017 ± 0.045	2.708TyrGlu: 2.708 ± 0.06	1.932TyrPhe: 1.932 ± 0.048	2.41TyrGly: 2.41 ± 0.05	0.736TyrHis: 0.736 ± 0.03	2.809TyrIle: 2.809 ± 0.053	2.157TyrLys: 2.157 ± 0.05	3.636TyrLeu: 3.636 ± 0.062	0.807TyrMet: 0.807 ± 0.027	1.679TyrAsn: 1.679 ± 0.041	1.374TyrPro: 1.374 ± 0.036	1.355TyrGln: 1.355 ± 0.039	1.508TyrArg: 1.508 ± 0.039	2.209TyrSer: 2.209 ± 0.056	1.834TyrThr: 1.834 ± 0.043	2.334TyrVal: 2.334 ± 0.043	0.36TyrTrp: 0.36 ± 0.019	1.48TyrTyr: 1.48 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3553 proteins (1035309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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