Amino acid dipepetide frequency for Scopulibacillus darangshiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.489AlaAla: 6.489 ± 0.074	0.703AlaCys: 0.703 ± 0.026	3.747AlaAsp: 3.747 ± 0.056	4.575AlaGlu: 4.575 ± 0.063	3.615AlaPhe: 3.615 ± 0.056	5.861AlaGly: 5.861 ± 0.075	1.38AlaHis: 1.38 ± 0.028	6.071AlaIle: 6.071 ± 0.078	5.106AlaLys: 5.106 ± 0.07	7.44AlaLeu: 7.44 ± 0.083	2.151AlaMet: 2.151 ± 0.041	2.72AlaAsn: 2.72 ± 0.042	2.247AlaPro: 2.247 ± 0.042	1.982AlaGln: 1.982 ± 0.039	2.749AlaArg: 2.749 ± 0.046	4.202AlaSer: 4.202 ± 0.054	3.314AlaThr: 3.314 ± 0.055	5.815AlaVal: 5.815 ± 0.069	0.637AlaTrp: 0.637 ± 0.024	2.465AlaTyr: 2.465 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.498CysAla: 0.498 ± 0.021	0.104CysCys: 0.104 ± 0.01	0.482CysAsp: 0.482 ± 0.019	0.465CysGlu: 0.465 ± 0.019	0.366CysPhe: 0.366 ± 0.017	0.779CysGly: 0.779 ± 0.028	0.267CysHis: 0.267 ± 0.016	0.527CysIle: 0.527 ± 0.02	0.394CysLys: 0.394 ± 0.02	0.861CysLeu: 0.861 ± 0.023	0.196CysMet: 0.196 ± 0.012	0.302CysAsn: 0.302 ± 0.014	0.405CysPro: 0.405 ± 0.018	0.314CysGln: 0.314 ± 0.017	0.369CysArg: 0.369 ± 0.015	0.553CysSer: 0.553 ± 0.022	0.388CysThr: 0.388 ± 0.016	0.444CysVal: 0.444 ± 0.017	0.084CysTrp: 0.084 ± 0.009	0.299CysTyr: 0.299 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.616AspAla: 3.616 ± 0.058	0.432AspCys: 0.432 ± 0.02	3.112AspAsp: 3.112 ± 0.055	3.753AspGlu: 3.753 ± 0.067	2.483AspPhe: 2.483 ± 0.047	3.695AspGly: 3.695 ± 0.068	1.541AspHis: 1.541 ± 0.039	4.756AspIle: 4.756 ± 0.062	3.656AspLys: 3.656 ± 0.062	5.39AspLeu: 5.39 ± 0.066	1.549AspMet: 1.549 ± 0.038	2.118AspAsn: 2.118 ± 0.045	2.271AspPro: 2.271 ± 0.045	2.26AspGln: 2.26 ± 0.042	2.461AspArg: 2.461 ± 0.048	2.607AspSer: 2.607 ± 0.047	2.477AspThr: 2.477 ± 0.039	3.994AspVal: 3.994 ± 0.06	0.709AspTrp: 0.709 ± 0.024	2.227AspTyr: 2.227 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.249GluAla: 5.249 ± 0.07	0.442GluCys: 0.442 ± 0.018	3.573GluAsp: 3.573 ± 0.06	5.263GluGlu: 5.263 ± 0.089	1.994GluPhe: 1.994 ± 0.041	4.251GluGly: 4.251 ± 0.067	1.477GluHis: 1.477 ± 0.035	4.469GluIle: 4.469 ± 0.064	6.019GluLys: 6.019 ± 0.077	6.042GluLeu: 6.042 ± 0.077	1.972GluMet: 1.972 ± 0.037	3.341GluAsn: 3.341 ± 0.053	2.023GluPro: 2.023 ± 0.042	2.825GluGln: 2.825 ± 0.053	3.373GluArg: 3.373 ± 0.062	3.389GluSer: 3.389 ± 0.059	3.578GluThr: 3.578 ± 0.049	3.897GluVal: 3.897 ± 0.059	0.785GluTrp: 0.785 ± 0.028	1.843GluTyr: 1.843 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.039PheAla: 3.039 ± 0.051	0.41PheCys: 0.41 ± 0.018	2.534PheAsp: 2.534 ± 0.04	2.473PheGlu: 2.473 ± 0.053	2.256PhePhe: 2.256 ± 0.055	3.399PheGly: 3.399 ± 0.057	0.983PheHis: 0.983 ± 0.027	3.824PheIle: 3.824 ± 0.069	2.566PheLys: 2.566 ± 0.043	4.366PheLeu: 4.366 ± 0.072	1.144PheMet: 1.144 ± 0.032	2.036PheAsn: 2.036 ± 0.041	1.697PhePro: 1.697 ± 0.039	1.475PheGln: 1.475 ± 0.036	1.59PheArg: 1.59 ± 0.035	3.062PheSer: 3.062 ± 0.055	2.479PheThr: 2.479 ± 0.047	3.013PheVal: 3.013 ± 0.053	0.517PheTrp: 0.517 ± 0.025	1.72PheTyr: 1.72 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.187GlyAla: 5.187 ± 0.078	0.712GlyCys: 0.712 ± 0.022	3.574GlyAsp: 3.574 ± 0.057	4.293GlyGlu: 4.293 ± 0.06	3.641GlyPhe: 3.641 ± 0.06	5.436GlyGly: 5.436 ± 0.083	1.708GlyHis: 1.708 ± 0.039	5.998GlyIle: 5.998 ± 0.073	5.453GlyLys: 5.453 ± 0.078	7.089GlyLeu: 7.089 ± 0.075	2.215GlyMet: 2.215 ± 0.045	2.759GlyAsn: 2.759 ± 0.043	2.059GlyPro: 2.059 ± 0.041	2.477GlyGln: 2.477 ± 0.038	2.929GlyArg: 2.929 ± 0.044	4.199GlySer: 4.199 ± 0.056	4.003GlyThr: 4.003 ± 0.061	5.353GlyVal: 5.353 ± 0.076	0.92GlyTrp: 0.92 ± 0.029	2.883GlyTyr: 2.883 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.5HisAla: 1.5 ± 0.034	0.24HisCys: 0.24 ± 0.014	1.235HisAsp: 1.235 ± 0.031	1.296HisGlu: 1.296 ± 0.035	1.192HisPhe: 1.192 ± 0.032	1.575HisGly: 1.575 ± 0.038	0.782HisHis: 0.782 ± 0.028	1.664HisIle: 1.664 ± 0.037	1.101HisLys: 1.101 ± 0.03	2.336HisLeu: 2.336 ± 0.042	0.561HisMet: 0.561 ± 0.021	0.835HisAsn: 0.835 ± 0.025	1.276HisPro: 1.276 ± 0.034	0.898HisGln: 0.898 ± 0.028	0.989HisArg: 0.989 ± 0.027	1.321HisSer: 1.321 ± 0.032	1.092HisThr: 1.092 ± 0.027	1.589HisVal: 1.589 ± 0.031	0.263HisTrp: 0.263 ± 0.015	0.958HisTyr: 0.958 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.926IleAla: 5.926 ± 0.081	0.715IleCys: 0.715 ± 0.024	4.587IleAsp: 4.587 ± 0.064	5.052IleGlu: 5.052 ± 0.062	3.288IlePhe: 3.288 ± 0.067	6.117IleGly: 6.117 ± 0.086	1.682IleHis: 1.682 ± 0.035	6.06IleIle: 6.06 ± 0.093	5.003IleLys: 5.003 ± 0.059	7.073IleLeu: 7.073 ± 0.096	1.851IleMet: 1.851 ± 0.045	3.455IleAsn: 3.455 ± 0.048	3.278IlePro: 3.278 ± 0.051	2.624IleGln: 2.624 ± 0.049	3.153IleArg: 3.153 ± 0.04	4.803IleSer: 4.803 ± 0.064	4.109IleThr: 4.109 ± 0.053	5.385IleVal: 5.385 ± 0.078	0.734IleTrp: 0.734 ± 0.022	2.459IleTyr: 2.459 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.577LysAla: 5.577 ± 0.069	0.361LysCys: 0.361 ± 0.02	4.324LysAsp: 4.324 ± 0.069	6.123LysGlu: 6.123 ± 0.063	1.776LysPhe: 1.776 ± 0.04	5.149LysGly: 5.149 ± 0.064	1.449LysHis: 1.449 ± 0.032	4.549LysIle: 4.549 ± 0.061	6.281LysLys: 6.281 ± 0.09	5.785LysLeu: 5.785 ± 0.065	2.209LysMet: 2.209 ± 0.04	3.345LysAsn: 3.345 ± 0.052	2.58LysPro: 2.58 ± 0.04	2.968LysGln: 2.968 ± 0.051	3.568LysArg: 3.568 ± 0.057	3.69LysSer: 3.69 ± 0.053	3.738LysThr: 3.738 ± 0.059	4.804LysVal: 4.804 ± 0.068	0.819LysTrp: 0.819 ± 0.024	2.129LysTyr: 2.129 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.31LeuAla: 7.31 ± 0.077	0.747LeuCys: 0.747 ± 0.023	5.027LeuAsp: 5.027 ± 0.057	5.908LeuGlu: 5.908 ± 0.073	4.698LeuPhe: 4.698 ± 0.074	6.679LeuGly: 6.679 ± 0.077	1.854LeuHis: 1.854 ± 0.04	7.434LeuIle: 7.434 ± 0.103	6.917LeuLys: 6.917 ± 0.079	9.341LeuLeu: 9.341 ± 0.111	2.512LeuMet: 2.512 ± 0.048	4.354LeuAsn: 4.354 ± 0.062	3.974LeuPro: 3.974 ± 0.053	3.134LeuGln: 3.134 ± 0.052	3.63LeuArg: 3.63 ± 0.049	6.927LeuSer: 6.927 ± 0.078	5.721LeuThr: 5.721 ± 0.065	5.919LeuVal: 5.919 ± 0.074	0.903LeuTrp: 0.903 ± 0.027	3.136LeuTyr: 3.136 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.418MetAla: 2.418 ± 0.047	0.17MetCys: 0.17 ± 0.012	1.54MetAsp: 1.54 ± 0.035	1.696MetGlu: 1.696 ± 0.035	1.035MetPhe: 1.035 ± 0.031	1.978MetGly: 1.978 ± 0.041	0.451MetHis: 0.451 ± 0.019	2.309MetIle: 2.309 ± 0.046	2.262MetLys: 2.262 ± 0.037	2.506MetLeu: 2.506 ± 0.041	0.864MetMet: 0.864 ± 0.023	1.38MetAsn: 1.38 ± 0.028	1.178MetPro: 1.178 ± 0.033	0.776MetGln: 0.776 ± 0.029	1.068MetArg: 1.068 ± 0.03	1.743MetSer: 1.743 ± 0.039	1.902MetThr: 1.902 ± 0.036	1.864MetVal: 1.864 ± 0.037	0.228MetTrp: 0.228 ± 0.013	0.702MetTyr: 0.702 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.807AsnAla: 2.807 ± 0.052	0.334AsnCys: 0.334 ± 0.017	2.589AsnAsp: 2.589 ± 0.048	3.03AsnGlu: 3.03 ± 0.054	1.522AsnPhe: 1.522 ± 0.038	3.364AsnGly: 3.364 ± 0.056	1.149AsnHis: 1.149 ± 0.03	3.258AsnIle: 3.258 ± 0.052	3.239AsnLys: 3.239 ± 0.057	3.724AsnLeu: 3.724 ± 0.056	1.174AsnMet: 1.174 ± 0.03	2.138AsnAsn: 2.138 ± 0.044	2.038AsnPro: 2.038 ± 0.037	1.872AsnGln: 1.872 ± 0.035	2.035AsnArg: 2.035 ± 0.043	2.02AsnSer: 2.02 ± 0.045	2.121AsnThr: 2.121 ± 0.042	2.971AsnVal: 2.971 ± 0.047	0.576AsnTrp: 0.576 ± 0.023	1.481AsnTyr: 1.481 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.52ProAla: 2.52 ± 0.048	0.246ProCys: 0.246 ± 0.014	2.386ProAsp: 2.386 ± 0.039	3.037ProGlu: 3.037 ± 0.048	2.111ProPhe: 2.111 ± 0.044	2.704ProGly: 2.704 ± 0.046	0.894ProHis: 0.894 ± 0.026	2.857ProIle: 2.857 ± 0.045	2.506ProLys: 2.506 ± 0.047	3.561ProLeu: 3.561 ± 0.052	0.962ProMet: 0.962 ± 0.027	1.755ProAsn: 1.755 ± 0.042	1.129ProPro: 1.129 ± 0.031	1.118ProGln: 1.118 ± 0.031	1.21ProArg: 1.21 ± 0.028	2.259ProSer: 2.259 ± 0.041	1.829ProThr: 1.829 ± 0.035	2.989ProVal: 2.989 ± 0.049	0.461ProTrp: 0.461 ± 0.021	1.502ProTyr: 1.502 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.765GlnAla: 2.765 ± 0.052	0.222GlnCys: 0.222 ± 0.014	1.722GlnAsp: 1.722 ± 0.036	2.341GlnGlu: 2.341 ± 0.044	1.438GlnPhe: 1.438 ± 0.032	2.215GlnGly: 2.215 ± 0.047	0.863GlnHis: 0.863 ± 0.024	2.38GlnIle: 2.38 ± 0.046	2.763GlnLys: 2.763 ± 0.047	3.644GlnLeu: 3.644 ± 0.057	1.118GlnMet: 1.118 ± 0.028	1.544GlnAsn: 1.544 ± 0.035	1.273GlnPro: 1.273 ± 0.032	1.466GlnGln: 1.466 ± 0.046	1.458GlnArg: 1.458 ± 0.034	2.188GlnSer: 2.188 ± 0.04	2.106GlnThr: 2.106 ± 0.039	2.114GlnVal: 2.114 ± 0.037	0.413GlnTrp: 0.413 ± 0.02	1.184GlnTyr: 1.184 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.571ArgAla: 2.571 ± 0.042	0.288ArgCys: 0.288 ± 0.017	2.293ArgAsp: 2.293 ± 0.043	3.025ArgGlu: 3.025 ± 0.062	1.931ArgPhe: 1.931 ± 0.036	2.554ArgGly: 2.554 ± 0.044	1.08ArgHis: 1.08 ± 0.031	3.078ArgIle: 3.078 ± 0.053	3.231ArgLys: 3.231 ± 0.053	4.278ArgLeu: 4.278 ± 0.055	1.325ArgMet: 1.325 ± 0.029	1.687ArgAsn: 1.687 ± 0.037	1.441ArgPro: 1.441 ± 0.036	1.663ArgGln: 1.663 ± 0.037	2.079ArgArg: 2.079 ± 0.05	2.42ArgSer: 2.42 ± 0.059	2.067ArgThr: 2.067 ± 0.041	2.727ArgVal: 2.727 ± 0.048	0.423ArgTrp: 0.423 ± 0.019	1.603ArgTyr: 1.603 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.046SerAla: 4.046 ± 0.063	0.474SerCys: 0.474 ± 0.021	3.236SerAsp: 3.236 ± 0.051	3.703SerGlu: 3.703 ± 0.057	3.128SerPhe: 3.128 ± 0.058	4.856SerGly: 4.856 ± 0.066	1.433SerHis: 1.433 ± 0.029	4.513SerIle: 4.513 ± 0.063	3.73SerLys: 3.73 ± 0.063	6.061SerLeu: 6.061 ± 0.078	1.697SerMet: 1.697 ± 0.038	2.276SerAsn: 2.276 ± 0.044	2.244SerPro: 2.244 ± 0.037	1.946SerGln: 1.946 ± 0.044	2.507SerArg: 2.507 ± 0.052	3.703SerSer: 3.703 ± 0.06	2.759SerThr: 2.759 ± 0.05	4.13SerVal: 4.13 ± 0.061	0.7SerTrp: 0.7 ± 0.027	2.103SerTyr: 2.103 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.2ThrAla: 4.2 ± 0.057	0.434ThrCys: 0.434 ± 0.019	2.801ThrAsp: 2.801 ± 0.05	3.051ThrGlu: 3.051 ± 0.047	2.64ThrPhe: 2.64 ± 0.05	4.316ThrGly: 4.316 ± 0.067	1.016ThrHis: 1.016 ± 0.029	4.351ThrIle: 4.351 ± 0.069	3.288ThrLys: 3.288 ± 0.051	5.273ThrLeu: 5.273 ± 0.065	1.371ThrMet: 1.371 ± 0.034	2.256ThrAsn: 2.256 ± 0.047	2.288ThrPro: 2.288 ± 0.042	1.409ThrGln: 1.409 ± 0.036	1.878ThrArg: 1.878 ± 0.041	3.095ThrSer: 3.095 ± 0.055	2.739ThrThr: 2.739 ± 0.047	4.201ThrVal: 4.201 ± 0.064	0.523ThrTrp: 0.523 ± 0.02	1.788ThrTyr: 1.788 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	4.758ValAla: 4.758 ± 0.062	0.663ValCys: 0.663 ± 0.024	3.669ValAsp: 3.669 ± 0.057	3.912ValGlu: 3.912 ± 0.062	3.143ValPhe: 3.143 ± 0.046	4.577ValGly: 4.577 ± 0.069	1.415ValHis: 1.415 ± 0.038	6.125ValIle: 6.125 ± 0.079	4.8ValLys: 4.8 ± 0.065	6.578ValLeu: 6.578 ± 0.079	2.028ValMet: 2.028 ± 0.048	3.181ValAsn: 3.181 ± 0.052	2.848ValPro: 2.848 ± 0.049	2.136ValGln: 2.136 ± 0.036	2.657ValArg: 2.657 ± 0.046	4.449ValSer: 4.449 ± 0.058	4.148ValThr: 4.148 ± 0.055	4.876ValVal: 4.876 ± 0.072	0.667ValTrp: 0.667 ± 0.023	2.178ValTyr: 2.178 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.668TrpAla: 0.668 ± 0.025	0.083TrpCys: 0.083 ± 0.007	0.627TrpAsp: 0.627 ± 0.024	0.679TrpGlu: 0.679 ± 0.024	0.597TrpPhe: 0.597 ± 0.022	0.779TrpGly: 0.779 ± 0.027	0.302TrpHis: 0.302 ± 0.016	0.791TrpIle: 0.791 ± 0.029	0.673TrpLys: 0.673 ± 0.023	1.304TrpLeu: 1.304 ± 0.035	0.357TrpMet: 0.357 ± 0.017	0.461TrpAsn: 0.461 ± 0.018	0.321TrpPro: 0.321 ± 0.018	0.417TrpGln: 0.417 ± 0.017	0.473TrpArg: 0.473 ± 0.017	0.623TrpSer: 0.623 ± 0.023	0.555TrpThr: 0.555 ± 0.021	0.734TrpVal: 0.734 ± 0.026	0.155TrpTrp: 0.155 ± 0.012	0.361TrpTyr: 0.361 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.128TyrAla: 2.128 ± 0.038	0.316TyrCys: 0.316 ± 0.018	2.047TyrAsp: 2.047 ± 0.046	2.131TyrGlu: 2.131 ± 0.044	1.728TyrPhe: 1.728 ± 0.039	2.601TyrGly: 2.601 ± 0.047	0.977TyrHis: 0.977 ± 0.029	2.338TyrIle: 2.338 ± 0.043	2.236TyrLys: 2.236 ± 0.04	3.475TyrLeu: 3.475 ± 0.05	0.812TyrMet: 0.812 ± 0.025	1.499TyrAsn: 1.499 ± 0.034	1.466TyrPro: 1.466 ± 0.039	1.459TyrGln: 1.459 ± 0.036	1.587TyrArg: 1.587 ± 0.042	1.994TyrSer: 1.994 ± 0.038	1.793TyrThr: 1.793 ± 0.04	1.99TyrVal: 1.99 ± 0.041	0.443TyrTrp: 0.443 ± 0.019	1.369TyrTyr: 1.369 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4593 proteins (1339328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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