Amino acid dipepetide frequency for Streptococcus phage Javan384

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.986AlaAla: 0.986 ± 0.321
0.358AlaCys: 0.358 ± 0.182
3.853AlaAsp: 3.853 ± 0.612
4.928AlaGlu: 4.928 ± 0.604
2.33AlaPhe: 2.33 ± 0.404
4.211AlaGly: 4.211 ± 0.897
0.986AlaHis: 0.986 ± 0.239
6.272AlaIle: 6.272 ± 0.953
5.197AlaLys: 5.197 ± 0.909
5.287AlaLeu: 5.287 ± 0.788
2.24AlaMet: 2.24 ± 0.459
3.047AlaAsn: 3.047 ± 0.713
1.792AlaPro: 1.792 ± 0.592
1.703AlaGln: 1.703 ± 0.462
2.867AlaArg: 2.867 ± 0.604
2.957AlaSer: 2.957 ± 0.456
3.047AlaThr: 3.047 ± 0.596
3.315AlaVal: 3.315 ± 0.628
0.806AlaTrp: 0.806 ± 0.299
3.763AlaTyr: 3.763 ± 0.574
0.0AlaXaa: 0.0 ± 0.0
Cys
0.269CysAla: 0.269 ± 0.156
0.09CysCys: 0.09 ± 0.088
0.269CysAsp: 0.269 ± 0.146
0.717CysGlu: 0.717 ± 0.266
0.538CysPhe: 0.538 ± 0.23
0.538CysGly: 0.538 ± 0.225
0.0CysHis: 0.0 ± 0.0
0.627CysIle: 0.627 ± 0.268
0.358CysLys: 0.358 ± 0.174
0.538CysLeu: 0.538 ± 0.211
0.0CysMet: 0.0 ± 0.0
0.358CysAsn: 0.358 ± 0.174
0.179CysPro: 0.179 ± 0.136
0.269CysGln: 0.269 ± 0.172
0.448CysArg: 0.448 ± 0.198
0.358CysSer: 0.358 ± 0.17
0.179CysThr: 0.179 ± 0.147
0.269CysVal: 0.269 ± 0.174
0.179CysTrp: 0.179 ± 0.129
0.538CysTyr: 0.538 ± 0.286
0.0CysXaa: 0.0 ± 0.0
Asp
2.778AspAla: 2.778 ± 0.525
0.627AspCys: 0.627 ± 0.248
4.48AspAsp: 4.48 ± 0.643
4.211AspGlu: 4.211 ± 0.737
2.778AspPhe: 2.778 ± 0.49
5.197AspGly: 5.197 ± 0.941
0.448AspHis: 0.448 ± 0.182
4.659AspIle: 4.659 ± 0.635
4.211AspLys: 4.211 ± 0.629
5.376AspLeu: 5.376 ± 0.849
0.986AspMet: 0.986 ± 0.372
4.749AspAsn: 4.749 ± 0.817
0.806AspPro: 0.806 ± 0.259
0.896AspGln: 0.896 ± 0.268
3.584AspArg: 3.584 ± 0.669
3.763AspSer: 3.763 ± 0.51
3.405AspThr: 3.405 ± 0.625
3.584AspVal: 3.584 ± 0.516
0.896AspTrp: 0.896 ± 0.362
3.584AspTyr: 3.584 ± 0.684
0.0AspXaa: 0.0 ± 0.0
Glu
4.749GluAla: 4.749 ± 0.681
0.538GluCys: 0.538 ± 0.222
3.047GluAsp: 3.047 ± 0.618
5.735GluGlu: 5.735 ± 0.881
2.599GluPhe: 2.599 ± 0.402
2.509GluGly: 2.509 ± 0.477
0.717GluHis: 0.717 ± 0.242
7.168GluIle: 7.168 ± 0.877
7.527GluLys: 7.527 ± 1.037
9.946GluLeu: 9.946 ± 0.947
1.971GluMet: 1.971 ± 0.282
4.48GluAsn: 4.48 ± 0.73
1.882GluPro: 1.882 ± 0.347
3.674GluGln: 3.674 ± 0.479
3.495GluArg: 3.495 ± 0.484
3.495GluSer: 3.495 ± 0.589
4.122GluThr: 4.122 ± 0.733
4.659GluVal: 4.659 ± 0.755
0.986GluTrp: 0.986 ± 0.337
2.061GluTyr: 2.061 ± 0.307
0.0GluXaa: 0.0 ± 0.0
Phe
2.599PheAla: 2.599 ± 0.406
0.179PheCys: 0.179 ± 0.13
3.674PheAsp: 3.674 ± 0.653
3.405PheGlu: 3.405 ± 0.599
1.165PhePhe: 1.165 ± 0.303
3.136PheGly: 3.136 ± 0.679
0.448PheHis: 0.448 ± 0.219
3.763PheIle: 3.763 ± 0.531
4.48PheLys: 4.48 ± 0.689
2.419PheLeu: 2.419 ± 0.428
0.896PheMet: 0.896 ± 0.229
3.136PheAsn: 3.136 ± 0.459
1.254PhePro: 1.254 ± 0.33
0.538PheGln: 0.538 ± 0.228
1.523PheArg: 1.523 ± 0.389
2.599PheSer: 2.599 ± 0.478
2.599PheThr: 2.599 ± 0.384
2.509PheVal: 2.509 ± 0.491
0.269PheTrp: 0.269 ± 0.154
1.613PheTyr: 1.613 ± 0.503
0.0PheXaa: 0.0 ± 0.0
Gly
3.763GlyAla: 3.763 ± 0.753
0.358GlyCys: 0.358 ± 0.199
3.853GlyAsp: 3.853 ± 0.626
2.419GlyGlu: 2.419 ± 0.445
2.957GlyPhe: 2.957 ± 0.473
4.57GlyGly: 4.57 ± 1.126
0.896GlyHis: 0.896 ± 0.288
5.556GlyIle: 5.556 ± 0.949
5.197GlyLys: 5.197 ± 0.649
5.376GlyLeu: 5.376 ± 0.734
2.24GlyMet: 2.24 ± 0.568
3.763GlyAsn: 3.763 ± 0.471
0.806GlyPro: 0.806 ± 0.321
2.151GlyGln: 2.151 ± 0.422
1.165GlyArg: 1.165 ± 0.353
4.928GlySer: 4.928 ± 0.665
5.108GlyThr: 5.108 ± 0.913
4.211GlyVal: 4.211 ± 0.68
0.717GlyTrp: 0.717 ± 0.247
3.405GlyTyr: 3.405 ± 0.564
0.0GlyXaa: 0.0 ± 0.0
His
1.254HisAla: 1.254 ± 0.338
0.358HisCys: 0.358 ± 0.181
1.434HisAsp: 1.434 ± 0.337
1.613HisGlu: 1.613 ± 0.354
0.358HisPhe: 0.358 ± 0.159
1.254HisGly: 1.254 ± 0.341
0.0HisHis: 0.0 ± 0.0
0.896HisIle: 0.896 ± 0.241
0.986HisLys: 0.986 ± 0.292
0.986HisLeu: 0.986 ± 0.241
0.09HisMet: 0.09 ± 0.071
0.896HisAsn: 0.896 ± 0.281
0.358HisPro: 0.358 ± 0.189
0.269HisGln: 0.269 ± 0.161
0.358HisArg: 0.358 ± 0.184
1.165HisSer: 1.165 ± 0.267
0.627HisThr: 0.627 ± 0.253
0.806HisVal: 0.806 ± 0.367
0.179HisTrp: 0.179 ± 0.124
0.269HisTyr: 0.269 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
5.108IleAla: 5.108 ± 0.845
0.627IleCys: 0.627 ± 0.262
5.197IleAsp: 5.197 ± 0.539
6.631IleGlu: 6.631 ± 0.953
2.867IlePhe: 2.867 ± 0.525
4.211IleGly: 4.211 ± 0.625
0.986IleHis: 0.986 ± 0.239
4.928IleIle: 4.928 ± 0.748
7.885IleLys: 7.885 ± 0.936
4.928IleLeu: 4.928 ± 0.641
1.254IleMet: 1.254 ± 0.317
5.556IleAsn: 5.556 ± 0.897
2.778IlePro: 2.778 ± 0.463
2.599IleGln: 2.599 ± 0.421
3.315IleArg: 3.315 ± 0.522
6.81IleSer: 6.81 ± 0.791
5.108IleThr: 5.108 ± 0.57
4.659IleVal: 4.659 ± 0.751
0.986IleTrp: 0.986 ± 0.262
3.136IleTyr: 3.136 ± 0.473
0.0IleXaa: 0.0 ± 0.0
Lys
5.466LysAla: 5.466 ± 0.698
0.358LysCys: 0.358 ± 0.187
5.197LysAsp: 5.197 ± 0.705
8.961LysGlu: 8.961 ± 1.039
3.495LysPhe: 3.495 ± 0.614
5.197LysGly: 5.197 ± 0.577
0.986LysHis: 0.986 ± 0.287
6.093LysIle: 6.093 ± 0.862
7.168LysLys: 7.168 ± 0.991
6.362LysLeu: 6.362 ± 0.781
2.419LysMet: 2.419 ± 0.566
5.287LysAsn: 5.287 ± 0.583
2.778LysPro: 2.778 ± 0.513
3.943LysGln: 3.943 ± 0.666
4.032LysArg: 4.032 ± 0.63
3.584LysSer: 3.584 ± 0.475
5.287LysThr: 5.287 ± 0.627
6.183LysVal: 6.183 ± 0.602
1.434LysTrp: 1.434 ± 0.323
4.749LysTyr: 4.749 ± 0.617
0.0LysXaa: 0.0 ± 0.0
Leu
6.093LeuAla: 6.093 ± 0.83
0.806LeuCys: 0.806 ± 0.254
4.391LeuAsp: 4.391 ± 0.652
6.272LeuGlu: 6.272 ± 0.946
3.495LeuPhe: 3.495 ± 0.501
5.108LeuGly: 5.108 ± 0.744
1.344LeuHis: 1.344 ± 0.307
5.018LeuIle: 5.018 ± 0.622
7.168LeuLys: 7.168 ± 0.848
6.541LeuLeu: 6.541 ± 0.849
1.882LeuMet: 1.882 ± 0.453
5.376LeuAsn: 5.376 ± 0.647
1.792LeuPro: 1.792 ± 0.367
2.599LeuGln: 2.599 ± 0.43
2.24LeuArg: 2.24 ± 0.423
6.004LeuSer: 6.004 ± 0.654
6.541LeuThr: 6.541 ± 0.71
4.839LeuVal: 4.839 ± 0.592
0.806LeuTrp: 0.806 ± 0.239
3.315LeuTyr: 3.315 ± 0.544
0.0LeuXaa: 0.0 ± 0.0
Met
1.434MetAla: 1.434 ± 0.433
0.09MetCys: 0.09 ± 0.088
1.254MetAsp: 1.254 ± 0.346
2.33MetGlu: 2.33 ± 0.49
1.075MetPhe: 1.075 ± 0.353
0.806MetGly: 0.806 ± 0.246
0.448MetHis: 0.448 ± 0.174
1.703MetIle: 1.703 ± 0.445
2.599MetLys: 2.599 ± 0.526
1.971MetLeu: 1.971 ± 0.624
0.358MetMet: 0.358 ± 0.163
2.33MetAsn: 2.33 ± 0.465
0.806MetPro: 0.806 ± 0.232
1.344MetGln: 1.344 ± 0.35
0.717MetArg: 0.717 ± 0.272
1.523MetSer: 1.523 ± 0.287
1.703MetThr: 1.703 ± 0.413
0.986MetVal: 0.986 ± 0.329
0.09MetTrp: 0.09 ± 0.084
0.717MetTyr: 0.717 ± 0.267
0.0MetXaa: 0.0 ± 0.0
Asn
3.136AsnAla: 3.136 ± 0.572
0.269AsnCys: 0.269 ± 0.155
3.047AsnAsp: 3.047 ± 0.534
5.108AsnGlu: 5.108 ± 0.946
2.24AsnPhe: 2.24 ± 0.467
4.57AsnGly: 4.57 ± 0.755
1.613AsnHis: 1.613 ± 0.382
4.391AsnIle: 4.391 ± 0.709
5.645AsnLys: 5.645 ± 0.729
4.839AsnLeu: 4.839 ± 0.757
1.613AsnMet: 1.613 ± 0.304
4.301AsnAsn: 4.301 ± 0.664
2.599AsnPro: 2.599 ± 0.568
2.419AsnGln: 2.419 ± 0.441
2.778AsnArg: 2.778 ± 0.616
4.211AsnSer: 4.211 ± 0.463
3.405AsnThr: 3.405 ± 0.703
3.943AsnVal: 3.943 ± 0.618
0.986AsnTrp: 0.986 ± 0.324
2.867AsnTyr: 2.867 ± 0.707
0.0AsnXaa: 0.0 ± 0.0
Pro
1.344ProAla: 1.344 ± 0.346
0.0ProCys: 0.0 ± 0.0
1.523ProAsp: 1.523 ± 0.445
1.523ProGlu: 1.523 ± 0.416
1.165ProPhe: 1.165 ± 0.284
0.448ProGly: 0.448 ± 0.192
0.627ProHis: 0.627 ± 0.235
1.882ProIle: 1.882 ± 0.467
2.24ProLys: 2.24 ± 0.511
1.792ProLeu: 1.792 ± 0.314
0.717ProMet: 0.717 ± 0.301
2.24ProAsn: 2.24 ± 0.506
0.448ProPro: 0.448 ± 0.171
1.523ProGln: 1.523 ± 0.417
1.434ProArg: 1.434 ± 0.443
2.599ProSer: 2.599 ± 0.652
1.882ProThr: 1.882 ± 0.425
1.971ProVal: 1.971 ± 0.392
0.09ProTrp: 0.09 ± 0.091
0.986ProTyr: 0.986 ± 0.22
0.0ProXaa: 0.0 ± 0.0
Gln
2.599GlnAla: 2.599 ± 0.533
0.448GlnCys: 0.448 ± 0.174
1.165GlnAsp: 1.165 ± 0.287
2.33GlnGlu: 2.33 ± 0.534
1.254GlnPhe: 1.254 ± 0.405
2.509GlnGly: 2.509 ± 0.408
0.627GlnHis: 0.627 ± 0.224
2.061GlnIle: 2.061 ± 0.357
2.867GlnLys: 2.867 ± 0.57
3.584GlnLeu: 3.584 ± 0.53
1.075GlnMet: 1.075 ± 0.306
2.151GlnAsn: 2.151 ± 0.389
0.538GlnPro: 0.538 ± 0.202
0.986GlnGln: 0.986 ± 0.356
0.896GlnArg: 0.896 ± 0.282
1.792GlnSer: 1.792 ± 0.31
2.867GlnThr: 2.867 ± 0.546
1.971GlnVal: 1.971 ± 0.417
0.0GlnTrp: 0.0 ± 0.0
1.792GlnTyr: 1.792 ± 0.491
0.0GlnXaa: 0.0 ± 0.0
Arg
1.703ArgAla: 1.703 ± 0.434
0.179ArgCys: 0.179 ± 0.119
2.151ArgAsp: 2.151 ± 0.442
2.33ArgGlu: 2.33 ± 0.466
1.613ArgPhe: 1.613 ± 0.412
2.061ArgGly: 2.061 ± 0.444
0.448ArgHis: 0.448 ± 0.196
3.405ArgIle: 3.405 ± 0.533
3.495ArgLys: 3.495 ± 0.605
4.48ArgLeu: 4.48 ± 0.715
1.254ArgMet: 1.254 ± 0.339
1.703ArgAsn: 1.703 ± 0.473
1.075ArgPro: 1.075 ± 0.334
1.434ArgGln: 1.434 ± 0.47
0.986ArgArg: 0.986 ± 0.344
1.703ArgSer: 1.703 ± 0.307
2.33ArgThr: 2.33 ± 0.419
1.971ArgVal: 1.971 ± 0.448
0.448ArgTrp: 0.448 ± 0.188
1.882ArgTyr: 1.882 ± 0.471
0.0ArgXaa: 0.0 ± 0.0
Ser
4.032SerAla: 4.032 ± 0.699
0.179SerCys: 0.179 ± 0.117
5.645SerAsp: 5.645 ± 0.838
4.57SerGlu: 4.57 ± 0.549
2.688SerPhe: 2.688 ± 0.659
3.674SerGly: 3.674 ± 0.83
1.075SerHis: 1.075 ± 0.254
5.735SerIle: 5.735 ± 0.543
5.197SerLys: 5.197 ± 0.571
4.659SerLeu: 4.659 ± 0.674
1.165SerMet: 1.165 ± 0.29
4.48SerAsn: 4.48 ± 0.52
1.523SerPro: 1.523 ± 0.304
2.061SerGln: 2.061 ± 0.453
1.434SerArg: 1.434 ± 0.328
4.301SerSer: 4.301 ± 0.57
3.495SerThr: 3.495 ± 0.641
3.226SerVal: 3.226 ± 0.476
1.344SerTrp: 1.344 ± 0.328
2.24SerTyr: 2.24 ± 0.418
0.0SerXaa: 0.0 ± 0.0
Thr
4.48ThrAla: 4.48 ± 0.594
0.269ThrCys: 0.269 ± 0.141
3.315ThrAsp: 3.315 ± 0.603
3.853ThrGlu: 3.853 ± 0.546
3.495ThrPhe: 3.495 ± 0.565
5.556ThrGly: 5.556 ± 0.662
0.717ThrHis: 0.717 ± 0.338
5.735ThrIle: 5.735 ± 0.761
5.735ThrLys: 5.735 ± 0.71
4.391ThrLeu: 4.391 ± 0.643
1.434ThrMet: 1.434 ± 0.313
2.867ThrAsn: 2.867 ± 0.5
1.792ThrPro: 1.792 ± 0.318
1.792ThrGln: 1.792 ± 0.449
2.509ThrArg: 2.509 ± 0.524
3.584ThrSer: 3.584 ± 0.502
4.032ThrThr: 4.032 ± 0.594
3.763ThrVal: 3.763 ± 0.858
0.538ThrTrp: 0.538 ± 0.278
3.047ThrTyr: 3.047 ± 0.56
0.0ThrXaa: 0.0 ± 0.0
Val
4.749ValAla: 4.749 ± 0.709
0.269ValCys: 0.269 ± 0.151
3.853ValAsp: 3.853 ± 0.58
5.824ValGlu: 5.824 ± 0.788
2.509ValPhe: 2.509 ± 0.405
4.032ValGly: 4.032 ± 0.689
0.806ValHis: 0.806 ± 0.255
4.749ValIle: 4.749 ± 0.553
4.839ValLys: 4.839 ± 0.709
3.943ValLeu: 3.943 ± 0.581
1.344ValMet: 1.344 ± 0.285
4.57ValAsn: 4.57 ± 0.443
2.151ValPro: 2.151 ± 0.491
1.165ValGln: 1.165 ± 0.267
1.434ValArg: 1.434 ± 0.274
3.943ValSer: 3.943 ± 0.57
3.047ValThr: 3.047 ± 0.613
3.853ValVal: 3.853 ± 0.498
0.717ValTrp: 0.717 ± 0.237
1.971ValTyr: 1.971 ± 0.343
0.0ValXaa: 0.0 ± 0.0
Trp
0.627TrpAla: 0.627 ± 0.197
0.09TrpCys: 0.09 ± 0.084
0.627TrpAsp: 0.627 ± 0.227
0.717TrpGlu: 0.717 ± 0.225
0.986TrpPhe: 0.986 ± 0.213
0.806TrpGly: 0.806 ± 0.289
0.358TrpHis: 0.358 ± 0.19
0.627TrpIle: 0.627 ± 0.237
1.523TrpLys: 1.523 ± 0.419
0.806TrpLeu: 0.806 ± 0.374
0.09TrpMet: 0.09 ± 0.095
0.448TrpAsn: 0.448 ± 0.17
0.0TrpPro: 0.0 ± 0.0
0.448TrpGln: 0.448 ± 0.29
0.538TrpArg: 0.538 ± 0.206
1.075TrpSer: 1.075 ± 0.346
0.986TrpThr: 0.986 ± 0.319
0.538TrpVal: 0.538 ± 0.244
0.269TrpTrp: 0.269 ± 0.135
0.448TrpTyr: 0.448 ± 0.264
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.778TyrAla: 2.778 ± 0.528
0.627TyrCys: 0.627 ± 0.233
3.047TyrAsp: 3.047 ± 0.62
1.971TyrGlu: 1.971 ± 0.498
2.599TyrPhe: 2.599 ± 0.489
3.047TyrGly: 3.047 ± 0.478
0.627TyrHis: 0.627 ± 0.202
4.301TyrIle: 4.301 ± 0.858
4.659TyrLys: 4.659 ± 0.734
3.405TyrLeu: 3.405 ± 0.493
1.165TyrMet: 1.165 ± 0.269
2.24TyrAsn: 2.24 ± 0.381
1.075TyrPro: 1.075 ± 0.332
1.703TyrGln: 1.703 ± 0.469
0.896TyrArg: 0.896 ± 0.232
2.33TyrSer: 2.33 ± 0.405
3.136TyrThr: 3.136 ± 0.581
2.509TyrVal: 2.509 ± 0.406
0.269TyrTrp: 0.269 ± 0.123
2.33TyrTyr: 2.33 ± 0.429
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (11161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski