Amino acid dipepetide frequency for Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.743AlaAla: 20.743 ± 0.194	1.133AlaCys: 1.133 ± 0.025	7.513AlaAsp: 7.513 ± 0.072	8.143AlaGlu: 8.143 ± 0.089	5.155AlaPhe: 5.155 ± 0.065	12.111AlaGly: 12.111 ± 0.105	2.517AlaHis: 2.517 ± 0.039	5.956AlaIle: 5.956 ± 0.058	4.006AlaLys: 4.006 ± 0.067	15.248AlaLeu: 15.248 ± 0.127	3.424AlaMet: 3.424 ± 0.05	2.564AlaAsn: 2.564 ± 0.043	7.419AlaPro: 7.419 ± 0.078	4.337AlaGln: 4.337 ± 0.055	10.48AlaArg: 10.48 ± 0.11	6.601AlaSer: 6.601 ± 0.075	6.4AlaThr: 6.4 ± 0.065	10.022AlaVal: 10.022 ± 0.087	1.485AlaTrp: 1.485 ± 0.032	2.669AlaTyr: 2.669 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.107CysAla: 1.107 ± 0.027	0.114CysCys: 0.114 ± 0.009	0.468CysAsp: 0.468 ± 0.018	0.39CysGlu: 0.39 ± 0.016	0.298CysPhe: 0.298 ± 0.014	0.877CysGly: 0.877 ± 0.024	0.226CysHis: 0.226 ± 0.012	0.3CysIle: 0.3 ± 0.014	0.158CysLys: 0.158 ± 0.01	0.753CysLeu: 0.753 ± 0.022	0.156CysMet: 0.156 ± 0.012	0.165CysAsn: 0.165 ± 0.011	0.48CysPro: 0.48 ± 0.019	0.212CysGln: 0.212 ± 0.012	0.637CysArg: 0.637 ± 0.019	0.42CysSer: 0.42 ± 0.014	0.343CysThr: 0.343 ± 0.016	0.641CysVal: 0.641 ± 0.022	0.111CysTrp: 0.111 ± 0.009	0.174CysTyr: 0.174 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.447AspAla: 7.447 ± 0.082	0.407AspCys: 0.407 ± 0.015	2.96AspAsp: 2.96 ± 0.052	3.289AspGlu: 3.289 ± 0.047	2.067AspPhe: 2.067 ± 0.033	5.369AspGly: 5.369 ± 0.071	1.178AspHis: 1.178 ± 0.034	2.606AspIle: 2.606 ± 0.045	1.61AspLys: 1.61 ± 0.035	6.247AspLeu: 6.247 ± 0.062	1.201AspMet: 1.201 ± 0.023	1.045AspAsn: 1.045 ± 0.028	3.676AspPro: 3.676 ± 0.045	1.509AspGln: 1.509 ± 0.034	4.133AspArg: 4.133 ± 0.057	1.722AspSer: 1.722 ± 0.032	2.678AspThr: 2.678 ± 0.05	4.213AspVal: 4.213 ± 0.05	0.854AspTrp: 0.854 ± 0.023	1.344AspTyr: 1.344 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.407GluAla: 8.407 ± 0.081	0.321GluCys: 0.321 ± 0.013	2.792GluAsp: 2.792 ± 0.048	3.152GluGlu: 3.152 ± 0.059	1.452GluPhe: 1.452 ± 0.031	4.522GluGly: 4.522 ± 0.055	1.175GluHis: 1.175 ± 0.026	2.985GluIle: 2.985 ± 0.046	2.086GluLys: 2.086 ± 0.042	4.923GluLeu: 4.923 ± 0.059	1.37GluMet: 1.37 ± 0.032	1.262GluAsn: 1.262 ± 0.032	2.827GluPro: 2.827 ± 0.045	1.874GluGln: 1.874 ± 0.039	5.165GluArg: 5.165 ± 0.065	2.059GluSer: 2.059 ± 0.039	3.253GluThr: 3.253 ± 0.046	4.367GluVal: 4.367 ± 0.055	0.64GluTrp: 0.64 ± 0.019	0.845GluTyr: 0.845 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.968PheAla: 4.968 ± 0.067	0.374PheCys: 0.374 ± 0.015	2.426PheAsp: 2.426 ± 0.04	2.046PheGlu: 2.046 ± 0.029	1.377PhePhe: 1.377 ± 0.034	3.692PheGly: 3.692 ± 0.047	0.737PheHis: 0.737 ± 0.019	1.542PheIle: 1.542 ± 0.033	0.938PheLys: 0.938 ± 0.027	3.503PheLeu: 3.503 ± 0.05	0.734PheMet: 0.734 ± 0.021	0.945PheAsn: 0.945 ± 0.025	1.665PhePro: 1.665 ± 0.033	0.936PheGln: 0.936 ± 0.026	2.329PheArg: 2.329 ± 0.038	2.166PheSer: 2.166 ± 0.039	2.008PheThr: 2.008 ± 0.038	2.95PheVal: 2.95 ± 0.047	0.499PheTrp: 0.499 ± 0.02	0.874PheTyr: 0.874 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.968GlyAla: 10.968 ± 0.096	0.809GlyCys: 0.809 ± 0.025	4.221GlyAsp: 4.221 ± 0.058	4.783GlyGlu: 4.783 ± 0.061	3.631GlyPhe: 3.631 ± 0.044	7.595GlyGly: 7.595 ± 0.092	1.921GlyHis: 1.921 ± 0.037	4.454GlyIle: 4.454 ± 0.055	2.949GlyLys: 2.949 ± 0.053	9.351GlyLeu: 9.351 ± 0.085	2.15GlyMet: 2.15 ± 0.035	1.831GlyAsn: 1.831 ± 0.039	4.145GlyPro: 4.145 ± 0.068	2.709GlyGln: 2.709 ± 0.046	6.894GlyArg: 6.894 ± 0.076	4.408GlySer: 4.408 ± 0.061	4.903GlyThr: 4.903 ± 0.059	6.443GlyVal: 6.443 ± 0.072	1.302GlyTrp: 1.302 ± 0.03	2.143GlyTyr: 2.143 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.473HisAla: 2.473 ± 0.048	0.196HisCys: 0.196 ± 0.01	1.131HisAsp: 1.131 ± 0.03	0.975HisGlu: 0.975 ± 0.026	0.829HisPhe: 0.829 ± 0.021	1.973HisGly: 1.973 ± 0.039	0.536HisHis: 0.536 ± 0.022	0.81HisIle: 0.81 ± 0.024	0.455HisLys: 0.455 ± 0.019	2.185HisLeu: 2.185 ± 0.042	0.513HisMet: 0.513 ± 0.019	0.362HisAsn: 0.362 ± 0.017	1.42HisPro: 1.42 ± 0.032	0.539HisGln: 0.539 ± 0.02	1.501HisArg: 1.501 ± 0.031	0.778HisSer: 0.778 ± 0.02	0.808HisThr: 0.808 ± 0.025	1.669HisVal: 1.669 ± 0.035	0.331HisTrp: 0.331 ± 0.014	0.468HisTyr: 0.468 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.065IleAla: 7.065 ± 0.073	0.405IleCys: 0.405 ± 0.016	2.98IleAsp: 2.98 ± 0.045	2.961IleGlu: 2.961 ± 0.039	1.482IlePhe: 1.482 ± 0.035	4.378IleGly: 4.378 ± 0.058	0.877IleHis: 0.877 ± 0.027	1.907IleIle: 1.907 ± 0.04	1.231IleLys: 1.231 ± 0.032	4.145IleLeu: 4.145 ± 0.06	0.829IleMet: 0.829 ± 0.026	1.122IleAsn: 1.122 ± 0.031	2.231IlePro: 2.231 ± 0.039	1.026IleGln: 1.026 ± 0.026	2.87IleArg: 2.87 ± 0.042	2.42IleSer: 2.42 ± 0.041	2.514IleThr: 2.514 ± 0.045	3.868IleVal: 3.868 ± 0.056	0.494IleTrp: 0.494 ± 0.019	1.024IleTyr: 1.024 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.627LysAla: 4.627 ± 0.068	0.148LysCys: 0.148 ± 0.011	1.703LysAsp: 1.703 ± 0.035	1.547LysGlu: 1.547 ± 0.037	0.767LysPhe: 0.767 ± 0.023	2.664LysGly: 2.664 ± 0.049	0.492LysHis: 0.492 ± 0.02	1.436LysIle: 1.436 ± 0.033	1.122LysLys: 1.122 ± 0.03	2.921LysLeu: 2.921 ± 0.05	0.662LysMet: 0.662 ± 0.022	0.68LysAsn: 0.68 ± 0.024	2.018LysPro: 2.018 ± 0.04	0.805LysGln: 0.805 ± 0.025	2.187LysArg: 2.187 ± 0.041	1.58LysSer: 1.58 ± 0.035	1.776LysThr: 1.776 ± 0.038	2.693LysVal: 2.693 ± 0.039	0.33LysTrp: 0.33 ± 0.014	0.529LysTyr: 0.529 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.472LeuAla: 15.472 ± 0.121	0.838LeuCys: 0.838 ± 0.026	6.31LeuAsp: 6.31 ± 0.075	5.266LeuGlu: 5.266 ± 0.069	3.665LeuPhe: 3.665 ± 0.056	8.693LeuGly: 8.693 ± 0.076	1.784LeuHis: 1.784 ± 0.03	4.43LeuIle: 4.43 ± 0.055	3.924LeuLys: 3.924 ± 0.053	9.653LeuLeu: 9.653 ± 0.095	2.348LeuMet: 2.348 ± 0.04	2.261LeuAsn: 2.261 ± 0.046	6.067LeuPro: 6.067 ± 0.068	2.377LeuGln: 2.377 ± 0.043	6.639LeuArg: 6.639 ± 0.061	6.35LeuSer: 6.35 ± 0.069	5.525LeuThr: 5.525 ± 0.065	8.41LeuVal: 8.41 ± 0.084	1.137LeuTrp: 1.137 ± 0.03	2.043LeuTyr: 2.043 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.078MetAla: 3.078 ± 0.047	0.144MetCys: 0.144 ± 0.009	1.086MetAsp: 1.086 ± 0.026	1.108MetGlu: 1.108 ± 0.031	0.628MetPhe: 0.628 ± 0.023	1.807MetGly: 1.807 ± 0.037	0.376MetHis: 0.376 ± 0.015	1.039MetIle: 1.039 ± 0.03	0.803MetLys: 0.803 ± 0.024	2.29MetLeu: 2.29 ± 0.04	0.555MetMet: 0.555 ± 0.024	0.617MetAsn: 0.617 ± 0.02	1.416MetPro: 1.416 ± 0.03	0.593MetGln: 0.593 ± 0.018	1.745MetArg: 1.745 ± 0.031	1.539MetSer: 1.539 ± 0.027	1.564MetThr: 1.564 ± 0.029	1.76MetVal: 1.76 ± 0.037	0.201MetTrp: 0.201 ± 0.01	0.285MetTyr: 0.285 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.892AsnAla: 2.892 ± 0.048	0.214AsnCys: 0.214 ± 0.013	1.095AsnAsp: 1.095 ± 0.024	1.027AsnGlu: 1.027 ± 0.028	0.789AsnPhe: 0.789 ± 0.023	2.101AsnGly: 2.101 ± 0.04	0.405AsnHis: 0.405 ± 0.014	1.054AsnIle: 1.054 ± 0.032	0.6AsnLys: 0.6 ± 0.022	2.21AsnLeu: 2.21 ± 0.032	0.482AsnMet: 0.482 ± 0.017	0.536AsnAsn: 0.536 ± 0.02	1.623AsnPro: 1.623 ± 0.039	0.603AsnGln: 0.603 ± 0.022	1.623AsnArg: 1.623 ± 0.031	0.926AsnSer: 0.926 ± 0.029	1.094AsnThr: 1.094 ± 0.029	1.796AsnVal: 1.796 ± 0.034	0.367AsnTrp: 0.367 ± 0.017	0.572AsnTyr: 0.572 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.994ProAla: 7.994 ± 0.091	0.324ProCys: 0.324 ± 0.016	3.884ProAsp: 3.884 ± 0.051	3.889ProGlu: 3.889 ± 0.048	2.251ProPhe: 2.251 ± 0.039	5.09ProGly: 5.09 ± 0.08	1.164ProHis: 1.164 ± 0.027	2.075ProIle: 2.075 ± 0.038	1.74ProLys: 1.74 ± 0.031	5.326ProLeu: 5.326 ± 0.062	1.191ProMet: 1.191 ± 0.028	1.269ProAsn: 1.269 ± 0.031	3.374ProPro: 3.374 ± 0.069	1.843ProGln: 1.843 ± 0.037	3.561ProArg: 3.561 ± 0.055	2.853ProSer: 2.853 ± 0.049	2.605ProThr: 2.605 ± 0.039	4.631ProVal: 4.631 ± 0.053	0.685ProTrp: 0.685 ± 0.024	1.127ProTyr: 1.127 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.914GlnAla: 3.914 ± 0.06	0.182GlnCys: 0.182 ± 0.011	1.409GlnAsp: 1.409 ± 0.031	1.359GlnGlu: 1.359 ± 0.028	0.893GlnPhe: 0.893 ± 0.024	2.292GlnGly: 2.292 ± 0.041	0.536GlnHis: 0.536 ± 0.02	1.554GlnIle: 1.554 ± 0.037	0.984GlnLys: 0.984 ± 0.028	2.675GlnLeu: 2.675 ± 0.055	0.814GlnMet: 0.814 ± 0.022	0.708GlnAsn: 0.708 ± 0.022	1.702GlnPro: 1.702 ± 0.039	1.08GlnGln: 1.08 ± 0.042	2.314GlnArg: 2.314 ± 0.043	1.572GlnSer: 1.572 ± 0.032	1.425GlnThr: 1.425 ± 0.037	2.494GlnVal: 2.494 ± 0.043	0.38GlnTrp: 0.38 ± 0.015	0.518GlnTyr: 0.518 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.32ArgAla: 9.32 ± 0.092	0.528ArgCys: 0.528 ± 0.018	4.142ArgAsp: 4.142 ± 0.05	4.112ArgGlu: 4.112 ± 0.064	3.053ArgPhe: 3.053 ± 0.044	4.937ArgGly: 4.937 ± 0.058	1.819ArgHis: 1.819 ± 0.034	3.899ArgIle: 3.899 ± 0.05	2.081ArgLys: 2.081 ± 0.038	8.775ArgLeu: 8.775 ± 0.098	1.708ArgMet: 1.708 ± 0.037	1.656ArgAsn: 1.656 ± 0.035	4.245ArgPro: 4.245 ± 0.063	2.457ArgGln: 2.457 ± 0.041	6.552ArgArg: 6.552 ± 0.092	3.652ArgSer: 3.652 ± 0.047	3.754ArgThr: 3.754 ± 0.049	5.097ArgVal: 5.097 ± 0.061	0.948ArgTrp: 0.948 ± 0.025	1.538ArgTyr: 1.538 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.481SerAla: 6.481 ± 0.064	0.44SerCys: 0.44 ± 0.019	2.712SerAsp: 2.712 ± 0.039	2.519SerGlu: 2.519 ± 0.039	2.178SerPhe: 2.178 ± 0.035	5.433SerGly: 5.433 ± 0.059	1.025SerHis: 1.025 ± 0.024	2.279SerIle: 2.279 ± 0.035	1.281SerLys: 1.281 ± 0.029	5.125SerLeu: 5.125 ± 0.066	1.118SerMet: 1.118 ± 0.027	1.107SerAsn: 1.107 ± 0.03	2.958SerPro: 2.958 ± 0.045	1.467SerGln: 1.467 ± 0.042	3.578SerArg: 3.578 ± 0.05	2.682SerSer: 2.682 ± 0.052	2.517SerThr: 2.517 ± 0.043	3.828SerVal: 3.828 ± 0.05	0.721SerTrp: 0.721 ± 0.021	1.099SerTyr: 1.099 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.515ThrAla: 6.515 ± 0.068	0.435ThrCys: 0.435 ± 0.017	2.645ThrAsp: 2.645 ± 0.043	2.449ThrGlu: 2.449 ± 0.042	2.073ThrPhe: 2.073 ± 0.037	5.182ThrGly: 5.182 ± 0.064	1.019ThrHis: 1.019 ± 0.023	2.498ThrIle: 2.498 ± 0.044	1.327ThrLys: 1.327 ± 0.035	6.058ThrLeu: 6.058 ± 0.067	0.944ThrMet: 0.944 ± 0.025	1.098ThrAsn: 1.098 ± 0.03	3.493ThrPro: 3.493 ± 0.049	1.386ThrGln: 1.386 ± 0.03	3.547ThrArg: 3.547 ± 0.049	2.673ThrSer: 2.673 ± 0.042	2.772ThrThr: 2.772 ± 0.057	4.269ThrVal: 4.269 ± 0.065	0.588ThrTrp: 0.588 ± 0.022	1.285ThrTyr: 1.285 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.662ValAla: 10.662 ± 0.101	0.656ValCys: 0.656 ± 0.021	4.187ValAsp: 4.187 ± 0.042	4.853ValGlu: 4.853 ± 0.056	2.78ValPhe: 2.78 ± 0.04	5.918ValGly: 5.918 ± 0.06	1.464ValHis: 1.464 ± 0.031	3.663ValIle: 3.663 ± 0.051	2.464ValLys: 2.464 ± 0.043	8.189ValLeu: 8.189 ± 0.072	1.752ValMet: 1.752 ± 0.036	1.856ValAsn: 1.856 ± 0.04	4.4ValPro: 4.4 ± 0.052	1.942ValGln: 1.942 ± 0.04	5.635ValArg: 5.635 ± 0.069	4.297ValSer: 4.297 ± 0.052	4.627ValThr: 4.627 ± 0.061	6.835ValVal: 6.835 ± 0.064	0.874ValTrp: 0.874 ± 0.025	1.417ValTyr: 1.417 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.267TrpAla: 1.267 ± 0.026	0.135TrpCys: 0.135 ± 0.008	0.584TrpAsp: 0.584 ± 0.019	0.503TrpGlu: 0.503 ± 0.019	0.481TrpPhe: 0.481 ± 0.018	0.876TrpGly: 0.876 ± 0.025	0.314TrpHis: 0.314 ± 0.015	0.557TrpIle: 0.557 ± 0.021	0.403TrpLys: 0.403 ± 0.018	1.501TrpLeu: 1.501 ± 0.033	0.304TrpMet: 0.304 ± 0.014	0.391TrpAsn: 0.391 ± 0.014	0.705TrpPro: 0.705 ± 0.022	0.496TrpGln: 0.496 ± 0.018	1.232TrpArg: 1.232 ± 0.026	0.803TrpSer: 0.803 ± 0.025	0.717TrpThr: 0.717 ± 0.024	0.762TrpVal: 0.762 ± 0.024	0.209TrpTrp: 0.209 ± 0.013	0.224TrpTyr: 0.224 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.523TyrAla: 2.523 ± 0.042	0.227TyrCys: 0.227 ± 0.011	1.306TyrAsp: 1.306 ± 0.03	1.104TyrGlu: 1.104 ± 0.028	0.86TyrPhe: 0.86 ± 0.024	2.098TyrGly: 2.098 ± 0.04	0.386TyrHis: 0.386 ± 0.014	0.784TyrIle: 0.784 ± 0.025	0.53TyrLys: 0.53 ± 0.02	2.116TyrLeu: 2.116 ± 0.037	0.382TyrMet: 0.382 ± 0.017	0.532TyrAsn: 0.532 ± 0.025	1.012TyrPro: 1.012 ± 0.027	0.615TyrGln: 0.615 ± 0.018	1.653TyrArg: 1.653 ± 0.033	1.046TyrSer: 1.046 ± 0.024	0.973TyrThr: 0.973 ± 0.032	1.721TyrVal: 1.721 ± 0.04	0.306TyrTrp: 0.306 ± 0.016	0.514TyrTyr: 0.514 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4971 proteins (1618488 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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