Amino acid dipepetide frequency for Ornatilinea apprima

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.888AlaAla: 11.888 ± 0.15	1.022AlaCys: 1.022 ± 0.034	4.729AlaAsp: 4.729 ± 0.065	6.261AlaGlu: 6.261 ± 0.09	3.735AlaPhe: 3.735 ± 0.064	8.049AlaGly: 8.049 ± 0.106	1.73AlaHis: 1.73 ± 0.037	5.408AlaIle: 5.408 ± 0.077	2.934AlaLys: 2.934 ± 0.059	11.404AlaLeu: 11.404 ± 0.133	2.34AlaMet: 2.34 ± 0.059	3.011AlaAsn: 3.011 ± 0.061	3.948AlaPro: 3.948 ± 0.072	4.379AlaGln: 4.379 ± 0.074	6.038AlaArg: 6.038 ± 0.087	5.404AlaSer: 5.404 ± 0.08	3.779AlaThr: 3.779 ± 0.074	7.239AlaVal: 7.239 ± 0.09	1.55AlaTrp: 1.55 ± 0.046	2.838AlaTyr: 2.838 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.028	0.087CysCys: 0.087 ± 0.009	0.463CysAsp: 0.463 ± 0.021	0.511CysGlu: 0.511 ± 0.022	0.309CysPhe: 0.309 ± 0.015	0.888CysGly: 0.888 ± 0.032	0.164CysHis: 0.164 ± 0.011	0.407CysIle: 0.407 ± 0.021	0.306CysLys: 0.306 ± 0.018	0.921CysLeu: 0.921 ± 0.032	0.185CysMet: 0.185 ± 0.012	0.26CysAsn: 0.26 ± 0.016	0.587CysPro: 0.587 ± 0.026	0.464CysGln: 0.464 ± 0.021	0.449CysArg: 0.449 ± 0.021	0.518CysSer: 0.518 ± 0.025	0.431CysThr: 0.431 ± 0.021	0.591CysVal: 0.591 ± 0.024	0.124CysTrp: 0.124 ± 0.011	0.232CysTyr: 0.232 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.427AspAla: 4.427 ± 0.064	0.422AspCys: 0.422 ± 0.017	2.375AspAsp: 2.375 ± 0.059	3.537AspGlu: 3.537 ± 0.058	2.232AspPhe: 2.232 ± 0.048	3.766AspGly: 3.766 ± 0.068	1.045AspHis: 1.045 ± 0.033	2.709AspIle: 2.709 ± 0.053	1.398AspLys: 1.398 ± 0.038	6.158AspLeu: 6.158 ± 0.093	1.203AspMet: 1.203 ± 0.034	1.345AspAsn: 1.345 ± 0.042	2.971AspPro: 2.971 ± 0.055	2.273AspGln: 2.273 ± 0.047	2.694AspArg: 2.694 ± 0.048	2.49AspSer: 2.49 ± 0.076	2.298AspThr: 2.298 ± 0.064	3.515AspVal: 3.515 ± 0.061	0.989AspTrp: 0.989 ± 0.027	1.718AspTyr: 1.718 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.15GluAla: 6.15 ± 0.089	0.359GluCys: 0.359 ± 0.016	3.147GluAsp: 3.147 ± 0.069	4.706GluGlu: 4.706 ± 0.087	2.084GluPhe: 2.084 ± 0.042	3.786GluGly: 3.786 ± 0.067	1.046GluHis: 1.046 ± 0.034	4.555GluIle: 4.555 ± 0.078	3.585GluLys: 3.585 ± 0.064	5.966GluLeu: 5.966 ± 0.074	2.12GluMet: 2.12 ± 0.052	2.692GluAsn: 2.692 ± 0.053	2.524GluPro: 2.524 ± 0.055	2.943GluGln: 2.943 ± 0.056	3.91GluArg: 3.91 ± 0.067	3.338GluSer: 3.338 ± 0.06	3.516GluThr: 3.516 ± 0.062	4.375GluVal: 4.375 ± 0.07	0.935GluTrp: 0.935 ± 0.033	1.677GluTyr: 1.677 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.382PheAla: 3.382 ± 0.057	0.408PheCys: 0.408 ± 0.02	2.297PheAsp: 2.297 ± 0.052	2.56PheGlu: 2.56 ± 0.047	1.954PhePhe: 1.954 ± 0.051	3.163PheGly: 3.163 ± 0.061	0.812PheHis: 0.812 ± 0.025	2.327PheIle: 2.327 ± 0.047	1.282PheLys: 1.282 ± 0.033	4.408PheLeu: 4.408 ± 0.081	0.836PheMet: 0.836 ± 0.028	1.535PheAsn: 1.535 ± 0.038	1.805PhePro: 1.805 ± 0.041	1.454PheGln: 1.454 ± 0.039	1.891PheArg: 1.891 ± 0.043	3.035PheSer: 3.035 ± 0.063	2.466PheThr: 2.466 ± 0.06	2.619PheVal: 2.619 ± 0.057	0.695PheTrp: 0.695 ± 0.029	1.292PheTyr: 1.292 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.335GlyAla: 6.335 ± 0.089	0.86GlyCys: 0.86 ± 0.032	3.383GlyAsp: 3.383 ± 0.052	4.705GlyGlu: 4.705 ± 0.079	3.3GlyPhe: 3.3 ± 0.058	5.721GlyGly: 5.721 ± 0.098	1.256GlyHis: 1.256 ± 0.034	4.597GlyIle: 4.597 ± 0.071	3.717GlyLys: 3.717 ± 0.058	8.822GlyLeu: 8.822 ± 0.102	2.397GlyMet: 2.397 ± 0.052	2.263GlyAsn: 2.263 ± 0.043	2.311GlyPro: 2.311 ± 0.051	3.016GlyGln: 3.016 ± 0.061	3.915GlyArg: 3.915 ± 0.07	4.397GlySer: 4.397 ± 0.08	3.414GlyThr: 3.414 ± 0.066	5.83GlyVal: 5.83 ± 0.075	1.471GlyTrp: 1.471 ± 0.048	2.61GlyTyr: 2.61 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.611HisAla: 1.611 ± 0.041	0.226HisCys: 0.226 ± 0.014	0.782HisAsp: 0.782 ± 0.029	0.896HisGlu: 0.896 ± 0.029	0.885HisPhe: 0.885 ± 0.03	1.293HisGly: 1.293 ± 0.04	0.55HisHis: 0.55 ± 0.023	1.176HisIle: 1.176 ± 0.028	0.571HisLys: 0.571 ± 0.02	2.281HisLeu: 2.281 ± 0.051	0.388HisMet: 0.388 ± 0.019	0.669HisAsn: 0.669 ± 0.024	1.396HisPro: 1.396 ± 0.039	0.862HisGln: 0.862 ± 0.03	1.079HisArg: 1.079 ± 0.036	1.042HisSer: 1.042 ± 0.031	0.992HisThr: 0.992 ± 0.029	1.015HisVal: 1.015 ± 0.032	0.324HisTrp: 0.324 ± 0.019	0.669HisTyr: 0.669 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.612IleAla: 5.612 ± 0.087	0.595IleCys: 0.595 ± 0.024	3.1IleAsp: 3.1 ± 0.063	3.871IleGlu: 3.871 ± 0.069	2.566IlePhe: 2.566 ± 0.052	4.689IleGly: 4.689 ± 0.075	1.28IleHis: 1.28 ± 0.034	3.346IleIle: 3.346 ± 0.061	1.947IleLys: 1.947 ± 0.048	6.461IleLeu: 6.461 ± 0.088	1.111IleMet: 1.111 ± 0.03	2.295IleAsn: 2.295 ± 0.045	3.339IlePro: 3.339 ± 0.06	2.582IleGln: 2.582 ± 0.048	3.242IleArg: 3.242 ± 0.061	4.144IleSer: 4.144 ± 0.064	3.525IleThr: 3.525 ± 0.065	3.756IleVal: 3.756 ± 0.067	0.797IleTrp: 0.797 ± 0.028	1.713IleTyr: 1.713 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.501LysAla: 3.501 ± 0.067	0.22LysCys: 0.22 ± 0.016	1.986LysAsp: 1.986 ± 0.043	2.616LysGlu: 2.616 ± 0.061	1.195LysPhe: 1.195 ± 0.033	2.473LysGly: 2.473 ± 0.054	0.617LysHis: 0.617 ± 0.023	2.544LysIle: 2.544 ± 0.051	2.061LysLys: 2.061 ± 0.053	3.438LysLeu: 3.438 ± 0.066	1.246LysMet: 1.246 ± 0.034	1.56LysAsn: 1.56 ± 0.041	1.968LysPro: 1.968 ± 0.043	1.569LysGln: 1.569 ± 0.04	2.003LysArg: 2.003 ± 0.05	2.04LysSer: 2.04 ± 0.043	2.371LysThr: 2.371 ± 0.054	2.765LysVal: 2.765 ± 0.054	0.495LysTrp: 0.495 ± 0.023	0.997LysTyr: 0.997 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.853LeuAla: 11.853 ± 0.14	0.922LeuCys: 0.922 ± 0.03	5.555LeuAsp: 5.555 ± 0.077	6.749LeuGlu: 6.749 ± 0.099	4.25LeuPhe: 4.25 ± 0.082	7.828LeuGly: 7.828 ± 0.103	1.864LeuHis: 1.864 ± 0.044	6.493LeuIle: 6.493 ± 0.081	4.232LeuLys: 4.232 ± 0.07	11.995LeuLeu: 11.995 ± 0.16	2.588LeuMet: 2.588 ± 0.046	3.856LeuAsn: 3.856 ± 0.063	6.209LeuPro: 6.209 ± 0.093	4.571LeuGln: 4.571 ± 0.065	6.526LeuArg: 6.526 ± 0.089	7.153LeuSer: 7.153 ± 0.084	5.879LeuThr: 5.879 ± 0.082	8.119LeuVal: 8.119 ± 0.107	1.47LeuTrp: 1.47 ± 0.048	2.752LeuTyr: 2.752 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.529MetAla: 2.529 ± 0.05	0.16MetCys: 0.16 ± 0.011	1.426MetAsp: 1.426 ± 0.04	1.572MetGlu: 1.572 ± 0.041	0.766MetPhe: 0.766 ± 0.03	1.983MetGly: 1.983 ± 0.037	0.398MetHis: 0.398 ± 0.02	1.472MetIle: 1.472 ± 0.037	1.189MetLys: 1.189 ± 0.027	2.693MetLeu: 2.693 ± 0.056	0.679MetMet: 0.679 ± 0.025	1.043MetAsn: 1.043 ± 0.029	1.388MetPro: 1.388 ± 0.036	1.075MetGln: 1.075 ± 0.03	1.512MetArg: 1.512 ± 0.041	1.41MetSer: 1.41 ± 0.034	1.264MetThr: 1.264 ± 0.035	2.036MetVal: 2.036 ± 0.04	0.25MetTrp: 0.25 ± 0.015	0.493MetTyr: 0.493 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.139AsnAla: 3.139 ± 0.056	0.313AsnCys: 0.313 ± 0.019	1.572AsnAsp: 1.572 ± 0.069	1.825AsnGlu: 1.825 ± 0.043	1.324AsnPhe: 1.324 ± 0.035	2.589AsnGly: 2.589 ± 0.063	0.761AsnHis: 0.761 ± 0.026	2.017AsnIle: 2.017 ± 0.044	1.002AsnLys: 1.002 ± 0.037	4.21AsnLeu: 4.21 ± 0.057	0.751AsnMet: 0.751 ± 0.027	1.158AsnAsn: 1.158 ± 0.037	2.553AsnPro: 2.553 ± 0.055	1.853AsnGln: 1.853 ± 0.048	2.121AsnArg: 2.121 ± 0.046	1.732AsnSer: 1.732 ± 0.041	1.795AsnThr: 1.795 ± 0.056	2.124AsnVal: 2.124 ± 0.042	0.598AsnTrp: 0.598 ± 0.023	1.097AsnTyr: 1.097 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.624ProAla: 5.624 ± 0.092	0.31ProCys: 0.31 ± 0.019	3.039ProAsp: 3.039 ± 0.057	3.819ProGlu: 3.819 ± 0.067	2.009ProPhe: 2.009 ± 0.053	3.929ProGly: 3.929 ± 0.066	0.941ProHis: 0.941 ± 0.029	2.601ProIle: 2.601 ± 0.051	1.492ProLys: 1.492 ± 0.046	5.036ProLeu: 5.036 ± 0.085	1.113ProMet: 1.113 ± 0.033	1.727ProAsn: 1.727 ± 0.044	2.355ProPro: 2.355 ± 0.055	2.307ProGln: 2.307 ± 0.046	2.394ProArg: 2.394 ± 0.056	2.768ProSer: 2.768 ± 0.051	2.995ProThr: 2.995 ± 0.084	4.066ProVal: 4.066 ± 0.058	0.648ProTrp: 0.648 ± 0.028	1.516ProTyr: 1.516 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.978GlnAla: 4.978 ± 0.072	0.239GlnCys: 0.239 ± 0.017	1.791GlnAsp: 1.791 ± 0.046	2.586GlnGlu: 2.586 ± 0.052	1.544GlnPhe: 1.544 ± 0.037	2.659GlnGly: 2.659 ± 0.053	0.839GlnHis: 0.839 ± 0.033	2.872GlnIle: 2.872 ± 0.055	1.917GlnLys: 1.917 ± 0.05	3.898GlnLeu: 3.898 ± 0.061	1.266GlnMet: 1.266 ± 0.035	1.608GlnAsn: 1.608 ± 0.04	2.831GlnPro: 2.831 ± 0.067	2.242GlnGln: 2.242 ± 0.054	2.794GlnArg: 2.794 ± 0.057	2.597GlnSer: 2.597 ± 0.05	2.486GlnThr: 2.486 ± 0.046	3.31GlnVal: 3.31 ± 0.063	0.596GlnTrp: 0.596 ± 0.025	1.106GlnTyr: 1.106 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.362ArgAla: 5.362 ± 0.078	0.455ArgCys: 0.455 ± 0.022	2.689ArgAsp: 2.689 ± 0.047	3.828ArgGlu: 3.828 ± 0.068	2.448ArgPhe: 2.448 ± 0.05	3.786ArgGly: 3.786 ± 0.067	1.024ArgHis: 1.024 ± 0.034	3.259ArgIle: 3.259 ± 0.049	2.454ArgLys: 2.454 ± 0.049	6.852ArgLeu: 6.852 ± 0.091	1.607ArgMet: 1.607 ± 0.035	1.693ArgAsn: 1.693 ± 0.038	2.527ArgPro: 2.527 ± 0.053	2.908ArgGln: 2.908 ± 0.063	3.71ArgArg: 3.71 ± 0.068	3.078ArgSer: 3.078 ± 0.061	2.354ArgThr: 2.354 ± 0.043	4.43ArgVal: 4.43 ± 0.072	1.002ArgTrp: 1.002 ± 0.032	1.822ArgTyr: 1.822 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.827SerAla: 5.827 ± 0.082	0.468SerCys: 0.468 ± 0.02	2.816SerAsp: 2.816 ± 0.063	3.386SerGlu: 3.386 ± 0.061	2.391SerPhe: 2.391 ± 0.059	5.192SerGly: 5.192 ± 0.064	1.105SerHis: 1.105 ± 0.035	3.613SerIle: 3.613 ± 0.056	1.886SerLys: 1.886 ± 0.044	6.975SerLeu: 6.975 ± 0.098	1.497SerMet: 1.497 ± 0.035	1.937SerAsn: 1.937 ± 0.049	3.092SerPro: 3.092 ± 0.065	2.64SerGln: 2.64 ± 0.051	3.232SerArg: 3.232 ± 0.051	3.507SerSer: 3.507 ± 0.071	2.975SerThr: 2.975 ± 0.063	3.974SerVal: 3.974 ± 0.06	0.715SerTrp: 0.715 ± 0.03	1.563SerTyr: 1.563 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.071ThrAla: 5.071 ± 0.088	0.483ThrCys: 0.483 ± 0.024	2.292ThrAsp: 2.292 ± 0.051	2.537ThrGlu: 2.537 ± 0.055	2.114ThrPhe: 2.114 ± 0.046	4.287ThrGly: 4.287 ± 0.077	1.096ThrHis: 1.096 ± 0.029	3.293ThrIle: 3.293 ± 0.071	1.321ThrLys: 1.321 ± 0.036	5.923ThrLeu: 5.923 ± 0.083	1.034ThrMet: 1.034 ± 0.031	1.663ThrAsn: 1.663 ± 0.049	3.494ThrPro: 3.494 ± 0.071	2.025ThrGln: 2.025 ± 0.043	3.053ThrArg: 3.053 ± 0.057	3.061ThrSer: 3.061 ± 0.058	2.695ThrThr: 2.695 ± 0.062	3.649ThrVal: 3.649 ± 0.075	0.777ThrTrp: 0.777 ± 0.028	1.533ThrTyr: 1.533 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.812ValAla: 5.812 ± 0.078	0.808ValCys: 0.808 ± 0.029	3.881ValAsp: 3.881 ± 0.063	4.988ValGlu: 4.988 ± 0.073	3.119ValPhe: 3.119 ± 0.058	5.071ValGly: 5.071 ± 0.075	1.187ValHis: 1.187 ± 0.033	4.903ValIle: 4.903 ± 0.078	2.787ValLys: 2.787 ± 0.059	7.872ValLeu: 7.872 ± 0.092	1.978ValMet: 1.978 ± 0.04	2.545ValAsn: 2.545 ± 0.049	3.171ValPro: 3.171 ± 0.055	2.535ValGln: 2.535 ± 0.049	3.83ValArg: 3.83 ± 0.068	4.617ValSer: 4.617 ± 0.069	3.855ValThr: 3.855 ± 0.087	5.792ValVal: 5.792 ± 0.085	1.092ValTrp: 1.092 ± 0.033	2.204ValTyr: 2.204 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.193TrpAla: 1.193 ± 0.041	0.117TrpCys: 0.117 ± 0.01	0.732TrpAsp: 0.732 ± 0.027	0.818TrpGlu: 0.818 ± 0.029	0.576TrpPhe: 0.576 ± 0.023	1.059TrpGly: 1.059 ± 0.04	0.258TrpHis: 0.258 ± 0.017	0.85TrpIle: 0.85 ± 0.028	0.751TrpLys: 0.751 ± 0.026	2.063TrpLeu: 2.063 ± 0.061	0.492TrpMet: 0.492 ± 0.019	0.592TrpAsn: 0.592 ± 0.021	0.627TrpPro: 0.627 ± 0.026	0.896TrpGln: 0.896 ± 0.031	0.908TrpArg: 0.908 ± 0.034	0.808TrpSer: 0.808 ± 0.027	0.64TrpThr: 0.64 ± 0.022	1.225TrpVal: 1.225 ± 0.033	0.262TrpTrp: 0.262 ± 0.017	0.434TrpTyr: 0.434 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.048	0.292TyrCys: 0.292 ± 0.016	1.508TyrAsp: 1.508 ± 0.051	1.643TyrGlu: 1.643 ± 0.043	1.42TyrPhe: 1.42 ± 0.039	2.112TyrGly: 2.112 ± 0.047	0.732TyrHis: 0.732 ± 0.021	1.528TyrIle: 1.528 ± 0.035	0.836TyrLys: 0.836 ± 0.031	3.487TyrLeu: 3.487 ± 0.057	0.51TyrMet: 0.51 ± 0.023	1.083TyrAsn: 1.083 ± 0.035	1.592TyrPro: 1.592 ± 0.041	1.563TyrGln: 1.563 ± 0.039	1.986TyrArg: 1.986 ± 0.041	1.653TyrSer: 1.653 ± 0.046	1.672TyrThr: 1.672 ± 0.043	1.619TyrVal: 1.619 ± 0.037	0.512TyrTrp: 0.512 ± 0.022	1.004TyrTyr: 1.004 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3344 proteins (1098332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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