Amino acid dipepetide frequency for Puniceibacterium sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.663AlaAla: 15.663 ± 0.168	1.119AlaCys: 1.119 ± 0.03	6.841AlaAsp: 6.841 ± 0.074	7.38AlaGlu: 7.38 ± 0.085	4.284AlaPhe: 4.284 ± 0.063	10.077AlaGly: 10.077 ± 0.118	2.235AlaHis: 2.235 ± 0.042	5.739AlaIle: 5.739 ± 0.066	3.672AlaLys: 3.672 ± 0.07	13.714AlaLeu: 13.714 ± 0.144	3.757AlaMet: 3.757 ± 0.05	2.758AlaAsn: 2.758 ± 0.046	5.6AlaPro: 5.6 ± 0.087	4.689AlaGln: 4.689 ± 0.071	8.505AlaArg: 8.505 ± 0.101	5.655AlaSer: 5.655 ± 0.068	6.273AlaThr: 6.273 ± 0.076	8.464AlaVal: 8.464 ± 0.087	1.313AlaTrp: 1.313 ± 0.032	2.535AlaTyr: 2.535 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.166CysAla: 1.166 ± 0.029	0.122CysCys: 0.122 ± 0.01	0.628CysAsp: 0.628 ± 0.023	0.43CysGlu: 0.43 ± 0.022	0.323CysPhe: 0.323 ± 0.014	0.933CysGly: 0.933 ± 0.034	0.282CysHis: 0.282 ± 0.014	0.443CysIle: 0.443 ± 0.019	0.217CysLys: 0.217 ± 0.013	0.909CysLeu: 0.909 ± 0.029	0.176CysMet: 0.176 ± 0.012	0.228CysAsn: 0.228 ± 0.012	0.495CysPro: 0.495 ± 0.022	0.262CysGln: 0.262 ± 0.013	0.576CysArg: 0.576 ± 0.023	0.491CysSer: 0.491 ± 0.02	0.448CysThr: 0.448 ± 0.021	0.635CysVal: 0.635 ± 0.024	0.121CysTrp: 0.121 ± 0.011	0.221CysTyr: 0.221 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.304AspAla: 7.304 ± 0.09	0.525AspCys: 0.525 ± 0.021	3.279AspAsp: 3.279 ± 0.065	3.257AspGlu: 3.257 ± 0.059	2.252AspPhe: 2.252 ± 0.046	5.559AspGly: 5.559 ± 0.081	1.401AspHis: 1.401 ± 0.038	3.203AspIle: 3.203 ± 0.055	1.668AspLys: 1.668 ± 0.036	6.77AspLeu: 6.77 ± 0.078	1.659AspMet: 1.659 ± 0.042	1.338AspAsn: 1.338 ± 0.037	3.63AspPro: 3.63 ± 0.054	1.935AspGln: 1.935 ± 0.044	4.116AspArg: 4.116 ± 0.066	2.471AspSer: 2.471 ± 0.049	3.28AspThr: 3.28 ± 0.057	4.294AspVal: 4.294 ± 0.068	1.116AspTrp: 1.116 ± 0.031	1.485AspTyr: 1.485 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.207GluAla: 7.207 ± 0.096	0.373GluCys: 0.373 ± 0.018	2.979GluAsp: 2.979 ± 0.062	3.074GluGlu: 3.074 ± 0.061	1.704GluPhe: 1.704 ± 0.037	4.264GluGly: 4.264 ± 0.063	1.126GluHis: 1.126 ± 0.03	3.478GluIle: 3.478 ± 0.053	2.07GluLys: 2.07 ± 0.048	4.981GluLeu: 4.981 ± 0.063	1.834GluMet: 1.834 ± 0.037	1.681GluAsn: 1.681 ± 0.036	2.353GluPro: 2.353 ± 0.048	1.941GluGln: 1.941 ± 0.043	3.868GluArg: 3.868 ± 0.064	2.413GluSer: 2.413 ± 0.048	3.718GluThr: 3.718 ± 0.051	4.19GluVal: 4.19 ± 0.058	0.659GluTrp: 0.659 ± 0.021	1.037GluTyr: 1.037 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.375PheAla: 4.375 ± 0.061	0.431PheCys: 0.431 ± 0.016	2.897PheAsp: 2.897 ± 0.05	2.112PheGlu: 2.112 ± 0.046	1.41PhePhe: 1.41 ± 0.038	3.778PheGly: 3.778 ± 0.06	0.757PheHis: 0.757 ± 0.024	1.621PheIle: 1.621 ± 0.039	0.974PheLys: 0.974 ± 0.028	3.4PheLeu: 3.4 ± 0.061	0.854PheMet: 0.854 ± 0.025	1.087PheAsn: 1.087 ± 0.029	1.542PhePro: 1.542 ± 0.029	1.09PheGln: 1.09 ± 0.028	2.121PheArg: 2.121 ± 0.044	2.271PheSer: 2.271 ± 0.044	2.09PheThr: 2.09 ± 0.045	2.767PheVal: 2.767 ± 0.045	0.559PheTrp: 0.559 ± 0.021	0.921PheTyr: 0.921 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.868GlyAla: 9.868 ± 0.118	0.879GlyCys: 0.879 ± 0.028	4.708GlyAsp: 4.708 ± 0.075	4.245GlyGlu: 4.245 ± 0.056	3.675GlyPhe: 3.675 ± 0.052	7.393GlyGly: 7.393 ± 0.154	1.979GlyHis: 1.979 ± 0.044	4.689GlyIle: 4.689 ± 0.068	3.068GlyLys: 3.068 ± 0.055	9.288GlyLeu: 9.288 ± 0.093	2.647GlyMet: 2.647 ± 0.044	2.194GlyAsn: 2.194 ± 0.05	3.661GlyPro: 3.661 ± 0.056	3.25GlyGln: 3.25 ± 0.054	5.546GlyArg: 5.546 ± 0.076	4.477GlySer: 4.477 ± 0.087	5.031GlyThr: 5.031 ± 0.086	6.522GlyVal: 6.522 ± 0.08	1.422GlyTrp: 1.422 ± 0.032	2.307GlyTyr: 2.307 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.285HisAla: 2.285 ± 0.045	0.23HisCys: 0.23 ± 0.013	1.275HisAsp: 1.275 ± 0.035	1.032HisGlu: 1.032 ± 0.026	0.841HisPhe: 0.841 ± 0.026	1.944HisGly: 1.944 ± 0.043	0.557HisHis: 0.557 ± 0.02	1.025HisIle: 1.025 ± 0.031	0.533HisLys: 0.533 ± 0.021	2.12HisLeu: 2.12 ± 0.042	0.547HisMet: 0.547 ± 0.02	0.473HisAsn: 0.473 ± 0.019	1.336HisPro: 1.336 ± 0.036	0.605HisGln: 0.605 ± 0.019	1.373HisArg: 1.373 ± 0.03	0.951HisSer: 0.951 ± 0.029	0.893HisThr: 0.893 ± 0.027	1.598HisVal: 1.598 ± 0.037	0.351HisTrp: 0.351 ± 0.016	0.522HisTyr: 0.522 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.001IleAla: 7.001 ± 0.08	0.631IleCys: 0.631 ± 0.023	3.531IleAsp: 3.531 ± 0.053	3.358IleGlu: 3.358 ± 0.052	1.839IlePhe: 1.839 ± 0.043	4.854IleGly: 4.854 ± 0.069	0.916IleHis: 0.916 ± 0.024	2.265IleIle: 2.265 ± 0.048	1.501IleLys: 1.501 ± 0.031	5.042IleLeu: 5.042 ± 0.071	1.076IleMet: 1.076 ± 0.027	1.387IleAsn: 1.387 ± 0.033	2.473IlePro: 2.473 ± 0.041	1.283IleGln: 1.283 ± 0.028	3.25IleArg: 3.25 ± 0.051	3.253IleSer: 3.253 ± 0.057	3.096IleThr: 3.096 ± 0.057	3.762IleVal: 3.762 ± 0.056	0.735IleTrp: 0.735 ± 0.025	1.187IleTyr: 1.187 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.77LysAla: 3.77 ± 0.062	0.184LysCys: 0.184 ± 0.01	1.786LysAsp: 1.786 ± 0.044	1.468LysGlu: 1.468 ± 0.042	0.906LysPhe: 0.906 ± 0.027	2.701LysGly: 2.701 ± 0.05	0.557LysHis: 0.557 ± 0.021	1.723LysIle: 1.723 ± 0.042	1.163LysLys: 1.163 ± 0.039	2.971LysLeu: 2.971 ± 0.047	0.9LysMet: 0.9 ± 0.028	0.82LysAsn: 0.82 ± 0.026	1.805LysPro: 1.805 ± 0.05	0.877LysGln: 0.877 ± 0.028	2.141LysArg: 2.141 ± 0.048	1.897LysSer: 1.897 ± 0.041	1.99LysThr: 1.99 ± 0.043	2.343LysVal: 2.343 ± 0.05	0.403LysTrp: 0.403 ± 0.018	0.664LysTyr: 0.664 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.579LeuAla: 12.579 ± 0.133	1.09LeuCys: 1.09 ± 0.028	6.118LeuAsp: 6.118 ± 0.077	5.077LeuGlu: 5.077 ± 0.063	3.582LeuPhe: 3.582 ± 0.065	8.637LeuGly: 8.637 ± 0.093	2.003LeuHis: 2.003 ± 0.044	5.453LeuIle: 5.453 ± 0.08	3.159LeuLys: 3.159 ± 0.053	9.4LeuLeu: 9.4 ± 0.12	2.747LeuMet: 2.747 ± 0.05	2.823LeuAsn: 2.823 ± 0.047	5.786LeuPro: 5.786 ± 0.093	2.884LeuGln: 2.884 ± 0.046	7.279LeuArg: 7.279 ± 0.084	7.203LeuSer: 7.203 ± 0.073	6.328LeuThr: 6.328 ± 0.086	6.868LeuVal: 6.868 ± 0.085	1.322LeuTrp: 1.322 ± 0.032	1.961LeuTyr: 1.961 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.454MetAla: 3.454 ± 0.052	0.186MetCys: 0.186 ± 0.011	1.478MetAsp: 1.478 ± 0.032	1.265MetGlu: 1.265 ± 0.037	0.857MetPhe: 0.857 ± 0.031	2.264MetGly: 2.264 ± 0.05	0.469MetHis: 0.469 ± 0.021	1.659MetIle: 1.659 ± 0.036	1.072MetLys: 1.072 ± 0.029	2.647MetLeu: 2.647 ± 0.047	0.757MetMet: 0.757 ± 0.023	0.852MetAsn: 0.852 ± 0.028	1.599MetPro: 1.599 ± 0.038	1.04MetGln: 1.04 ± 0.026	1.816MetArg: 1.816 ± 0.038	1.85MetSer: 1.85 ± 0.041	2.224MetThr: 2.224 ± 0.043	1.888MetVal: 1.888 ± 0.044	0.238MetTrp: 0.238 ± 0.012	0.367MetTyr: 0.367 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.214AsnAla: 3.214 ± 0.054	0.25AsnCys: 0.25 ± 0.014	1.471AsnAsp: 1.471 ± 0.036	1.15AsnGlu: 1.15 ± 0.028	0.97AsnPhe: 0.97 ± 0.026	2.474AsnGly: 2.474 ± 0.055	0.51AsnHis: 0.51 ± 0.023	1.429AsnIle: 1.429 ± 0.037	0.687AsnLys: 0.687 ± 0.026	2.658AsnLeu: 2.658 ± 0.045	0.719AsnMet: 0.719 ± 0.024	0.692AsnAsn: 0.692 ± 0.026	1.852AsnPro: 1.852 ± 0.037	0.721AsnGln: 0.721 ± 0.028	1.758AsnArg: 1.758 ± 0.04	1.286AsnSer: 1.286 ± 0.033	1.472AsnThr: 1.472 ± 0.039	1.937AsnVal: 1.937 ± 0.045	0.44AsnTrp: 0.44 ± 0.02	0.623AsnTyr: 0.623 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.358ProAla: 5.358 ± 0.087	0.391ProCys: 0.391 ± 0.019	4.0ProAsp: 4.0 ± 0.064	4.035ProGlu: 4.035 ± 0.062	1.937ProPhe: 1.937 ± 0.041	4.561ProGly: 4.561 ± 0.069	1.058ProHis: 1.058 ± 0.028	2.3ProIle: 2.3 ± 0.039	1.718ProLys: 1.718 ± 0.047	4.738ProLeu: 4.738 ± 0.063	1.276ProMet: 1.276 ± 0.034	1.277ProAsn: 1.277 ± 0.033	2.266ProPro: 2.266 ± 0.049	1.722ProGln: 1.722 ± 0.038	2.78ProArg: 2.78 ± 0.055	2.661ProSer: 2.661 ± 0.051	2.609ProThr: 2.609 ± 0.048	4.28ProVal: 4.28 ± 0.062	0.672ProTrp: 0.672 ± 0.02	1.179ProTyr: 1.179 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.957GlnAla: 3.957 ± 0.066	0.22GlnCys: 0.22 ± 0.014	1.799GlnAsp: 1.799 ± 0.041	1.609GlnGlu: 1.609 ± 0.039	1.127GlnPhe: 1.127 ± 0.028	2.718GlnGly: 2.718 ± 0.049	0.627GlnHis: 0.627 ± 0.021	2.175GlnIle: 2.175 ± 0.038	1.159GlnLys: 1.159 ± 0.029	2.985GlnLeu: 2.985 ± 0.049	1.071GlnMet: 1.071 ± 0.027	0.997GlnAsn: 0.997 ± 0.029	1.658GlnPro: 1.658 ± 0.038	1.114GlnGln: 1.114 ± 0.032	2.253GlnArg: 2.253 ± 0.051	2.009GlnSer: 2.009 ± 0.045	2.009GlnThr: 2.009 ± 0.042	2.385GlnVal: 2.385 ± 0.039	0.375GlnTrp: 0.375 ± 0.02	0.604GlnTyr: 0.604 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.791ArgAla: 7.791 ± 0.092	0.505ArgCys: 0.505 ± 0.02	4.378ArgAsp: 4.378 ± 0.06	3.426ArgGlu: 3.426 ± 0.065	2.577ArgPhe: 2.577 ± 0.045	4.533ArgGly: 4.533 ± 0.059	1.534ArgHis: 1.534 ± 0.034	3.944ArgIle: 3.944 ± 0.059	2.237ArgLys: 2.237 ± 0.046	7.093ArgLeu: 7.093 ± 0.09	2.027ArgMet: 2.027 ± 0.042	1.841ArgAsn: 1.841 ± 0.037	3.17ArgPro: 3.17 ± 0.057	2.316ArgGln: 2.316 ± 0.043	4.831ArgArg: 4.831 ± 0.085	3.465ArgSer: 3.465 ± 0.053	3.189ArgThr: 3.189 ± 0.051	4.59ArgVal: 4.59 ± 0.06	0.905ArgTrp: 0.905 ± 0.028	1.485ArgTyr: 1.485 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.262SerAla: 6.262 ± 0.069	0.449SerCys: 0.449 ± 0.021	3.53SerAsp: 3.53 ± 0.056	3.096SerGlu: 3.096 ± 0.056	2.264SerPhe: 2.264 ± 0.047	5.859SerGly: 5.859 ± 0.091	1.163SerHis: 1.163 ± 0.033	2.625SerIle: 2.625 ± 0.054	1.608SerLys: 1.608 ± 0.038	5.474SerLeu: 5.474 ± 0.07	1.437SerMet: 1.437 ± 0.034	1.442SerAsn: 1.442 ± 0.036	2.575SerPro: 2.575 ± 0.043	1.681SerGln: 1.681 ± 0.033	3.349SerArg: 3.349 ± 0.048	2.857SerSer: 2.857 ± 0.06	2.736SerThr: 2.736 ± 0.054	4.234SerVal: 4.234 ± 0.062	0.728SerTrp: 0.728 ± 0.025	1.351SerTyr: 1.351 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.53ThrAla: 6.53 ± 0.08	0.517ThrCys: 0.517 ± 0.023	3.392ThrAsp: 3.392 ± 0.058	3.003ThrGlu: 3.003 ± 0.049	2.104ThrPhe: 2.104 ± 0.04	5.687ThrGly: 5.687 ± 0.086	1.173ThrHis: 1.173 ± 0.027	2.75ThrIle: 2.75 ± 0.057	1.541ThrLys: 1.541 ± 0.036	6.552ThrLeu: 6.552 ± 0.088	1.359ThrMet: 1.359 ± 0.034	1.363ThrAsn: 1.363 ± 0.035	3.574ThrPro: 3.574 ± 0.057	1.787ThrGln: 1.787 ± 0.04	3.612ThrArg: 3.612 ± 0.055	2.991ThrSer: 2.991 ± 0.057	3.117ThrThr: 3.117 ± 0.055	4.418ThrVal: 4.418 ± 0.06	0.678ThrTrp: 0.678 ± 0.024	1.29ThrTyr: 1.29 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.724ValAla: 8.724 ± 0.08	0.644ValCys: 0.644 ± 0.021	4.027ValAsp: 4.027 ± 0.057	4.081ValGlu: 4.081 ± 0.057	2.929ValPhe: 2.929 ± 0.045	5.543ValGly: 5.543 ± 0.077	1.319ValHis: 1.319 ± 0.028	4.294ValIle: 4.294 ± 0.061	2.033ValLys: 2.033 ± 0.048	7.67ValLeu: 7.67 ± 0.089	2.238ValMet: 2.238 ± 0.04	1.991ValAsn: 1.991 ± 0.047	3.719ValPro: 3.719 ± 0.062	2.3ValGln: 2.3 ± 0.047	4.172ValArg: 4.172 ± 0.063	4.477ValSer: 4.477 ± 0.074	4.997ValThr: 4.997 ± 0.084	5.765ValVal: 5.765 ± 0.073	0.996ValTrp: 0.996 ± 0.028	1.462ValTyr: 1.462 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.316TrpAla: 1.316 ± 0.038	0.13TrpCys: 0.13 ± 0.01	0.804TrpAsp: 0.804 ± 0.028	0.623TrpGlu: 0.623 ± 0.022	0.538TrpPhe: 0.538 ± 0.021	0.975TrpGly: 0.975 ± 0.026	0.342TrpHis: 0.342 ± 0.014	0.706TrpIle: 0.706 ± 0.023	0.435TrpLys: 0.435 ± 0.019	1.585TrpLeu: 1.585 ± 0.038	0.416TrpMet: 0.416 ± 0.018	0.464TrpAsn: 0.464 ± 0.016	0.674TrpPro: 0.674 ± 0.024	0.62TrpGln: 0.62 ± 0.021	1.0TrpArg: 1.0 ± 0.026	0.825TrpSer: 0.825 ± 0.025	0.767TrpThr: 0.767 ± 0.022	0.871TrpVal: 0.871 ± 0.028	0.195TrpTrp: 0.195 ± 0.012	0.274TrpTyr: 0.274 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.449TyrAla: 2.449 ± 0.044	0.229TyrCys: 0.229 ± 0.014	1.62TyrAsp: 1.62 ± 0.035	1.232TyrGlu: 1.232 ± 0.033	0.937TyrPhe: 0.937 ± 0.028	2.096TyrGly: 2.096 ± 0.038	0.485TyrHis: 0.485 ± 0.022	0.915TyrIle: 0.915 ± 0.031	0.555TyrLys: 0.555 ± 0.02	2.301TyrLeu: 2.301 ± 0.043	0.484TyrMet: 0.484 ± 0.022	0.607TyrAsn: 0.607 ± 0.022	1.046TyrPro: 1.046 ± 0.027	0.732TyrGln: 0.732 ± 0.024	1.49TyrArg: 1.49 ± 0.038	1.218TyrSer: 1.218 ± 0.034	1.173TyrThr: 1.173 ± 0.032	1.57TyrVal: 1.57 ± 0.035	0.332TyrTrp: 0.332 ± 0.015	0.555TyrTyr: 0.555 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4262 proteins (1366683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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