Amino acid dipepetide frequency for Rhodococcus tukisamuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.229AlaAla: 21.229 ± 0.201	0.925AlaCys: 0.925 ± 0.027	8.592AlaAsp: 8.592 ± 0.096	8.049AlaGlu: 8.049 ± 0.085	3.413AlaPhe: 3.413 ± 0.05	12.926AlaGly: 12.926 ± 0.124	2.497AlaHis: 2.497 ± 0.039	4.384AlaIle: 4.384 ± 0.064	2.814AlaLys: 2.814 ± 0.06	13.821AlaLeu: 13.821 ± 0.118	2.712AlaMet: 2.712 ± 0.041	2.38AlaAsn: 2.38 ± 0.038	6.894AlaPro: 6.894 ± 0.091	3.838AlaGln: 3.838 ± 0.047	9.064AlaArg: 9.064 ± 0.095	6.348AlaSer: 6.348 ± 0.069	7.694AlaThr: 7.694 ± 0.078	12.748AlaVal: 12.748 ± 0.115	1.604AlaTrp: 1.604 ± 0.037	2.346AlaTyr: 2.346 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.027	0.09CysCys: 0.09 ± 0.008	0.431CysAsp: 0.431 ± 0.017	0.401CysGlu: 0.401 ± 0.015	0.213CysPhe: 0.213 ± 0.01	0.877CysGly: 0.877 ± 0.025	0.159CysHis: 0.159 ± 0.01	0.239CysIle: 0.239 ± 0.012	0.121CysLys: 0.121 ± 0.009	0.634CysLeu: 0.634 ± 0.02	0.124CysMet: 0.124 ± 0.008	0.154CysAsn: 0.154 ± 0.01	0.447CysPro: 0.447 ± 0.018	0.171CysGln: 0.171 ± 0.011	0.523CysArg: 0.523 ± 0.022	0.472CysSer: 0.472 ± 0.017	0.484CysThr: 0.484 ± 0.019	0.636CysVal: 0.636 ± 0.021	0.121CysTrp: 0.121 ± 0.01	0.162CysTyr: 0.162 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.162AspAla: 8.162 ± 0.078	0.436AspCys: 0.436 ± 0.018	3.653AspAsp: 3.653 ± 0.058	3.977AspGlu: 3.977 ± 0.059	1.737AspPhe: 1.737 ± 0.038	6.315AspGly: 6.315 ± 0.07	1.274AspHis: 1.274 ± 0.027	2.038AspIle: 2.038 ± 0.035	1.133AspLys: 1.133 ± 0.032	6.689AspLeu: 6.689 ± 0.094	0.92AspMet: 0.92 ± 0.026	1.065AspAsn: 1.065 ± 0.03	4.613AspPro: 4.613 ± 0.058	1.625AspGln: 1.625 ± 0.03	4.922AspArg: 4.922 ± 0.089	2.922AspSer: 2.922 ± 0.042	3.126AspThr: 3.126 ± 0.048	5.162AspVal: 5.162 ± 0.064	0.983AspTrp: 0.983 ± 0.025	1.251AspTyr: 1.251 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.277GluAla: 6.277 ± 0.074	0.358GluCys: 0.358 ± 0.016	2.624GluAsp: 2.624 ± 0.041	2.605GluGlu: 2.605 ± 0.04	1.95GluPhe: 1.95 ± 0.041	3.598GluGly: 3.598 ± 0.057	1.515GluHis: 1.515 ± 0.029	2.512GluIle: 2.512 ± 0.045	1.229GluLys: 1.229 ± 0.034	6.733GluLeu: 6.733 ± 0.107	1.055GluMet: 1.055 ± 0.028	1.212GluAsn: 1.212 ± 0.03	3.045GluPro: 3.045 ± 0.05	2.171GluGln: 2.171 ± 0.038	4.686GluArg: 4.686 ± 0.064	3.105GluSer: 3.105 ± 0.06	2.798GluThr: 2.798 ± 0.046	4.936GluVal: 4.936 ± 0.064	0.762GluTrp: 0.762 ± 0.021	1.147GluTyr: 1.147 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.129PheAla: 4.129 ± 0.051	0.251PheCys: 0.251 ± 0.014	2.446PheAsp: 2.446 ± 0.06	1.753PheGlu: 1.753 ± 0.043	0.942PhePhe: 0.942 ± 0.027	3.527PheGly: 3.527 ± 0.05	0.617PheHis: 0.617 ± 0.018	0.761PheIle: 0.761 ± 0.026	0.491PheLys: 0.491 ± 0.022	2.595PheLeu: 2.595 ± 0.05	0.464PheMet: 0.464 ± 0.018	0.636PheAsn: 0.636 ± 0.025	1.387PhePro: 1.387 ± 0.027	0.666PheGln: 0.666 ± 0.025	1.639PheArg: 1.639 ± 0.037	1.522PheSer: 1.522 ± 0.035	1.975PheThr: 1.975 ± 0.031	2.821PheVal: 2.821 ± 0.05	0.412PheTrp: 0.412 ± 0.015	0.601PheTyr: 0.601 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.297GlyAla: 11.297 ± 0.104	0.803GlyCys: 0.803 ± 0.027	5.12GlyAsp: 5.12 ± 0.058	4.921GlyGlu: 4.921 ± 0.068	3.098GlyPhe: 3.098 ± 0.041	8.611GlyGly: 8.611 ± 0.116	2.04GlyHis: 2.04 ± 0.039	3.992GlyIle: 3.992 ± 0.053	2.248GlyLys: 2.248 ± 0.044	9.18GlyLeu: 9.18 ± 0.097	2.167GlyMet: 2.167 ± 0.045	1.892GlyAsn: 1.892 ± 0.034	4.804GlyPro: 4.804 ± 0.062	2.768GlyGln: 2.768 ± 0.049	6.802GlyArg: 6.802 ± 0.083	5.72GlySer: 5.72 ± 0.077	5.909GlyThr: 5.909 ± 0.07	8.05GlyVal: 8.05 ± 0.072	1.641GlyTrp: 1.641 ± 0.035	2.299GlyTyr: 2.299 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.339HisAla: 2.339 ± 0.042	0.217HisCys: 0.217 ± 0.013	1.245HisAsp: 1.245 ± 0.029	1.086HisGlu: 1.086 ± 0.026	0.638HisPhe: 0.638 ± 0.018	2.06HisGly: 2.06 ± 0.034	0.626HisHis: 0.626 ± 0.026	0.594HisIle: 0.594 ± 0.021	0.317HisLys: 0.317 ± 0.016	2.128HisLeu: 2.128 ± 0.043	0.332HisMet: 0.332 ± 0.014	0.417HisAsn: 0.417 ± 0.016	1.601HisPro: 1.601 ± 0.036	0.579HisGln: 0.579 ± 0.023	1.77HisArg: 1.77 ± 0.035	1.025HisSer: 1.025 ± 0.026	1.148HisThr: 1.148 ± 0.032	1.62HisVal: 1.62 ± 0.028	0.345HisTrp: 0.345 ± 0.015	0.459HisTyr: 0.459 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.675IleAla: 5.675 ± 0.066	0.293IleCys: 0.293 ± 0.014	2.765IleAsp: 2.765 ± 0.04	2.313IleGlu: 2.313 ± 0.041	0.886IlePhe: 0.886 ± 0.026	4.248IleGly: 4.248 ± 0.064	0.641IleHis: 0.641 ± 0.021	1.0IleIle: 1.0 ± 0.03	0.674IleLys: 0.674 ± 0.025	2.89IleLeu: 2.89 ± 0.048	0.52IleMet: 0.52 ± 0.019	0.788IleAsn: 0.788 ± 0.025	2.073IlePro: 2.073 ± 0.035	0.723IleGln: 0.723 ± 0.021	2.396IleArg: 2.396 ± 0.037	2.01IleSer: 2.01 ± 0.039	2.417IleThr: 2.417 ± 0.043	3.47IleVal: 3.47 ± 0.057	0.397IleTrp: 0.397 ± 0.016	0.682IleTyr: 0.682 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.556LysAla: 2.556 ± 0.063	0.102LysCys: 0.102 ± 0.008	1.055LysAsp: 1.055 ± 0.034	0.885LysGlu: 0.885 ± 0.027	0.617LysPhe: 0.617 ± 0.018	1.512LysGly: 1.512 ± 0.036	0.386LysHis: 0.386 ± 0.016	0.955LysIle: 0.955 ± 0.032	0.638LysLys: 0.638 ± 0.031	1.974LysLeu: 1.974 ± 0.036	0.472LysMet: 0.472 ± 0.018	0.493LysAsn: 0.493 ± 0.018	1.164LysPro: 1.164 ± 0.035	0.618LysGln: 0.618 ± 0.023	1.314LysArg: 1.314 ± 0.037	1.178LysSer: 1.178 ± 0.03	1.266LysThr: 1.266 ± 0.036	1.907LysVal: 1.907 ± 0.043	0.276LysTrp: 0.276 ± 0.014	0.461LysTyr: 0.461 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.851LeuAla: 14.851 ± 0.129	0.772LeuCys: 0.772 ± 0.026	7.246LeuAsp: 7.246 ± 0.107	4.812LeuGlu: 4.812 ± 0.061	2.752LeuPhe: 2.752 ± 0.045	9.759LeuGly: 9.759 ± 0.1	1.912LeuHis: 1.912 ± 0.038	3.514LeuIle: 3.514 ± 0.061	1.501LeuLys: 1.501 ± 0.04	10.063LeuLeu: 10.063 ± 0.1	1.65LeuMet: 1.65 ± 0.037	1.755LeuAsn: 1.755 ± 0.032	5.931LeuPro: 5.931 ± 0.065	2.238LeuGln: 2.238 ± 0.041	7.689LeuArg: 7.689 ± 0.084	5.577LeuSer: 5.577 ± 0.061	6.684LeuThr: 6.684 ± 0.067	9.438LeuVal: 9.438 ± 0.081	1.201LeuTrp: 1.201 ± 0.029	1.636LeuTyr: 1.636 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.366MetAla: 2.366 ± 0.036	0.176MetCys: 0.176 ± 0.012	0.898MetAsp: 0.898 ± 0.021	0.653MetGlu: 0.653 ± 0.023	0.63MetPhe: 0.63 ± 0.021	1.405MetGly: 1.405 ± 0.036	0.426MetHis: 0.426 ± 0.018	0.831MetIle: 0.831 ± 0.027	0.428MetLys: 0.428 ± 0.019	1.974MetLeu: 1.974 ± 0.035	0.359MetMet: 0.359 ± 0.019	0.472MetAsn: 0.472 ± 0.019	1.176MetPro: 1.176 ± 0.027	0.519MetGln: 0.519 ± 0.019	1.491MetArg: 1.491 ± 0.032	1.587MetSer: 1.587 ± 0.036	1.743MetThr: 1.743 ± 0.036	1.646MetVal: 1.646 ± 0.043	0.274MetTrp: 0.274 ± 0.014	0.356MetTyr: 0.356 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.374AsnAla: 2.374 ± 0.037	0.181AsnCys: 0.181 ± 0.012	0.941AsnAsp: 0.941 ± 0.026	0.947AsnGlu: 0.947 ± 0.027	0.625AsnPhe: 0.625 ± 0.017	1.895AsnGly: 1.895 ± 0.045	0.417AsnHis: 0.417 ± 0.016	0.806AsnIle: 0.806 ± 0.025	0.432AsnLys: 0.432 ± 0.018	1.991AsnLeu: 1.991 ± 0.039	0.396AsnMet: 0.396 ± 0.015	0.471AsnAsn: 0.471 ± 0.019	1.682AsnPro: 1.682 ± 0.035	0.563AsnGln: 0.563 ± 0.019	1.357AsnArg: 1.357 ± 0.032	1.182AsnSer: 1.182 ± 0.028	1.26AsnThr: 1.26 ± 0.026	1.685AsnVal: 1.685 ± 0.035	0.348AsnTrp: 0.348 ± 0.016	0.494AsnTyr: 0.494 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.08ProAla: 8.08 ± 0.096	0.269ProCys: 0.269 ± 0.015	4.483ProAsp: 4.483 ± 0.056	3.932ProGlu: 3.932 ± 0.058	1.567ProPhe: 1.567 ± 0.033	5.815ProGly: 5.815 ± 0.076	1.084ProHis: 1.084 ± 0.028	1.92ProIle: 1.92 ± 0.035	1.163ProLys: 1.163 ± 0.034	4.942ProLeu: 4.942 ± 0.054	1.154ProMet: 1.154 ± 0.027	1.177ProAsn: 1.177 ± 0.028	2.98ProPro: 2.98 ± 0.072	1.565ProGln: 1.565 ± 0.038	3.502ProArg: 3.502 ± 0.046	3.092ProSer: 3.092 ± 0.048	3.683ProThr: 3.683 ± 0.051	5.467ProVal: 5.467 ± 0.08	0.807ProTrp: 0.807 ± 0.024	1.052ProTyr: 1.052 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.399GlnAla: 3.399 ± 0.047	0.176GlnCys: 0.176 ± 0.01	1.265GlnAsp: 1.265 ± 0.031	1.099GlnGlu: 1.099 ± 0.025	0.937GlnPhe: 0.937 ± 0.025	1.904GlnGly: 1.904 ± 0.044	0.598GlnHis: 0.598 ± 0.018	1.271GlnIle: 1.271 ± 0.028	0.557GlnLys: 0.557 ± 0.02	3.183GlnLeu: 3.183 ± 0.05	0.591GlnMet: 0.591 ± 0.022	0.543GlnAsn: 0.543 ± 0.02	1.554GlnPro: 1.554 ± 0.038	1.147GlnGln: 1.147 ± 0.035	2.254GlnArg: 2.254 ± 0.043	1.519GlnSer: 1.519 ± 0.03	1.368GlnThr: 1.368 ± 0.033	2.826GlnVal: 2.826 ± 0.048	0.561GlnTrp: 0.561 ± 0.021	0.609GlnTyr: 0.609 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.528ArgAla: 8.528 ± 0.093	0.542ArgCys: 0.542 ± 0.019	4.09ArgAsp: 4.09 ± 0.05	4.208ArgGlu: 4.208 ± 0.054	2.323ArgPhe: 2.323 ± 0.038	5.607ArgGly: 5.607 ± 0.063	1.646ArgHis: 1.646 ± 0.034	3.282ArgIle: 3.282 ± 0.045	1.518ArgLys: 1.518 ± 0.038	7.353ArgLeu: 7.353 ± 0.1	1.772ArgMet: 1.772 ± 0.034	1.459ArgAsn: 1.459 ± 0.038	4.172ArgPro: 4.172 ± 0.05	2.028ArgGln: 2.028 ± 0.04	6.532ArgArg: 6.532 ± 0.092	4.088ArgSer: 4.088 ± 0.053	4.596ArgThr: 4.596 ± 0.058	5.991ArgVal: 5.991 ± 0.065	1.278ArgTrp: 1.278 ± 0.028	1.709ArgTyr: 1.709 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.204SerAla: 7.204 ± 0.067	0.387SerCys: 0.387 ± 0.017	3.106SerAsp: 3.106 ± 0.043	2.629SerGlu: 2.629 ± 0.04	1.644SerPhe: 1.644 ± 0.032	6.067SerGly: 6.067 ± 0.064	0.98SerHis: 0.98 ± 0.025	2.146SerIle: 2.146 ± 0.037	1.127SerLys: 1.127 ± 0.032	5.066SerLeu: 5.066 ± 0.065	1.341SerMet: 1.341 ± 0.028	1.086SerAsn: 1.086 ± 0.027	3.096SerPro: 3.096 ± 0.05	1.363SerGln: 1.363 ± 0.03	3.631SerArg: 3.631 ± 0.054	3.082SerSer: 3.082 ± 0.048	3.642SerThr: 3.642 ± 0.051	4.997SerVal: 4.997 ± 0.056	0.954SerTrp: 0.954 ± 0.024	1.117SerTyr: 1.117 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.427ThrAla: 8.427 ± 0.09	0.428ThrCys: 0.428 ± 0.015	3.849ThrAsp: 3.849 ± 0.05	3.415ThrGlu: 3.415 ± 0.054	1.832ThrPhe: 1.832 ± 0.038	6.322ThrGly: 6.322 ± 0.068	1.141ThrHis: 1.141 ± 0.028	2.068ThrIle: 2.068 ± 0.041	1.176ThrLys: 1.176 ± 0.032	5.9ThrLeu: 5.9 ± 0.056	1.152ThrMet: 1.152 ± 0.024	1.195ThrAsn: 1.195 ± 0.032	3.923ThrPro: 3.923 ± 0.055	1.378ThrGln: 1.378 ± 0.03	3.816ThrArg: 3.816 ± 0.05	3.268ThrSer: 3.268 ± 0.045	4.054ThrThr: 4.054 ± 0.066	6.752ThrVal: 6.752 ± 0.075	0.8ThrTrp: 0.8 ± 0.023	1.241ThrTyr: 1.241 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	12.432ValAla: 12.432 ± 0.125	0.726ValCys: 0.726 ± 0.021	6.191ValAsp: 6.191 ± 0.08	4.979ValGlu: 4.979 ± 0.059	2.634ValPhe: 2.634 ± 0.046	7.925ValGly: 7.925 ± 0.079	1.877ValHis: 1.877 ± 0.032	3.369ValIle: 3.369 ± 0.056	1.605ValLys: 1.605 ± 0.034	9.881ValLeu: 9.881 ± 0.101	1.558ValMet: 1.558 ± 0.03	2.03ValAsn: 2.03 ± 0.035	5.279ValPro: 5.279 ± 0.07	2.207ValGln: 2.207 ± 0.036	6.446ValArg: 6.446 ± 0.068	4.918ValSer: 4.918 ± 0.055	6.174ValThr: 6.174 ± 0.074	9.262ValVal: 9.262 ± 0.095	1.115ValTrp: 1.115 ± 0.027	1.538ValTyr: 1.538 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.614TrpAla: 1.614 ± 0.033	0.151TrpCys: 0.151 ± 0.009	0.796TrpAsp: 0.796 ± 0.027	0.649TrpGlu: 0.649 ± 0.02	0.531TrpPhe: 0.531 ± 0.021	1.035TrpGly: 1.035 ± 0.026	0.322TrpHis: 0.322 ± 0.012	0.619TrpIle: 0.619 ± 0.02	0.312TrpLys: 0.312 ± 0.013	1.663TrpLeu: 1.663 ± 0.039	0.367TrpMet: 0.367 ± 0.014	0.392TrpAsn: 0.392 ± 0.016	0.739TrpPro: 0.739 ± 0.023	0.574TrpGln: 0.574 ± 0.018	1.146TrpArg: 1.146 ± 0.027	0.951TrpSer: 0.951 ± 0.024	0.941TrpThr: 0.941 ± 0.022	1.154TrpVal: 1.154 ± 0.031	0.339TrpTrp: 0.339 ± 0.018	0.306TrpTyr: 0.306 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.332TyrAla: 2.332 ± 0.046	0.182TyrCys: 0.182 ± 0.01	1.209TyrAsp: 1.209 ± 0.032	1.007TyrGlu: 1.007 ± 0.025	0.667TyrPhe: 0.667 ± 0.022	1.956TyrGly: 1.956 ± 0.035	0.388TyrHis: 0.388 ± 0.015	0.558TyrIle: 0.558 ± 0.021	0.347TyrLys: 0.347 ± 0.017	2.319TyrLeu: 2.319 ± 0.038	0.302TyrMet: 0.302 ± 0.018	0.43TyrAsn: 0.43 ± 0.015	1.174TyrPro: 1.174 ± 0.03	0.621TyrGln: 0.621 ± 0.021	1.743TyrArg: 1.743 ± 0.033	1.099TyrSer: 1.099 ± 0.03	1.175TyrThr: 1.175 ± 0.027	1.576TyrVal: 1.576 ± 0.042	0.382TyrTrp: 0.382 ± 0.016	0.431TyrTyr: 0.431 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4987 proteins (1634117 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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