Amino acid dipepetide frequency for Providencia phage vB_PreS_PR1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.85AlaAla: 6.85 ± 0.891
0.64AlaCys: 0.64 ± 0.127
4.353AlaAsp: 4.353 ± 0.351
6.017AlaGlu: 6.017 ± 0.544
2.529AlaPhe: 2.529 ± 0.227
4.289AlaGly: 4.289 ± 0.44
1.376AlaHis: 1.376 ± 0.219
4.897AlaIle: 4.897 ± 0.371
5.825AlaLys: 5.825 ± 0.604
7.618AlaLeu: 7.618 ± 0.511
1.952AlaMet: 1.952 ± 0.267
3.617AlaAsn: 3.617 ± 0.376
1.696AlaPro: 1.696 ± 0.202
2.273AlaGln: 2.273 ± 0.27
3.713AlaArg: 3.713 ± 0.382
4.993AlaSer: 4.993 ± 0.476
4.193AlaThr: 4.193 ± 0.346
4.961AlaVal: 4.961 ± 0.44
1.088AlaTrp: 1.088 ± 0.184
2.337AlaTyr: 2.337 ± 0.243
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.136
0.224CysCys: 0.224 ± 0.076
0.608CysAsp: 0.608 ± 0.156
0.64CysGlu: 0.64 ± 0.163
0.352CysPhe: 0.352 ± 0.102
0.896CysGly: 0.896 ± 0.194
0.192CysHis: 0.192 ± 0.083
0.64CysIle: 0.64 ± 0.151
0.48CysLys: 0.48 ± 0.117
0.64CysLeu: 0.64 ± 0.149
0.096CysMet: 0.096 ± 0.051
0.544CysAsn: 0.544 ± 0.125
0.448CysPro: 0.448 ± 0.127
0.384CysGln: 0.384 ± 0.145
0.416CysArg: 0.416 ± 0.129
0.672CysSer: 0.672 ± 0.154
0.672CysThr: 0.672 ± 0.131
0.608CysVal: 0.608 ± 0.139
0.032CysTrp: 0.032 ± 0.031
0.32CysTyr: 0.32 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
4.577AspAla: 4.577 ± 0.379
0.736AspCys: 0.736 ± 0.136
2.721AspAsp: 2.721 ± 0.27
4.097AspGlu: 4.097 ± 0.372
3.265AspPhe: 3.265 ± 0.334
4.353AspGly: 4.353 ± 0.403
0.896AspHis: 0.896 ± 0.212
4.225AspIle: 4.225 ± 0.476
4.193AspLys: 4.193 ± 0.364
6.786AspLeu: 6.786 ± 0.495
1.728AspMet: 1.728 ± 0.259
2.881AspAsn: 2.881 ± 0.293
2.561AspPro: 2.561 ± 0.301
1.984AspGln: 1.984 ± 0.22
2.817AspArg: 2.817 ± 0.284
4.353AspSer: 4.353 ± 0.37
3.585AspThr: 3.585 ± 0.355
3.425AspVal: 3.425 ± 0.322
0.96AspTrp: 0.96 ± 0.162
2.753AspTyr: 2.753 ± 0.288
0.0AspXaa: 0.0 ± 0.0
Glu
5.345GluAla: 5.345 ± 0.417
0.64GluCys: 0.64 ± 0.151
4.129GluAsp: 4.129 ± 0.373
5.057GluGlu: 5.057 ± 0.439
2.913GluPhe: 2.913 ± 0.277
3.521GluGly: 3.521 ± 0.323
1.28GluHis: 1.28 ± 0.218
5.089GluIle: 5.089 ± 0.338
4.673GluLys: 4.673 ± 0.31
7.234GluLeu: 7.234 ± 0.477
2.273GluMet: 2.273 ± 0.237
3.265GluAsn: 3.265 ± 0.333
1.6GluPro: 1.6 ± 0.253
2.817GluGln: 2.817 ± 0.327
3.105GluArg: 3.105 ± 0.351
4.385GluSer: 4.385 ± 0.36
4.097GluThr: 4.097 ± 0.36
5.953GluVal: 5.953 ± 0.498
0.864GluTrp: 0.864 ± 0.206
2.977GluTyr: 2.977 ± 0.351
0.0GluXaa: 0.0 ± 0.0
Phe
2.817PheAla: 2.817 ± 0.269
0.288PheCys: 0.288 ± 0.089
3.425PheAsp: 3.425 ± 0.329
2.433PheGlu: 2.433 ± 0.266
1.536PhePhe: 1.536 ± 0.191
2.881PheGly: 2.881 ± 0.334
0.928PheHis: 0.928 ± 0.193
2.721PheIle: 2.721 ± 0.264
2.721PheLys: 2.721 ± 0.32
2.913PheLeu: 2.913 ± 0.257
0.864PheMet: 0.864 ± 0.136
2.721PheAsn: 2.721 ± 0.304
1.568PhePro: 1.568 ± 0.228
1.12PheGln: 1.12 ± 0.176
1.696PheArg: 1.696 ± 0.236
2.881PheSer: 2.881 ± 0.381
2.785PheThr: 2.785 ± 0.248
2.945PheVal: 2.945 ± 0.356
0.448PheTrp: 0.448 ± 0.108
1.664PheTyr: 1.664 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
3.841GlyAla: 3.841 ± 0.405
0.864GlyCys: 0.864 ± 0.198
3.521GlyAsp: 3.521 ± 0.339
4.929GlyGlu: 4.929 ± 0.402
2.913GlyPhe: 2.913 ± 0.369
3.745GlyGly: 3.745 ± 0.408
0.96GlyHis: 0.96 ± 0.16
4.289GlyIle: 4.289 ± 0.344
5.409GlyLys: 5.409 ± 0.463
4.961GlyLeu: 4.961 ± 0.391
1.536GlyMet: 1.536 ± 0.174
3.233GlyAsn: 3.233 ± 0.324
0.64GlyPro: 0.64 ± 0.15
1.92GlyGln: 1.92 ± 0.288
2.977GlyArg: 2.977 ± 0.311
4.577GlySer: 4.577 ± 0.437
4.097GlyThr: 4.097 ± 0.582
4.673GlyVal: 4.673 ± 0.372
1.184GlyTrp: 1.184 ± 0.234
2.208GlyTyr: 2.208 ± 0.274
0.0GlyXaa: 0.0 ± 0.0
His
1.056HisAla: 1.056 ± 0.17
0.256HisCys: 0.256 ± 0.084
1.024HisAsp: 1.024 ± 0.203
0.992HisGlu: 0.992 ± 0.168
0.768HisPhe: 0.768 ± 0.166
1.6HisGly: 1.6 ± 0.205
0.416HisHis: 0.416 ± 0.132
1.536HisIle: 1.536 ± 0.226
1.312HisLys: 1.312 ± 0.248
1.728HisLeu: 1.728 ± 0.249
0.704HisMet: 0.704 ± 0.168
0.8HisAsn: 0.8 ± 0.139
0.832HisPro: 0.832 ± 0.182
0.64HisGln: 0.64 ± 0.137
0.928HisArg: 0.928 ± 0.169
1.28HisSer: 1.28 ± 0.199
0.992HisThr: 0.992 ± 0.174
0.992HisVal: 0.992 ± 0.213
0.032HisTrp: 0.032 ± 0.035
1.024HisTyr: 1.024 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
4.641IleAla: 4.641 ± 0.4
0.448IleCys: 0.448 ± 0.121
4.417IleAsp: 4.417 ± 0.428
4.865IleGlu: 4.865 ± 0.475
2.144IlePhe: 2.144 ± 0.251
3.073IleGly: 3.073 ± 0.321
1.376IleHis: 1.376 ± 0.212
4.065IleIle: 4.065 ± 0.377
4.449IleLys: 4.449 ± 0.342
5.441IleLeu: 5.441 ± 0.36
1.76IleMet: 1.76 ± 0.298
3.585IleAsn: 3.585 ± 0.37
3.137IlePro: 3.137 ± 0.35
2.497IleGln: 2.497 ± 0.276
3.361IleArg: 3.361 ± 0.299
4.417IleSer: 4.417 ± 0.363
4.577IleThr: 4.577 ± 0.456
4.289IleVal: 4.289 ± 0.442
0.576IleTrp: 0.576 ± 0.132
2.144IleTyr: 2.144 ± 0.263
0.0IleXaa: 0.0 ± 0.0
Lys
6.209LysAla: 6.209 ± 0.603
0.544LysCys: 0.544 ± 0.114
4.417LysAsp: 4.417 ± 0.429
5.057LysGlu: 5.057 ± 0.422
2.945LysPhe: 2.945 ± 0.283
3.617LysGly: 3.617 ± 0.318
1.248LysHis: 1.248 ± 0.198
4.097LysIle: 4.097 ± 0.305
3.969LysLys: 3.969 ± 0.326
6.625LysLeu: 6.625 ± 0.383
2.337LysMet: 2.337 ± 0.288
1.472LysAsn: 1.472 ± 0.173
2.753LysPro: 2.753 ± 0.329
2.561LysGln: 2.561 ± 0.283
2.561LysArg: 2.561 ± 0.292
4.609LysSer: 4.609 ± 0.404
3.809LysThr: 3.809 ± 0.548
4.321LysVal: 4.321 ± 0.323
0.992LysTrp: 0.992 ± 0.188
2.721LysTyr: 2.721 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
7.106LeuAla: 7.106 ± 0.459
0.768LeuCys: 0.768 ± 0.147
7.138LeuAsp: 7.138 ± 0.44
6.754LeuGlu: 6.754 ± 0.484
3.297LeuPhe: 3.297 ± 0.388
6.017LeuGly: 6.017 ± 0.362
1.472LeuHis: 1.472 ± 0.209
4.929LeuIle: 4.929 ± 0.455
5.377LeuLys: 5.377 ± 0.374
7.074LeuLeu: 7.074 ± 0.499
2.497LeuMet: 2.497 ± 0.314
4.897LeuAsn: 4.897 ± 0.386
3.649LeuPro: 3.649 ± 0.345
2.977LeuGln: 2.977 ± 0.296
3.937LeuArg: 3.937 ± 0.456
5.665LeuSer: 5.665 ± 0.372
5.633LeuThr: 5.633 ± 0.438
6.145LeuVal: 6.145 ± 0.465
0.704LeuTrp: 0.704 ± 0.131
2.497LeuTyr: 2.497 ± 0.294
0.0LeuXaa: 0.0 ± 0.0
Met
2.208MetAla: 2.208 ± 0.317
0.128MetCys: 0.128 ± 0.066
1.344MetAsp: 1.344 ± 0.191
2.401MetGlu: 2.401 ± 0.233
0.832MetPhe: 0.832 ± 0.183
1.408MetGly: 1.408 ± 0.212
0.768MetHis: 0.768 ± 0.15
1.888MetIle: 1.888 ± 0.23
1.952MetLys: 1.952 ± 0.225
2.305MetLeu: 2.305 ± 0.232
0.576MetMet: 0.576 ± 0.143
1.248MetAsn: 1.248 ± 0.225
1.184MetPro: 1.184 ± 0.183
1.344MetGln: 1.344 ± 0.257
1.088MetArg: 1.088 ± 0.171
2.048MetSer: 2.048 ± 0.238
1.952MetThr: 1.952 ± 0.24
1.568MetVal: 1.568 ± 0.225
0.256MetTrp: 0.256 ± 0.089
1.184MetTyr: 1.184 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
3.969AsnAla: 3.969 ± 0.453
0.352AsnCys: 0.352 ± 0.102
2.465AsnAsp: 2.465 ± 0.243
2.945AsnGlu: 2.945 ± 0.304
1.504AsnPhe: 1.504 ± 0.23
3.649AsnGly: 3.649 ± 0.497
0.896AsnHis: 0.896 ± 0.198
3.873AsnIle: 3.873 ± 0.301
3.457AsnLys: 3.457 ± 0.309
4.033AsnLeu: 4.033 ± 0.345
1.376AsnMet: 1.376 ± 0.204
2.881AsnAsn: 2.881 ± 0.273
2.721AsnPro: 2.721 ± 0.3
1.632AsnGln: 1.632 ± 0.207
1.888AsnArg: 1.888 ± 0.226
3.201AsnSer: 3.201 ± 0.36
2.529AsnThr: 2.529 ± 0.288
3.073AsnVal: 3.073 ± 0.285
0.704AsnTrp: 0.704 ± 0.124
1.792AsnTyr: 1.792 ± 0.219
0.0AsnXaa: 0.0 ± 0.0
Pro
2.849ProAla: 2.849 ± 0.325
0.16ProCys: 0.16 ± 0.066
2.785ProAsp: 2.785 ± 0.327
3.521ProGlu: 3.521 ± 0.328
1.536ProPhe: 1.536 ± 0.217
2.241ProGly: 2.241 ± 0.331
0.48ProHis: 0.48 ± 0.127
2.08ProIle: 2.08 ± 0.28
2.208ProLys: 2.208 ± 0.293
2.785ProLeu: 2.785 ± 0.275
1.056ProMet: 1.056 ± 0.199
1.856ProAsn: 1.856 ± 0.276
1.184ProPro: 1.184 ± 0.256
1.12ProGln: 1.12 ± 0.201
1.376ProArg: 1.376 ± 0.197
2.625ProSer: 2.625 ± 0.301
2.241ProThr: 2.241 ± 0.202
2.657ProVal: 2.657 ± 0.361
0.48ProTrp: 0.48 ± 0.118
1.024ProTyr: 1.024 ± 0.163
0.0ProXaa: 0.0 ± 0.0
Gln
2.561GlnAla: 2.561 ± 0.433
0.48GlnCys: 0.48 ± 0.105
2.08GlnAsp: 2.08 ± 0.287
2.593GlnGlu: 2.593 ± 0.253
1.408GlnPhe: 1.408 ± 0.215
2.048GlnGly: 2.048 ± 0.276
0.736GlnHis: 0.736 ± 0.157
2.112GlnIle: 2.112 ± 0.295
1.792GlnLys: 1.792 ± 0.255
3.361GlnLeu: 3.361 ± 0.29
1.312GlnMet: 1.312 ± 0.229
1.76GlnAsn: 1.76 ± 0.265
0.96GlnPro: 0.96 ± 0.215
1.472GlnGln: 1.472 ± 0.394
1.76GlnArg: 1.76 ± 0.297
2.08GlnSer: 2.08 ± 0.274
1.76GlnThr: 1.76 ± 0.331
2.689GlnVal: 2.689 ± 0.25
0.416GlnTrp: 0.416 ± 0.114
1.504GlnTyr: 1.504 ± 0.194
0.0GlnXaa: 0.0 ± 0.0
Arg
3.009ArgAla: 3.009 ± 0.312
0.32ArgCys: 0.32 ± 0.088
3.201ArgAsp: 3.201 ± 0.315
3.457ArgGlu: 3.457 ± 0.314
1.824ArgPhe: 1.824 ± 0.241
2.689ArgGly: 2.689 ± 0.296
0.736ArgHis: 0.736 ± 0.153
2.785ArgIle: 2.785 ± 0.254
3.105ArgLys: 3.105 ± 0.343
4.385ArgLeu: 4.385 ± 0.357
1.184ArgMet: 1.184 ± 0.205
2.625ArgAsn: 2.625 ± 0.279
1.312ArgPro: 1.312 ± 0.211
1.376ArgGln: 1.376 ± 0.19
2.176ArgArg: 2.176 ± 0.341
2.721ArgSer: 2.721 ± 0.312
2.369ArgThr: 2.369 ± 0.289
3.681ArgVal: 3.681 ± 0.289
0.416ArgTrp: 0.416 ± 0.118
1.856ArgTyr: 1.856 ± 0.271
0.0ArgXaa: 0.0 ± 0.0
Ser
4.801SerAla: 4.801 ± 0.368
0.736SerCys: 0.736 ± 0.171
3.841SerAsp: 3.841 ± 0.353
3.777SerGlu: 3.777 ± 0.389
3.425SerPhe: 3.425 ± 0.333
4.865SerGly: 4.865 ± 0.419
1.344SerHis: 1.344 ± 0.231
5.025SerIle: 5.025 ± 0.388
4.865SerLys: 4.865 ± 0.417
6.081SerLeu: 6.081 ± 0.536
2.305SerMet: 2.305 ± 0.31
2.849SerAsn: 2.849 ± 0.345
2.433SerPro: 2.433 ± 0.277
2.497SerGln: 2.497 ± 0.413
2.977SerArg: 2.977 ± 0.328
4.673SerSer: 4.673 ± 0.45
3.969SerThr: 3.969 ± 0.405
4.225SerVal: 4.225 ± 0.384
0.736SerTrp: 0.736 ± 0.143
2.208SerTyr: 2.208 ± 0.294
0.0SerXaa: 0.0 ± 0.0
Thr
4.353ThrAla: 4.353 ± 0.436
0.64ThrCys: 0.64 ± 0.134
3.457ThrAsp: 3.457 ± 0.324
3.201ThrGlu: 3.201 ± 0.29
2.977ThrPhe: 2.977 ± 0.296
4.353ThrGly: 4.353 ± 0.536
1.184ThrHis: 1.184 ± 0.212
3.617ThrIle: 3.617 ± 0.345
3.905ThrLys: 3.905 ± 0.346
5.089ThrLeu: 5.089 ± 0.398
1.344ThrMet: 1.344 ± 0.204
3.009ThrAsn: 3.009 ± 0.467
2.881ThrPro: 2.881 ± 0.28
2.08ThrGln: 2.08 ± 0.218
2.849ThrArg: 2.849 ± 0.349
4.737ThrSer: 4.737 ± 0.412
3.361ThrThr: 3.361 ± 0.407
4.097ThrVal: 4.097 ± 0.428
0.96ThrTrp: 0.96 ± 0.166
2.305ThrTyr: 2.305 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
4.705ValAla: 4.705 ± 0.431
0.704ValCys: 0.704 ± 0.153
4.449ValAsp: 4.449 ± 0.351
4.993ValGlu: 4.993 ± 0.353
3.073ValPhe: 3.073 ± 0.247
4.481ValGly: 4.481 ± 0.4
1.184ValHis: 1.184 ± 0.191
4.449ValIle: 4.449 ± 0.396
4.065ValLys: 4.065 ± 0.392
4.801ValLeu: 4.801 ± 0.43
1.6ValMet: 1.6 ± 0.223
3.041ValAsn: 3.041 ± 0.286
2.977ValPro: 2.977 ± 0.325
2.273ValGln: 2.273 ± 0.231
3.393ValArg: 3.393 ± 0.304
4.641ValSer: 4.641 ± 0.394
4.417ValThr: 4.417 ± 0.371
4.353ValVal: 4.353 ± 0.358
0.96ValTrp: 0.96 ± 0.191
2.881ValTyr: 2.881 ± 0.314
0.0ValXaa: 0.0 ± 0.0
Trp
1.024TrpAla: 1.024 ± 0.178
0.16TrpCys: 0.16 ± 0.067
0.928TrpAsp: 0.928 ± 0.178
1.216TrpGlu: 1.216 ± 0.227
0.448TrpPhe: 0.448 ± 0.133
0.672TrpGly: 0.672 ± 0.145
0.384TrpHis: 0.384 ± 0.103
0.864TrpIle: 0.864 ± 0.18
0.704TrpLys: 0.704 ± 0.139
1.344TrpLeu: 1.344 ± 0.232
0.256TrpMet: 0.256 ± 0.092
0.64TrpAsn: 0.64 ± 0.141
0.128TrpPro: 0.128 ± 0.061
0.48TrpGln: 0.48 ± 0.131
0.384TrpArg: 0.384 ± 0.113
0.768TrpSer: 0.768 ± 0.216
0.576TrpThr: 0.576 ± 0.143
0.96TrpVal: 0.96 ± 0.154
0.128TrpTrp: 0.128 ± 0.067
0.384TrpTyr: 0.384 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.881TyrAla: 2.881 ± 0.292
0.192TyrCys: 0.192 ± 0.084
2.593TyrAsp: 2.593 ± 0.281
2.305TyrGlu: 2.305 ± 0.27
1.664TyrPhe: 1.664 ± 0.257
2.08TyrGly: 2.08 ± 0.252
1.056TyrHis: 1.056 ± 0.184
2.08TyrIle: 2.08 ± 0.276
2.401TyrLys: 2.401 ± 0.32
3.329TyrLeu: 3.329 ± 0.323
0.896TyrMet: 0.896 ± 0.171
2.016TyrAsn: 2.016 ± 0.267
1.6TyrPro: 1.6 ± 0.218
1.44TyrGln: 1.44 ± 0.213
1.824TyrArg: 1.824 ± 0.252
2.305TyrSer: 2.305 ± 0.311
2.785TyrThr: 2.785 ± 0.312
1.824TyrVal: 1.824 ± 0.237
0.512TyrTrp: 0.512 ± 0.129
1.28TyrTyr: 1.28 ± 0.21
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 157 proteins (31244 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski