Amino acid dipepetide frequency for Phocoenobacter uteri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.335AlaAla: 4.335 ± 0.138
0.875AlaCys: 0.875 ± 0.04
3.894AlaAsp: 3.894 ± 0.101
5.401AlaGlu: 5.401 ± 0.149
3.137AlaPhe: 3.137 ± 0.081
5.276AlaGly: 5.276 ± 0.149
1.246AlaHis: 1.246 ± 0.059
6.218AlaIle: 6.218 ± 0.121
5.917AlaLys: 5.917 ± 0.131
7.933AlaLeu: 7.933 ± 0.15
2.117AlaMet: 2.117 ± 0.064
3.579AlaAsn: 3.579 ± 0.09
2.153AlaPro: 2.153 ± 0.063
3.418AlaGln: 3.418 ± 0.088
2.934AlaArg: 2.934 ± 0.08
4.096AlaSer: 4.096 ± 0.088
4.494AlaThr: 4.494 ± 0.107
5.398AlaVal: 5.398 ± 0.11
0.707AlaTrp: 0.707 ± 0.037
2.245AlaTyr: 2.245 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.036
0.139CysCys: 0.139 ± 0.017
0.658CysAsp: 0.658 ± 0.033
0.642CysGlu: 0.642 ± 0.031
0.509CysPhe: 0.509 ± 0.028
0.893CysGly: 0.893 ± 0.038
0.292CysHis: 0.292 ± 0.025
0.618CysIle: 0.618 ± 0.033
0.58CysLys: 0.58 ± 0.034
0.961CysLeu: 0.961 ± 0.041
0.177CysMet: 0.177 ± 0.016
0.427CysAsn: 0.427 ± 0.03
0.39CysPro: 0.39 ± 0.029
0.385CysGln: 0.385 ± 0.026
0.38CysArg: 0.38 ± 0.024
0.647CysSer: 0.647 ± 0.035
0.448CysThr: 0.448 ± 0.027
0.659CysVal: 0.659 ± 0.033
0.121CysTrp: 0.121 ± 0.012
0.379CysTyr: 0.379 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.148AspAla: 3.148 ± 0.083
0.528AspCys: 0.528 ± 0.03
2.923AspAsp: 2.923 ± 0.097
3.977AspGlu: 3.977 ± 0.104
2.721AspPhe: 2.721 ± 0.065
3.35AspGly: 3.35 ± 0.129
0.961AspHis: 0.961 ± 0.038
4.219AspIle: 4.219 ± 0.089
3.917AspLys: 3.917 ± 0.108
5.295AspLeu: 5.295 ± 0.088
1.128AspMet: 1.128 ± 0.041
2.784AspAsn: 2.784 ± 0.089
2.071AspPro: 2.071 ± 0.058
1.722AspGln: 1.722 ± 0.057
2.103AspArg: 2.103 ± 0.056
2.771AspSer: 2.771 ± 0.076
2.497AspThr: 2.497 ± 0.077
3.655AspVal: 3.655 ± 0.104
0.729AspTrp: 0.729 ± 0.037
2.26AspTyr: 2.26 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
4.555GluAla: 4.555 ± 0.127
0.492GluCys: 0.492 ± 0.029
2.721GluAsp: 2.721 ± 0.095
4.194GluGlu: 4.194 ± 0.124
2.584GluPhe: 2.584 ± 0.063
3.434GluGly: 3.434 ± 0.1
1.158GluHis: 1.158 ± 0.039
5.066GluIle: 5.066 ± 0.108
5.833GluLys: 5.833 ± 0.12
6.51GluLeu: 6.51 ± 0.12
1.823GluMet: 1.823 ± 0.06
4.096GluAsn: 4.096 ± 0.106
1.795GluPro: 1.795 ± 0.052
4.051GluGln: 4.051 ± 0.098
2.89GluArg: 2.89 ± 0.091
3.095GluSer: 3.095 ± 0.076
3.376GluThr: 3.376 ± 0.084
3.984GluVal: 3.984 ± 0.097
0.705GluTrp: 0.705 ± 0.034
1.883GluTyr: 1.883 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.488PheAla: 3.488 ± 0.092
0.593PheCys: 0.593 ± 0.032
2.946PheAsp: 2.946 ± 0.066
2.831PheGlu: 2.831 ± 0.073
2.125PhePhe: 2.125 ± 0.079
3.418PheGly: 3.418 ± 0.098
0.765PheHis: 0.765 ± 0.042
3.486PheIle: 3.486 ± 0.109
2.663PheLys: 2.663 ± 0.073
4.003PheLeu: 4.003 ± 0.11
1.008PheMet: 1.008 ± 0.04
2.487PheAsn: 2.487 ± 0.061
1.338PhePro: 1.338 ± 0.048
1.32PheGln: 1.32 ± 0.046
1.33PheArg: 1.33 ± 0.046
3.476PheSer: 3.476 ± 0.096
2.292PheThr: 2.292 ± 0.072
2.976PheVal: 2.976 ± 0.082
0.519PheTrp: 0.519 ± 0.031
1.666PheTyr: 1.666 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.707GlyAla: 4.707 ± 0.108
0.828GlyCys: 0.828 ± 0.042
3.423GlyAsp: 3.423 ± 0.102
4.044GlyGlu: 4.044 ± 0.094
3.279GlyPhe: 3.279 ± 0.076
4.776GlyGly: 4.776 ± 0.176
1.259GlyHis: 1.259 ± 0.054
5.325GlyIle: 5.325 ± 0.104
5.298GlyLys: 5.298 ± 0.123
6.596GlyLeu: 6.596 ± 0.133
1.696GlyMet: 1.696 ± 0.052
3.063GlyAsn: 3.063 ± 0.095
0.984GlyPro: 0.984 ± 0.041
2.417GlyGln: 2.417 ± 0.086
2.704GlyArg: 2.704 ± 0.088
3.808GlySer: 3.808 ± 0.106
3.464GlyThr: 3.464 ± 0.106
5.082GlyVal: 5.082 ± 0.102
0.82GlyTrp: 0.82 ± 0.042
2.582GlyTyr: 2.582 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.989HisAla: 0.989 ± 0.043
0.312HisCys: 0.312 ± 0.023
0.76HisAsp: 0.76 ± 0.032
0.672HisGlu: 0.672 ± 0.034
1.136HisPhe: 1.136 ± 0.044
1.002HisGly: 1.002 ± 0.043
0.577HisHis: 0.577 ± 0.036
1.62HisIle: 1.62 ± 0.05
1.295HisLys: 1.295 ± 0.05
2.221HisLeu: 2.221 ± 0.058
0.279HisMet: 0.279 ± 0.021
1.175HisAsn: 1.175 ± 0.056
0.842HisPro: 0.842 ± 0.041
1.085HisGln: 1.085 ± 0.044
0.89HisArg: 0.89 ± 0.04
1.492HisSer: 1.492 ± 0.053
1.032HisThr: 1.032 ± 0.042
0.696HisVal: 0.696 ± 0.034
0.267HisTrp: 0.267 ± 0.018
0.902HisTyr: 0.902 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.497IleAla: 6.497 ± 0.126
0.847IleCys: 0.847 ± 0.041
4.544IleAsp: 4.544 ± 0.088
4.964IleGlu: 4.964 ± 0.102
3.115IlePhe: 3.115 ± 0.094
5.191IleGly: 5.191 ± 0.112
1.263IleHis: 1.263 ± 0.046
5.279IleIle: 5.279 ± 0.128
4.977IleLys: 4.977 ± 0.112
6.969IleLeu: 6.969 ± 0.158
1.464IleMet: 1.464 ± 0.051
3.51IleAsn: 3.51 ± 0.087
2.902IlePro: 2.902 ± 0.079
2.765IleGln: 2.765 ± 0.072
2.727IleArg: 2.727 ± 0.077
5.007IleSer: 5.007 ± 0.093
4.417IleThr: 4.417 ± 0.096
4.544IleVal: 4.544 ± 0.093
0.705IleTrp: 0.705 ± 0.043
2.177IleTyr: 2.177 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.749LysAla: 5.749 ± 0.13
0.405LysCys: 0.405 ± 0.024
3.74LysAsp: 3.74 ± 0.112
5.092LysGlu: 5.092 ± 0.099
2.439LysPhe: 2.439 ± 0.068
4.549LysGly: 4.549 ± 0.141
1.262LysHis: 1.262 ± 0.046
4.932LysIle: 4.932 ± 0.096
5.178LysLys: 5.178 ± 0.12
6.633LysLeu: 6.633 ± 0.107
2.183LysMet: 2.183 ± 0.07
4.316LysAsn: 4.316 ± 0.11
2.554LysPro: 2.554 ± 0.077
3.764LysGln: 3.764 ± 0.096
2.907LysArg: 2.907 ± 0.087
3.934LysSer: 3.934 ± 0.104
3.977LysThr: 3.977 ± 0.083
4.88LysVal: 4.88 ± 0.118
0.711LysTrp: 0.711 ± 0.03
2.028LysTyr: 2.028 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.302LeuAla: 8.302 ± 0.153
0.956LeuCys: 0.956 ± 0.039
5.622LeuAsp: 5.622 ± 0.098
6.076LeuGlu: 6.076 ± 0.111
4.634LeuPhe: 4.634 ± 0.123
6.857LeuGly: 6.857 ± 0.135
1.833LeuHis: 1.833 ± 0.056
6.71LeuIle: 6.71 ± 0.144
6.546LeuLys: 6.546 ± 0.126
9.994LeuLeu: 9.994 ± 0.191
2.426LeuMet: 2.426 ± 0.072
5.423LeuAsn: 5.423 ± 0.112
4.271LeuPro: 4.271 ± 0.092
3.912LeuGln: 3.912 ± 0.102
3.839LeuArg: 3.839 ± 0.097
7.458LeuSer: 7.458 ± 0.124
5.984LeuThr: 5.984 ± 0.108
6.341LeuVal: 6.341 ± 0.129
0.902LeuTrp: 0.902 ± 0.037
2.574LeuTyr: 2.574 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.232MetAla: 2.232 ± 0.068
0.215MetCys: 0.215 ± 0.018
0.991MetAsp: 0.991 ± 0.037
1.121MetGlu: 1.121 ± 0.041
0.812MetPhe: 0.812 ± 0.046
1.669MetGly: 1.669 ± 0.05
0.383MetHis: 0.383 ± 0.032
1.651MetIle: 1.651 ± 0.06
1.869MetLys: 1.869 ± 0.064
2.491MetLeu: 2.491 ± 0.08
0.686MetMet: 0.686 ± 0.037
1.281MetAsn: 1.281 ± 0.042
1.038MetPro: 1.038 ± 0.043
1.155MetGln: 1.155 ± 0.044
0.984MetArg: 0.984 ± 0.04
1.481MetSer: 1.481 ± 0.05
1.489MetThr: 1.489 ± 0.055
1.476MetVal: 1.476 ± 0.045
0.233MetTrp: 0.233 ± 0.017
0.514MetTyr: 0.514 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
4.068AsnAla: 4.068 ± 0.112
0.467AsnCys: 0.467 ± 0.027
2.677AsnAsp: 2.677 ± 0.089
3.109AsnGlu: 3.109 ± 0.081
2.12AsnPhe: 2.12 ± 0.054
3.671AsnGly: 3.671 ± 0.112
1.049AsnHis: 1.049 ± 0.042
4.189AsnIle: 4.189 ± 0.099
3.852AsnLys: 3.852 ± 0.104
4.947AsnLeu: 4.947 ± 0.106
1.046AsnMet: 1.046 ± 0.048
3.033AsnAsn: 3.033 ± 0.123
2.327AsnPro: 2.327 ± 0.065
2.533AsnGln: 2.533 ± 0.071
1.967AsnArg: 1.967 ± 0.063
3.038AsnSer: 3.038 ± 0.099
2.786AsnThr: 2.786 ± 0.112
3.478AsnVal: 3.478 ± 0.095
0.56AsnTrp: 0.56 ± 0.033
1.896AsnTyr: 1.896 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.435ProAla: 2.435 ± 0.072
0.298ProCys: 0.298 ± 0.024
1.767ProAsp: 1.767 ± 0.064
2.754ProGlu: 2.754 ± 0.079
1.853ProPhe: 1.853 ± 0.066
1.112ProGly: 1.112 ± 0.053
0.732ProHis: 0.732 ± 0.035
2.551ProIle: 2.551 ± 0.066
2.532ProLys: 2.532 ± 0.07
3.62ProLeu: 3.62 ± 0.087
0.866ProMet: 0.866 ± 0.039
2.193ProAsn: 2.193 ± 0.066
0.964ProPro: 0.964 ± 0.041
1.754ProGln: 1.754 ± 0.05
1.189ProArg: 1.189 ± 0.047
2.071ProSer: 2.071 ± 0.064
2.199ProThr: 2.199 ± 0.065
2.357ProVal: 2.357 ± 0.069
0.298ProTrp: 0.298 ± 0.02
1.298ProTyr: 1.298 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.805GlnAla: 3.805 ± 0.094
0.377GlnCys: 0.377 ± 0.026
2.14GlnAsp: 2.14 ± 0.067
2.56GlnGlu: 2.56 ± 0.075
2.008GlnPhe: 2.008 ± 0.07
2.891GlnGly: 2.891 ± 0.08
1.025GlnHis: 1.025 ± 0.047
3.084GlnIle: 3.084 ± 0.074
3.56GlnLys: 3.56 ± 0.096
4.775GlnLeu: 4.775 ± 0.112
1.035GlnMet: 1.035 ± 0.051
2.59GlnAsn: 2.59 ± 0.085
1.513GlnPro: 1.513 ± 0.056
3.39GlnGln: 3.39 ± 0.113
2.054GlnArg: 2.054 ± 0.067
2.451GlnSer: 2.451 ± 0.068
2.204GlnThr: 2.204 ± 0.056
2.618GlnVal: 2.618 ± 0.065
0.615GlnTrp: 0.615 ± 0.036
1.435GlnTyr: 1.435 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
2.631ArgAla: 2.631 ± 0.068
0.399ArgCys: 0.399 ± 0.025
2.096ArgAsp: 2.096 ± 0.079
2.779ArgGlu: 2.779 ± 0.075
2.065ArgPhe: 2.065 ± 0.07
2.309ArgGly: 2.309 ± 0.057
0.861ArgHis: 0.861 ± 0.041
2.812ArgIle: 2.812 ± 0.086
2.656ArgLys: 2.656 ± 0.081
4.335ArgLeu: 4.335 ± 0.114
0.88ArgMet: 0.88 ± 0.032
1.991ArgAsn: 1.991 ± 0.065
1.322ArgPro: 1.322 ± 0.052
1.763ArgGln: 1.763 ± 0.056
1.797ArgArg: 1.797 ± 0.066
2.18ArgSer: 2.18 ± 0.064
1.871ArgThr: 1.871 ± 0.058
2.682ArgVal: 2.682 ± 0.074
0.453ArgTrp: 0.453 ± 0.025
1.569ArgTyr: 1.569 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.481SerAla: 4.481 ± 0.108
0.555SerCys: 0.555 ± 0.036
3.325SerAsp: 3.325 ± 0.082
3.792SerGlu: 3.792 ± 0.107
2.846SerPhe: 2.846 ± 0.078
4.429SerGly: 4.429 ± 0.119
1.385SerHis: 1.385 ± 0.046
4.303SerIle: 4.303 ± 0.089
3.827SerLys: 3.827 ± 0.094
6.273SerLeu: 6.273 ± 0.108
1.344SerMet: 1.344 ± 0.049
2.951SerAsn: 2.951 ± 0.088
2.033SerPro: 2.033 ± 0.063
2.988SerGln: 2.988 ± 0.076
2.355SerArg: 2.355 ± 0.064
3.816SerSer: 3.816 ± 0.082
3.148SerThr: 3.148 ± 0.073
4.016SerVal: 4.016 ± 0.091
0.68SerTrp: 0.68 ± 0.031
2.122SerTyr: 2.122 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.66ThrAla: 4.66 ± 0.114
0.405ThrCys: 0.405 ± 0.023
2.841ThrAsp: 2.841 ± 0.104
3.503ThrGlu: 3.503 ± 0.067
2.41ThrPhe: 2.41 ± 0.065
3.876ThrGly: 3.876 ± 0.094
1.123ThrHis: 1.123 ± 0.043
4.033ThrIle: 4.033 ± 0.11
3.41ThrLys: 3.41 ± 0.078
5.978ThrLeu: 5.978 ± 0.098
1.131ThrMet: 1.131 ± 0.047
2.555ThrAsn: 2.555 ± 0.106
2.549ThrPro: 2.549 ± 0.067
2.678ThrGln: 2.678 ± 0.081
1.951ThrArg: 1.951 ± 0.065
2.899ThrSer: 2.899 ± 0.08
3.211ThrThr: 3.211 ± 0.095
3.806ThrVal: 3.806 ± 0.143
0.472ThrTrp: 0.472 ± 0.029
1.491ThrTyr: 1.491 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.678ValAla: 5.678 ± 0.114
0.68ValCys: 0.68 ± 0.032
3.442ValAsp: 3.442 ± 0.088
4.582ValGlu: 4.582 ± 0.118
2.669ValPhe: 2.669 ± 0.075
4.529ValGly: 4.529 ± 0.09
1.0ValHis: 1.0 ± 0.037
5.019ValIle: 5.019 ± 0.086
4.701ValLys: 4.701 ± 0.126
6.279ValLeu: 6.279 ± 0.109
1.704ValMet: 1.704 ± 0.049
3.317ValAsn: 3.317 ± 0.086
2.259ValPro: 2.259 ± 0.063
2.169ValGln: 2.169 ± 0.064
2.481ValArg: 2.481 ± 0.072
4.267ValSer: 4.267 ± 0.089
4.062ValThr: 4.062 ± 0.118
4.877ValVal: 4.877 ± 0.116
0.598ValTrp: 0.598 ± 0.034
1.781ValTyr: 1.781 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.04
0.156TrpCys: 0.156 ± 0.014
0.536TrpAsp: 0.536 ± 0.033
0.55TrpGlu: 0.55 ± 0.026
0.527TrpPhe: 0.527 ± 0.028
0.722TrpGly: 0.722 ± 0.04
0.293TrpHis: 0.293 ± 0.023
0.708TrpIle: 0.708 ± 0.032
0.65TrpLys: 0.65 ± 0.039
1.415TrpLeu: 1.415 ± 0.055
0.194TrpMet: 0.194 ± 0.017
0.539TrpAsn: 0.539 ± 0.029
0.15TrpPro: 0.15 ± 0.016
0.872TrpGln: 0.872 ± 0.046
0.524TrpArg: 0.524 ± 0.028
0.538TrpSer: 0.538 ± 0.031
0.418TrpThr: 0.418 ± 0.024
0.705TrpVal: 0.705 ± 0.036
0.164TrpTrp: 0.164 ± 0.016
0.356TrpTyr: 0.356 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.055
0.431TyrCys: 0.431 ± 0.027
1.713TyrAsp: 1.713 ± 0.053
1.601TyrGlu: 1.601 ± 0.056
1.741TyrPhe: 1.741 ± 0.066
2.202TyrGly: 2.202 ± 0.063
0.778TyrHis: 0.778 ± 0.036
2.038TyrIle: 2.038 ± 0.069
1.973TyrLys: 1.973 ± 0.057
3.434TyrLeu: 3.434 ± 0.073
0.585TyrMet: 0.585 ± 0.033
1.5TyrAsn: 1.5 ± 0.058
1.388TyrPro: 1.388 ± 0.054
1.989TyrGln: 1.989 ± 0.055
1.446TyrArg: 1.446 ± 0.056
2.144TyrSer: 2.144 ± 0.069
1.617TyrThr: 1.617 ± 0.057
1.861TyrVal: 1.861 ± 0.055
0.453TyrTrp: 0.453 ± 0.031
1.153TyrTyr: 1.153 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1947 proteins (633974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski