Amino acid dipepetide frequency for Streptococcus satellite phage Javan434

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.645AlaAla: 0.645 ± 0.433
0.0AlaCys: 0.0 ± 0.0
3.87AlaAsp: 3.87 ± 1.36
7.417AlaGlu: 7.417 ± 1.948
3.547AlaPhe: 3.547 ± 1.085
3.547AlaGly: 3.547 ± 1.038
0.645AlaHis: 0.645 ± 0.448
4.192AlaIle: 4.192 ± 1.456
5.805AlaLys: 5.805 ± 0.995
3.225AlaLeu: 3.225 ± 1.216
2.257AlaMet: 2.257 ± 1.277
1.612AlaAsn: 1.612 ± 0.69
1.29AlaPro: 1.29 ± 0.484
2.58AlaGln: 2.58 ± 0.914
2.902AlaArg: 2.902 ± 0.654
4.515AlaSer: 4.515 ± 1.131
5.805AlaThr: 5.805 ± 1.186
4.192AlaVal: 4.192 ± 0.761
0.645AlaTrp: 0.645 ± 0.326
1.612AlaTyr: 1.612 ± 0.558
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.326
0.0CysCys: 0.0 ± 0.0
1.29CysAsp: 1.29 ± 0.779
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.322CysIle: 0.322 ± 0.327
0.0CysLys: 0.0 ± 0.0
0.322CysLeu: 0.322 ± 0.38
0.322CysMet: 0.322 ± 0.304
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.322CysGln: 0.322 ± 0.323
0.322CysArg: 0.322 ± 0.278
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.967AspAla: 0.967 ± 0.48
0.322AspCys: 0.322 ± 0.327
2.58AspAsp: 2.58 ± 0.844
3.87AspGlu: 3.87 ± 1.178
3.225AspPhe: 3.225 ± 0.649
2.58AspGly: 2.58 ± 0.824
0.645AspHis: 0.645 ± 0.399
5.805AspIle: 5.805 ± 0.954
5.16AspLys: 5.16 ± 1.118
7.094AspLeu: 7.094 ± 1.576
1.29AspMet: 1.29 ± 0.599
3.225AspAsn: 3.225 ± 0.997
1.29AspPro: 1.29 ± 0.692
0.967AspGln: 0.967 ± 0.613
4.515AspArg: 4.515 ± 1.307
2.902AspSer: 2.902 ± 0.993
2.902AspThr: 2.902 ± 0.763
3.547AspVal: 3.547 ± 0.859
0.0AspTrp: 0.0 ± 0.0
3.547AspTyr: 3.547 ± 1.176
0.0AspXaa: 0.0 ± 0.0
Glu
4.837GluAla: 4.837 ± 1.612
0.322GluCys: 0.322 ± 0.326
3.87GluAsp: 3.87 ± 1.155
6.127GluGlu: 6.127 ± 1.281
2.902GluPhe: 2.902 ± 0.929
2.902GluGly: 2.902 ± 1.056
1.29GluHis: 1.29 ± 0.579
6.45GluIle: 6.45 ± 1.079
8.384GluLys: 8.384 ± 1.027
9.352GluLeu: 9.352 ± 0.863
2.58GluMet: 2.58 ± 0.878
3.547GluAsn: 3.547 ± 0.92
3.225GluPro: 3.225 ± 1.193
2.902GluGln: 2.902 ± 0.99
5.482GluArg: 5.482 ± 1.162
3.547GluSer: 3.547 ± 1.313
5.16GluThr: 5.16 ± 0.883
5.482GluVal: 5.482 ± 1.855
0.0GluTrp: 0.0 ± 0.0
4.515GluTyr: 4.515 ± 1.068
0.0GluXaa: 0.0 ± 0.0
Phe
1.29PheAla: 1.29 ± 0.716
0.322PheCys: 0.322 ± 0.323
3.547PheAsp: 3.547 ± 0.901
4.192PheGlu: 4.192 ± 1.283
2.58PhePhe: 2.58 ± 1.265
3.225PheGly: 3.225 ± 1.029
0.967PheHis: 0.967 ± 0.433
2.257PheIle: 2.257 ± 0.639
3.547PheLys: 3.547 ± 0.931
4.837PheLeu: 4.837 ± 1.023
0.645PheMet: 0.645 ± 0.469
1.612PheAsn: 1.612 ± 0.76
0.322PhePro: 0.322 ± 0.443
2.257PheGln: 2.257 ± 0.668
2.902PheArg: 2.902 ± 0.716
2.58PheSer: 2.58 ± 0.704
1.935PheThr: 1.935 ± 0.877
1.935PheVal: 1.935 ± 0.584
0.645PheTrp: 0.645 ± 0.487
2.58PheTyr: 2.58 ± 0.663
0.0PheXaa: 0.0 ± 0.0
Gly
2.902GlyAla: 2.902 ± 1.084
0.322GlyCys: 0.322 ± 0.278
3.225GlyAsp: 3.225 ± 1.147
4.192GlyGlu: 4.192 ± 0.875
3.547GlyPhe: 3.547 ± 0.969
1.935GlyGly: 1.935 ± 0.696
0.967GlyHis: 0.967 ± 0.459
3.225GlyIle: 3.225 ± 0.853
3.225GlyLys: 3.225 ± 0.957
5.482GlyLeu: 5.482 ± 1.384
2.58GlyMet: 2.58 ± 0.854
1.935GlyAsn: 1.935 ± 0.544
0.0GlyPro: 0.0 ± 0.0
3.225GlyGln: 3.225 ± 0.791
1.935GlyArg: 1.935 ± 0.454
1.935GlySer: 1.935 ± 0.835
2.58GlyThr: 2.58 ± 1.083
2.902GlyVal: 2.902 ± 0.852
0.322GlyTrp: 0.322 ± 0.26
3.87GlyTyr: 3.87 ± 0.773
0.0GlyXaa: 0.0 ± 0.0
His
1.612HisAla: 1.612 ± 0.626
0.0HisCys: 0.0 ± 0.0
0.322HisAsp: 0.322 ± 0.326
0.967HisGlu: 0.967 ± 0.373
1.612HisPhe: 1.612 ± 0.582
2.58HisGly: 2.58 ± 0.764
0.322HisHis: 0.322 ± 0.26
0.967HisIle: 0.967 ± 0.422
1.935HisLys: 1.935 ± 0.928
1.29HisLeu: 1.29 ± 0.468
0.0HisMet: 0.0 ± 0.0
0.967HisAsn: 0.967 ± 0.641
0.322HisPro: 0.322 ± 0.38
0.0HisGln: 0.0 ± 0.0
1.29HisArg: 1.29 ± 0.765
1.935HisSer: 1.935 ± 0.628
0.645HisThr: 0.645 ± 0.385
0.967HisVal: 0.967 ± 0.373
0.322HisTrp: 0.322 ± 0.26
0.967HisTyr: 0.967 ± 0.571
0.0HisXaa: 0.0 ± 0.0
Ile
4.837IleAla: 4.837 ± 0.955
0.322IleCys: 0.322 ± 0.323
4.837IleAsp: 4.837 ± 0.894
5.805IleGlu: 5.805 ± 1.916
3.225IlePhe: 3.225 ± 0.809
2.58IleGly: 2.58 ± 0.691
1.612IleHis: 1.612 ± 0.672
3.87IleIle: 3.87 ± 0.772
6.127IleLys: 6.127 ± 1.369
6.127IleLeu: 6.127 ± 0.981
1.29IleMet: 1.29 ± 0.757
3.547IleAsn: 3.547 ± 1.044
3.225IlePro: 3.225 ± 0.834
2.58IleGln: 2.58 ± 0.674
3.225IleArg: 3.225 ± 0.995
5.16IleSer: 5.16 ± 1.155
4.515IleThr: 4.515 ± 1.354
0.322IleVal: 0.322 ± 0.316
0.967IleTrp: 0.967 ± 0.587
2.902IleTyr: 2.902 ± 0.714
0.0IleXaa: 0.0 ± 0.0
Lys
8.062LysAla: 8.062 ± 1.717
0.0LysCys: 0.0 ± 0.0
4.837LysAsp: 4.837 ± 1.273
9.029LysGlu: 9.029 ± 1.597
2.902LysPhe: 2.902 ± 0.768
5.16LysGly: 5.16 ± 1.479
4.515LysHis: 4.515 ± 1.154
7.417LysIle: 7.417 ± 1.06
7.739LysLys: 7.739 ± 1.708
6.772LysLeu: 6.772 ± 1.873
1.935LysMet: 1.935 ± 0.676
4.515LysAsn: 4.515 ± 1.041
3.547LysPro: 3.547 ± 1.254
5.482LysGln: 5.482 ± 1.054
7.417LysArg: 7.417 ± 1.381
5.482LysSer: 5.482 ± 1.582
5.482LysThr: 5.482 ± 1.276
5.16LysVal: 5.16 ± 1.24
1.29LysTrp: 1.29 ± 0.567
0.967LysTyr: 0.967 ± 0.66
0.0LysXaa: 0.0 ± 0.0
Leu
7.094LeuAla: 7.094 ± 1.475
0.322LeuCys: 0.322 ± 0.3
6.772LeuAsp: 6.772 ± 1.723
9.997LeuGlu: 9.997 ± 1.427
3.547LeuPhe: 3.547 ± 1.058
3.225LeuGly: 3.225 ± 0.967
1.935LeuHis: 1.935 ± 0.889
5.16LeuIle: 5.16 ± 1.003
9.029LeuLys: 9.029 ± 1.583
8.707LeuLeu: 8.707 ± 1.862
1.29LeuMet: 1.29 ± 0.691
6.45LeuAsn: 6.45 ± 1.744
3.547LeuPro: 3.547 ± 1.375
4.837LeuGln: 4.837 ± 1.031
2.58LeuArg: 2.58 ± 0.861
4.837LeuSer: 4.837 ± 1.105
7.094LeuThr: 7.094 ± 1.274
3.547LeuVal: 3.547 ± 1.184
0.645LeuTrp: 0.645 ± 0.394
2.902LeuTyr: 2.902 ± 0.976
0.0LeuXaa: 0.0 ± 0.0
Met
2.58MetAla: 2.58 ± 0.919
0.0MetCys: 0.0 ± 0.0
3.225MetAsp: 3.225 ± 0.963
1.29MetGlu: 1.29 ± 0.482
1.29MetPhe: 1.29 ± 0.776
1.29MetGly: 1.29 ± 0.533
0.0MetHis: 0.0 ± 0.0
0.967MetIle: 0.967 ± 0.426
2.902MetLys: 2.902 ± 1.107
0.967MetLeu: 0.967 ± 0.422
0.322MetMet: 0.322 ± 0.373
2.58MetAsn: 2.58 ± 0.537
0.322MetPro: 0.322 ± 0.294
1.612MetGln: 1.612 ± 0.502
1.612MetArg: 1.612 ± 0.907
0.645MetSer: 0.645 ± 0.441
4.515MetThr: 4.515 ± 1.248
0.645MetVal: 0.645 ± 0.522
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.902AsnAla: 2.902 ± 0.788
0.0AsnCys: 0.0 ± 0.0
1.935AsnAsp: 1.935 ± 0.738
3.547AsnGlu: 3.547 ± 0.573
0.645AsnPhe: 0.645 ± 0.469
3.87AsnGly: 3.87 ± 1.249
0.967AsnHis: 0.967 ± 0.443
1.935AsnIle: 1.935 ± 0.901
4.192AsnLys: 4.192 ± 0.617
4.515AsnLeu: 4.515 ± 1.406
2.257AsnMet: 2.257 ± 0.854
2.58AsnAsn: 2.58 ± 1.804
2.902AsnPro: 2.902 ± 1.16
0.967AsnGln: 0.967 ± 0.601
2.58AsnArg: 2.58 ± 0.771
4.837AsnSer: 4.837 ± 1.078
1.935AsnThr: 1.935 ± 1.003
2.257AsnVal: 2.257 ± 0.58
0.0AsnTrp: 0.0 ± 0.0
1.612AsnTyr: 1.612 ± 0.515
0.0AsnXaa: 0.0 ± 0.0
Pro
1.935ProAla: 1.935 ± 0.61
0.0ProCys: 0.0 ± 0.0
1.935ProAsp: 1.935 ± 0.586
3.225ProGlu: 3.225 ± 1.364
1.612ProPhe: 1.612 ± 1.009
0.645ProGly: 0.645 ± 0.456
0.0ProHis: 0.0 ± 0.0
1.935ProIle: 1.935 ± 0.578
3.225ProLys: 3.225 ± 0.833
2.58ProLeu: 2.58 ± 0.852
0.322ProMet: 0.322 ± 0.323
2.902ProAsn: 2.902 ± 0.803
0.645ProPro: 0.645 ± 0.394
1.29ProGln: 1.29 ± 0.657
2.58ProArg: 2.58 ± 0.925
1.612ProSer: 1.612 ± 0.719
1.612ProThr: 1.612 ± 0.805
1.612ProVal: 1.612 ± 0.725
0.0ProTrp: 0.0 ± 0.0
1.612ProTyr: 1.612 ± 0.479
0.0ProXaa: 0.0 ± 0.0
Gln
5.16GlnAla: 5.16 ± 1.385
0.0GlnCys: 0.0 ± 0.0
1.612GlnAsp: 1.612 ± 0.579
2.902GlnGlu: 2.902 ± 0.917
2.257GlnPhe: 2.257 ± 0.798
2.58GlnGly: 2.58 ± 0.909
0.645GlnHis: 0.645 ± 0.347
2.902GlnIle: 2.902 ± 0.939
7.094GlnLys: 7.094 ± 1.435
3.547GlnLeu: 3.547 ± 1.075
0.645GlnMet: 0.645 ± 0.443
1.935GlnAsn: 1.935 ± 0.838
0.967GlnPro: 0.967 ± 0.727
2.902GlnGln: 2.902 ± 0.917
2.257GlnArg: 2.257 ± 0.735
2.58GlnSer: 2.58 ± 0.897
2.902GlnThr: 2.902 ± 1.076
1.935GlnVal: 1.935 ± 0.593
0.645GlnTrp: 0.645 ± 0.364
1.935GlnTyr: 1.935 ± 0.83
0.0GlnXaa: 0.0 ± 0.0
Arg
3.225ArgAla: 3.225 ± 0.969
0.0ArgCys: 0.0 ± 0.0
3.547ArgAsp: 3.547 ± 0.95
5.482ArgGlu: 5.482 ± 0.968
3.547ArgPhe: 3.547 ± 1.108
2.257ArgGly: 2.257 ± 0.655
1.935ArgHis: 1.935 ± 0.797
4.515ArgIle: 4.515 ± 0.792
5.16ArgLys: 5.16 ± 1.216
5.805ArgLeu: 5.805 ± 1.38
0.967ArgMet: 0.967 ± 0.549
2.257ArgAsn: 2.257 ± 1.155
1.29ArgPro: 1.29 ± 0.708
2.902ArgGln: 2.902 ± 0.754
2.58ArgArg: 2.58 ± 0.957
2.257ArgSer: 2.257 ± 0.677
1.29ArgThr: 1.29 ± 0.732
2.257ArgVal: 2.257 ± 0.742
0.0ArgTrp: 0.0 ± 0.0
3.225ArgTyr: 3.225 ± 1.342
0.0ArgXaa: 0.0 ± 0.0
Ser
1.612SerAla: 1.612 ± 0.608
0.322SerCys: 0.322 ± 0.38
4.192SerAsp: 4.192 ± 0.927
5.16SerGlu: 5.16 ± 1.157
1.935SerPhe: 1.935 ± 0.534
1.935SerGly: 1.935 ± 0.773
0.645SerHis: 0.645 ± 0.347
4.515SerIle: 4.515 ± 0.92
4.837SerLys: 4.837 ± 0.866
6.45SerLeu: 6.45 ± 1.399
2.58SerMet: 2.58 ± 0.861
1.612SerAsn: 1.612 ± 0.562
1.612SerPro: 1.612 ± 0.467
2.902SerGln: 2.902 ± 0.775
2.58SerArg: 2.58 ± 1.271
2.58SerSer: 2.58 ± 0.979
3.87SerThr: 3.87 ± 0.993
3.547SerVal: 3.547 ± 0.913
0.322SerTrp: 0.322 ± 0.278
2.902SerTyr: 2.902 ± 1.092
0.0SerXaa: 0.0 ± 0.0
Thr
4.515ThrAla: 4.515 ± 0.985
0.322ThrCys: 0.322 ± 0.304
1.935ThrAsp: 1.935 ± 0.577
3.547ThrGlu: 3.547 ± 0.59
3.225ThrPhe: 3.225 ± 1.375
5.16ThrGly: 5.16 ± 1.293
0.645ThrHis: 0.645 ± 0.555
2.902ThrIle: 2.902 ± 0.757
7.094ThrLys: 7.094 ± 1.764
7.417ThrLeu: 7.417 ± 1.347
1.935ThrMet: 1.935 ± 0.669
0.645ThrAsn: 0.645 ± 0.326
1.935ThrPro: 1.935 ± 0.569
4.837ThrGln: 4.837 ± 1.261
2.902ThrArg: 2.902 ± 0.515
3.547ThrSer: 3.547 ± 0.979
4.515ThrThr: 4.515 ± 1.214
2.58ThrVal: 2.58 ± 1.085
0.967ThrTrp: 0.967 ± 0.476
2.257ThrTyr: 2.257 ± 1.073
0.0ThrXaa: 0.0 ± 0.0
Val
3.547ValAla: 3.547 ± 0.962
0.0ValCys: 0.0 ± 0.0
1.612ValAsp: 1.612 ± 0.765
3.225ValGlu: 3.225 ± 1.447
0.322ValPhe: 0.322 ± 0.278
3.225ValGly: 3.225 ± 0.972
0.322ValHis: 0.322 ± 0.278
4.192ValIle: 4.192 ± 1.437
5.482ValLys: 5.482 ± 1.648
3.547ValLeu: 3.547 ± 0.948
1.29ValMet: 1.29 ± 0.598
1.612ValAsn: 1.612 ± 0.687
1.612ValPro: 1.612 ± 0.712
2.257ValGln: 2.257 ± 0.691
1.935ValArg: 1.935 ± 0.722
3.225ValSer: 3.225 ± 0.683
4.515ValThr: 4.515 ± 1.428
4.515ValVal: 4.515 ± 1.524
0.322ValTrp: 0.322 ± 0.26
2.58ValTyr: 2.58 ± 0.832
0.0ValXaa: 0.0 ± 0.0
Trp
0.645TrpAla: 0.645 ± 0.559
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.322TrpGlu: 0.322 ± 0.319
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.322TrpIle: 0.322 ± 0.38
1.29TrpLys: 1.29 ± 0.554
2.257TrpLeu: 2.257 ± 0.844
0.0TrpMet: 0.0 ± 0.0
0.322TrpAsn: 0.322 ± 0.3
0.645TrpPro: 0.645 ± 0.386
0.322TrpGln: 0.322 ± 0.364
0.0TrpArg: 0.0 ± 0.0
0.645TrpSer: 0.645 ± 0.396
0.0TrpThr: 0.0 ± 0.0
0.322TrpVal: 0.322 ± 0.327
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.612TyrAla: 1.612 ± 0.736
0.645TyrCys: 0.645 ± 0.447
1.29TyrAsp: 1.29 ± 0.635
2.58TyrGlu: 2.58 ± 0.917
2.257TyrPhe: 2.257 ± 0.691
1.612TyrGly: 1.612 ± 0.79
0.967TyrHis: 0.967 ± 0.553
3.225TyrIle: 3.225 ± 0.99
5.482TyrLys: 5.482 ± 1.525
3.547TyrLeu: 3.547 ± 0.881
1.935TyrMet: 1.935 ± 0.732
2.58TyrAsn: 2.58 ± 0.984
2.58TyrPro: 2.58 ± 0.949
2.257TyrGln: 2.257 ± 0.773
2.902TyrArg: 2.902 ± 1.152
1.29TyrSer: 1.29 ± 0.528
1.612TyrThr: 1.612 ± 0.6
1.612TyrVal: 1.612 ± 0.764
0.0TyrTrp: 0.0 ± 0.0
3.547TyrTyr: 3.547 ± 0.868
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (3102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski