Amino acid dipepetide frequency for Puniceicoccales bacterium CK1056

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.724AlaAla: 7.724 ± 0.122	0.935AlaCys: 0.935 ± 0.034	4.934AlaAsp: 4.934 ± 0.116	5.4AlaGlu: 5.4 ± 0.079	3.959AlaPhe: 3.959 ± 0.065	7.503AlaGly: 7.503 ± 0.122	1.502AlaHis: 1.502 ± 0.047	5.112AlaIle: 5.112 ± 0.076	3.384AlaLys: 3.384 ± 0.085	8.618AlaLeu: 8.618 ± 0.11	2.015AlaMet: 2.015 ± 0.052	2.94AlaAsn: 2.94 ± 0.063	3.377AlaPro: 3.377 ± 0.053	2.619AlaGln: 2.619 ± 0.059	4.644AlaArg: 4.644 ± 0.084	5.579AlaSer: 5.579 ± 0.092	4.401AlaThr: 4.401 ± 0.084	5.787AlaVal: 5.787 ± 0.105	1.262AlaTrp: 1.262 ± 0.037	2.486AlaTyr: 2.486 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.805CysAla: 0.805 ± 0.032	0.13CysCys: 0.13 ± 0.012	0.499CysAsp: 0.499 ± 0.025	0.527CysGlu: 0.527 ± 0.026	0.417CysPhe: 0.417 ± 0.021	0.833CysGly: 0.833 ± 0.032	0.348CysHis: 0.348 ± 0.032	0.461CysIle: 0.461 ± 0.024	0.29CysLys: 0.29 ± 0.017	1.106CysLeu: 1.106 ± 0.041	0.194CysMet: 0.194 ± 0.014	0.242CysAsn: 0.242 ± 0.018	0.534CysPro: 0.534 ± 0.027	0.298CysGln: 0.298 ± 0.019	0.566CysArg: 0.566 ± 0.023	0.572CysSer: 0.572 ± 0.025	0.411CysThr: 0.411 ± 0.022	0.592CysVal: 0.592 ± 0.028	0.114CysTrp: 0.114 ± 0.009	0.273CysTyr: 0.273 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.612AspAla: 4.612 ± 0.094	0.58AspCys: 0.58 ± 0.026	3.207AspAsp: 3.207 ± 0.103	3.712AspGlu: 3.712 ± 0.059	2.887AspPhe: 2.887 ± 0.071	5.364AspGly: 5.364 ± 0.153	1.15AspHis: 1.15 ± 0.041	3.282AspIle: 3.282 ± 0.081	2.129AspLys: 2.129 ± 0.047	6.261AspLeu: 6.261 ± 0.118	1.098AspMet: 1.098 ± 0.037	2.09AspAsn: 2.09 ± 0.074	4.035AspPro: 4.035 ± 0.07	1.877AspGln: 1.877 ± 0.046	3.217AspArg: 3.217 ± 0.064	3.798AspSer: 3.798 ± 0.098	3.061AspThr: 3.061 ± 0.129	3.418AspVal: 3.418 ± 0.084	1.324AspTrp: 1.324 ± 0.037	1.96AspTyr: 1.96 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.571GluAla: 6.571 ± 0.119	0.467GluCys: 0.467 ± 0.022	3.703GluAsp: 3.703 ± 0.072	5.082GluGlu: 5.082 ± 0.102	2.659GluPhe: 2.659 ± 0.047	4.885GluGly: 4.885 ± 0.073	1.211GluHis: 1.211 ± 0.039	4.284GluIle: 4.284 ± 0.069	3.541GluLys: 3.541 ± 0.089	6.386GluLeu: 6.386 ± 0.091	1.615GluMet: 1.615 ± 0.038	2.597GluAsn: 2.597 ± 0.058	2.622GluPro: 2.622 ± 0.05	2.342GluGln: 2.342 ± 0.058	3.849GluArg: 3.849 ± 0.084	4.487GluSer: 4.487 ± 0.073	3.701GluThr: 3.701 ± 0.053	4.527GluVal: 4.527 ± 0.071	1.138GluTrp: 1.138 ± 0.04	1.662GluTyr: 1.662 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.472PheAla: 3.472 ± 0.056	0.469PheCys: 0.469 ± 0.021	2.799PheAsp: 2.799 ± 0.061	2.897PheGlu: 2.897 ± 0.054	2.125PhePhe: 2.125 ± 0.059	3.753PheGly: 3.753 ± 0.081	0.96PheHis: 0.96 ± 0.03	2.487PheIle: 2.487 ± 0.053	1.76PheLys: 1.76 ± 0.043	4.604PheLeu: 4.604 ± 0.088	0.904PheMet: 0.904 ± 0.03	1.812PheAsn: 1.812 ± 0.046	2.163PhePro: 2.163 ± 0.049	1.474PheGln: 1.474 ± 0.039	2.419PheArg: 2.419 ± 0.055	3.42PheSer: 3.42 ± 0.053	2.496PheThr: 2.496 ± 0.061	2.745PheVal: 2.745 ± 0.053	0.692PheTrp: 0.692 ± 0.032	1.428PheTyr: 1.428 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.067GlyAla: 6.067 ± 0.121	0.804GlyCys: 0.804 ± 0.027	4.894GlyAsp: 4.894 ± 0.18	5.028GlyGlu: 5.028 ± 0.069	4.024GlyPhe: 4.024 ± 0.05	6.505GlyGly: 6.505 ± 0.179	1.613GlyHis: 1.613 ± 0.039	5.303GlyIle: 5.303 ± 0.072	4.089GlyLys: 4.089 ± 0.096	8.176GlyLeu: 8.176 ± 0.097	1.992GlyMet: 1.992 ± 0.047	3.369GlyAsn: 3.369 ± 0.107	3.012GlyPro: 3.012 ± 0.053	2.855GlyGln: 2.855 ± 0.057	4.124GlyArg: 4.124 ± 0.071	5.807GlySer: 5.807 ± 0.142	5.048GlyThr: 5.048 ± 0.119	5.285GlyVal: 5.285 ± 0.082	1.539GlyTrp: 1.539 ± 0.046	2.71GlyTyr: 2.71 ± 0.056	0.001GlyXaa: 0.001 ± 0.001
His	1.62HisAla: 1.62 ± 0.04	0.227HisCys: 0.227 ± 0.018	1.003HisAsp: 1.003 ± 0.031	1.149HisGlu: 1.149 ± 0.036	1.037HisPhe: 1.037 ± 0.039	1.726HisGly: 1.726 ± 0.053	0.577HisHis: 0.577 ± 0.027	1.019HisIle: 1.019 ± 0.035	0.725HisLys: 0.725 ± 0.025	2.172HisLeu: 2.172 ± 0.054	0.43HisMet: 0.43 ± 0.021	0.668HisAsn: 0.668 ± 0.027	1.397HisPro: 1.397 ± 0.045	0.612HisGln: 0.612 ± 0.024	1.186HisArg: 1.186 ± 0.039	1.241HisSer: 1.241 ± 0.037	0.915HisThr: 0.915 ± 0.031	1.222HisVal: 1.222 ± 0.035	0.387HisTrp: 0.387 ± 0.022	0.735HisTyr: 0.735 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.907IleAla: 4.907 ± 0.076	0.593IleCys: 0.593 ± 0.027	3.89IleAsp: 3.89 ± 0.103	4.266IleGlu: 4.266 ± 0.069	2.42IlePhe: 2.42 ± 0.055	4.829IleGly: 4.829 ± 0.089	1.352IleHis: 1.352 ± 0.039	3.088IleIle: 3.088 ± 0.072	2.118IleLys: 2.118 ± 0.046	6.127IleLeu: 6.127 ± 0.084	0.977IleMet: 0.977 ± 0.032	2.214IleAsn: 2.214 ± 0.071	3.225IlePro: 3.225 ± 0.067	2.057IleGln: 2.057 ± 0.043	3.65IleArg: 3.65 ± 0.064	4.004IleSer: 4.004 ± 0.071	3.09IleThr: 3.09 ± 0.075	3.718IleVal: 3.718 ± 0.066	0.765IleTrp: 0.765 ± 0.03	1.657IleTyr: 1.657 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.2LysAla: 4.2 ± 0.088	0.289LysCys: 0.289 ± 0.017	2.387LysAsp: 2.387 ± 0.049	3.107LysGlu: 3.107 ± 0.09	1.391LysPhe: 1.391 ± 0.046	3.172LysGly: 3.172 ± 0.069	0.848LysHis: 0.848 ± 0.032	2.463LysIle: 2.463 ± 0.058	2.408LysLys: 2.408 ± 0.101	3.762LysLeu: 3.762 ± 0.072	0.984LysMet: 0.984 ± 0.035	1.481LysAsn: 1.481 ± 0.046	2.188LysPro: 2.188 ± 0.06	1.395LysGln: 1.395 ± 0.042	2.65LysArg: 2.65 ± 0.07	2.729LysSer: 2.729 ± 0.066	2.369LysThr: 2.369 ± 0.056	2.948LysVal: 2.948 ± 0.062	0.696LysTrp: 0.696 ± 0.028	1.003LysTyr: 1.003 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.749LeuAla: 8.749 ± 0.109	0.992LeuCys: 0.992 ± 0.035	5.904LeuAsp: 5.904 ± 0.106	7.161LeuGlu: 7.161 ± 0.103	4.368LeuPhe: 4.368 ± 0.087	7.608LeuGly: 7.608 ± 0.112	1.93LeuHis: 1.93 ± 0.048	5.66LeuIle: 5.66 ± 0.087	4.814LeuLys: 4.814 ± 0.098	9.844LeuLeu: 9.844 ± 0.174	2.178LeuMet: 2.178 ± 0.06	3.882LeuAsn: 3.882 ± 0.082	5.334LeuPro: 5.334 ± 0.09	3.423LeuGln: 3.423 ± 0.061	5.558LeuArg: 5.558 ± 0.103	7.025LeuSer: 7.025 ± 0.089	5.436LeuThr: 5.436 ± 0.114	6.821LeuVal: 6.821 ± 0.086	1.172LeuTrp: 1.172 ± 0.04	2.739LeuTyr: 2.739 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.09MetAla: 2.09 ± 0.052	0.142MetCys: 0.142 ± 0.012	1.366MetAsp: 1.366 ± 0.035	1.706MetGlu: 1.706 ± 0.049	0.58MetPhe: 0.58 ± 0.027	1.871MetGly: 1.871 ± 0.044	0.39MetHis: 0.39 ± 0.019	1.178MetIle: 1.178 ± 0.034	1.404MetLys: 1.404 ± 0.043	1.873MetLeu: 1.873 ± 0.05	0.469MetMet: 0.469 ± 0.024	0.876MetAsn: 0.876 ± 0.031	1.105MetPro: 1.105 ± 0.035	0.777MetGln: 0.777 ± 0.029	1.288MetArg: 1.288 ± 0.04	1.345MetSer: 1.345 ± 0.039	1.272MetThr: 1.272 ± 0.032	1.401MetVal: 1.401 ± 0.038	0.179MetTrp: 0.179 ± 0.013	0.353MetTyr: 0.353 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.08AsnAla: 3.08 ± 0.078	0.36AsnCys: 0.36 ± 0.022	1.936AsnAsp: 1.936 ± 0.082	1.962AsnGlu: 1.962 ± 0.042	1.595AsnPhe: 1.595 ± 0.038	3.325AsnGly: 3.325 ± 0.088	0.717AsnHis: 0.717 ± 0.032	2.073AsnIle: 2.073 ± 0.053	1.358AsnLys: 1.358 ± 0.036	3.919AsnLeu: 3.919 ± 0.07	0.757AsnMet: 0.757 ± 0.025	1.452AsnAsn: 1.452 ± 0.05	2.882AsnPro: 2.882 ± 0.058	1.199AsnGln: 1.199 ± 0.035	2.154AsnArg: 2.154 ± 0.047	2.33AsnSer: 2.33 ± 0.067	2.054AsnThr: 2.054 ± 0.061	2.222AsnVal: 2.222 ± 0.071	0.747AsnTrp: 0.747 ± 0.027	1.137AsnTyr: 1.137 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.311ProAla: 4.311 ± 0.079	0.35ProCys: 0.35 ± 0.022	3.847ProAsp: 3.847 ± 0.069	4.616ProGlu: 4.616 ± 0.078	2.347ProPhe: 2.347 ± 0.054	4.296ProGly: 4.296 ± 0.062	1.02ProHis: 1.02 ± 0.034	2.38ProIle: 2.38 ± 0.05	1.731ProLys: 1.731 ± 0.05	4.457ProLeu: 4.457 ± 0.084	0.993ProMet: 0.993 ± 0.035	1.78ProAsn: 1.78 ± 0.042	1.965ProPro: 1.965 ± 0.057	1.445ProGln: 1.445 ± 0.037	2.11ProArg: 2.11 ± 0.052	3.117ProSer: 3.117 ± 0.059	2.488ProThr: 2.488 ± 0.059	4.328ProVal: 4.328 ± 0.071	0.736ProTrp: 0.736 ± 0.033	1.355ProTyr: 1.355 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.104GlnAla: 3.104 ± 0.064	0.239GlnCys: 0.239 ± 0.019	1.613GlnAsp: 1.613 ± 0.045	2.096GlnGlu: 2.096 ± 0.051	1.445GlnPhe: 1.445 ± 0.036	2.138GlnGly: 2.138 ± 0.041	0.6GlnHis: 0.6 ± 0.027	2.068GlnIle: 2.068 ± 0.044	1.495GlnLys: 1.495 ± 0.052	3.609GlnLeu: 3.609 ± 0.066	0.827GlnMet: 0.827 ± 0.027	1.162GlnAsn: 1.162 ± 0.033	1.652GlnPro: 1.652 ± 0.038	1.194GlnGln: 1.194 ± 0.037	1.898GlnArg: 1.898 ± 0.054	2.264GlnSer: 2.264 ± 0.046	1.803GlnThr: 1.803 ± 0.044	2.341GlnVal: 2.341 ± 0.044	0.534GlnTrp: 0.534 ± 0.024	0.909GlnTyr: 0.909 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.953ArgAla: 3.953 ± 0.079	0.474ArgCys: 0.474 ± 0.022	3.065ArgAsp: 3.065 ± 0.058	4.222ArgGlu: 4.222 ± 0.087	2.851ArgPhe: 2.851 ± 0.06	3.437ArgGly: 3.437 ± 0.064	1.202ArgHis: 1.202 ± 0.046	3.891ArgIle: 3.891 ± 0.072	2.824ArgLys: 2.824 ± 0.07	5.983ArgLeu: 5.983 ± 0.103	1.435ArgMet: 1.435 ± 0.042	2.145ArgAsn: 2.145 ± 0.045	2.337ArgPro: 2.337 ± 0.054	2.17ArgGln: 2.17 ± 0.063	3.201ArgArg: 3.201 ± 0.084	3.317ArgSer: 3.317 ± 0.064	2.743ArgThr: 2.743 ± 0.057	3.642ArgVal: 3.642 ± 0.06	0.915ArgTrp: 0.915 ± 0.033	1.738ArgTyr: 1.738 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.307SerAla: 5.307 ± 0.09	0.588SerCys: 0.588 ± 0.027	3.657SerAsp: 3.657 ± 0.077	3.99SerGlu: 3.99 ± 0.068	3.063SerPhe: 3.063 ± 0.055	6.971SerGly: 6.971 ± 0.16	1.236SerHis: 1.236 ± 0.037	4.029SerIle: 4.029 ± 0.078	2.357SerLys: 2.357 ± 0.054	7.129SerLeu: 7.129 ± 0.097	1.475SerMet: 1.475 ± 0.042	2.281SerAsn: 2.281 ± 0.055	3.327SerPro: 3.327 ± 0.061	1.917SerGln: 1.917 ± 0.037	3.658SerArg: 3.658 ± 0.069	4.504SerSer: 4.504 ± 0.104	3.658SerThr: 3.658 ± 0.097	4.731SerVal: 4.731 ± 0.106	1.119SerTrp: 1.119 ± 0.039	1.813SerTyr: 1.813 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.53ThrAla: 4.53 ± 0.088	0.47ThrCys: 0.47 ± 0.021	3.281ThrAsp: 3.281 ± 0.106	3.097ThrGlu: 3.097 ± 0.056	2.482ThrPhe: 2.482 ± 0.066	5.671ThrGly: 5.671 ± 0.128	1.068ThrHis: 1.068 ± 0.034	3.503ThrIle: 3.503 ± 0.11	1.619ThrLys: 1.619 ± 0.041	5.623ThrLeu: 5.623 ± 0.102	0.909ThrMet: 0.909 ± 0.031	1.909ThrAsn: 1.909 ± 0.065	3.032ThrPro: 3.032 ± 0.063	1.525ThrGln: 1.525 ± 0.038	2.758ThrArg: 2.758 ± 0.054	3.368ThrSer: 3.368 ± 0.078	3.102ThrThr: 3.102 ± 0.1	4.297ThrVal: 4.297 ± 0.101	0.819ThrTrp: 0.819 ± 0.026	1.593ThrTyr: 1.593 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.569ValAla: 5.569 ± 0.086	0.685ValCys: 0.685 ± 0.028	4.427ValAsp: 4.427 ± 0.101	4.665ValGlu: 4.665 ± 0.076	3.014ValPhe: 3.014 ± 0.052	5.012ValGly: 5.012 ± 0.086	1.352ValHis: 1.352 ± 0.04	4.128ValIle: 4.128 ± 0.074	2.451ValLys: 2.451 ± 0.058	6.484ValLeu: 6.484 ± 0.087	1.399ValMet: 1.399 ± 0.042	2.499ValAsn: 2.499 ± 0.068	3.305ValPro: 3.305 ± 0.063	2.12ValGln: 2.12 ± 0.048	3.773ValArg: 3.773 ± 0.06	4.893ValSer: 4.893 ± 0.092	3.997ValThr: 3.997 ± 0.111	4.959ValVal: 4.959 ± 0.081	0.905ValTrp: 0.905 ± 0.03	1.99ValTyr: 1.99 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.151TrpAla: 1.151 ± 0.043	0.146TrpCys: 0.146 ± 0.013	0.931TrpAsp: 0.931 ± 0.036	0.995TrpGlu: 0.995 ± 0.036	0.697TrpPhe: 0.697 ± 0.031	0.983TrpGly: 0.983 ± 0.033	0.343TrpHis: 0.343 ± 0.019	1.102TrpIle: 1.102 ± 0.04	0.879TrpLys: 0.879 ± 0.031	1.527TrpLeu: 1.527 ± 0.043	0.46TrpMet: 0.46 ± 0.024	0.701TrpAsn: 0.701 ± 0.03	0.629TrpPro: 0.629 ± 0.031	0.635TrpGln: 0.635 ± 0.025	0.915TrpArg: 0.915 ± 0.035	1.07TrpSer: 1.07 ± 0.036	0.953TrpThr: 0.953 ± 0.033	0.978TrpVal: 0.978 ± 0.032	0.273TrpTrp: 0.273 ± 0.018	0.413TrpTyr: 0.413 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.358TyrAla: 2.358 ± 0.05	0.273TyrCys: 0.273 ± 0.018	1.721TyrAsp: 1.721 ± 0.049	1.651TyrGlu: 1.651 ± 0.042	1.517TyrPhe: 1.517 ± 0.045	2.362TyrGly: 2.362 ± 0.047	0.629TyrHis: 0.629 ± 0.03	1.437TyrIle: 1.437 ± 0.04	1.092TyrLys: 1.092 ± 0.037	2.935TyrLeu: 2.935 ± 0.061	0.552TyrMet: 0.552 ± 0.028	1.163TyrAsn: 1.163 ± 0.033	1.551TyrPro: 1.551 ± 0.044	1.06TyrGln: 1.06 ± 0.032	1.93TyrArg: 1.93 ± 0.053	1.942TyrSer: 1.942 ± 0.045	1.655TyrThr: 1.655 ± 0.043	1.662TyrVal: 1.662 ± 0.035	0.463TyrTrp: 0.463 ± 0.022	1.07TyrTyr: 1.07 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2818 proteins (1091845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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