Amino acid dipepetide frequency for Acinetobacter brisouii CIP 110357

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.904AlaAla: 7.904 ± 0.118	1.078AlaCys: 1.078 ± 0.032	4.426AlaAsp: 4.426 ± 0.074	5.637AlaGlu: 5.637 ± 0.092	3.397AlaPhe: 3.397 ± 0.066	6.079AlaGly: 6.079 ± 0.098	2.062AlaHis: 2.062 ± 0.06	6.096AlaIle: 6.096 ± 0.089	4.959AlaLys: 4.959 ± 0.089	9.946AlaLeu: 9.946 ± 0.138	2.544AlaMet: 2.544 ± 0.058	3.331AlaAsn: 3.331 ± 0.061	3.061AlaPro: 3.061 ± 0.063	5.332AlaGln: 5.332 ± 0.099	3.645AlaArg: 3.645 ± 0.072	5.077AlaSer: 5.077 ± 0.073	4.75AlaThr: 4.75 ± 0.075	6.008AlaVal: 6.008 ± 0.088	1.213AlaTrp: 1.213 ± 0.037	2.701AlaTyr: 2.701 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.784CysAla: 0.784 ± 0.029	0.161CysCys: 0.161 ± 0.015	0.49CysAsp: 0.49 ± 0.023	0.533CysGlu: 0.533 ± 0.023	0.485CysPhe: 0.485 ± 0.024	0.879CysGly: 0.879 ± 0.035	0.267CysHis: 0.267 ± 0.017	0.713CysIle: 0.713 ± 0.027	0.388CysLys: 0.388 ± 0.021	1.1CysLeu: 1.1 ± 0.039	0.229CysMet: 0.229 ± 0.018	0.321CysAsn: 0.321 ± 0.021	0.448CysPro: 0.448 ± 0.026	0.561CysGln: 0.561 ± 0.027	0.455CysArg: 0.455 ± 0.021	0.692CysSer: 0.692 ± 0.029	0.465CysThr: 0.465 ± 0.024	0.665CysVal: 0.665 ± 0.025	0.119CysTrp: 0.119 ± 0.013	0.351CysTyr: 0.351 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.622AspAla: 4.622 ± 0.088	0.444AspCys: 0.444 ± 0.023	2.57AspAsp: 2.57 ± 0.061	3.199AspGlu: 3.199 ± 0.062	2.304AspPhe: 2.304 ± 0.049	2.98AspGly: 2.98 ± 0.078	1.349AspHis: 1.349 ± 0.041	3.411AspIle: 3.411 ± 0.064	2.278AspLys: 2.278 ± 0.06	5.675AspLeu: 5.675 ± 0.079	1.242AspMet: 1.242 ± 0.035	1.708AspAsn: 1.708 ± 0.044	2.032AspPro: 2.032 ± 0.045	2.858AspGln: 2.858 ± 0.064	2.277AspArg: 2.277 ± 0.054	2.554AspSer: 2.554 ± 0.059	2.352AspThr: 2.352 ± 0.057	3.745AspVal: 3.745 ± 0.069	0.811AspTrp: 0.811 ± 0.033	1.92AspTyr: 1.92 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.653GluAla: 4.653 ± 0.081	0.413GluCys: 0.413 ± 0.024	2.517GluAsp: 2.517 ± 0.057	2.758GluGlu: 2.758 ± 0.065	2.274GluPhe: 2.274 ± 0.046	2.949GluGly: 2.949 ± 0.064	1.826GluHis: 1.826 ± 0.046	3.943GluIle: 3.943 ± 0.069	3.583GluLys: 3.583 ± 0.062	6.175GluLeu: 6.175 ± 0.09	1.488GluMet: 1.488 ± 0.045	2.541GluAsn: 2.541 ± 0.06	1.776GluPro: 1.776 ± 0.054	4.746GluGln: 4.746 ± 0.104	2.987GluArg: 2.987 ± 0.06	2.714GluSer: 2.714 ± 0.057	2.824GluThr: 2.824 ± 0.067	3.662GluVal: 3.662 ± 0.068	0.73GluTrp: 0.73 ± 0.031	1.702GluTyr: 1.702 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.955PheAla: 3.955 ± 0.072	0.536PheCys: 0.536 ± 0.027	2.485PheAsp: 2.485 ± 0.055	2.394PheGlu: 2.394 ± 0.056	1.834PhePhe: 1.834 ± 0.053	3.116PheGly: 3.116 ± 0.059	0.904PheHis: 0.904 ± 0.031	2.806PheIle: 2.806 ± 0.059	2.209PheLys: 2.209 ± 0.055	3.886PheLeu: 3.886 ± 0.084	1.097PheMet: 1.097 ± 0.037	1.986PheAsn: 1.986 ± 0.051	1.474PhePro: 1.474 ± 0.038	1.778PheGln: 1.778 ± 0.048	1.453PheArg: 1.453 ± 0.046	3.056PheSer: 3.056 ± 0.07	2.033PheThr: 2.033 ± 0.046	2.673PheVal: 2.673 ± 0.058	0.598PheTrp: 0.598 ± 0.028	1.43PheTyr: 1.43 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.144GlyAla: 5.144 ± 0.093	0.808GlyCys: 0.808 ± 0.036	2.901GlyAsp: 2.901 ± 0.077	3.559GlyGlu: 3.559 ± 0.066	3.216GlyPhe: 3.216 ± 0.063	4.658GlyGly: 4.658 ± 0.107	1.694GlyHis: 1.694 ± 0.047	4.789GlyIle: 4.789 ± 0.081	3.599GlyLys: 3.599 ± 0.066	7.269GlyLeu: 7.269 ± 0.093	1.846GlyMet: 1.846 ± 0.051	2.401GlyAsn: 2.401 ± 0.072	1.349GlyPro: 1.349 ± 0.041	3.357GlyGln: 3.357 ± 0.073	2.921GlyArg: 2.921 ± 0.061	3.668GlySer: 3.668 ± 0.071	3.492GlyThr: 3.492 ± 0.07	4.878GlyVal: 4.878 ± 0.078	0.966GlyTrp: 0.966 ± 0.03	2.356GlyTyr: 2.356 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.355HisAla: 2.355 ± 0.056	0.311HisCys: 0.311 ± 0.02	1.274HisAsp: 1.274 ± 0.041	1.358HisGlu: 1.358 ± 0.04	1.27HisPhe: 1.27 ± 0.034	1.739HisGly: 1.739 ± 0.053	0.86HisHis: 0.86 ± 0.039	1.747HisIle: 1.747 ± 0.043	1.038HisLys: 1.038 ± 0.032	2.843HisLeu: 2.843 ± 0.062	0.607HisMet: 0.607 ± 0.029	0.927HisAsn: 0.927 ± 0.03	1.495HisPro: 1.495 ± 0.039	1.496HisGln: 1.496 ± 0.047	1.106HisArg: 1.106 ± 0.036	1.435HisSer: 1.435 ± 0.039	1.215HisThr: 1.215 ± 0.03	1.675HisVal: 1.675 ± 0.049	0.404HisTrp: 0.404 ± 0.02	1.023HisTyr: 1.023 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.678IleAla: 6.678 ± 0.092	0.784IleCys: 0.784 ± 0.031	3.937IleAsp: 3.937 ± 0.066	4.341IleGlu: 4.341 ± 0.081	2.686IlePhe: 2.686 ± 0.067	4.81IleGly: 4.81 ± 0.086	1.592IleHis: 1.592 ± 0.047	3.856IleIle: 3.856 ± 0.073	2.985IleLys: 2.985 ± 0.063	6.606IleLeu: 6.606 ± 0.096	1.39IleMet: 1.39 ± 0.037	2.708IleAsn: 2.708 ± 0.058	2.864IlePro: 2.864 ± 0.059	3.876IleGln: 3.876 ± 0.074	3.065IleArg: 3.065 ± 0.065	4.263IleSer: 4.263 ± 0.082	3.392IleThr: 3.392 ± 0.061	4.316IleVal: 4.316 ± 0.078	0.71IleTrp: 0.71 ± 0.032	2.024IleTyr: 2.024 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.716LysAla: 4.716 ± 0.077	0.315LysCys: 0.315 ± 0.019	2.562LysAsp: 2.562 ± 0.066	2.62LysGlu: 2.62 ± 0.065	1.816LysPhe: 1.816 ± 0.047	2.825LysGly: 2.825 ± 0.062	1.353LysHis: 1.353 ± 0.038	3.849LysIle: 3.849 ± 0.071	3.035LysLys: 3.035 ± 0.068	4.934LysLeu: 4.934 ± 0.07	1.419LysMet: 1.419 ± 0.042	2.612LysAsn: 2.612 ± 0.067	2.171LysPro: 2.171 ± 0.052	3.46LysGln: 3.46 ± 0.067	2.452LysArg: 2.452 ± 0.054	2.809LysSer: 2.809 ± 0.059	3.163LysThr: 3.163 ± 0.075	3.45LysVal: 3.45 ± 0.063	0.529LysTrp: 0.529 ± 0.029	1.504LysTyr: 1.504 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	9.967LeuAla: 9.967 ± 0.126	1.193LeuCys: 1.193 ± 0.041	5.616LeuAsp: 5.616 ± 0.074	5.879LeuGlu: 5.879 ± 0.098	4.196LeuPhe: 4.196 ± 0.079	7.267LeuGly: 7.267 ± 0.094	2.457LeuHis: 2.457 ± 0.06	6.93LeuIle: 6.93 ± 0.093	6.249LeuLys: 6.249 ± 0.089	10.715LeuLeu: 10.715 ± 0.16	2.575LeuMet: 2.575 ± 0.062	5.161LeuAsn: 5.161 ± 0.079	4.869LeuPro: 4.869 ± 0.08	5.551LeuGln: 5.551 ± 0.119	4.46LeuArg: 4.46 ± 0.08	7.394LeuSer: 7.394 ± 0.108	5.804LeuThr: 5.804 ± 0.081	6.475LeuVal: 6.475 ± 0.083	1.321LeuTrp: 1.321 ± 0.045	2.837LeuTyr: 2.837 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.199MetAla: 2.199 ± 0.048	0.196MetCys: 0.196 ± 0.017	1.003MetAsp: 1.003 ± 0.035	0.859MetGlu: 0.859 ± 0.028	0.848MetPhe: 0.848 ± 0.029	1.69MetGly: 1.69 ± 0.046	0.616MetHis: 0.616 ± 0.027	1.725MetIle: 1.725 ± 0.048	1.275MetLys: 1.275 ± 0.036	2.819MetLeu: 2.819 ± 0.07	0.743MetMet: 0.743 ± 0.03	1.217MetAsn: 1.217 ± 0.04	1.2MetPro: 1.2 ± 0.035	1.686MetGln: 1.686 ± 0.05	1.151MetArg: 1.151 ± 0.035	1.942MetSer: 1.942 ± 0.047	1.555MetThr: 1.555 ± 0.04	1.589MetVal: 1.589 ± 0.044	0.244MetTrp: 0.244 ± 0.017	0.572MetTyr: 0.572 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.656AsnAla: 3.656 ± 0.074	0.375AsnCys: 0.375 ± 0.02	2.033AsnAsp: 2.033 ± 0.062	2.008AsnGlu: 2.008 ± 0.047	1.744AsnPhe: 1.744 ± 0.044	2.505AsnGly: 2.505 ± 0.063	1.06AsnHis: 1.06 ± 0.035	2.961AsnIle: 2.961 ± 0.063	2.087AsnLys: 2.087 ± 0.056	4.398AsnLeu: 4.398 ± 0.074	0.988AsnMet: 0.988 ± 0.029	1.843AsnAsn: 1.843 ± 0.056	2.281AsnPro: 2.281 ± 0.05	2.476AsnGln: 2.476 ± 0.056	1.756AsnArg: 1.756 ± 0.038	2.396AsnSer: 2.396 ± 0.058	2.352AsnThr: 2.352 ± 0.057	2.563AsnVal: 2.563 ± 0.061	0.591AsnTrp: 0.591 ± 0.024	1.499AsnTyr: 1.499 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.332ProAla: 3.332 ± 0.071	0.305ProCys: 0.305 ± 0.019	2.271ProAsp: 2.271 ± 0.052	3.452ProGlu: 3.452 ± 0.063	1.733ProPhe: 1.733 ± 0.05	1.521ProGly: 1.521 ± 0.051	1.017ProHis: 1.017 ± 0.034	2.567ProIle: 2.567 ± 0.054	2.309ProLys: 2.309 ± 0.055	3.942ProLeu: 3.942 ± 0.064	1.04ProMet: 1.04 ± 0.035	1.987ProAsn: 1.987 ± 0.049	1.12ProPro: 1.12 ± 0.039	2.163ProGln: 2.163 ± 0.053	1.506ProArg: 1.506 ± 0.043	2.36ProSer: 2.36 ± 0.047	2.117ProThr: 2.117 ± 0.052	3.215ProVal: 3.215 ± 0.063	0.493ProTrp: 0.493 ± 0.023	1.359ProTyr: 1.359 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.791GlnAla: 5.791 ± 0.098	0.418GlnCys: 0.418 ± 0.021	2.83GlnAsp: 2.83 ± 0.068	2.726GlnGlu: 2.726 ± 0.058	2.252GlnPhe: 2.252 ± 0.051	3.527GlnGly: 3.527 ± 0.071	2.302GlnHis: 2.302 ± 0.064	3.794GlnIle: 3.794 ± 0.072	2.892GlnLys: 2.892 ± 0.058	6.591GlnLeu: 6.591 ± 0.121	1.228GlnMet: 1.228 ± 0.039	2.287GlnAsn: 2.287 ± 0.056	2.507GlnPro: 2.507 ± 0.06	5.838GlnGln: 5.838 ± 0.189	3.072GlnArg: 3.072 ± 0.071	3.127GlnSer: 3.127 ± 0.071	2.859GlnThr: 2.859 ± 0.061	3.888GlnVal: 3.888 ± 0.066	0.714GlnTrp: 0.714 ± 0.031	1.917GlnTyr: 1.917 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	3.45ArgAla: 3.45 ± 0.064	0.401ArgCys: 0.401 ± 0.023	2.268ArgAsp: 2.268 ± 0.052	2.755ArgGlu: 2.755 ± 0.061	2.088ArgPhe: 2.088 ± 0.051	2.49ArgGly: 2.49 ± 0.053	1.252ArgHis: 1.252 ± 0.039	3.1ArgIle: 3.1 ± 0.065	2.149ArgLys: 2.149 ± 0.049	5.049ArgLeu: 5.049 ± 0.076	1.151ArgMet: 1.151 ± 0.034	1.748ArgAsn: 1.748 ± 0.039	1.719ArgPro: 1.719 ± 0.05	2.784ArgGln: 2.784 ± 0.056	2.271ArgArg: 2.271 ± 0.067	2.391ArgSer: 2.391 ± 0.054	1.988ArgThr: 1.988 ± 0.052	3.013ArgVal: 3.013 ± 0.062	0.541ArgTrp: 0.541 ± 0.023	1.84ArgTyr: 1.84 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.074SerAla: 5.074 ± 0.074	0.614SerCys: 0.614 ± 0.025	2.843SerAsp: 2.843 ± 0.063	3.178SerGlu: 3.178 ± 0.061	2.683SerPhe: 2.683 ± 0.052	4.207SerGly: 4.207 ± 0.07	1.533SerHis: 1.533 ± 0.037	4.102SerIle: 4.102 ± 0.068	3.01SerLys: 3.01 ± 0.053	6.5SerLeu: 6.5 ± 0.091	1.595SerMet: 1.595 ± 0.043	2.505SerAsn: 2.505 ± 0.062	2.283SerPro: 2.283 ± 0.056	3.185SerGln: 3.185 ± 0.063	2.537SerArg: 2.537 ± 0.046	4.05SerSer: 4.05 ± 0.077	3.205SerThr: 3.205 ± 0.067	3.934SerVal: 3.934 ± 0.066	0.682SerTrp: 0.682 ± 0.031	2.022SerTyr: 2.022 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.947ThrAla: 4.947 ± 0.087	0.455ThrCys: 0.455 ± 0.025	2.535ThrAsp: 2.535 ± 0.062	2.932ThrGlu: 2.932 ± 0.063	1.94ThrPhe: 1.94 ± 0.047	4.227ThrGly: 4.227 ± 0.075	1.447ThrHis: 1.447 ± 0.04	3.078ThrIle: 3.078 ± 0.067	2.12ThrLys: 2.12 ± 0.063	5.905ThrLeu: 5.905 ± 0.079	1.015ThrMet: 1.015 ± 0.033	1.82ThrAsn: 1.82 ± 0.055	2.749ThrPro: 2.749 ± 0.055	3.106ThrGln: 3.106 ± 0.065	2.212ThrArg: 2.212 ± 0.05	3.058ThrSer: 3.058 ± 0.061	3.159ThrThr: 3.159 ± 0.072	3.675ThrVal: 3.675 ± 0.063	0.701ThrTrp: 0.701 ± 0.028	1.454ThrTyr: 1.454 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	6.204ValAla: 6.204 ± 0.085	0.78ValCys: 0.78 ± 0.029	3.617ValAsp: 3.617 ± 0.065	4.088ValGlu: 4.088 ± 0.072	2.782ValPhe: 2.782 ± 0.06	4.518ValGly: 4.518 ± 0.065	1.426ValHis: 1.426 ± 0.042	4.692ValIle: 4.692 ± 0.07	3.474ValLys: 3.474 ± 0.074	7.195ValLeu: 7.195 ± 0.093	1.894ValMet: 1.894 ± 0.049	2.717ValAsn: 2.717 ± 0.057	2.656ValPro: 2.656 ± 0.056	3.197ValGln: 3.197 ± 0.059	2.796ValArg: 2.796 ± 0.059	3.942ValSer: 3.942 ± 0.074	3.704ValThr: 3.704 ± 0.072	5.017ValVal: 5.017 ± 0.087	0.841ValTrp: 0.841 ± 0.033	1.921ValTyr: 1.921 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.94TrpAla: 0.94 ± 0.033	0.163TrpCys: 0.163 ± 0.013	0.543TrpAsp: 0.543 ± 0.025	0.475TrpGlu: 0.475 ± 0.024	0.648TrpPhe: 0.648 ± 0.025	0.731TrpGly: 0.731 ± 0.03	0.367TrpHis: 0.367 ± 0.022	0.877TrpIle: 0.877 ± 0.034	0.611TrpLys: 0.611 ± 0.026	1.739TrpLeu: 1.739 ± 0.056	0.418TrpMet: 0.418 ± 0.022	0.53TrpAsn: 0.53 ± 0.025	0.318TrpPro: 0.318 ± 0.02	0.995TrpGln: 0.995 ± 0.039	0.617TrpArg: 0.617 ± 0.025	0.799TrpSer: 0.799 ± 0.027	0.577TrpThr: 0.577 ± 0.026	0.936TrpVal: 0.936 ± 0.035	0.19TrpTrp: 0.19 ± 0.014	0.377TrpTyr: 0.377 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.873TyrAla: 2.873 ± 0.056	0.36TyrCys: 0.36 ± 0.02	1.61TyrAsp: 1.61 ± 0.043	1.511TyrGlu: 1.511 ± 0.043	1.503TyrPhe: 1.503 ± 0.04	2.154TyrGly: 2.154 ± 0.055	0.794TyrHis: 0.794 ± 0.031	1.845TyrIle: 1.845 ± 0.049	1.341TyrLys: 1.341 ± 0.042	3.629TyrLeu: 3.629 ± 0.08	0.619TyrMet: 0.619 ± 0.024	1.223TyrAsn: 1.223 ± 0.046	1.437TyrPro: 1.437 ± 0.042	2.117TyrGln: 2.117 ± 0.052	1.709TyrArg: 1.709 ± 0.045	2.014TyrSer: 2.014 ± 0.041	1.528TyrThr: 1.528 ± 0.041	2.086TyrVal: 2.086 ± 0.052	0.455TyrTrp: 0.455 ± 0.023	1.002TyrTyr: 1.002 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2927 proteins (896350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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