Amino acid dipepetide frequency for Imjin virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.62AlaAla: 1.62 ± 0.329
0.81AlaCys: 0.81 ± 0.743
2.16AlaAsp: 2.16 ± 0.521
3.78AlaGlu: 3.78 ± 0.166
1.62AlaPhe: 1.62 ± 0.51
2.97AlaGly: 2.97 ± 0.821
1.89AlaHis: 1.89 ± 0.671
2.43AlaIle: 2.43 ± 0.952
2.43AlaLys: 2.43 ± 0.653
4.32AlaLeu: 4.32 ± 1.043
1.08AlaMet: 1.08 ± 0.263
2.43AlaAsn: 2.43 ± 0.654
0.81AlaPro: 0.81 ± 0.33
2.16AlaGln: 2.16 ± 0.879
1.62AlaArg: 1.62 ± 0.29
3.24AlaSer: 3.24 ± 0.579
4.32AlaThr: 4.32 ± 1.119
3.78AlaVal: 3.78 ± 0.355
0.81AlaTrp: 0.81 ± 0.165
2.97AlaTyr: 2.97 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
1.62CysAla: 1.62 ± 0.532
0.27CysCys: 0.27 ± 0.248
1.35CysAsp: 1.35 ± 0.772
1.35CysGlu: 1.35 ± 0.534
1.35CysPhe: 1.35 ± 0.534
1.08CysGly: 1.08 ± 0.631
0.54CysHis: 0.54 ± 0.154
1.62CysIle: 1.62 ± 0.773
1.89CysLys: 1.89 ± 0.684
2.16CysLeu: 2.16 ± 1.262
0.81CysMet: 0.81 ± 0.33
1.89CysAsn: 1.89 ± 1.017
1.89CysPro: 1.89 ± 1.483
0.54CysGln: 0.54 ± 0.495
0.81CysArg: 0.81 ± 0.743
1.62CysSer: 1.62 ± 0.773
2.16CysThr: 2.16 ± 0.616
2.43CysVal: 2.43 ± 0.768
0.54CysTrp: 0.54 ± 0.154
1.08CysTyr: 1.08 ± 0.631
0.0CysXaa: 0.0 ± 0.0
Asp
2.97AspAla: 2.97 ± 0.326
1.62AspCys: 1.62 ± 0.462
3.78AspAsp: 3.78 ± 1.089
2.7AspGlu: 2.7 ± 0.728
3.24AspPhe: 3.24 ± 1.218
1.89AspGly: 1.89 ± 0.427
1.62AspHis: 1.62 ± 0.18
4.59AspIle: 4.59 ± 0.928
4.32AspLys: 4.32 ± 0.097
5.4AspLeu: 5.4 ± 1.456
0.81AspMet: 0.81 ± 0.379
3.78AspAsn: 3.78 ± 0.641
2.97AspPro: 2.97 ± 0.816
2.43AspGln: 2.43 ± 0.449
1.62AspArg: 1.62 ± 0.604
4.05AspSer: 4.05 ± 0.55
2.97AspThr: 2.97 ± 0.599
2.16AspVal: 2.16 ± 0.534
1.35AspTrp: 1.35 ± 0.715
2.43AspTyr: 2.43 ± 0.897
0.0AspXaa: 0.0 ± 0.0
Glu
1.89GluAla: 1.89 ± 0.671
2.7GluCys: 2.7 ± 1.46
2.43GluAsp: 2.43 ± 0.966
3.51GluGlu: 3.51 ± 2.191
2.97GluPhe: 2.97 ± 0.926
3.78GluGly: 3.78 ± 0.669
0.81GluHis: 0.81 ± 0.165
4.32GluIle: 4.32 ± 0.721
6.21GluLys: 6.21 ± 0.34
5.13GluLeu: 5.13 ± 1.07
0.81GluMet: 0.81 ± 0.429
1.89GluAsn: 1.89 ± 0.684
2.16GluPro: 2.16 ± 0.605
0.81GluGln: 0.81 ± 0.379
2.7GluArg: 2.7 ± 0.846
3.51GluSer: 3.51 ± 1.202
4.59GluThr: 4.59 ± 0.785
4.32GluVal: 4.32 ± 1.043
1.89GluTrp: 1.89 ± 0.427
3.78GluTyr: 3.78 ± 0.63
0.0GluXaa: 0.0 ± 0.0
Phe
2.16PheAla: 2.16 ± 0.97
1.89PheCys: 1.89 ± 1.11
2.43PheAsp: 2.43 ± 0.66
4.59PheGlu: 4.59 ± 0.488
3.24PhePhe: 3.24 ± 0.203
1.62PheGly: 1.62 ± 0.51
1.62PheHis: 1.62 ± 0.462
2.7PheIle: 2.7 ± 0.57
4.86PheLys: 4.86 ± 0.929
5.13PheLeu: 5.13 ± 1.07
1.35PheMet: 1.35 ± 0.396
2.97PheAsn: 2.97 ± 0.56
1.08PhePro: 1.08 ± 0.267
1.89PheGln: 1.89 ± 0.427
2.16PheArg: 2.16 ± 0.521
5.94PheSer: 5.94 ± 1.197
2.97PheThr: 2.97 ± 1.306
1.62PheVal: 1.62 ± 0.462
0.27PheTrp: 0.27 ± 0.143
1.08PheTyr: 1.08 ± 0.454
0.0PheXaa: 0.0 ± 0.0
Gly
3.78GlyAla: 3.78 ± 0.976
1.08GlyCys: 1.08 ± 0.308
4.05GlyAsp: 4.05 ± 1.712
1.62GlyGlu: 1.62 ± 0.532
3.51GlyPhe: 3.51 ± 0.397
1.35GlyGly: 1.35 ± 0.285
1.62GlyHis: 1.62 ± 0.773
4.86GlyIle: 4.86 ± 0.408
2.97GlyLys: 2.97 ± 0.684
5.67GlyLeu: 5.67 ± 0.828
1.89GlyMet: 1.89 ± 0.42
3.24GlyAsn: 3.24 ± 0.484
1.08GlyPro: 1.08 ± 0.795
1.89GlyGln: 1.89 ± 0.754
1.89GlyArg: 1.89 ± 0.754
3.24GlySer: 3.24 ± 1.218
4.05GlyThr: 4.05 ± 0.57
3.24GlyVal: 3.24 ± 0.36
1.35GlyTrp: 1.35 ± 0.534
2.43GlyTyr: 2.43 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
1.08HisAla: 1.08 ± 0.572
1.08HisCys: 1.08 ± 0.631
1.08HisAsp: 1.08 ± 0.267
2.7HisGlu: 2.7 ± 0.791
1.35HisPhe: 1.35 ± 0.227
1.62HisGly: 1.62 ± 0.462
0.54HisHis: 0.54 ± 0.286
2.7HisIle: 2.7 ± 0.715
1.62HisLys: 1.62 ± 0.18
1.89HisLeu: 1.89 ± 0.427
0.81HisMet: 0.81 ± 0.165
1.08HisAsn: 1.08 ± 0.308
0.81HisPro: 0.81 ± 0.429
0.54HisGln: 0.54 ± 0.154
0.54HisArg: 0.54 ± 0.154
2.7HisSer: 2.7 ± 1.754
1.08HisThr: 1.08 ± 0.267
0.81HisVal: 0.81 ± 0.429
0.54HisTrp: 0.54 ± 0.495
1.62HisTyr: 1.62 ± 0.51
0.0HisXaa: 0.0 ± 0.0
Ile
3.78IleAla: 3.78 ± 1.167
1.62IleCys: 1.62 ± 0.329
3.78IleAsp: 3.78 ± 0.434
4.59IleGlu: 4.59 ± 1.11
4.05IlePhe: 4.05 ± 0.597
3.24IleGly: 3.24 ± 1.208
2.16IleHis: 2.16 ± 0.521
6.21IleIle: 6.21 ± 0.427
4.32IleLys: 4.32 ± 1.461
4.86IleLeu: 4.86 ± 0.561
1.62IleMet: 1.62 ± 0.51
4.59IleAsn: 4.59 ± 0.8
4.05IlePro: 4.05 ± 0.356
6.21IleGln: 6.21 ± 1.62
1.89IleArg: 1.89 ± 0.588
4.05IleSer: 4.05 ± 0.546
5.13IleThr: 5.13 ± 0.812
4.59IleVal: 4.59 ± 0.488
0.54IleTrp: 0.54 ± 0.154
2.43IleTyr: 2.43 ± 0.28
0.0IleXaa: 0.0 ± 0.0
Lys
4.32LysAla: 4.32 ± 0.612
1.08LysCys: 1.08 ± 0.631
4.32LysAsp: 4.32 ± 0.67
5.4LysGlu: 5.4 ± 0.723
4.59LysPhe: 4.59 ± 0.749
3.24LysGly: 3.24 ± 0.579
2.16LysHis: 2.16 ± 0.149
6.479LysIle: 6.479 ± 0.318
4.05LysLys: 4.05 ± 1.53
6.479LysLeu: 6.479 ± 1.879
0.54LysMet: 0.54 ± 0.154
2.43LysAsn: 2.43 ± 0.576
2.16LysPro: 2.16 ± 0.439
3.51LysGln: 3.51 ± 0.68
2.97LysArg: 2.97 ± 0.56
4.86LysSer: 4.86 ± 0.881
5.13LysThr: 5.13 ± 1.136
5.67LysVal: 5.67 ± 0.774
0.27LysTrp: 0.27 ± 0.143
1.89LysTyr: 1.89 ± 1.001
0.0LysXaa: 0.0 ± 0.0
Leu
6.21LeuAla: 6.21 ± 0.573
1.08LeuCys: 1.08 ± 0.631
4.86LeuAsp: 4.86 ± 0.887
6.479LeuGlu: 6.479 ± 0.105
5.4LeuPhe: 5.4 ± 1.158
4.59LeuGly: 4.59 ± 0.785
2.7LeuHis: 2.7 ± 0.57
5.94LeuIle: 5.94 ± 1.197
5.67LeuLys: 5.67 ± 0.944
9.719LeuLeu: 9.719 ± 0.678
1.62LeuMet: 1.62 ± 0.972
6.479LeuAsn: 6.479 ± 1.116
3.51LeuPro: 3.51 ± 1.333
4.86LeuGln: 4.86 ± 0.652
4.86LeuArg: 4.86 ± 1.607
6.21LeuSer: 6.21 ± 0.336
4.05LeuThr: 4.05 ± 1.604
5.13LeuVal: 5.13 ± 0.746
0.81LeuTrp: 0.81 ± 0.165
4.59LeuTyr: 4.59 ± 0.426
0.0LeuXaa: 0.0 ± 0.0
Met
0.54MetAla: 0.54 ± 0.367
0.27MetCys: 0.27 ± 0.248
1.08MetAsp: 1.08 ± 1.168
0.54MetGlu: 0.54 ± 0.367
0.81MetPhe: 0.81 ± 0.429
1.08MetGly: 1.08 ± 0.727
0.0MetHis: 0.0 ± 0.0
1.08MetIle: 1.08 ± 0.308
2.16MetLys: 2.16 ± 0.149
2.43MetLeu: 2.43 ± 0.836
0.54MetMet: 0.54 ± 0.286
1.35MetAsn: 1.35 ± 0.285
0.54MetPro: 0.54 ± 0.154
1.35MetGln: 1.35 ± 0.533
0.54MetArg: 0.54 ± 0.154
1.62MetSer: 1.62 ± 0.644
2.16MetThr: 2.16 ± 0.489
0.81MetVal: 0.81 ± 0.429
0.27MetTrp: 0.27 ± 0.143
0.54MetTyr: 0.54 ± 0.286
0.0MetXaa: 0.0 ± 0.0
Asn
1.62AsnAla: 1.62 ± 0.29
0.81AsnCys: 0.81 ± 0.33
2.7AsnAsp: 2.7 ± 0.579
1.08AsnGlu: 1.08 ± 0.454
1.08AsnPhe: 1.08 ± 0.572
3.24AsnGly: 3.24 ± 0.841
0.54AsnHis: 0.54 ± 0.154
2.97AsnIle: 2.97 ± 0.684
3.24AsnLys: 3.24 ± 0.702
5.67AsnLeu: 5.67 ± 1.436
1.08AsnMet: 1.08 ± 0.308
1.89AsnAsn: 1.89 ± 0.684
3.24AsnPro: 3.24 ± 0.36
1.35AsnGln: 1.35 ± 0.285
2.16AsnArg: 2.16 ± 0.605
2.16AsnSer: 2.16 ± 0.602
3.24AsnThr: 3.24 ± 0.484
4.86AsnVal: 4.86 ± 0.516
1.08AsnTrp: 1.08 ± 0.454
1.35AsnTyr: 1.35 ± 0.715
0.0AsnXaa: 0.0 ± 0.0
Pro
1.62ProAla: 1.62 ± 0.18
0.81ProCys: 0.81 ± 0.165
4.05ProAsp: 4.05 ± 1.959
2.16ProGlu: 2.16 ± 0.895
1.08ProPhe: 1.08 ± 0.308
3.51ProGly: 3.51 ± 1.244
1.35ProHis: 1.35 ± 0.877
2.97ProIle: 2.97 ± 0.5
1.62ProLys: 1.62 ± 0.532
2.7ProLeu: 2.7 ± 0.09
0.81ProMet: 0.81 ± 0.429
1.08ProAsn: 1.08 ± 0.245
0.81ProPro: 0.81 ± 0.379
1.62ProGln: 1.62 ± 0.532
0.54ProArg: 0.54 ± 0.154
2.97ProSer: 2.97 ± 0.599
2.43ProThr: 2.43 ± 0.897
2.16ProVal: 2.16 ± 0.521
0.81ProTrp: 0.81 ± 0.33
0.81ProTyr: 0.81 ± 0.165
0.0ProXaa: 0.0 ± 0.0
Gln
2.7GlnAla: 2.7 ± 0.728
0.81GlnCys: 0.81 ± 0.33
1.89GlnAsp: 1.89 ± 1.053
2.16GlnGlu: 2.16 ± 0.521
0.81GlnPhe: 0.81 ± 0.33
2.7GlnGly: 2.7 ± 0.57
1.08GlnHis: 1.08 ± 0.572
3.78GlnIle: 3.78 ± 0.349
4.05GlnLys: 4.05 ± 1.045
4.32GlnLeu: 4.32 ± 1.035
0.27GlnMet: 0.27 ± 0.248
1.35GlnAsn: 1.35 ± 0.227
0.81GlnPro: 0.81 ± 0.165
1.89GlnGln: 1.89 ± 0.671
2.43GlnArg: 2.43 ± 0.506
4.32GlnSer: 4.32 ± 1.462
2.97GlnThr: 2.97 ± 1.163
2.16GlnVal: 2.16 ± 0.149
0.54GlnTrp: 0.54 ± 0.286
1.35GlnTyr: 1.35 ± 0.396
0.0GlnXaa: 0.0 ± 0.0
Arg
1.08ArgAla: 1.08 ± 0.245
1.35ArgCys: 1.35 ± 0.227
3.24ArgAsp: 3.24 ± 0.702
1.62ArgGlu: 1.62 ± 0.887
2.7ArgPhe: 2.7 ± 0.715
3.24ArgGly: 3.24 ± 0.579
1.62ArgHis: 1.62 ± 0.29
2.43ArgIle: 2.43 ± 0.897
3.24ArgLys: 3.24 ± 1.029
3.78ArgLeu: 3.78 ± 0.84
0.81ArgMet: 0.81 ± 0.379
1.35ArgAsn: 1.35 ± 0.396
0.81ArgPro: 0.81 ± 0.429
1.89ArgGln: 1.89 ± 1.218
1.08ArgArg: 1.08 ± 0.439
3.24ArgSer: 3.24 ± 0.579
2.16ArgThr: 2.16 ± 1.101
1.62ArgVal: 1.62 ± 0.532
0.81ArgTrp: 0.81 ± 0.165
2.16ArgTyr: 2.16 ± 0.521
0.0ArgXaa: 0.0 ± 0.0
Ser
2.16SerAla: 2.16 ± 0.439
2.16SerCys: 2.16 ± 0.975
3.78SerAsp: 3.78 ± 0.76
4.59SerGlu: 4.59 ± 1.184
4.32SerPhe: 4.32 ± 0.416
4.59SerGly: 4.59 ± 0.696
0.81SerHis: 0.81 ± 0.387
5.13SerIle: 5.13 ± 0.634
5.94SerLys: 5.94 ± 1.855
8.909SerLeu: 8.909 ± 0.652
0.81SerMet: 0.81 ± 0.33
1.62SerAsn: 1.62 ± 0.661
2.7SerPro: 2.7 ± 0.419
2.7SerGln: 2.7 ± 0.728
2.97SerArg: 2.97 ± 0.594
5.67SerSer: 5.67 ± 1.69
6.21SerThr: 6.21 ± 1.074
4.05SerVal: 4.05 ± 0.356
1.08SerTrp: 1.08 ± 0.308
2.43SerTyr: 2.43 ± 0.28
0.0SerXaa: 0.0 ± 0.0
Thr
3.51ThrAla: 3.51 ± 0.687
2.7ThrCys: 2.7 ± 1.403
2.7ThrAsp: 2.7 ± 1.666
5.4ThrGlu: 5.4 ± 1.154
3.51ThrPhe: 3.51 ± 0.525
4.59ThrGly: 4.59 ± 2.079
3.24ThrHis: 3.24 ± 1.893
4.32ThrIle: 4.32 ± 1.06
3.78ThrLys: 3.78 ± 0.855
5.13ThrLeu: 5.13 ± 1.037
1.08ThrMet: 1.08 ± 0.267
1.08ThrAsn: 1.08 ± 0.245
2.43ThrPro: 2.43 ± 0.28
2.7ThrGln: 2.7 ± 1.464
2.97ThrArg: 2.97 ± 0.951
4.05ThrSer: 4.05 ± 0.967
4.05ThrThr: 4.05 ± 0.55
5.4ThrVal: 5.4 ± 0.668
0.27ThrTrp: 0.27 ± 0.248
1.89ThrTyr: 1.89 ± 0.42
0.0ThrXaa: 0.0 ± 0.0
Val
2.7ValAla: 2.7 ± 0.09
2.43ValCys: 2.43 ± 1.16
4.86ValAsp: 4.86 ± 0.887
3.78ValGlu: 3.78 ± 0.987
2.7ValPhe: 2.7 ± 0.77
1.89ValGly: 1.89 ± 0.427
0.81ValHis: 0.81 ± 0.387
4.86ValIle: 4.86 ± 0.408
5.13ValLys: 5.13 ± 1.027
5.67ValLeu: 5.67 ± 0.274
1.08ValMet: 1.08 ± 0.245
1.62ValAsn: 1.62 ± 0.532
1.89ValPro: 1.89 ± 0.588
2.43ValGln: 2.43 ± 0.494
4.32ValArg: 4.32 ± 1.631
4.32ValSer: 4.32 ± 0.5
2.97ValThr: 2.97 ± 1.236
2.16ValVal: 2.16 ± 0.811
1.89ValTrp: 1.89 ± 0.738
2.97ValTyr: 2.97 ± 0.926
0.0ValXaa: 0.0 ± 0.0
Trp
1.08TrpAla: 1.08 ± 0.267
0.54TrpCys: 0.54 ± 0.154
0.54TrpAsp: 0.54 ± 0.286
0.27TrpGlu: 0.27 ± 0.143
1.62TrpPhe: 1.62 ± 0.329
1.89TrpGly: 1.89 ± 0.684
0.27TrpHis: 0.27 ± 0.143
1.08TrpIle: 1.08 ± 0.454
1.08TrpLys: 1.08 ± 0.267
1.89TrpLeu: 1.89 ± 0.427
0.27TrpMet: 0.27 ± 0.409
1.08TrpAsn: 1.08 ± 0.454
0.27TrpPro: 0.27 ± 0.143
0.27TrpGln: 0.27 ± 0.143
0.54TrpArg: 0.54 ± 0.154
0.81TrpSer: 0.81 ± 0.429
0.81TrpThr: 0.81 ± 0.387
1.35TrpVal: 1.35 ± 0.534
0.0TrpTrp: 0.0 ± 0.0
0.27TrpTyr: 0.27 ± 0.248
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.81TyrAla: 0.81 ± 0.379
1.89TyrCys: 1.89 ± 1.017
1.62TyrAsp: 1.62 ± 0.532
1.89TyrGlu: 1.89 ± 0.671
1.62TyrPhe: 1.62 ± 0.29
2.7TyrGly: 2.7 ± 0.346
0.81TyrHis: 0.81 ± 0.165
3.24TyrIle: 3.24 ± 1.318
2.97TyrLys: 2.97 ± 0.594
3.51TyrLeu: 3.51 ± 0.687
1.35TyrMet: 1.35 ± 0.757
2.16TyrAsn: 2.16 ± 0.439
1.89TyrPro: 1.89 ± 0.427
1.35TyrGln: 1.35 ± 0.227
1.62TyrArg: 1.62 ± 0.532
4.05TyrSer: 4.05 ± 0.823
1.35TyrThr: 1.35 ± 0.285
2.16TyrVal: 2.16 ± 0.811
0.81TyrTrp: 0.81 ± 0.429
1.08TyrTyr: 1.08 ± 0.572
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski