Amino acid dipepetide frequency for Hymenobacter daecheongensis DSM 21074

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.201AlaAla: 15.201 ± 0.154	0.77AlaCys: 0.77 ± 0.024	5.71AlaAsp: 5.71 ± 0.069	5.912AlaGlu: 5.912 ± 0.078	3.779AlaPhe: 3.779 ± 0.063	9.294AlaGly: 9.294 ± 0.109	2.018AlaHis: 2.018 ± 0.046	3.972AlaIle: 3.972 ± 0.061	3.684AlaLys: 3.684 ± 0.079	11.585AlaLeu: 11.585 ± 0.144	1.871AlaMet: 1.871 ± 0.042	3.445AlaAsn: 3.445 ± 0.071	5.784AlaPro: 5.784 ± 0.115	5.059AlaGln: 5.059 ± 0.069	6.323AlaArg: 6.323 ± 0.09	5.217AlaSer: 5.217 ± 0.08	7.174AlaThr: 7.174 ± 0.131	7.267AlaVal: 7.267 ± 0.089	1.163AlaTrp: 1.163 ± 0.039	3.094AlaTyr: 3.094 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.66CysAla: 0.66 ± 0.024	0.113CysCys: 0.113 ± 0.01	0.333CysAsp: 0.333 ± 0.017	0.319CysGlu: 0.319 ± 0.016	0.314CysPhe: 0.314 ± 0.015	0.652CysGly: 0.652 ± 0.026	0.209CysHis: 0.209 ± 0.015	0.326CysIle: 0.326 ± 0.019	0.181CysLys: 0.181 ± 0.013	0.759CysLeu: 0.759 ± 0.025	0.111CysMet: 0.111 ± 0.009	0.23CysAsn: 0.23 ± 0.014	0.411CysPro: 0.411 ± 0.023	0.306CysGln: 0.306 ± 0.017	0.456CysArg: 0.456 ± 0.018	0.414CysSer: 0.414 ± 0.018	0.417CysThr: 0.417 ± 0.017	0.44CysVal: 0.44 ± 0.018	0.083CysTrp: 0.083 ± 0.008	0.271CysTyr: 0.271 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.009AspAla: 5.009 ± 0.068	0.332AspCys: 0.332 ± 0.017	2.359AspAsp: 2.359 ± 0.051	3.055AspGlu: 3.055 ± 0.057	2.667AspPhe: 2.667 ± 0.043	3.731AspGly: 3.731 ± 0.068	0.91AspHis: 0.91 ± 0.03	2.354AspIle: 2.354 ± 0.045	2.264AspLys: 2.264 ± 0.049	4.954AspLeu: 4.954 ± 0.069	0.97AspMet: 0.97 ± 0.03	1.885AspAsn: 1.885 ± 0.036	2.415AspPro: 2.415 ± 0.04	1.989AspGln: 1.989 ± 0.041	2.41AspArg: 2.41 ± 0.045	2.537AspSer: 2.537 ± 0.049	2.62AspThr: 2.62 ± 0.048	3.485AspVal: 3.485 ± 0.058	0.675AspTrp: 0.675 ± 0.021	2.101AspTyr: 2.101 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.823GluAla: 5.823 ± 0.085	0.269GluCys: 0.269 ± 0.016	2.105GluAsp: 2.105 ± 0.049	3.109GluGlu: 3.109 ± 0.07	2.103GluPhe: 2.103 ± 0.045	3.288GluGly: 3.288 ± 0.054	1.102GluHis: 1.102 ± 0.03	2.715GluIle: 2.715 ± 0.056	2.862GluLys: 2.862 ± 0.062	6.121GluLeu: 6.121 ± 0.091	1.313GluMet: 1.313 ± 0.027	2.028GluAsn: 2.028 ± 0.041	2.251GluPro: 2.251 ± 0.05	2.951GluGln: 2.951 ± 0.061	3.168GluArg: 3.168 ± 0.064	2.228GluSer: 2.228 ± 0.043	2.873GluThr: 2.873 ± 0.046	3.747GluVal: 3.747 ± 0.067	0.617GluTrp: 0.617 ± 0.024	1.694GluTyr: 1.694 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.844PheAla: 3.844 ± 0.061	0.348PheCys: 0.348 ± 0.016	2.444PheAsp: 2.444 ± 0.048	2.231PheGlu: 2.231 ± 0.047	1.909PhePhe: 1.909 ± 0.043	3.577PheGly: 3.577 ± 0.057	0.775PheHis: 0.775 ± 0.029	1.745PheIle: 1.745 ± 0.04	1.44PheLys: 1.44 ± 0.039	3.92PheLeu: 3.92 ± 0.068	0.755PheMet: 0.755 ± 0.027	1.684PheAsn: 1.684 ± 0.038	1.736PhePro: 1.736 ± 0.037	1.597PheGln: 1.597 ± 0.04	2.764PheArg: 2.764 ± 0.055	2.709PheSer: 2.709 ± 0.054	2.797PheThr: 2.797 ± 0.063	2.946PheVal: 2.946 ± 0.048	0.529PheTrp: 0.529 ± 0.025	1.5PheTyr: 1.5 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.661GlyAla: 6.661 ± 0.087	0.671GlyCys: 0.671 ± 0.026	3.036GlyAsp: 3.036 ± 0.057	3.489GlyGlu: 3.489 ± 0.054	3.361GlyPhe: 3.361 ± 0.056	6.241GlyGly: 6.241 ± 0.112	1.605GlyHis: 1.605 ± 0.039	3.825GlyIle: 3.825 ± 0.059	3.441GlyLys: 3.441 ± 0.06	8.451GlyLeu: 8.451 ± 0.097	1.536GlyMet: 1.536 ± 0.041	2.743GlyAsn: 2.743 ± 0.061	3.189GlyPro: 3.189 ± 0.064	3.878GlyGln: 3.878 ± 0.063	4.951GlyArg: 4.951 ± 0.069	4.701GlySer: 4.701 ± 0.092	5.63GlyThr: 5.63 ± 0.125	5.089GlyVal: 5.089 ± 0.065	1.044GlyTrp: 1.044 ± 0.033	2.832GlyTyr: 2.832 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.828HisAla: 1.828 ± 0.043	0.201HisCys: 0.201 ± 0.013	1.096HisAsp: 1.096 ± 0.033	1.131HisGlu: 1.131 ± 0.031	1.021HisPhe: 1.021 ± 0.024	1.548HisGly: 1.548 ± 0.038	0.587HisHis: 0.587 ± 0.026	0.976HisIle: 0.976 ± 0.034	0.656HisLys: 0.656 ± 0.025	2.386HisLeu: 2.386 ± 0.054	0.318HisMet: 0.318 ± 0.017	0.711HisAsn: 0.711 ± 0.024	1.294HisPro: 1.294 ± 0.031	0.919HisGln: 0.919 ± 0.03	1.214HisArg: 1.214 ± 0.038	0.946HisSer: 0.946 ± 0.026	1.202HisThr: 1.202 ± 0.034	1.169HisVal: 1.169 ± 0.032	0.299HisTrp: 0.299 ± 0.017	0.863HisTyr: 0.863 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	3.915IleAla: 3.915 ± 0.068	0.408IleCys: 0.408 ± 0.018	2.505IleAsp: 2.505 ± 0.05	2.586IleGlu: 2.586 ± 0.054	1.744IlePhe: 1.744 ± 0.049	3.75IleGly: 3.75 ± 0.064	0.811IleHis: 0.811 ± 0.025	2.462IleIle: 2.462 ± 0.061	1.823IleLys: 1.823 ± 0.045	3.936IleLeu: 3.936 ± 0.064	0.853IleMet: 0.853 ± 0.024	1.767IleAsn: 1.767 ± 0.042	2.183IlePro: 2.183 ± 0.046	1.691IleGln: 1.691 ± 0.036	2.904IleArg: 2.904 ± 0.056	2.998IleSer: 2.998 ± 0.051	3.016IleThr: 3.016 ± 0.057	3.035IleVal: 3.035 ± 0.048	0.465IleTrp: 0.465 ± 0.018	1.376IleTyr: 1.376 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.201LysAla: 4.201 ± 0.07	0.174LysCys: 0.174 ± 0.014	2.048LysAsp: 2.048 ± 0.048	2.292LysGlu: 2.292 ± 0.056	1.426LysPhe: 1.426 ± 0.037	2.725LysGly: 2.725 ± 0.058	0.762LysHis: 0.762 ± 0.028	1.971LysIle: 1.971 ± 0.053	2.307LysLys: 2.307 ± 0.063	4.206LysLeu: 4.206 ± 0.071	1.071LysMet: 1.071 ± 0.031	1.603LysAsn: 1.603 ± 0.043	2.189LysPro: 2.189 ± 0.047	1.754LysGln: 1.754 ± 0.039	2.019LysArg: 2.019 ± 0.048	2.107LysSer: 2.107 ± 0.042	2.502LysThr: 2.502 ± 0.05	2.829LysVal: 2.829 ± 0.064	0.393LysTrp: 0.393 ± 0.02	1.355LysTyr: 1.355 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.22LeuAla: 12.22 ± 0.139	0.744LeuCys: 0.744 ± 0.027	5.473LeuAsp: 5.473 ± 0.076	5.097LeuGlu: 5.097 ± 0.079	4.117LeuPhe: 4.117 ± 0.058	7.903LeuGly: 7.903 ± 0.112	2.391LeuHis: 2.391 ± 0.047	4.326LeuIle: 4.326 ± 0.065	4.063LeuLys: 4.063 ± 0.065	14.025LeuLeu: 14.025 ± 0.176	1.948LeuMet: 1.948 ± 0.045	4.289LeuAsn: 4.289 ± 0.068	6.385LeuPro: 6.385 ± 0.089	4.133LeuGln: 4.133 ± 0.067	8.018LeuArg: 8.018 ± 0.113	6.596LeuSer: 6.596 ± 0.078	7.491LeuThr: 7.491 ± 0.088	7.211LeuVal: 7.211 ± 0.097	1.069LeuTrp: 1.069 ± 0.035	3.197LeuTyr: 3.197 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.0MetAla: 2.0 ± 0.048	0.105MetCys: 0.105 ± 0.008	0.787MetAsp: 0.787 ± 0.028	0.896MetGlu: 0.896 ± 0.031	0.585MetPhe: 0.585 ± 0.024	1.294MetGly: 1.294 ± 0.039	0.398MetHis: 0.398 ± 0.018	0.746MetIle: 0.746 ± 0.031	1.159MetLys: 1.159 ± 0.033	2.179MetLeu: 2.179 ± 0.042	0.449MetMet: 0.449 ± 0.02	0.782MetAsn: 0.782 ± 0.027	1.263MetPro: 1.263 ± 0.032	0.899MetGln: 0.899 ± 0.032	1.262MetArg: 1.262 ± 0.028	1.142MetSer: 1.142 ± 0.029	1.103MetThr: 1.103 ± 0.033	1.234MetVal: 1.234 ± 0.034	0.146MetTrp: 0.146 ± 0.009	0.43MetTyr: 0.43 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.494AsnAla: 3.494 ± 0.059	0.256AsnCys: 0.256 ± 0.016	1.799AsnAsp: 1.799 ± 0.045	1.762AsnGlu: 1.762 ± 0.043	1.605AsnPhe: 1.605 ± 0.045	3.116AsnGly: 3.116 ± 0.065	0.655AsnHis: 0.655 ± 0.023	1.822AsnIle: 1.822 ± 0.039	1.421AsnLys: 1.421 ± 0.038	3.85AsnLeu: 3.85 ± 0.061	0.717AsnMet: 0.717 ± 0.022	1.509AsnAsn: 1.509 ± 0.053	2.559AsnPro: 2.559 ± 0.05	1.627AsnGln: 1.627 ± 0.038	2.145AsnArg: 2.145 ± 0.045	2.096AsnSer: 2.096 ± 0.043	2.315AsnThr: 2.315 ± 0.061	2.524AsnVal: 2.524 ± 0.05	0.441AsnTrp: 0.441 ± 0.02	1.371AsnTyr: 1.371 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	8.045ProAla: 8.045 ± 0.127	0.266ProCys: 0.266 ± 0.014	3.35ProAsp: 3.35 ± 0.057	3.515ProGlu: 3.515 ± 0.063	1.86ProPhe: 1.86 ± 0.039	4.065ProGly: 4.065 ± 0.063	1.024ProHis: 1.024 ± 0.033	2.022ProIle: 2.022 ± 0.041	1.835ProLys: 1.835 ± 0.043	5.147ProLeu: 5.147 ± 0.081	0.789ProMet: 0.789 ± 0.024	2.044ProAsn: 2.044 ± 0.047	2.242ProPro: 2.242 ± 0.058	2.024ProGln: 2.024 ± 0.035	2.628ProArg: 2.628 ± 0.058	2.311ProSer: 2.311 ± 0.047	3.581ProThr: 3.581 ± 0.068	4.124ProVal: 4.124 ± 0.071	0.548ProTrp: 0.548 ± 0.025	1.565ProTyr: 1.565 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.874GlnAla: 4.874 ± 0.078	0.22GlnCys: 0.22 ± 0.012	1.879GlnAsp: 1.879 ± 0.04	2.413GlnGlu: 2.413 ± 0.052	1.651GlnPhe: 1.651 ± 0.039	2.821GlnGly: 2.821 ± 0.051	1.196GlnHis: 1.196 ± 0.032	1.868GlnIle: 1.868 ± 0.041	1.795GlnLys: 1.795 ± 0.041	5.565GlnLeu: 5.565 ± 0.074	0.929GlnMet: 0.929 ± 0.03	1.682GlnAsn: 1.682 ± 0.038	3.011GlnPro: 3.011 ± 0.059	3.137GlnGln: 3.137 ± 0.071	3.144GlnArg: 3.144 ± 0.061	2.038GlnSer: 2.038 ± 0.042	2.51GlnThr: 2.51 ± 0.053	3.149GlnVal: 3.149 ± 0.048	0.511GlnTrp: 0.511 ± 0.022	1.508GlnTyr: 1.508 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	5.654ArgAla: 5.654 ± 0.091	0.396ArgCys: 0.396 ± 0.019	2.639ArgAsp: 2.639 ± 0.052	3.378ArgGlu: 3.378 ± 0.051	2.78ArgPhe: 2.78 ± 0.049	3.727ArgGly: 3.727 ± 0.059	1.613ArgHis: 1.613 ± 0.04	2.966ArgIle: 2.966 ± 0.048	2.326ArgLys: 2.326 ± 0.054	7.562ArgLeu: 7.562 ± 0.103	1.298ArgMet: 1.298 ± 0.033	2.205ArgAsn: 2.205 ± 0.048	3.494ArgPro: 3.494 ± 0.07	3.719ArgGln: 3.719 ± 0.069	4.778ArgArg: 4.778 ± 0.085	2.647ArgSer: 2.647 ± 0.047	3.646ArgThr: 3.646 ± 0.053	4.315ArgVal: 4.315 ± 0.073	0.868ArgTrp: 0.868 ± 0.027	2.5ArgTyr: 2.5 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.553SerAla: 5.553 ± 0.079	0.469SerCys: 0.469 ± 0.022	2.38SerAsp: 2.38 ± 0.047	2.39SerGlu: 2.39 ± 0.05	2.746SerPhe: 2.746 ± 0.054	4.851SerGly: 4.851 ± 0.098	0.971SerHis: 0.971 ± 0.032	2.667SerIle: 2.667 ± 0.053	2.005SerLys: 2.005 ± 0.047	5.713SerLeu: 5.713 ± 0.065	0.995SerMet: 0.995 ± 0.034	1.924SerAsn: 1.924 ± 0.045	2.85SerPro: 2.85 ± 0.052	2.101SerGln: 2.101 ± 0.044	3.156SerArg: 3.156 ± 0.048	3.32SerSer: 3.32 ± 0.071	3.413SerThr: 3.413 ± 0.076	4.035SerVal: 4.035 ± 0.079	0.691SerTrp: 0.691 ± 0.026	2.064SerTyr: 2.064 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.152ThrAla: 7.152 ± 0.125	0.365ThrCys: 0.365 ± 0.016	3.401ThrAsp: 3.401 ± 0.048	3.016ThrGlu: 3.016 ± 0.05	2.63ThrPhe: 2.63 ± 0.055	5.44ThrGly: 5.44 ± 0.104	1.108ThrHis: 1.108 ± 0.035	2.879ThrIle: 2.879 ± 0.056	2.147ThrLys: 2.147 ± 0.05	6.936ThrLeu: 6.936 ± 0.098	0.99ThrMet: 0.99 ± 0.03	2.274ThrAsn: 2.274 ± 0.053	3.927ThrPro: 3.927 ± 0.057	2.386ThrGln: 2.386 ± 0.055	3.172ThrArg: 3.172 ± 0.053	3.56ThrSer: 3.56 ± 0.079	4.521ThrThr: 4.521 ± 0.103	4.805ThrVal: 4.805 ± 0.095	0.672ThrTrp: 0.672 ± 0.023	2.232ThrTyr: 2.232 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	7.914ValAla: 7.914 ± 0.096	0.54ValCys: 0.54 ± 0.023	2.972ValAsp: 2.972 ± 0.055	3.551ValGlu: 3.551 ± 0.059	2.796ValPhe: 2.796 ± 0.05	5.089ValGly: 5.089 ± 0.073	1.171ValHis: 1.171 ± 0.036	2.92ValIle: 2.92 ± 0.049	2.817ValLys: 2.817 ± 0.059	8.107ValLeu: 8.107 ± 0.089	1.186ValMet: 1.186 ± 0.031	2.417ValAsn: 2.417 ± 0.048	3.751ValPro: 3.751 ± 0.057	3.15ValGln: 3.15 ± 0.055	4.828ValArg: 4.828 ± 0.069	4.137ValSer: 4.137 ± 0.067	4.104ValThr: 4.104 ± 0.095	5.677ValVal: 5.677 ± 0.089	0.759ValTrp: 0.759 ± 0.024	2.166ValTyr: 2.166 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	1.036TrpAla: 1.036 ± 0.031	0.091TrpCys: 0.091 ± 0.008	0.487TrpAsp: 0.487 ± 0.022	0.555TrpGlu: 0.555 ± 0.02	0.485TrpPhe: 0.485 ± 0.02	0.707TrpGly: 0.707 ± 0.025	0.304TrpHis: 0.304 ± 0.015	0.413TrpIle: 0.413 ± 0.02	0.447TrpLys: 0.447 ± 0.022	1.686TrpLeu: 1.686 ± 0.043	0.239TrpMet: 0.239 ± 0.013	0.46TrpAsn: 0.46 ± 0.024	0.479TrpPro: 0.479 ± 0.019	0.82TrpGln: 0.82 ± 0.029	0.786TrpArg: 0.786 ± 0.026	0.606TrpSer: 0.606 ± 0.026	0.627TrpThr: 0.627 ± 0.023	0.76TrpVal: 0.76 ± 0.027	0.178TrpTrp: 0.178 ± 0.013	0.392TrpTyr: 0.392 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.238TyrAla: 3.238 ± 0.057	0.27TyrCys: 0.27 ± 0.016	1.918TyrAsp: 1.918 ± 0.038	1.67TyrGlu: 1.67 ± 0.041	1.673TyrPhe: 1.673 ± 0.036	2.554TyrGly: 2.554 ± 0.05	0.756TyrHis: 0.756 ± 0.024	1.254TyrIle: 1.254 ± 0.035	1.26TyrLys: 1.26 ± 0.038	3.607TyrLeu: 3.607 ± 0.058	0.521TyrMet: 0.521 ± 0.021	1.398TyrAsn: 1.398 ± 0.035	1.571TyrPro: 1.571 ± 0.037	1.76TyrGln: 1.76 ± 0.045	2.385TyrArg: 2.385 ± 0.047	1.986TyrSer: 1.986 ± 0.046	2.073TyrThr: 2.073 ± 0.048	2.21TyrVal: 2.21 ± 0.045	0.407TyrTrp: 0.407 ± 0.019	1.371TyrTyr: 1.371 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3657 proteins (1260074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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