Amino acid dipepetide frequency for Desulfobacterium vacuolatum DSM 3385

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.106AlaAla: 7.106 ± 0.096	1.238AlaCys: 1.238 ± 0.034	3.962AlaAsp: 3.962 ± 0.059	3.865AlaGlu: 3.865 ± 0.063	3.546AlaPhe: 3.546 ± 0.06	6.552AlaGly: 6.552 ± 0.077	1.854AlaHis: 1.854 ± 0.036	4.97AlaIle: 4.97 ± 0.057	3.878AlaLys: 3.878 ± 0.067	8.65AlaLeu: 8.65 ± 0.088	3.125AlaMet: 3.125 ± 0.048	2.27AlaAsn: 2.27 ± 0.041	2.899AlaPro: 2.899 ± 0.063	2.605AlaGln: 2.605 ± 0.046	4.405AlaArg: 4.405 ± 0.058	4.234AlaSer: 4.234 ± 0.061	4.053AlaThr: 4.053 ± 0.056	6.165AlaVal: 6.165 ± 0.072	0.908AlaTrp: 0.908 ± 0.027	2.073AlaTyr: 2.073 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.031	0.268CysCys: 0.268 ± 0.016	0.727CysAsp: 0.727 ± 0.026	0.654CysGlu: 0.654 ± 0.023	0.675CysPhe: 0.675 ± 0.021	1.264CysGly: 1.264 ± 0.039	0.501CysHis: 0.501 ± 0.024	0.873CysIle: 0.873 ± 0.026	0.623CysLys: 0.623 ± 0.028	1.225CysLeu: 1.225 ± 0.033	0.388CysMet: 0.388 ± 0.017	0.503CysAsn: 0.503 ± 0.018	0.843CysPro: 0.843 ± 0.026	0.439CysGln: 0.439 ± 0.017	0.865CysArg: 0.865 ± 0.025	0.847CysSer: 0.847 ± 0.028	0.719CysThr: 0.719 ± 0.022	0.86CysVal: 0.86 ± 0.027	0.118CysTrp: 0.118 ± 0.009	0.384CysTyr: 0.384 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.352AspAla: 4.352 ± 0.065	0.594AspCys: 0.594 ± 0.022	2.872AspAsp: 2.872 ± 0.055	3.368AspGlu: 3.368 ± 0.058	2.687AspPhe: 2.687 ± 0.044	3.43AspGly: 3.43 ± 0.051	1.324AspHis: 1.324 ± 0.032	4.84AspIle: 4.84 ± 0.064	3.295AspLys: 3.295 ± 0.052	5.639AspLeu: 5.639 ± 0.073	1.728AspMet: 1.728 ± 0.035	2.227AspAsn: 2.227 ± 0.042	2.629AspPro: 2.629 ± 0.042	1.709AspGln: 1.709 ± 0.038	2.667AspArg: 2.667 ± 0.041	2.631AspSer: 2.631 ± 0.045	3.035AspThr: 3.035 ± 0.054	3.621AspVal: 3.621 ± 0.056	0.553AspTrp: 0.553 ± 0.021	1.782AspTyr: 1.782 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.496GluAla: 4.496 ± 0.072	0.575GluCys: 0.575 ± 0.022	3.075GluAsp: 3.075 ± 0.052	3.737GluGlu: 3.737 ± 0.061	2.229GluPhe: 2.229 ± 0.043	3.207GluGly: 3.207 ± 0.049	1.19GluHis: 1.19 ± 0.03	5.137GluIle: 5.137 ± 0.066	6.342GluLys: 6.342 ± 0.089	5.59GluLeu: 5.59 ± 0.074	2.11GluMet: 2.11 ± 0.043	3.404GluAsn: 3.404 ± 0.05	1.911GluPro: 1.911 ± 0.039	2.356GluGln: 2.356 ± 0.048	2.716GluArg: 2.716 ± 0.049	3.235GluSer: 3.235 ± 0.056	3.762GluThr: 3.762 ± 0.052	3.573GluVal: 3.573 ± 0.05	0.566GluTrp: 0.566 ± 0.023	1.677GluTyr: 1.677 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.06PheAla: 3.06 ± 0.049	0.739PheCys: 0.739 ± 0.022	2.697PheAsp: 2.697 ± 0.04	2.409PheGlu: 2.409 ± 0.045	2.671PhePhe: 2.671 ± 0.06	3.024PheGly: 3.024 ± 0.057	1.084PheHis: 1.084 ± 0.031	3.118PheIle: 3.118 ± 0.051	2.74PheLys: 2.74 ± 0.051	4.47PheLeu: 4.47 ± 0.071	1.515PheMet: 1.515 ± 0.034	2.039PheAsn: 2.039 ± 0.039	1.916PhePro: 1.916 ± 0.037	1.538PheGln: 1.538 ± 0.032	1.747PheArg: 1.747 ± 0.037	3.578PheSer: 3.578 ± 0.059	2.502PheThr: 2.502 ± 0.038	2.7PheVal: 2.7 ± 0.049	0.518PheTrp: 0.518 ± 0.022	1.544PheTyr: 1.544 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.629GlyAla: 5.629 ± 0.075	1.191GlyCys: 1.191 ± 0.032	3.681GlyAsp: 3.681 ± 0.054	4.227GlyGlu: 4.227 ± 0.054	3.633GlyPhe: 3.633 ± 0.056	5.435GlyGly: 5.435 ± 0.078	1.639GlyHis: 1.639 ± 0.036	6.306GlyIle: 6.306 ± 0.08	5.298GlyLys: 5.298 ± 0.064	6.801GlyLeu: 6.801 ± 0.091	2.65GlyMet: 2.65 ± 0.047	2.814GlyAsn: 2.814 ± 0.045	2.179GlyPro: 2.179 ± 0.042	2.272GlyGln: 2.272 ± 0.045	3.466GlyArg: 3.466 ± 0.05	3.946GlySer: 3.946 ± 0.056	4.118GlyThr: 4.118 ± 0.056	5.395GlyVal: 5.395 ± 0.071	0.822GlyTrp: 0.822 ± 0.028	2.569GlyTyr: 2.569 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.691HisAla: 1.691 ± 0.037	0.405HisCys: 0.405 ± 0.017	1.287HisAsp: 1.287 ± 0.027	1.281HisGlu: 1.281 ± 0.029	1.06HisPhe: 1.06 ± 0.029	1.97HisGly: 1.97 ± 0.033	0.694HisHis: 0.694 ± 0.023	1.565HisIle: 1.565 ± 0.03	1.17HisLys: 1.17 ± 0.03	2.304HisLeu: 2.304 ± 0.044	0.651HisMet: 0.651 ± 0.02	0.802HisAsn: 0.802 ± 0.023	1.303HisPro: 1.303 ± 0.03	0.758HisGln: 0.758 ± 0.023	1.321HisArg: 1.321 ± 0.034	1.154HisSer: 1.154 ± 0.031	1.228HisThr: 1.228 ± 0.034	1.412HisVal: 1.412 ± 0.032	0.259HisTrp: 0.259 ± 0.013	0.673HisTyr: 0.673 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.302IleAla: 5.302 ± 0.069	1.053IleCys: 1.053 ± 0.028	3.908IleAsp: 3.908 ± 0.055	4.206IleGlu: 4.206 ± 0.061	3.405IlePhe: 3.405 ± 0.058	4.203IleGly: 4.203 ± 0.062	1.858IleHis: 1.858 ± 0.037	5.172IleIle: 5.172 ± 0.076	4.883IleLys: 4.883 ± 0.064	6.997IleLeu: 6.997 ± 0.085	1.995IleMet: 1.995 ± 0.035	3.247IleAsn: 3.247 ± 0.049	3.774IlePro: 3.774 ± 0.057	2.458IleGln: 2.458 ± 0.044	3.384IleArg: 3.384 ± 0.048	5.257IleSer: 5.257 ± 0.068	4.262IleThr: 4.262 ± 0.063	4.345IleVal: 4.345 ± 0.063	0.618IleTrp: 0.618 ± 0.023	1.974IleTyr: 1.974 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.131LysAla: 5.131 ± 0.071	0.62LysCys: 0.62 ± 0.022	3.411LysAsp: 3.411 ± 0.048	4.934LysGlu: 4.934 ± 0.065	2.086LysPhe: 2.086 ± 0.04	4.82LysGly: 4.82 ± 0.067	1.096LysHis: 1.096 ± 0.028	5.244LysIle: 5.244 ± 0.073	6.608LysLys: 6.608 ± 0.084	4.716LysLeu: 4.716 ± 0.064	2.02LysMet: 2.02 ± 0.042	3.523LysAsn: 3.523 ± 0.051	2.253LysPro: 2.253 ± 0.041	2.299LysGln: 2.299 ± 0.049	3.03LysArg: 3.03 ± 0.051	3.616LysSer: 3.616 ± 0.051	3.991LysThr: 3.991 ± 0.054	3.578LysVal: 3.578 ± 0.056	0.623LysTrp: 0.623 ± 0.022	1.78LysTyr: 1.78 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	7.684LeuAla: 7.684 ± 0.078	1.389LeuCys: 1.389 ± 0.032	5.534LeuAsp: 5.534 ± 0.072	6.358LeuGlu: 6.358 ± 0.083	4.924LeuPhe: 4.924 ± 0.067	6.978LeuGly: 6.978 ± 0.084	1.85LeuHis: 1.85 ± 0.038	6.174LeuIle: 6.174 ± 0.081	6.901LeuLys: 6.901 ± 0.08	8.949LeuLeu: 8.949 ± 0.092	2.869LeuMet: 2.869 ± 0.051	4.165LeuAsn: 4.165 ± 0.054	4.513LeuPro: 4.513 ± 0.058	2.66LeuGln: 2.66 ± 0.051	3.821LeuArg: 3.821 ± 0.058	6.746LeuSer: 6.746 ± 0.074	5.287LeuThr: 5.287 ± 0.063	5.932LeuVal: 5.932 ± 0.064	0.868LeuTrp: 0.868 ± 0.025	2.558LeuTyr: 2.558 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.432MetAla: 3.432 ± 0.045	0.296MetCys: 0.296 ± 0.013	2.418MetAsp: 2.418 ± 0.045	2.553MetGlu: 2.553 ± 0.045	0.948MetPhe: 0.948 ± 0.028	3.022MetGly: 3.022 ± 0.044	0.471MetHis: 0.471 ± 0.018	2.043MetIle: 2.043 ± 0.041	2.142MetLys: 2.142 ± 0.041	2.471MetLeu: 2.471 ± 0.038	0.907MetMet: 0.907 ± 0.029	1.303MetAsn: 1.303 ± 0.033	1.383MetPro: 1.383 ± 0.032	0.821MetGln: 0.821 ± 0.021	1.055MetArg: 1.055 ± 0.029	1.596MetSer: 1.596 ± 0.04	1.859MetThr: 1.859 ± 0.036	2.495MetVal: 2.495 ± 0.04	0.207MetTrp: 0.207 ± 0.012	0.498MetTyr: 0.498 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.178AsnAla: 3.178 ± 0.047	0.57AsnCys: 0.57 ± 0.02	1.943AsnAsp: 1.943 ± 0.04	2.097AsnGlu: 2.097 ± 0.036	1.735AsnPhe: 1.735 ± 0.038	2.779AsnGly: 2.779 ± 0.046	1.029AsnHis: 1.029 ± 0.025	3.537AsnIle: 3.537 ± 0.052	2.387AsnLys: 2.387 ± 0.047	3.924AsnLeu: 3.924 ± 0.064	1.14AsnMet: 1.14 ± 0.028	1.696AsnAsn: 1.696 ± 0.037	2.222AsnPro: 2.222 ± 0.043	1.412AsnGln: 1.412 ± 0.034	2.361AsnArg: 2.361 ± 0.041	2.051AsnSer: 2.051 ± 0.041	2.28AsnThr: 2.28 ± 0.042	2.359AsnVal: 2.359 ± 0.042	0.434AsnTrp: 0.434 ± 0.018	1.175AsnTyr: 1.175 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.074ProAla: 3.074 ± 0.054	0.577ProCys: 0.577 ± 0.022	2.994ProAsp: 2.994 ± 0.057	3.525ProGlu: 3.525 ± 0.048	2.112ProPhe: 2.112 ± 0.041	4.094ProGly: 4.094 ± 0.065	1.165ProHis: 1.165 ± 0.032	2.159ProIle: 2.159 ± 0.04	1.794ProLys: 1.794 ± 0.034	4.211ProLeu: 4.211 ± 0.057	1.311ProMet: 1.311 ± 0.03	1.183ProAsn: 1.183 ± 0.029	1.92ProPro: 1.92 ± 0.045	1.358ProGln: 1.358 ± 0.029	2.1ProArg: 2.1 ± 0.039	2.311ProSer: 2.311 ± 0.045	1.837ProThr: 1.837 ± 0.037	3.79ProVal: 3.79 ± 0.054	0.555ProTrp: 0.555 ± 0.021	1.158ProTyr: 1.158 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.87GlnAla: 2.87 ± 0.055	0.462GlnCys: 0.462 ± 0.018	1.601GlnAsp: 1.601 ± 0.035	2.127GlnGlu: 2.127 ± 0.041	1.329GlnPhe: 1.329 ± 0.034	2.637GlnGly: 2.637 ± 0.043	0.63GlnHis: 0.63 ± 0.023	2.27GlnIle: 2.27 ± 0.043	2.582GlnLys: 2.582 ± 0.053	2.977GlnLeu: 2.977 ± 0.047	1.085GlnMet: 1.085 ± 0.029	1.405GlnAsn: 1.405 ± 0.032	1.079GlnPro: 1.079 ± 0.027	1.215GlnGln: 1.215 ± 0.034	1.694GlnArg: 1.694 ± 0.039	1.797GlnSer: 1.797 ± 0.037	1.773GlnThr: 1.773 ± 0.031	2.211GlnVal: 2.211 ± 0.041	0.473GlnTrp: 0.473 ± 0.018	0.943GlnTyr: 0.943 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.376ArgAla: 3.376 ± 0.057	0.655ArgCys: 0.655 ± 0.024	2.722ArgAsp: 2.722 ± 0.043	3.647ArgGlu: 3.647 ± 0.065	2.343ArgPhe: 2.343 ± 0.041	3.123ArgGly: 3.123 ± 0.042	1.183ArgHis: 1.183 ± 0.03	3.681ArgIle: 3.681 ± 0.059	3.221ArgLys: 3.221 ± 0.053	4.824ArgLeu: 4.824 ± 0.057	1.438ArgMet: 1.438 ± 0.028	1.895ArgAsn: 1.895 ± 0.036	1.777ArgPro: 1.777 ± 0.038	2.026ArgGln: 2.026 ± 0.044	2.408ArgArg: 2.408 ± 0.05	2.471ArgSer: 2.471 ± 0.043	2.245ArgThr: 2.245 ± 0.038	3.268ArgVal: 3.268 ± 0.057	0.508ArgTrp: 0.508 ± 0.018	1.579ArgTyr: 1.579 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.135SerAla: 4.135 ± 0.048	0.827SerCys: 0.827 ± 0.025	3.004SerAsp: 3.004 ± 0.051	2.849SerGlu: 2.849 ± 0.053	2.794SerPhe: 2.794 ± 0.05	5.041SerGly: 5.041 ± 0.055	1.68SerHis: 1.68 ± 0.038	3.989SerIle: 3.989 ± 0.052	2.904SerLys: 2.904 ± 0.052	6.067SerLeu: 6.067 ± 0.067	2.03SerMet: 2.03 ± 0.04	1.935SerAsn: 1.935 ± 0.043	2.876SerPro: 2.876 ± 0.056	2.1SerGln: 2.1 ± 0.042	3.509SerArg: 3.509 ± 0.055	3.591SerSer: 3.591 ± 0.056	2.97SerThr: 2.97 ± 0.055	3.764SerVal: 3.764 ± 0.049	0.691SerTrp: 0.691 ± 0.026	1.572SerTyr: 1.572 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.695ThrAla: 4.695 ± 0.065	0.762ThrCys: 0.762 ± 0.026	2.918ThrAsp: 2.918 ± 0.049	2.596ThrGlu: 2.596 ± 0.047	2.308ThrPhe: 2.308 ± 0.048	5.073ThrGly: 5.073 ± 0.064	1.362ThrHis: 1.362 ± 0.031	3.81ThrIle: 3.81 ± 0.054	2.241ThrLys: 2.241 ± 0.043	6.093ThrLeu: 6.093 ± 0.084	1.623ThrMet: 1.623 ± 0.031	1.661ThrAsn: 1.661 ± 0.033	3.155ThrPro: 3.155 ± 0.054	1.695ThrGln: 1.695 ± 0.034	2.975ThrArg: 2.975 ± 0.05	2.92ThrSer: 2.92 ± 0.048	2.957ThrThr: 2.957 ± 0.049	3.916ThrVal: 3.916 ± 0.058	0.592ThrTrp: 0.592 ± 0.023	1.419ThrTyr: 1.419 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	5.322ValAla: 5.322 ± 0.075	1.034ValCys: 1.034 ± 0.03	3.972ValAsp: 3.972 ± 0.064	4.135ValGlu: 4.135 ± 0.052	3.109ValPhe: 3.109 ± 0.057	4.471ValGly: 4.471 ± 0.059	1.355ValHis: 1.355 ± 0.029	4.813ValIle: 4.813 ± 0.055	4.175ValLys: 4.175 ± 0.058	6.361ValLeu: 6.361 ± 0.072	2.234ValMet: 2.234 ± 0.039	2.687ValAsn: 2.687 ± 0.047	2.867ValPro: 2.867 ± 0.042	1.917ValGln: 1.917 ± 0.038	2.824ValArg: 2.824 ± 0.045	4.206ValSer: 4.206 ± 0.061	3.872ValThr: 3.872 ± 0.056	4.982ValVal: 4.982 ± 0.073	0.586ValTrp: 0.586 ± 0.021	1.688ValTyr: 1.688 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.729TrpAla: 0.729 ± 0.024	0.15TrpCys: 0.15 ± 0.01	0.596TrpAsp: 0.596 ± 0.022	0.693TrpGlu: 0.693 ± 0.022	0.524TrpPhe: 0.524 ± 0.024	0.84TrpGly: 0.84 ± 0.029	0.262TrpHis: 0.262 ± 0.012	0.723TrpIle: 0.723 ± 0.027	0.706TrpLys: 0.706 ± 0.026	1.032TrpLeu: 1.032 ± 0.03	0.336TrpMet: 0.336 ± 0.014	0.431TrpAsn: 0.431 ± 0.018	0.384TrpPro: 0.384 ± 0.019	0.451TrpGln: 0.451 ± 0.019	0.421TrpArg: 0.421 ± 0.018	0.53TrpSer: 0.53 ± 0.022	0.453TrpThr: 0.453 ± 0.018	0.663TrpVal: 0.663 ± 0.021	0.149TrpTrp: 0.149 ± 0.012	0.304TrpTyr: 0.304 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.041TyrAla: 2.041 ± 0.04	0.427TyrCys: 0.427 ± 0.026	1.662TyrAsp: 1.662 ± 0.036	1.625TyrGlu: 1.625 ± 0.04	1.494TyrPhe: 1.494 ± 0.037	2.107TyrGly: 2.107 ± 0.039	0.759TyrHis: 0.759 ± 0.024	1.878TyrIle: 1.878 ± 0.037	1.488TyrLys: 1.488 ± 0.033	2.862TyrLeu: 2.862 ± 0.044	0.765TyrMet: 0.765 ± 0.024	1.118TyrAsn: 1.118 ± 0.029	1.347TyrPro: 1.347 ± 0.03	1.071TyrGln: 1.071 ± 0.033	1.619TyrArg: 1.619 ± 0.033	1.611TyrSer: 1.611 ± 0.038	1.572TyrThr: 1.572 ± 0.036	1.578TyrVal: 1.578 ± 0.033	0.326TyrTrp: 0.326 ± 0.017	0.991TyrTyr: 0.991 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4083 proteins (1418271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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