Amino acid dipepetide frequency for Butyrivibrio sp. ob235

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.708AlaAla: 6.708 ± 0.2
0.976AlaCys: 0.976 ± 0.025
4.916AlaAsp: 4.916 ± 0.065
5.608AlaGlu: 5.608 ± 0.108
3.227AlaPhe: 3.227 ± 0.056
5.466AlaGly: 5.466 ± 0.07
1.004AlaHis: 1.004 ± 0.028
5.329AlaIle: 5.329 ± 0.068
4.962AlaLys: 4.962 ± 0.099
6.322AlaLeu: 6.322 ± 0.072
2.255AlaMet: 2.255 ± 0.038
2.845AlaAsn: 2.845 ± 0.062
2.064AlaPro: 2.064 ± 0.055
1.995AlaGln: 1.995 ± 0.05
2.57AlaArg: 2.57 ± 0.044
4.109AlaSer: 4.109 ± 0.064
3.603AlaThr: 3.603 ± 0.064
5.378AlaVal: 5.378 ± 0.067
0.606AlaTrp: 0.606 ± 0.018
2.795AlaTyr: 2.795 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.909CysAla: 0.909 ± 0.02
0.248CysCys: 0.248 ± 0.016
0.925CysAsp: 0.925 ± 0.026
0.884CysGlu: 0.884 ± 0.026
0.625CysPhe: 0.625 ± 0.019
1.41CysGly: 1.41 ± 0.032
0.264CysHis: 0.264 ± 0.014
1.027CysIle: 1.027 ± 0.028
0.935CysLys: 0.935 ± 0.029
1.042CysLeu: 1.042 ± 0.033
0.403CysMet: 0.403 ± 0.016
0.611CysAsn: 0.611 ± 0.019
0.509CysPro: 0.509 ± 0.022
0.288CysGln: 0.288 ± 0.016
0.601CysArg: 0.601 ± 0.022
0.85CysSer: 0.85 ± 0.025
0.672CysThr: 0.672 ± 0.025
0.935CysVal: 0.935 ± 0.028
0.117CysTrp: 0.117 ± 0.009
0.582CysTyr: 0.582 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.62AspAla: 4.62 ± 0.074
0.744AspCys: 0.744 ± 0.022
4.125AspAsp: 4.125 ± 0.07
5.896AspGlu: 5.896 ± 0.071
3.095AspPhe: 3.095 ± 0.053
4.752AspGly: 4.752 ± 0.067
0.937AspHis: 0.937 ± 0.026
5.232AspIle: 5.232 ± 0.07
4.555AspLys: 4.555 ± 0.071
4.707AspLeu: 4.707 ± 0.064
2.058AspMet: 2.058 ± 0.041
3.075AspAsn: 3.075 ± 0.059
1.99AspPro: 1.99 ± 0.043
1.272AspGln: 1.272 ± 0.029
2.478AspArg: 2.478 ± 0.039
3.806AspSer: 3.806 ± 0.056
3.352AspThr: 3.352 ± 0.055
4.138AspVal: 4.138 ± 0.058
0.61AspTrp: 0.61 ± 0.024
3.324AspTyr: 3.324 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.448GluAla: 5.448 ± 0.106
0.789GluCys: 0.789 ± 0.021
4.844GluAsp: 4.844 ± 0.068
6.813GluGlu: 6.813 ± 0.109
2.874GluPhe: 2.874 ± 0.046
4.446GluGly: 4.446 ± 0.058
1.248GluHis: 1.248 ± 0.03
5.644GluIle: 5.644 ± 0.083
6.754GluLys: 6.754 ± 0.085
6.504GluLeu: 6.504 ± 0.071
2.246GluMet: 2.246 ± 0.037
4.516GluAsn: 4.516 ± 0.063
1.793GluPro: 1.793 ± 0.045
2.2GluGln: 2.2 ± 0.041
2.987GluArg: 2.987 ± 0.047
3.769GluSer: 3.769 ± 0.054
3.717GluThr: 3.717 ± 0.054
4.285GluVal: 4.285 ± 0.062
0.673GluTrp: 0.673 ± 0.022
3.376GluTyr: 3.376 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.028PheAla: 3.028 ± 0.048
0.745PheCys: 0.745 ± 0.021
3.11PheAsp: 3.11 ± 0.05
2.905PheGlu: 2.905 ± 0.043
2.132PhePhe: 2.132 ± 0.046
3.117PheGly: 3.117 ± 0.051
0.745PheHis: 0.745 ± 0.02
3.327PheIle: 3.327 ± 0.063
2.551PheLys: 2.551 ± 0.047
3.802PheLeu: 3.802 ± 0.07
1.346PheMet: 1.346 ± 0.032
1.812PheAsn: 1.812 ± 0.035
1.315PhePro: 1.315 ± 0.03
0.941PheGln: 0.941 ± 0.026
1.723PheArg: 1.723 ± 0.038
3.112PheSer: 3.112 ± 0.054
2.401PheThr: 2.401 ± 0.044
3.047PheVal: 3.047 ± 0.052
0.44PheTrp: 0.44 ± 0.018
1.914PheTyr: 1.914 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.809GlyAla: 4.809 ± 0.07
1.19GlyCys: 1.19 ± 0.035
4.114GlyAsp: 4.114 ± 0.052
4.723GlyGlu: 4.723 ± 0.067
3.283GlyPhe: 3.283 ± 0.05
4.505GlyGly: 4.505 ± 0.074
1.162GlyHis: 1.162 ± 0.028
5.969GlyIle: 5.969 ± 0.076
5.53GlyLys: 5.53 ± 0.074
5.462GlyLeu: 5.462 ± 0.061
2.356GlyMet: 2.356 ± 0.042
3.451GlyAsn: 3.451 ± 0.059
1.191GlyPro: 1.191 ± 0.026
1.82GlyGln: 1.82 ± 0.038
2.744GlyArg: 2.744 ± 0.048
4.175GlySer: 4.175 ± 0.062
4.085GlyThr: 4.085 ± 0.06
4.555GlyVal: 4.555 ± 0.058
0.709GlyTrp: 0.709 ± 0.024
3.344GlyTyr: 3.344 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.033HisAla: 1.033 ± 0.026
0.248HisCys: 0.248 ± 0.014
1.025HisAsp: 1.025 ± 0.029
1.105HisGlu: 1.105 ± 0.029
0.816HisPhe: 0.816 ± 0.024
1.186HisGly: 1.186 ± 0.026
0.352HisHis: 0.352 ± 0.019
1.355HisIle: 1.355 ± 0.032
0.991HisLys: 0.991 ± 0.031
1.26HisLeu: 1.26 ± 0.03
0.521HisMet: 0.521 ± 0.02
0.73HisAsn: 0.73 ± 0.023
0.732HisPro: 0.732 ± 0.023
0.37HisGln: 0.37 ± 0.015
0.688HisArg: 0.688 ± 0.021
0.905HisSer: 0.905 ± 0.027
0.827HisThr: 0.827 ± 0.023
1.033HisVal: 1.033 ± 0.028
0.154HisTrp: 0.154 ± 0.013
0.729HisTyr: 0.729 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.749IleAla: 5.749 ± 0.069
1.307IleCys: 1.307 ± 0.033
4.875IleAsp: 4.875 ± 0.059
5.07IleGlu: 5.07 ± 0.06
3.196IlePhe: 3.196 ± 0.055
5.164IleGly: 5.164 ± 0.069
1.271IleHis: 1.271 ± 0.033
5.825IleIle: 5.825 ± 0.089
4.988IleLys: 4.988 ± 0.064
6.625IleLeu: 6.625 ± 0.074
2.137IleMet: 2.137 ± 0.044
3.439IleAsn: 3.439 ± 0.049
3.165IlePro: 3.165 ± 0.057
1.9IleGln: 1.9 ± 0.035
3.518IleArg: 3.518 ± 0.06
5.472IleSer: 5.472 ± 0.066
4.584IleThr: 4.584 ± 0.058
4.962IleVal: 4.962 ± 0.067
0.675IleTrp: 0.675 ± 0.025
3.062IleTyr: 3.062 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.486LysAla: 5.486 ± 0.092
0.803LysCys: 0.803 ± 0.025
4.65LysAsp: 4.65 ± 0.056
6.144LysGlu: 6.144 ± 0.069
2.193LysPhe: 2.193 ± 0.04
4.32LysGly: 4.32 ± 0.063
1.097LysHis: 1.097 ± 0.029
5.092LysIle: 5.092 ± 0.066
7.024LysLys: 7.024 ± 0.086
5.617LysLeu: 5.617 ± 0.065
2.137LysMet: 2.137 ± 0.039
4.086LysAsn: 4.086 ± 0.061
2.079LysPro: 2.079 ± 0.042
2.043LysGln: 2.043 ± 0.04
3.115LysArg: 3.115 ± 0.049
4.032LysSer: 4.032 ± 0.064
3.881LysThr: 3.881 ± 0.059
4.449LysVal: 4.449 ± 0.061
0.67LysTrp: 0.67 ± 0.023
3.355LysTyr: 3.355 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
5.742LeuAla: 5.742 ± 0.069
1.316LeuCys: 1.316 ± 0.029
5.133LeuAsp: 5.133 ± 0.061
5.411LeuGlu: 5.411 ± 0.065
3.954LeuPhe: 3.954 ± 0.067
5.431LeuGly: 5.431 ± 0.067
1.306LeuHis: 1.306 ± 0.033
6.274LeuIle: 6.274 ± 0.094
5.913LeuLys: 5.913 ± 0.071
7.439LeuLeu: 7.439 ± 0.11
2.569LeuMet: 2.569 ± 0.047
3.651LeuAsn: 3.651 ± 0.052
3.073LeuPro: 3.073 ± 0.052
2.298LeuGln: 2.298 ± 0.046
3.418LeuArg: 3.418 ± 0.062
6.533LeuSer: 6.533 ± 0.069
4.684LeuThr: 4.684 ± 0.067
5.118LeuVal: 5.118 ± 0.071
0.731LeuTrp: 0.731 ± 0.024
3.353LeuTyr: 3.353 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.338MetAla: 2.338 ± 0.045
0.369MetCys: 0.369 ± 0.017
1.978MetAsp: 1.978 ± 0.04
2.097MetGlu: 2.097 ± 0.039
1.119MetPhe: 1.119 ± 0.039
2.019MetGly: 2.019 ± 0.042
0.514MetHis: 0.514 ± 0.02
2.323MetIle: 2.323 ± 0.044
2.428MetLys: 2.428 ± 0.041
2.626MetLeu: 2.626 ± 0.052
0.982MetMet: 0.982 ± 0.027
1.656MetAsn: 1.656 ± 0.031
1.176MetPro: 1.176 ± 0.026
0.936MetGln: 0.936 ± 0.027
1.224MetArg: 1.224 ± 0.032
1.93MetSer: 1.93 ± 0.039
1.742MetThr: 1.742 ± 0.037
1.889MetVal: 1.889 ± 0.042
0.22MetTrp: 0.22 ± 0.014
1.002MetTyr: 1.002 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.499AsnAla: 3.499 ± 0.057
0.642AsnCys: 0.642 ± 0.022
2.749AsnAsp: 2.749 ± 0.045
3.267AsnGlu: 3.267 ± 0.05
1.721AsnPhe: 1.721 ± 0.039
3.703AsnGly: 3.703 ± 0.055
0.82AsnHis: 0.82 ± 0.026
3.782AsnIle: 3.782 ± 0.053
3.215AsnLys: 3.215 ± 0.052
3.717AsnLeu: 3.717 ± 0.055
1.509AsnMet: 1.509 ± 0.033
2.489AsnAsn: 2.489 ± 0.051
1.927AsnPro: 1.927 ± 0.037
1.241AsnGln: 1.241 ± 0.038
1.947AsnArg: 1.947 ± 0.044
3.013AsnSer: 3.013 ± 0.052
2.67AsnThr: 2.67 ± 0.052
3.178AsnVal: 3.178 ± 0.046
0.423AsnTrp: 0.423 ± 0.018
2.155AsnTyr: 2.155 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.277ProAla: 2.277 ± 0.057
0.375ProCys: 0.375 ± 0.017
2.485ProAsp: 2.485 ± 0.048
3.266ProGlu: 3.266 ± 0.058
1.487ProPhe: 1.487 ± 0.036
2.225ProGly: 2.225 ± 0.048
0.508ProHis: 0.508 ± 0.02
2.207ProIle: 2.207 ± 0.036
1.81ProLys: 1.81 ± 0.041
2.375ProLeu: 2.375 ± 0.045
0.888ProMet: 0.888 ± 0.022
1.107ProAsn: 1.107 ± 0.029
0.585ProPro: 0.585 ± 0.022
0.91ProGln: 0.91 ± 0.025
0.885ProArg: 0.885 ± 0.029
1.843ProSer: 1.843 ± 0.033
1.566ProThr: 1.566 ± 0.035
2.59ProVal: 2.59 ± 0.046
0.3ProTrp: 0.3 ± 0.015
1.425ProTyr: 1.425 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
1.843GlnAla: 1.843 ± 0.042
0.288GlnCys: 0.288 ± 0.014
1.446GlnAsp: 1.446 ± 0.034
1.916GlnGlu: 1.916 ± 0.046
1.078GlnPhe: 1.078 ± 0.027
1.647GlnGly: 1.647 ± 0.035
0.37GlnHis: 0.37 ± 0.017
2.229GlnIle: 2.229 ± 0.042
2.147GlnLys: 2.147 ± 0.041
2.217GlnLeu: 2.217 ± 0.035
0.955GlnMet: 0.955 ± 0.031
1.478GlnAsn: 1.478 ± 0.038
0.766GlnPro: 0.766 ± 0.024
0.955GlnGln: 0.955 ± 0.028
1.126GlnArg: 1.126 ± 0.028
1.433GlnSer: 1.433 ± 0.034
1.433GlnThr: 1.433 ± 0.037
1.621GlnVal: 1.621 ± 0.03
0.24GlnTrp: 0.24 ± 0.013
1.22GlnTyr: 1.22 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.538ArgAla: 2.538 ± 0.045
0.532ArgCys: 0.532 ± 0.023
2.521ArgAsp: 2.521 ± 0.044
3.155ArgGlu: 3.155 ± 0.049
1.809ArgPhe: 1.809 ± 0.034
2.311ArgGly: 2.311 ± 0.039
0.722ArgHis: 0.722 ± 0.021
3.539ArgIle: 3.539 ± 0.06
3.212ArgLys: 3.212 ± 0.054
3.427ArgLeu: 3.427 ± 0.049
1.353ArgMet: 1.353 ± 0.033
2.062ArgAsn: 2.062 ± 0.037
1.11ArgPro: 1.11 ± 0.029
1.213ArgGln: 1.213 ± 0.027
1.872ArgArg: 1.872 ± 0.033
2.153ArgSer: 2.153 ± 0.043
2.085ArgThr: 2.085 ± 0.035
2.472ArgVal: 2.472 ± 0.046
0.374ArgTrp: 0.374 ± 0.018
1.761ArgTyr: 1.761 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.473SerAla: 4.473 ± 0.064
0.791SerCys: 0.791 ± 0.025
4.423SerAsp: 4.423 ± 0.07
4.779SerGlu: 4.779 ± 0.067
3.074SerPhe: 3.074 ± 0.051
5.183SerGly: 5.183 ± 0.065
0.96SerHis: 0.96 ± 0.028
4.549SerIle: 4.549 ± 0.061
4.08SerLys: 4.08 ± 0.063
5.154SerLeu: 5.154 ± 0.066
1.865SerMet: 1.865 ± 0.039
2.647SerAsn: 2.647 ± 0.052
1.708SerPro: 1.708 ± 0.037
1.616SerGln: 1.616 ± 0.039
2.469SerArg: 2.469 ± 0.041
4.052SerSer: 4.052 ± 0.081
3.108SerThr: 3.108 ± 0.051
4.358SerVal: 4.358 ± 0.056
0.581SerTrp: 0.581 ± 0.02
2.767SerTyr: 2.767 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.319ThrAla: 4.319 ± 0.076
0.627ThrCys: 0.627 ± 0.022
3.693ThrAsp: 3.693 ± 0.061
3.951ThrGlu: 3.951 ± 0.064
2.349ThrPhe: 2.349 ± 0.044
4.478ThrGly: 4.478 ± 0.058
0.796ThrHis: 0.796 ± 0.024
4.23ThrIle: 4.23 ± 0.068
3.208ThrLys: 3.208 ± 0.055
4.484ThrLeu: 4.484 ± 0.057
1.443ThrMet: 1.443 ± 0.029
2.234ThrAsn: 2.234 ± 0.049
2.028ThrPro: 2.028 ± 0.041
1.323ThrGln: 1.323 ± 0.037
1.835ThrArg: 1.835 ± 0.038
3.229ThrSer: 3.229 ± 0.052
3.005ThrThr: 3.005 ± 0.054
4.318ThrVal: 4.318 ± 0.06
0.498ThrTrp: 0.498 ± 0.018
2.383ThrTyr: 2.383 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
4.587ValAla: 4.587 ± 0.053
1.082ValCys: 1.082 ± 0.035
3.969ValAsp: 3.969 ± 0.056
4.013ValGlu: 4.013 ± 0.061
3.068ValPhe: 3.068 ± 0.053
4.126ValGly: 4.126 ± 0.054
0.978ValHis: 0.978 ± 0.026
5.263ValIle: 5.263 ± 0.075
4.536ValLys: 4.536 ± 0.059
6.047ValLeu: 6.047 ± 0.078
2.022ValMet: 2.022 ± 0.042
3.052ValAsn: 3.052 ± 0.051
2.311ValPro: 2.311 ± 0.042
1.599ValGln: 1.599 ± 0.033
2.719ValArg: 2.719 ± 0.048
4.742ValSer: 4.742 ± 0.06
4.157ValThr: 4.157 ± 0.061
4.668ValVal: 4.668 ± 0.065
0.601ValTrp: 0.601 ± 0.021
2.717ValTyr: 2.717 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.02
0.151TrpCys: 0.151 ± 0.011
0.603TrpAsp: 0.603 ± 0.02
0.603TrpGlu: 0.603 ± 0.021
0.392TrpPhe: 0.392 ± 0.017
0.668TrpGly: 0.668 ± 0.023
0.193TrpHis: 0.193 ± 0.013
0.691TrpIle: 0.691 ± 0.023
0.63TrpLys: 0.63 ± 0.022
0.791TrpLeu: 0.791 ± 0.026
0.312TrpMet: 0.312 ± 0.013
0.607TrpAsn: 0.607 ± 0.022
0.211TrpPro: 0.211 ± 0.012
0.318TrpGln: 0.318 ± 0.017
0.338TrpArg: 0.338 ± 0.015
0.519TrpSer: 0.519 ± 0.019
0.456TrpThr: 0.456 ± 0.019
0.504TrpVal: 0.504 ± 0.016
0.117TrpTrp: 0.117 ± 0.011
0.463TrpTyr: 0.463 ± 0.023
0.001TrpXaa: 0.001 ± 0.001
Tyr
2.804TyrAla: 2.804 ± 0.048
0.616TyrCys: 0.616 ± 0.021
3.182TyrAsp: 3.182 ± 0.043
3.322TyrGlu: 3.322 ± 0.049
2.023TyrPhe: 2.023 ± 0.045
3.018TyrGly: 3.018 ± 0.048
0.815TyrHis: 0.815 ± 0.024
3.1TyrIle: 3.1 ± 0.056
2.804TyrLys: 2.804 ± 0.048
3.731TyrLeu: 3.731 ± 0.055
1.208TyrMet: 1.208 ± 0.031
2.12TyrAsn: 2.12 ± 0.042
1.381TyrPro: 1.381 ± 0.031
1.166TyrGln: 1.166 ± 0.032
1.965TyrArg: 1.965 ± 0.039
2.96TyrSer: 2.96 ± 0.05
2.402TyrThr: 2.402 ± 0.046
2.758TyrVal: 2.758 ± 0.046
0.354TyrTrp: 0.354 ± 0.016
2.249TyrTyr: 2.249 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.001XaaTyr: 0.001 ± 0.001
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4267 proteins (1415274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski