Amino acid dipepetide frequency for Saccharopolyspora rectivirgula

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.73AlaAla: 17.73 ± 0.191	0.995AlaCys: 0.995 ± 0.033	7.29AlaAsp: 7.29 ± 0.102	10.513AlaGlu: 10.513 ± 0.115	3.201AlaPhe: 3.201 ± 0.069	11.141AlaGly: 11.141 ± 0.125	2.364AlaHis: 2.364 ± 0.056	3.962AlaIle: 3.962 ± 0.07	2.978AlaLys: 2.978 ± 0.055	12.785AlaLeu: 12.785 ± 0.153	2.362AlaMet: 2.362 ± 0.051	2.284AlaAsn: 2.284 ± 0.049	5.469AlaPro: 5.469 ± 0.08	4.088AlaGln: 4.088 ± 0.064	8.512AlaArg: 8.512 ± 0.112	5.449AlaSer: 5.449 ± 0.077	5.735AlaThr: 5.735 ± 0.08	11.762AlaVal: 11.762 ± 0.135	1.523AlaTrp: 1.523 ± 0.042	2.069AlaTyr: 2.069 ± 0.05	0.001AlaXaa: 0.001 ± 0.001
Cys	1.12CysAla: 1.12 ± 0.034	0.11CysCys: 0.11 ± 0.011	0.473CysAsp: 0.473 ± 0.022	0.439CysGlu: 0.439 ± 0.021	0.243CysPhe: 0.243 ± 0.014	0.997CysGly: 0.997 ± 0.032	0.185CysHis: 0.185 ± 0.013	0.213CysIle: 0.213 ± 0.015	0.126CysLys: 0.126 ± 0.011	0.737CysLeu: 0.737 ± 0.026	0.14CysMet: 0.14 ± 0.012	0.164CysAsn: 0.164 ± 0.012	0.503CysPro: 0.503 ± 0.024	0.274CysGln: 0.274 ± 0.017	0.62CysArg: 0.62 ± 0.025	0.582CysSer: 0.582 ± 0.027	0.536CysThr: 0.536 ± 0.026	0.64CysVal: 0.64 ± 0.025	0.155CysTrp: 0.155 ± 0.014	0.212CysTyr: 0.212 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.127AspAla: 6.127 ± 0.09	0.43AspCys: 0.43 ± 0.022	3.173AspAsp: 3.173 ± 0.062	4.377AspGlu: 4.377 ± 0.068	1.715AspPhe: 1.715 ± 0.041	5.054AspGly: 5.054 ± 0.071	1.21AspHis: 1.21 ± 0.035	1.974AspIle: 1.974 ± 0.058	1.136AspLys: 1.136 ± 0.038	5.824AspLeu: 5.824 ± 0.073	0.832AspMet: 0.832 ± 0.029	1.052AspAsn: 1.052 ± 0.035	4.483AspPro: 4.483 ± 0.064	1.99AspGln: 1.99 ± 0.043	4.405AspArg: 4.405 ± 0.075	2.759AspSer: 2.759 ± 0.046	2.62AspThr: 2.62 ± 0.043	5.033AspVal: 5.033 ± 0.072	0.879AspTrp: 0.879 ± 0.03	1.25AspTyr: 1.25 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.297GluAla: 7.297 ± 0.094	0.435GluCys: 0.435 ± 0.022	3.086GluAsp: 3.086 ± 0.059	4.538GluGlu: 4.538 ± 0.077	2.03GluPhe: 2.03 ± 0.045	3.985GluGly: 3.985 ± 0.07	2.085GluHis: 2.085 ± 0.049	2.845GluIle: 2.845 ± 0.061	1.788GluLys: 1.788 ± 0.052	8.892GluLeu: 8.892 ± 0.103	1.131GluMet: 1.131 ± 0.029	1.429GluAsn: 1.429 ± 0.039	3.84GluPro: 3.84 ± 0.074	3.865GluGln: 3.865 ± 0.074	5.727GluArg: 5.727 ± 0.086	2.845GluSer: 2.845 ± 0.051	2.978GluThr: 2.978 ± 0.061	6.052GluVal: 6.052 ± 0.08	0.914GluTrp: 0.914 ± 0.034	1.203GluTyr: 1.203 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.067	0.331PheCys: 0.331 ± 0.016	2.005PheAsp: 2.005 ± 0.045	1.525PheGlu: 1.525 ± 0.039	0.96PhePhe: 0.96 ± 0.036	3.224PheGly: 3.224 ± 0.063	0.646PheHis: 0.646 ± 0.026	0.899PheIle: 0.899 ± 0.028	0.495PheLys: 0.495 ± 0.021	2.551PheLeu: 2.551 ± 0.057	0.363PheMet: 0.363 ± 0.021	0.678PheAsn: 0.678 ± 0.025	1.429PhePro: 1.429 ± 0.042	0.824PheGln: 0.824 ± 0.027	1.935PheArg: 1.935 ± 0.043	1.705PheSer: 1.705 ± 0.046	1.954PheThr: 1.954 ± 0.048	2.334PheVal: 2.334 ± 0.059	0.42PheTrp: 0.42 ± 0.023	0.624PheTyr: 0.624 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.177GlyAla: 9.177 ± 0.105	0.881GlyCys: 0.881 ± 0.033	4.425GlyAsp: 4.425 ± 0.069	5.712GlyGlu: 5.712 ± 0.072	2.989GlyPhe: 2.989 ± 0.058	7.734GlyGly: 7.734 ± 0.112	1.944GlyHis: 1.944 ± 0.048	3.753GlyIle: 3.753 ± 0.066	2.77GlyLys: 2.77 ± 0.059	8.883GlyLeu: 8.883 ± 0.103	2.18GlyMet: 2.18 ± 0.051	1.853GlyAsn: 1.853 ± 0.042	4.291GlyPro: 4.291 ± 0.071	3.125GlyGln: 3.125 ± 0.056	6.32GlyArg: 6.32 ± 0.096	5.1GlySer: 5.1 ± 0.072	5.117GlyThr: 5.117 ± 0.067	7.782GlyVal: 7.782 ± 0.103	1.611GlyTrp: 1.611 ± 0.044	2.228GlyTyr: 2.228 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.047	0.259HisCys: 0.259 ± 0.018	1.187HisAsp: 1.187 ± 0.035	1.203HisGlu: 1.203 ± 0.038	0.605HisPhe: 0.605 ± 0.021	2.219HisGly: 2.219 ± 0.046	0.68HisHis: 0.68 ± 0.028	0.693HisIle: 0.693 ± 0.026	0.36HisLys: 0.36 ± 0.02	2.366HisLeu: 2.366 ± 0.05	0.308HisMet: 0.308 ± 0.019	0.444HisAsn: 0.444 ± 0.021	1.814HisPro: 1.814 ± 0.044	0.804HisGln: 0.804 ± 0.025	2.118HisArg: 2.118 ± 0.049	1.04HisSer: 1.04 ± 0.036	1.102HisThr: 1.102 ± 0.031	1.76HisVal: 1.76 ± 0.042	0.387HisTrp: 0.387 ± 0.019	0.552HisTyr: 0.552 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.18IleAla: 5.18 ± 0.088	0.367IleCys: 0.367 ± 0.017	2.503IleAsp: 2.503 ± 0.06	2.332IleGlu: 2.332 ± 0.048	0.823IlePhe: 0.823 ± 0.034	4.006IleGly: 4.006 ± 0.067	0.625IleHis: 0.625 ± 0.026	1.108IleIle: 1.108 ± 0.039	0.834IleLys: 0.834 ± 0.031	2.203IleLeu: 2.203 ± 0.045	0.496IleMet: 0.496 ± 0.024	1.026IleAsn: 1.026 ± 0.032	2.113IlePro: 2.113 ± 0.05	0.821IleGln: 0.821 ± 0.03	2.516IleArg: 2.516 ± 0.043	2.264IleSer: 2.264 ± 0.048	2.658IleThr: 2.658 ± 0.058	2.926IleVal: 2.926 ± 0.053	0.362IleTrp: 0.362 ± 0.02	0.701IleTyr: 0.701 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.802LysAla: 2.802 ± 0.06	0.142LysCys: 0.142 ± 0.013	1.071LysAsp: 1.071 ± 0.034	1.271LysGlu: 1.271 ± 0.048	0.645LysPhe: 0.645 ± 0.024	1.523LysGly: 1.523 ± 0.053	0.558LysHis: 0.558 ± 0.022	1.052LysIle: 1.052 ± 0.038	0.8LysLys: 0.8 ± 0.036	2.586LysLeu: 2.586 ± 0.058	0.457LysMet: 0.457 ± 0.021	0.553LysAsn: 0.553 ± 0.025	1.612LysPro: 1.612 ± 0.043	0.972LysGln: 0.972 ± 0.032	1.697LysArg: 1.697 ± 0.046	1.191LysSer: 1.191 ± 0.038	1.348LysThr: 1.348 ± 0.038	2.127LysVal: 2.127 ± 0.045	0.313LysTrp: 0.313 ± 0.019	0.485LysTyr: 0.485 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.317LeuAla: 14.317 ± 0.158	0.817LeuCys: 0.817 ± 0.026	6.353LeuAsp: 6.353 ± 0.084	5.736LeuGlu: 5.736 ± 0.08	2.645LeuPhe: 2.645 ± 0.053	9.105LeuGly: 9.105 ± 0.11	2.312LeuHis: 2.312 ± 0.052	3.399LeuIle: 3.399 ± 0.063	1.815LeuLys: 1.815 ± 0.048	11.537LeuLeu: 11.537 ± 0.158	1.467LeuMet: 1.467 ± 0.043	1.992LeuAsn: 1.992 ± 0.044	6.454LeuPro: 6.454 ± 0.08	3.288LeuGln: 3.288 ± 0.05	9.093LeuArg: 9.093 ± 0.114	5.744LeuSer: 5.744 ± 0.081	5.687LeuThr: 5.687 ± 0.079	9.709LeuVal: 9.709 ± 0.134	1.245LeuTrp: 1.245 ± 0.039	1.618LeuTyr: 1.618 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.256MetAla: 2.256 ± 0.051	0.153MetCys: 0.153 ± 0.012	0.772MetAsp: 0.772 ± 0.03	0.729MetGlu: 0.729 ± 0.029	0.521MetPhe: 0.521 ± 0.025	1.262MetGly: 1.262 ± 0.036	0.348MetHis: 0.348 ± 0.02	0.673MetIle: 0.673 ± 0.026	0.394MetLys: 0.394 ± 0.02	1.916MetLeu: 1.916 ± 0.048	0.306MetMet: 0.306 ± 0.022	0.428MetAsn: 0.428 ± 0.02	1.112MetPro: 1.112 ± 0.028	0.574MetGln: 0.574 ± 0.025	1.593MetArg: 1.593 ± 0.034	1.341MetSer: 1.341 ± 0.028	1.444MetThr: 1.444 ± 0.04	1.462MetVal: 1.462 ± 0.041	0.203MetTrp: 0.203 ± 0.014	0.274MetTyr: 0.274 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.525AsnAla: 2.525 ± 0.053	0.208AsnCys: 0.208 ± 0.013	1.068AsnAsp: 1.068 ± 0.035	1.059AsnGlu: 1.059 ± 0.029	0.568AsnPhe: 0.568 ± 0.023	2.087AsnGly: 2.087 ± 0.052	0.432AsnHis: 0.432 ± 0.02	0.797AsnIle: 0.797 ± 0.03	0.507AsnLys: 0.507 ± 0.026	1.964AsnLeu: 1.964 ± 0.044	0.367AsnMet: 0.367 ± 0.018	0.519AsnAsn: 0.519 ± 0.024	1.757AsnPro: 1.757 ± 0.048	0.698AsnGln: 0.698 ± 0.029	1.672AsnArg: 1.672 ± 0.039	1.219AsnSer: 1.219 ± 0.038	1.204AsnThr: 1.204 ± 0.033	1.494AsnVal: 1.494 ± 0.035	0.351AsnTrp: 0.351 ± 0.017	0.531AsnTyr: 0.531 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.965ProAla: 6.965 ± 0.1	0.351ProCys: 0.351 ± 0.021	4.216ProAsp: 4.216 ± 0.083	5.367ProGlu: 5.367 ± 0.079	1.574ProPhe: 1.574 ± 0.036	5.899ProGly: 5.899 ± 0.09	1.275ProHis: 1.275 ± 0.037	1.588ProIle: 1.588 ± 0.045	1.388ProLys: 1.388 ± 0.04	5.09ProLeu: 5.09 ± 0.084	0.952ProMet: 0.952 ± 0.031	1.287ProAsn: 1.287 ± 0.039	3.318ProPro: 3.318 ± 0.079	2.271ProGln: 2.271 ± 0.058	3.691ProArg: 3.691 ± 0.057	2.938ProSer: 2.938 ± 0.058	2.778ProThr: 2.778 ± 0.052	5.658ProVal: 5.658 ± 0.08	0.872ProTrp: 0.872 ± 0.031	1.135ProTyr: 1.135 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.302GlnAla: 4.302 ± 0.075	0.223GlnCys: 0.223 ± 0.015	1.508GlnAsp: 1.508 ± 0.044	2.022GlnGlu: 2.022 ± 0.051	0.878GlnPhe: 0.878 ± 0.031	2.166GlnGly: 2.166 ± 0.051	1.005GlnHis: 1.005 ± 0.039	1.39GlnIle: 1.39 ± 0.043	0.659GlnLys: 0.659 ± 0.029	4.897GlnLeu: 4.897 ± 0.087	0.592GlnMet: 0.592 ± 0.024	0.624GlnAsn: 0.624 ± 0.024	2.45GlnPro: 2.45 ± 0.056	2.424GlnGln: 2.424 ± 0.065	3.758GlnArg: 3.758 ± 0.069	1.345GlnSer: 1.345 ± 0.04	1.39GlnThr: 1.39 ± 0.037	3.278GlnVal: 3.278 ± 0.053	0.51GlnTrp: 0.51 ± 0.021	0.673GlnTyr: 0.673 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.609ArgAla: 8.609 ± 0.111	0.67ArgCys: 0.67 ± 0.028	3.834ArgAsp: 3.834 ± 0.063	5.439ArgGlu: 5.439 ± 0.089	2.311ArgPhe: 2.311 ± 0.051	5.702ArgGly: 5.702 ± 0.072	1.631ArgHis: 1.631 ± 0.038	3.488ArgIle: 3.488 ± 0.067	2.257ArgLys: 2.257 ± 0.054	7.812ArgLeu: 7.812 ± 0.105	1.966ArgMet: 1.966 ± 0.041	1.873ArgAsn: 1.873 ± 0.049	4.285ArgPro: 4.285 ± 0.087	2.923ArgGln: 2.923 ± 0.056	7.142ArgArg: 7.142 ± 0.107	4.465ArgSer: 4.465 ± 0.077	4.672ArgThr: 4.672 ± 0.072	6.015ArgVal: 6.015 ± 0.08	1.371ArgTrp: 1.371 ± 0.037	1.882ArgTyr: 1.882 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.425SerAla: 6.425 ± 0.084	0.481SerCys: 0.481 ± 0.025	2.866SerAsp: 2.866 ± 0.051	3.192SerGlu: 3.192 ± 0.06	1.628SerPhe: 1.628 ± 0.045	6.073SerGly: 6.073 ± 0.079	0.865SerHis: 0.865 ± 0.028	1.782SerIle: 1.782 ± 0.042	1.23SerLys: 1.23 ± 0.041	4.626SerLeu: 4.626 ± 0.08	1.215SerMet: 1.215 ± 0.028	1.125SerAsn: 1.125 ± 0.036	2.988SerPro: 2.988 ± 0.061	1.545SerGln: 1.545 ± 0.043	3.786SerArg: 3.786 ± 0.059	3.342SerSer: 3.342 ± 0.083	3.234SerThr: 3.234 ± 0.066	4.427SerVal: 4.427 ± 0.074	1.014SerTrp: 1.014 ± 0.034	1.191SerTyr: 1.191 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.442ThrAla: 7.442 ± 0.091	0.441ThrCys: 0.441 ± 0.021	3.082ThrAsp: 3.082 ± 0.055	3.723ThrGlu: 3.723 ± 0.063	1.422ThrPhe: 1.422 ± 0.043	6.197ThrGly: 6.197 ± 0.067	1.026ThrHis: 1.026 ± 0.035	1.979ThrIle: 1.979 ± 0.047	1.28ThrLys: 1.28 ± 0.043	4.543ThrLeu: 4.543 ± 0.069	0.853ThrMet: 0.853 ± 0.029	1.096ThrAsn: 1.096 ± 0.04	3.506ThrPro: 3.506 ± 0.056	1.339ThrGln: 1.339 ± 0.04	3.411ThrArg: 3.411 ± 0.053	3.129ThrSer: 3.129 ± 0.055	3.468ThrThr: 3.468 ± 0.071	4.98ThrVal: 4.98 ± 0.081	0.778ThrTrp: 0.778 ± 0.03	1.08ThrTyr: 1.08 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.214ValAla: 10.214 ± 0.123	0.814ValCys: 0.814 ± 0.028	5.507ValAsp: 5.507 ± 0.077	5.859ValGlu: 5.859 ± 0.068	2.655ValPhe: 2.655 ± 0.056	6.548ValGly: 6.548 ± 0.086	2.23ValHis: 2.23 ± 0.048	3.231ValIle: 3.231 ± 0.061	1.683ValLys: 1.683 ± 0.047	10.938ValLeu: 10.938 ± 0.126	1.244ValMet: 1.244 ± 0.036	1.87ValAsn: 1.87 ± 0.046	5.213ValPro: 5.213 ± 0.082	2.812ValGln: 2.812 ± 0.055	7.154ValArg: 7.154 ± 0.087	4.676ValSer: 4.676 ± 0.065	4.922ValThr: 4.922 ± 0.07	9.47ValVal: 9.47 ± 0.139	1.027ValTrp: 1.027 ± 0.03	1.505ValTyr: 1.505 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.448TrpAla: 1.448 ± 0.047	0.158TrpCys: 0.158 ± 0.014	0.667TrpAsp: 0.667 ± 0.025	0.781TrpGlu: 0.781 ± 0.028	0.549TrpPhe: 0.549 ± 0.025	0.98TrpGly: 0.98 ± 0.033	0.343TrpHis: 0.343 ± 0.02	0.529TrpIle: 0.529 ± 0.022	0.344TrpLys: 0.344 ± 0.018	1.949TrpLeu: 1.949 ± 0.049	0.324TrpMet: 0.324 ± 0.017	0.341TrpAsn: 0.341 ± 0.016	0.782TrpPro: 0.782 ± 0.031	0.678TrpGln: 0.678 ± 0.027	1.281TrpArg: 1.281 ± 0.036	0.833TrpSer: 0.833 ± 0.03	0.867TrpThr: 0.867 ± 0.03	1.111TrpVal: 1.111 ± 0.034	0.354TrpTrp: 0.354 ± 0.02	0.305TrpTyr: 0.305 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.205TyrAla: 2.205 ± 0.045	0.202TyrCys: 0.202 ± 0.014	1.238TyrAsp: 1.238 ± 0.038	1.145TyrGlu: 1.145 ± 0.036	0.688TyrPhe: 0.688 ± 0.028	1.972TyrGly: 1.972 ± 0.05	0.461TyrHis: 0.461 ± 0.021	0.512TyrIle: 0.512 ± 0.024	0.358TyrLys: 0.358 ± 0.019	2.235TyrLeu: 2.235 ± 0.049	0.205TyrMet: 0.205 ± 0.014	0.389TyrAsn: 0.389 ± 0.022	1.194TyrPro: 1.194 ± 0.037	0.777TyrGln: 0.777 ± 0.027	1.918TyrArg: 1.918 ± 0.05	1.067TyrSer: 1.067 ± 0.034	1.062TyrThr: 1.062 ± 0.035	1.554TyrVal: 1.554 ± 0.043	0.334TyrTrp: 0.334 ± 0.018	0.511TyrTyr: 0.511 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3222 proteins (1004369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---