Amino acid dipepetide frequency for Chryseobacterium sp. NBC 122

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.724AlaAla: 4.724 ± 0.111	0.499AlaCys: 0.499 ± 0.025	3.696AlaAsp: 3.696 ± 0.069	4.716AlaGlu: 4.716 ± 0.084	3.182AlaPhe: 3.182 ± 0.061	4.566AlaGly: 4.566 ± 0.095	1.091AlaHis: 1.091 ± 0.035	4.526AlaIle: 4.526 ± 0.08	5.211AlaLys: 5.211 ± 0.087	5.787AlaLeu: 5.787 ± 0.087	1.636AlaMet: 1.636 ± 0.046	3.303AlaAsn: 3.303 ± 0.076	1.809AlaPro: 1.809 ± 0.053	2.545AlaGln: 2.545 ± 0.065	2.02AlaArg: 2.02 ± 0.052	3.64AlaSer: 3.64 ± 0.059	3.457AlaThr: 3.457 ± 0.083	4.577AlaVal: 4.577 ± 0.072	0.539AlaTrp: 0.539 ± 0.026	2.263AlaTyr: 2.263 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.463CysAla: 0.463 ± 0.023	0.099CysCys: 0.099 ± 0.01	0.429CysAsp: 0.429 ± 0.022	0.458CysGlu: 0.458 ± 0.023	0.447CysPhe: 0.447 ± 0.025	0.633CysGly: 0.633 ± 0.035	0.174CysHis: 0.174 ± 0.016	0.571CysIle: 0.571 ± 0.026	0.446CysLys: 0.446 ± 0.022	0.573CysLeu: 0.573 ± 0.028	0.167CysMet: 0.167 ± 0.015	0.358CysAsn: 0.358 ± 0.022	0.326CysPro: 0.326 ± 0.023	0.183CysGln: 0.183 ± 0.017	0.258CysArg: 0.258 ± 0.019	0.541CysSer: 0.541 ± 0.024	0.406CysThr: 0.406 ± 0.025	0.393CysVal: 0.393 ± 0.021	0.058CysTrp: 0.058 ± 0.008	0.293CysTyr: 0.293 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.328AspAla: 3.328 ± 0.067	0.377AspCys: 0.377 ± 0.02	2.666AspAsp: 2.666 ± 0.061	4.07AspGlu: 4.07 ± 0.075	3.985AspPhe: 3.985 ± 0.073	3.376AspGly: 3.376 ± 0.072	1.085AspHis: 1.085 ± 0.038	3.898AspIle: 3.898 ± 0.069	3.914AspLys: 3.914 ± 0.073	5.422AspLeu: 5.422 ± 0.072	1.033AspMet: 1.033 ± 0.037	2.536AspAsn: 2.536 ± 0.059	1.702AspPro: 1.702 ± 0.048	1.951AspGln: 1.951 ± 0.055	2.007AspArg: 2.007 ± 0.051	3.08AspSer: 3.08 ± 0.06	2.154AspThr: 2.154 ± 0.054	2.945AspVal: 2.945 ± 0.058	0.742AspTrp: 0.742 ± 0.034	2.784AspTyr: 2.784 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.948GluAla: 3.948 ± 0.072	0.321GluCys: 0.321 ± 0.018	3.299GluAsp: 3.299 ± 0.07	4.916GluGlu: 4.916 ± 0.106	3.23GluPhe: 3.23 ± 0.068	3.464GluGly: 3.464 ± 0.066	1.151GluHis: 1.151 ± 0.039	6.27GluIle: 6.27 ± 0.094	7.135GluLys: 7.135 ± 0.112	5.803GluLeu: 5.803 ± 0.107	1.816GluMet: 1.816 ± 0.044	5.408GluAsn: 5.408 ± 0.092	1.525GluPro: 1.525 ± 0.042	2.293GluGln: 2.293 ± 0.048	2.469GluArg: 2.469 ± 0.049	3.306GluSer: 3.306 ± 0.062	3.709GluThr: 3.709 ± 0.069	4.433GluVal: 4.433 ± 0.085	0.601GluTrp: 0.601 ± 0.026	2.323GluTyr: 2.323 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.543PheAla: 3.543 ± 0.071	0.475PheCys: 0.475 ± 0.026	3.16PheAsp: 3.16 ± 0.059	3.404PheGlu: 3.404 ± 0.079	3.051PhePhe: 3.051 ± 0.078	3.867PheGly: 3.867 ± 0.08	0.966PheHis: 0.966 ± 0.032	4.052PheIle: 4.052 ± 0.086	3.833PheLys: 3.833 ± 0.066	5.303PheLeu: 5.303 ± 0.088	1.243PheMet: 1.243 ± 0.039	3.159PheAsn: 3.159 ± 0.062	2.009PhePro: 2.009 ± 0.045	1.763PheGln: 1.763 ± 0.048	1.9PheArg: 1.9 ± 0.042	4.297PheSer: 4.297 ± 0.084	3.118PheThr: 3.118 ± 0.071	3.188PheVal: 3.188 ± 0.063	0.652PheTrp: 0.652 ± 0.028	2.357PheTyr: 2.357 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.995GlyAla: 3.995 ± 0.074	0.531GlyCys: 0.531 ± 0.036	3.149GlyAsp: 3.149 ± 0.068	3.669GlyGlu: 3.669 ± 0.068	3.726GlyPhe: 3.726 ± 0.079	4.462GlyGly: 4.462 ± 0.103	1.027GlyHis: 1.027 ± 0.038	5.698GlyIle: 5.698 ± 0.083	5.794GlyLys: 5.794 ± 0.098	5.515GlyLeu: 5.515 ± 0.081	1.684GlyMet: 1.684 ± 0.043	3.915GlyAsn: 3.915 ± 0.081	1.268GlyPro: 1.268 ± 0.036	1.909GlyGln: 1.909 ± 0.05	2.093GlyArg: 2.093 ± 0.054	3.933GlySer: 3.933 ± 0.087	3.922GlyThr: 3.922 ± 0.073	3.836GlyVal: 3.836 ± 0.07	0.71GlyTrp: 0.71 ± 0.027	2.589GlyTyr: 2.589 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.945HisAla: 0.945 ± 0.031	0.198HisCys: 0.198 ± 0.014	0.852HisAsp: 0.852 ± 0.039	1.024HisGlu: 1.024 ± 0.033	1.271HisPhe: 1.271 ± 0.039	1.089HisGly: 1.089 ± 0.037	0.503HisHis: 0.503 ± 0.027	1.212HisIle: 1.212 ± 0.034	1.083HisLys: 1.083 ± 0.036	1.951HisLeu: 1.951 ± 0.048	0.313HisMet: 0.313 ± 0.018	0.86HisAsn: 0.86 ± 0.034	0.935HisPro: 0.935 ± 0.031	0.882HisGln: 0.882 ± 0.033	0.699HisArg: 0.699 ± 0.026	1.155HisSer: 1.155 ± 0.037	0.84HisThr: 0.84 ± 0.034	0.72HisVal: 0.72 ± 0.03	0.217HisTrp: 0.217 ± 0.018	0.839HisTyr: 0.839 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.285IleAla: 5.285 ± 0.074	0.663IleCys: 0.663 ± 0.029	4.454IleAsp: 4.454 ± 0.077	5.099IleGlu: 5.099 ± 0.079	4.227IlePhe: 4.227 ± 0.097	4.939IleGly: 4.939 ± 0.093	1.358IleHis: 1.358 ± 0.041	6.207IleIle: 6.207 ± 0.106	5.763IleLys: 5.763 ± 0.092	7.691IleLeu: 7.691 ± 0.111	1.519IleMet: 1.519 ± 0.045	4.534IleAsn: 4.534 ± 0.084	3.433IlePro: 3.433 ± 0.073	2.711IleGln: 2.711 ± 0.058	2.579IleArg: 2.579 ± 0.052	6.064IleSer: 6.064 ± 0.079	4.451IleThr: 4.451 ± 0.081	4.292IleVal: 4.292 ± 0.08	0.69IleTrp: 0.69 ± 0.024	2.889IleTyr: 2.889 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.858LysAla: 4.858 ± 0.079	0.373LysCys: 0.373 ± 0.021	4.586LysAsp: 4.586 ± 0.082	6.43LysGlu: 6.43 ± 0.096	3.709LysPhe: 3.709 ± 0.064	4.447LysGly: 4.447 ± 0.077	1.201LysHis: 1.201 ± 0.038	7.534LysIle: 7.534 ± 0.084	7.523LysLys: 7.523 ± 0.119	6.427LysLeu: 6.427 ± 0.101	2.587LysMet: 2.587 ± 0.055	6.341LysAsn: 6.341 ± 0.089	2.732LysPro: 2.732 ± 0.064	2.493LysGln: 2.493 ± 0.06	2.657LysArg: 2.657 ± 0.058	4.9LysSer: 4.9 ± 0.084	5.004LysThr: 5.004 ± 0.077	4.936LysVal: 4.936 ± 0.07	0.748LysTrp: 0.748 ± 0.03	3.257LysTyr: 3.257 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.911LeuAla: 5.911 ± 0.088	0.659LeuCys: 0.659 ± 0.028	4.641LeuAsp: 4.641 ± 0.084	6.043LeuGlu: 6.043 ± 0.096	4.998LeuPhe: 4.998 ± 0.085	5.765LeuGly: 5.765 ± 0.088	1.671LeuHis: 1.671 ± 0.043	6.985LeuIle: 6.985 ± 0.1	8.359LeuLys: 8.359 ± 0.113	8.591LeuLeu: 8.591 ± 0.123	2.472LeuMet: 2.472 ± 0.057	5.588LeuAsn: 5.588 ± 0.087	3.585LeuPro: 3.585 ± 0.064	3.492LeuGln: 3.492 ± 0.081	3.052LeuArg: 3.052 ± 0.069	6.476LeuSer: 6.476 ± 0.087	4.752LeuThr: 4.752 ± 0.079	5.117LeuVal: 5.117 ± 0.074	0.779LeuTrp: 0.779 ± 0.028	3.132LeuTyr: 3.132 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.682MetAla: 1.682 ± 0.041	0.135MetCys: 0.135 ± 0.013	1.22MetAsp: 1.22 ± 0.041	1.531MetGlu: 1.531 ± 0.038	0.97MetPhe: 0.97 ± 0.039	1.542MetGly: 1.542 ± 0.046	0.39MetHis: 0.39 ± 0.023	1.912MetIle: 1.912 ± 0.044	2.698MetLys: 2.698 ± 0.064	2.019MetLeu: 2.019 ± 0.044	0.877MetMet: 0.877 ± 0.036	1.606MetAsn: 1.606 ± 0.04	0.924MetPro: 0.924 ± 0.036	0.872MetGln: 0.872 ± 0.029	0.896MetArg: 0.896 ± 0.03	1.493MetSer: 1.493 ± 0.036	1.351MetThr: 1.351 ± 0.038	1.505MetVal: 1.505 ± 0.039	0.176MetTrp: 0.176 ± 0.016	0.681MetTyr: 0.681 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.913AsnAla: 3.913 ± 0.066	0.437AsnCys: 0.437 ± 0.025	2.936AsnAsp: 2.936 ± 0.062	3.588AsnGlu: 3.588 ± 0.07	3.598AsnPhe: 3.598 ± 0.069	3.967AsnGly: 3.967 ± 0.08	1.141AsnHis: 1.141 ± 0.038	5.079AsnIle: 5.079 ± 0.073	4.19AsnLys: 4.19 ± 0.079	5.899AsnLeu: 5.899 ± 0.106	1.273AsnMet: 1.273 ± 0.036	3.482AsnAsn: 3.482 ± 0.088	2.893AsnPro: 2.893 ± 0.06	2.329AsnGln: 2.329 ± 0.059	2.127AsnArg: 2.127 ± 0.045	4.012AsnSer: 4.012 ± 0.088	3.151AsnThr: 3.151 ± 0.06	3.352AsnVal: 3.352 ± 0.069	0.747AsnTrp: 0.747 ± 0.031	2.909AsnTyr: 2.909 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	2.231ProAla: 2.231 ± 0.064	0.216ProCys: 0.216 ± 0.015	1.983ProAsp: 1.983 ± 0.043	3.08ProGlu: 3.08 ± 0.056	1.944ProPhe: 1.944 ± 0.051	1.962ProGly: 1.962 ± 0.05	0.604ProHis: 0.604 ± 0.025	2.409ProIle: 2.409 ± 0.053	2.77ProLys: 2.77 ± 0.063	2.922ProLeu: 2.922 ± 0.053	0.849ProMet: 0.849 ± 0.032	2.122ProAsn: 2.122 ± 0.058	0.929ProPro: 0.929 ± 0.046	1.358ProGln: 1.358 ± 0.037	1.03ProArg: 1.03 ± 0.032	1.991ProSer: 1.991 ± 0.051	1.957ProThr: 1.957 ± 0.052	2.655ProVal: 2.655 ± 0.057	0.294ProTrp: 0.294 ± 0.019	1.408ProTyr: 1.408 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.807GlnAla: 1.807 ± 0.053	0.166GlnCys: 0.166 ± 0.014	1.698GlnAsp: 1.698 ± 0.047	2.328GlnGlu: 2.328 ± 0.049	1.852GlnPhe: 1.852 ± 0.049	1.709GlnGly: 1.709 ± 0.051	0.622GlnHis: 0.622 ± 0.026	2.969GlnIle: 2.969 ± 0.058	3.697GlnLys: 3.697 ± 0.075	3.482GlnLeu: 3.482 ± 0.068	0.978GlnMet: 0.978 ± 0.032	2.801GlnAsn: 2.801 ± 0.058	1.187GlnPro: 1.187 ± 0.039	1.593GlnGln: 1.593 ± 0.049	1.325GlnArg: 1.325 ± 0.041	2.08GlnSer: 2.08 ± 0.045	1.987GlnThr: 1.987 ± 0.055	1.833GlnVal: 1.833 ± 0.049	0.336GlnTrp: 0.336 ± 0.021	1.479GlnTyr: 1.479 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	1.908ArgAla: 1.908 ± 0.047	0.233ArgCys: 0.233 ± 0.016	1.724ArgAsp: 1.724 ± 0.05	2.423ArgGlu: 2.423 ± 0.06	1.866ArgPhe: 1.866 ± 0.048	1.832ArgGly: 1.832 ± 0.047	0.593ArgHis: 0.593 ± 0.029	2.978ArgIle: 2.978 ± 0.055	3.204ArgLys: 3.204 ± 0.059	2.968ArgLeu: 2.968 ± 0.055	1.027ArgMet: 1.027 ± 0.037	2.481ArgAsn: 2.481 ± 0.056	1.05ArgPro: 1.05 ± 0.035	1.224ArgGln: 1.224 ± 0.042	1.326ArgArg: 1.326 ± 0.047	1.808ArgSer: 1.808 ± 0.049	1.932ArgThr: 1.932 ± 0.048	1.847ArgVal: 1.847 ± 0.045	0.352ArgTrp: 0.352 ± 0.021	1.327ArgTyr: 1.327 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.434SerAla: 4.434 ± 0.076	0.649SerCys: 0.649 ± 0.026	3.456SerAsp: 3.456 ± 0.062	4.155SerGlu: 4.155 ± 0.075	3.757SerPhe: 3.757 ± 0.064	4.759SerGly: 4.759 ± 0.083	1.124SerHis: 1.124 ± 0.033	4.519SerIle: 4.519 ± 0.073	4.79SerLys: 4.79 ± 0.065	5.949SerLeu: 5.949 ± 0.083	1.406SerMet: 1.406 ± 0.039	3.227SerAsn: 3.227 ± 0.072	2.246SerPro: 2.246 ± 0.051	2.343SerGln: 2.343 ± 0.057	2.088SerArg: 2.088 ± 0.051	4.253SerSer: 4.253 ± 0.087	3.345SerThr: 3.345 ± 0.076	4.223SerVal: 4.223 ± 0.074	0.697SerTrp: 0.697 ± 0.033	2.556SerTyr: 2.556 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.85ThrAla: 3.85 ± 0.079	0.331ThrCys: 0.331 ± 0.022	3.196ThrAsp: 3.196 ± 0.064	3.82ThrGlu: 3.82 ± 0.059	2.826ThrPhe: 2.826 ± 0.063	4.035ThrGly: 4.035 ± 0.077	0.916ThrHis: 0.916 ± 0.03	3.963ThrIle: 3.963 ± 0.074	3.835ThrLys: 3.835 ± 0.062	5.076ThrLeu: 5.076 ± 0.071	1.044ThrMet: 1.044 ± 0.032	2.812ThrAsn: 2.812 ± 0.06	2.321ThrPro: 2.321 ± 0.057	1.878ThrGln: 1.878 ± 0.046	1.565ThrArg: 1.565 ± 0.045	3.342ThrSer: 3.342 ± 0.074	3.063ThrThr: 3.063 ± 0.068	3.965ThrVal: 3.965 ± 0.073	0.527ThrTrp: 0.527 ± 0.028	2.098ThrTyr: 2.098 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.075ValAla: 4.075 ± 0.073	0.5ValCys: 0.5 ± 0.022	3.154ValAsp: 3.154 ± 0.061	3.731ValGlu: 3.731 ± 0.073	3.454ValPhe: 3.454 ± 0.059	3.766ValGly: 3.766 ± 0.077	0.937ValHis: 0.937 ± 0.032	4.71ValIle: 4.71 ± 0.083	4.785ValLys: 4.785 ± 0.068	5.768ValLeu: 5.768 ± 0.08	1.479ValMet: 1.479 ± 0.04	3.467ValAsn: 3.467 ± 0.07	2.166ValPro: 2.166 ± 0.047	1.959ValGln: 1.959 ± 0.05	1.988ValArg: 1.988 ± 0.047	4.292ValSer: 4.292 ± 0.076	3.241ValThr: 3.241 ± 0.076	3.735ValVal: 3.735 ± 0.08	0.557ValTrp: 0.557 ± 0.025	2.302ValTyr: 2.302 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.581TrpAla: 0.581 ± 0.026	0.076TrpCys: 0.076 ± 0.008	0.524TrpAsp: 0.524 ± 0.029	0.662TrpGlu: 0.662 ± 0.032	0.591TrpPhe: 0.591 ± 0.028	0.599TrpGly: 0.599 ± 0.026	0.18TrpHis: 0.18 ± 0.017	0.774TrpIle: 0.774 ± 0.028	0.897TrpLys: 0.897 ± 0.034	0.929TrpLeu: 0.929 ± 0.032	0.343TrpMet: 0.343 ± 0.022	0.69TrpAsn: 0.69 ± 0.029	0.174TrpPro: 0.174 ± 0.014	0.404TrpGln: 0.404 ± 0.021	0.356TrpArg: 0.356 ± 0.019	0.59TrpSer: 0.59 ± 0.024	0.567TrpThr: 0.567 ± 0.027	0.557TrpVal: 0.557 ± 0.028	0.124TrpTrp: 0.124 ± 0.013	0.373TrpTyr: 0.373 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.306TyrAla: 2.306 ± 0.051	0.34TyrCys: 0.34 ± 0.02	2.235TyrAsp: 2.235 ± 0.061	2.273TyrGlu: 2.273 ± 0.056	2.657TyrPhe: 2.657 ± 0.061	2.645TyrGly: 2.645 ± 0.055	0.854TyrHis: 0.854 ± 0.03	2.583TyrIle: 2.583 ± 0.055	2.816TyrLys: 2.816 ± 0.056	3.994TyrLeu: 3.994 ± 0.076	0.729TyrMet: 0.729 ± 0.031	2.333TyrAsn: 2.333 ± 0.062	1.499TyrPro: 1.499 ± 0.047	1.747TyrGln: 1.747 ± 0.043	1.666TyrArg: 1.666 ± 0.047	2.724TyrSer: 2.724 ± 0.063	2.054TyrThr: 2.054 ± 0.048	1.959TyrVal: 1.959 ± 0.048	0.445TyrTrp: 0.445 ± 0.023	1.838TyrTyr: 1.838 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2837 proteins (898352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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