Amino acid dipepetide frequency for Dysgonomonas mossii DSM 22836

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.478AlaAla: 4.478 ± 0.081
0.66AlaCys: 0.66 ± 0.024
3.652AlaAsp: 3.652 ± 0.069
4.005AlaGlu: 4.005 ± 0.058
2.997AlaPhe: 2.997 ± 0.056
4.36AlaGly: 4.36 ± 0.075
0.993AlaHis: 0.993 ± 0.03
5.378AlaIle: 5.378 ± 0.081
4.623AlaLys: 4.623 ± 0.078
5.873AlaLeu: 5.873 ± 0.07
1.548AlaMet: 1.548 ± 0.04
3.215AlaAsn: 3.215 ± 0.062
1.825AlaPro: 1.825 ± 0.044
2.404AlaGln: 2.404 ± 0.05
2.287AlaArg: 2.287 ± 0.048
4.178AlaSer: 4.178 ± 0.072
3.516AlaThr: 3.516 ± 0.056
3.993AlaVal: 3.993 ± 0.07
0.717AlaTrp: 0.717 ± 0.027
2.901AlaTyr: 2.901 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.529CysAla: 0.529 ± 0.025
0.14CysCys: 0.14 ± 0.013
0.541CysAsp: 0.541 ± 0.02
0.526CysGlu: 0.526 ± 0.021
0.514CysPhe: 0.514 ± 0.019
0.774CysGly: 0.774 ± 0.032
0.209CysHis: 0.209 ± 0.013
0.837CysIle: 0.837 ± 0.029
0.615CysLys: 0.615 ± 0.023
0.859CysLeu: 0.859 ± 0.026
0.227CysMet: 0.227 ± 0.014
0.491CysAsn: 0.491 ± 0.02
0.379CysPro: 0.379 ± 0.022
0.232CysGln: 0.232 ± 0.016
0.345CysArg: 0.345 ± 0.018
0.664CysSer: 0.664 ± 0.027
0.494CysThr: 0.494 ± 0.021
0.578CysVal: 0.578 ± 0.022
0.106CysTrp: 0.106 ± 0.009
0.391CysTyr: 0.391 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.55AspAla: 3.55 ± 0.056
0.543AspCys: 0.543 ± 0.022
2.915AspAsp: 2.915 ± 0.048
3.692AspGlu: 3.692 ± 0.059
3.187AspPhe: 3.187 ± 0.053
3.76AspGly: 3.76 ± 0.065
0.837AspHis: 0.837 ± 0.026
5.113AspIle: 5.113 ± 0.068
4.948AspLys: 4.948 ± 0.072
4.849AspLeu: 4.849 ± 0.07
1.598AspMet: 1.598 ± 0.037
3.388AspAsn: 3.388 ± 0.057
1.943AspPro: 1.943 ± 0.046
1.527AspGln: 1.527 ± 0.041
2.222AspArg: 2.222 ± 0.046
3.445AspSer: 3.445 ± 0.059
2.717AspThr: 2.717 ± 0.049
3.533AspVal: 3.533 ± 0.055
0.859AspTrp: 0.859 ± 0.027
2.908AspTyr: 2.908 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
4.299GluAla: 4.299 ± 0.073
0.439GluCys: 0.439 ± 0.019
3.438GluAsp: 3.438 ± 0.064
4.491GluGlu: 4.491 ± 0.079
2.542GluPhe: 2.542 ± 0.048
3.734GluGly: 3.734 ± 0.061
1.044GluHis: 1.044 ± 0.032
5.171GluIle: 5.171 ± 0.078
5.765GluLys: 5.765 ± 0.079
5.689GluLeu: 5.689 ± 0.085
1.671GluMet: 1.671 ± 0.035
3.916GluAsn: 3.916 ± 0.067
1.626GluPro: 1.626 ± 0.039
2.323GluGln: 2.323 ± 0.052
2.769GluArg: 2.769 ± 0.054
3.491GluSer: 3.491 ± 0.054
3.186GluThr: 3.186 ± 0.056
3.904GluVal: 3.904 ± 0.069
0.8GluTrp: 0.8 ± 0.027
3.058GluTyr: 3.058 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
2.963PheAla: 2.963 ± 0.046
0.537PheCys: 0.537 ± 0.022
3.112PheAsp: 3.112 ± 0.053
2.777PheGlu: 2.777 ± 0.05
2.488PhePhe: 2.488 ± 0.05
3.209PheGly: 3.209 ± 0.059
0.775PheHis: 0.775 ± 0.024
3.822PheIle: 3.822 ± 0.062
2.936PheLys: 2.936 ± 0.056
4.228PheLeu: 4.228 ± 0.058
1.187PheMet: 1.187 ± 0.037
2.713PheAsn: 2.713 ± 0.058
1.554PhePro: 1.554 ± 0.034
1.313PheGln: 1.313 ± 0.03
1.887PheArg: 1.887 ± 0.038
3.831PheSer: 3.831 ± 0.065
2.749PheThr: 2.749 ± 0.051
3.066PheVal: 3.066 ± 0.055
0.56PheTrp: 0.56 ± 0.022
2.131PheTyr: 2.131 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.01GlyAla: 4.01 ± 0.069
0.674GlyCys: 0.674 ± 0.028
3.384GlyAsp: 3.384 ± 0.05
3.816GlyGlu: 3.816 ± 0.058
3.239GlyPhe: 3.239 ± 0.058
4.537GlyGly: 4.537 ± 0.084
1.138GlyHis: 1.138 ± 0.032
5.572GlyIle: 5.572 ± 0.073
5.098GlyLys: 5.098 ± 0.066
5.808GlyLeu: 5.808 ± 0.066
1.751GlyMet: 1.751 ± 0.036
3.609GlyAsn: 3.609 ± 0.056
1.104GlyPro: 1.104 ± 0.033
1.948GlyGln: 1.948 ± 0.043
2.429GlyArg: 2.429 ± 0.051
3.926GlySer: 3.926 ± 0.07
3.823GlyThr: 3.823 ± 0.064
4.473GlyVal: 4.473 ± 0.076
0.915GlyTrp: 0.915 ± 0.033
3.4GlyTyr: 3.4 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
0.952HisAla: 0.952 ± 0.033
0.197HisCys: 0.197 ± 0.013
0.866HisAsp: 0.866 ± 0.03
0.922HisGlu: 0.922 ± 0.031
0.907HisPhe: 0.907 ± 0.03
1.081HisGly: 1.081 ± 0.034
0.375HisHis: 0.375 ± 0.02
1.404HisIle: 1.404 ± 0.042
1.119HisLys: 1.119 ± 0.032
1.587HisLeu: 1.587 ± 0.037
0.314HisMet: 0.314 ± 0.018
0.942HisAsn: 0.942 ± 0.028
0.842HisPro: 0.842 ± 0.025
0.578HisGln: 0.578 ± 0.022
0.653HisArg: 0.653 ± 0.024
1.032HisSer: 1.032 ± 0.029
0.944HisThr: 0.944 ± 0.03
0.874HisVal: 0.874 ± 0.029
0.215HisTrp: 0.215 ± 0.013
0.783HisTyr: 0.783 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.561IleAla: 5.561 ± 0.075
0.912IleCys: 0.912 ± 0.029
4.991IleAsp: 4.991 ± 0.067
5.39IleGlu: 5.39 ± 0.073
3.63IlePhe: 3.63 ± 0.069
5.06IleGly: 5.06 ± 0.081
1.384IleHis: 1.384 ± 0.038
6.191IleIle: 6.191 ± 0.107
5.88IleLys: 5.88 ± 0.07
7.279IleLeu: 7.279 ± 0.107
1.591IleMet: 1.591 ± 0.043
4.591IleAsn: 4.591 ± 0.07
3.485IlePro: 3.485 ± 0.06
2.476IleGln: 2.476 ± 0.046
3.206IleArg: 3.206 ± 0.054
5.952IleSer: 5.952 ± 0.078
4.426IleThr: 4.426 ± 0.061
4.958IleVal: 4.958 ± 0.076
0.754IleTrp: 0.754 ± 0.027
3.338IleTyr: 3.338 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.983LysAla: 4.983 ± 0.083
0.445LysCys: 0.445 ± 0.022
5.007LysAsp: 5.007 ± 0.069
6.466LysGlu: 6.466 ± 0.084
2.58LysPhe: 2.58 ± 0.047
4.829LysGly: 4.829 ± 0.07
1.285LysHis: 1.285 ± 0.034
5.687LysIle: 5.687 ± 0.063
6.295LysLys: 6.295 ± 0.083
6.009LysLeu: 6.009 ± 0.066
2.255LysMet: 2.255 ± 0.039
4.564LysAsn: 4.564 ± 0.071
2.442LysPro: 2.442 ± 0.048
2.806LysGln: 2.806 ± 0.054
3.013LysArg: 3.013 ± 0.052
4.398LysSer: 4.398 ± 0.061
4.171LysThr: 4.171 ± 0.067
4.669LysVal: 4.669 ± 0.07
0.8LysTrp: 0.8 ± 0.026
3.681LysTyr: 3.681 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
5.626LeuAla: 5.626 ± 0.071
0.984LeuCys: 0.984 ± 0.033
4.977LeuAsp: 4.977 ± 0.068
4.993LeuGlu: 4.993 ± 0.079
4.758LeuPhe: 4.758 ± 0.068
5.481LeuGly: 5.481 ± 0.074
1.502LeuHis: 1.502 ± 0.041
6.771LeuIle: 6.771 ± 0.107
6.973LeuLys: 6.973 ± 0.082
8.447LeuLeu: 8.447 ± 0.105
2.125LeuMet: 2.125 ± 0.046
5.268LeuAsn: 5.268 ± 0.071
3.595LeuPro: 3.595 ± 0.056
2.961LeuGln: 2.961 ± 0.052
3.565LeuArg: 3.565 ± 0.061
7.246LeuSer: 7.246 ± 0.081
4.96LeuThr: 4.96 ± 0.061
4.764LeuVal: 4.764 ± 0.067
0.924LeuTrp: 0.924 ± 0.032
3.81LeuTyr: 3.81 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.721MetAla: 1.721 ± 0.046
0.203MetCys: 0.203 ± 0.014
1.33MetAsp: 1.33 ± 0.032
1.468MetGlu: 1.468 ± 0.041
1.032MetPhe: 1.032 ± 0.034
1.668MetGly: 1.668 ± 0.045
0.403MetHis: 0.403 ± 0.019
1.702MetIle: 1.702 ± 0.042
2.471MetLys: 2.471 ± 0.042
2.195MetLeu: 2.195 ± 0.045
0.68MetMet: 0.68 ± 0.028
1.488MetAsn: 1.488 ± 0.037
0.974MetPro: 0.974 ± 0.03
0.971MetGln: 0.971 ± 0.033
1.109MetArg: 1.109 ± 0.034
1.641MetSer: 1.641 ± 0.039
1.311MetThr: 1.311 ± 0.037
1.368MetVal: 1.368 ± 0.038
0.216MetTrp: 0.216 ± 0.015
0.874MetTyr: 0.874 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.386AsnAla: 3.386 ± 0.054
0.457AsnCys: 0.457 ± 0.021
2.964AsnAsp: 2.964 ± 0.052
3.389AsnGlu: 3.389 ± 0.057
2.495AsnPhe: 2.495 ± 0.052
3.637AsnGly: 3.637 ± 0.063
0.866AsnHis: 0.866 ± 0.028
5.309AsnIle: 5.309 ± 0.083
4.558AsnLys: 4.558 ± 0.064
4.947AsnLeu: 4.947 ± 0.072
1.483AsnMet: 1.483 ± 0.032
3.56AsnAsn: 3.56 ± 0.068
2.602AsnPro: 2.602 ± 0.051
1.894AsnGln: 1.894 ± 0.046
2.363AsnArg: 2.363 ± 0.05
3.45AsnSer: 3.45 ± 0.063
3.243AsnThr: 3.243 ± 0.062
3.315AsnVal: 3.315 ± 0.058
0.677AsnTrp: 0.677 ± 0.026
2.676AsnTyr: 2.676 ± 0.062
0.001AsnXaa: 0.001 ± 0.001
Pro
2.223ProAla: 2.223 ± 0.04
0.238ProCys: 0.238 ± 0.015
2.296ProAsp: 2.296 ± 0.049
2.767ProGlu: 2.767 ± 0.045
1.823ProPhe: 1.823 ± 0.036
1.881ProGly: 1.881 ± 0.036
0.626ProHis: 0.626 ± 0.025
2.705ProIle: 2.705 ± 0.047
2.198ProLys: 2.198 ± 0.054
3.105ProLeu: 3.105 ± 0.053
0.782ProMet: 0.782 ± 0.029
1.889ProAsn: 1.889 ± 0.044
0.798ProPro: 0.798 ± 0.026
1.299ProGln: 1.299 ± 0.036
1.066ProArg: 1.066 ± 0.03
2.36ProSer: 2.36 ± 0.051
1.931ProThr: 1.931 ± 0.042
2.461ProVal: 2.461 ± 0.048
0.365ProTrp: 0.365 ± 0.018
1.698ProTyr: 1.698 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.187GlnAla: 2.187 ± 0.048
0.229GlnCys: 0.229 ± 0.013
1.653GlnAsp: 1.653 ± 0.038
2.173GlnGlu: 2.173 ± 0.048
1.368GlnPhe: 1.368 ± 0.034
1.905GlnGly: 1.905 ± 0.046
0.523GlnHis: 0.523 ± 0.022
2.71GlnIle: 2.71 ± 0.053
2.808GlnLys: 2.808 ± 0.048
3.03GlnLeu: 3.03 ± 0.054
0.926GlnMet: 0.926 ± 0.023
1.957GlnAsn: 1.957 ± 0.046
1.079GlnPro: 1.079 ± 0.03
1.451GlnGln: 1.451 ± 0.042
1.433GlnArg: 1.433 ± 0.04
2.141GlnSer: 2.141 ± 0.045
1.963GlnThr: 1.963 ± 0.047
1.921GlnVal: 1.921 ± 0.044
0.401GlnTrp: 0.401 ± 0.02
1.53GlnTyr: 1.53 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.16ArgAla: 2.16 ± 0.049
0.318ArgCys: 0.318 ± 0.016
2.025ArgAsp: 2.025 ± 0.042
2.546ArgGlu: 2.546 ± 0.059
1.94ArgPhe: 1.94 ± 0.045
2.21ArgGly: 2.21 ± 0.05
0.669ArgHis: 0.669 ± 0.028
3.451ArgIle: 3.451 ± 0.055
3.176ArgLys: 3.176 ± 0.058
3.654ArgLeu: 3.654 ± 0.055
1.151ArgMet: 1.151 ± 0.033
2.388ArgAsn: 2.388 ± 0.047
1.265ArgPro: 1.265 ± 0.042
1.377ArgGln: 1.377 ± 0.036
1.692ArgArg: 1.692 ± 0.04
2.285ArgSer: 2.285 ± 0.041
2.043ArgThr: 2.043 ± 0.04
2.293ArgVal: 2.293 ± 0.041
0.523ArgTrp: 0.523 ± 0.023
1.935ArgTyr: 1.935 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.086SerAla: 4.086 ± 0.062
0.732SerCys: 0.732 ± 0.023
3.971SerAsp: 3.971 ± 0.064
3.911SerGlu: 3.911 ± 0.064
3.652SerPhe: 3.652 ± 0.057
4.682SerGly: 4.682 ± 0.069
1.116SerHis: 1.116 ± 0.031
5.449SerIle: 5.449 ± 0.079
4.497SerLys: 4.497 ± 0.06
6.553SerLeu: 6.553 ± 0.088
1.501SerMet: 1.501 ± 0.041
3.404SerAsn: 3.404 ± 0.057
2.36SerPro: 2.36 ± 0.047
2.204SerGln: 2.204 ± 0.042
2.433SerArg: 2.433 ± 0.048
4.508SerSer: 4.508 ± 0.092
3.425SerThr: 3.425 ± 0.053
4.327SerVal: 4.327 ± 0.059
0.786SerTrp: 0.786 ± 0.026
3.14SerTyr: 3.14 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.457ThrAla: 3.457 ± 0.061
0.422ThrCys: 0.422 ± 0.02
3.349ThrAsp: 3.349 ± 0.058
3.254ThrGlu: 3.254 ± 0.051
2.8ThrPhe: 2.8 ± 0.049
4.147ThrGly: 4.147 ± 0.059
0.951ThrHis: 0.951 ± 0.027
4.601ThrIle: 4.601 ± 0.065
3.513ThrLys: 3.513 ± 0.065
5.008ThrLeu: 5.008 ± 0.064
1.112ThrMet: 1.112 ± 0.033
2.799ThrAsn: 2.799 ± 0.054
2.393ThrPro: 2.393 ± 0.052
1.806ThrGln: 1.806 ± 0.043
1.818ThrArg: 1.818 ± 0.041
3.648ThrSer: 3.648 ± 0.059
3.179ThrThr: 3.179 ± 0.063
3.661ThrVal: 3.661 ± 0.058
0.578ThrTrp: 0.578 ± 0.025
2.43ThrTyr: 2.43 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.012ValAla: 4.012 ± 0.07
0.716ValCys: 0.716 ± 0.026
3.699ValAsp: 3.699 ± 0.056
3.76ValGlu: 3.76 ± 0.061
2.996ValPhe: 2.996 ± 0.056
3.938ValGly: 3.938 ± 0.063
0.91ValHis: 0.91 ± 0.03
4.683ValIle: 4.683 ± 0.068
4.627ValLys: 4.627 ± 0.07
5.473ValLeu: 5.473 ± 0.069
1.419ValMet: 1.419 ± 0.036
3.394ValAsn: 3.394 ± 0.055
2.158ValPro: 2.158 ± 0.051
1.812ValGln: 1.812 ± 0.039
2.349ValArg: 2.349 ± 0.045
4.547ValSer: 4.547 ± 0.065
3.423ValThr: 3.423 ± 0.053
4.19ValVal: 4.19 ± 0.073
0.677ValTrp: 0.677 ± 0.024
2.6ValTyr: 2.6 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.707TrpAla: 0.707 ± 0.026
0.138TrpCys: 0.138 ± 0.009
0.73TrpAsp: 0.73 ± 0.027
0.632TrpGlu: 0.632 ± 0.024
0.513TrpPhe: 0.513 ± 0.019
0.874TrpGly: 0.874 ± 0.03
0.215TrpHis: 0.215 ± 0.015
0.902TrpIle: 0.902 ± 0.032
0.824TrpLys: 0.824 ± 0.026
1.077TrpLeu: 1.077 ± 0.031
0.35TrpMet: 0.35 ± 0.017
0.75TrpAsn: 0.75 ± 0.023
0.228TrpPro: 0.228 ± 0.013
0.462TrpGln: 0.462 ± 0.021
0.51TrpArg: 0.51 ± 0.022
0.709TrpSer: 0.709 ± 0.025
0.601TrpThr: 0.601 ± 0.024
0.715TrpVal: 0.715 ± 0.027
0.173TrpTrp: 0.173 ± 0.012
0.507TrpTyr: 0.507 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.712TyrAla: 2.712 ± 0.051
0.468TyrCys: 0.468 ± 0.02
2.634TyrAsp: 2.634 ± 0.054
2.378TyrGlu: 2.378 ± 0.044
2.376TyrPhe: 2.376 ± 0.05
2.888TyrGly: 2.888 ± 0.056
0.767TyrHis: 0.767 ± 0.028
3.599TyrIle: 3.599 ± 0.061
3.461TyrLys: 3.461 ± 0.061
4.058TyrLeu: 4.058 ± 0.064
1.154TyrMet: 1.154 ± 0.035
2.941TyrAsn: 2.941 ± 0.057
1.858TyrPro: 1.858 ± 0.042
1.548TyrGln: 1.548 ± 0.04
1.954TyrArg: 1.954 ± 0.042
3.285TyrSer: 3.285 ± 0.065
2.82TyrThr: 2.82 ± 0.055
2.321TyrVal: 2.321 ± 0.043
0.569TyrTrp: 0.569 ± 0.024
2.256TyrTyr: 2.256 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3424 proteins (1182442 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski