Amino acid dipepetide frequency for Clostridium celatum DSM 1785

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.659AlaAla: 3.659 ± 0.086	0.662AlaCys: 0.662 ± 0.026	2.558AlaAsp: 2.558 ± 0.057	3.654AlaGlu: 3.654 ± 0.074	2.505AlaPhe: 2.505 ± 0.055	3.667AlaGly: 3.667 ± 0.067	0.765AlaHis: 0.765 ± 0.028	6.119AlaIle: 6.119 ± 0.084	4.699AlaLys: 4.699 ± 0.06	5.75AlaLeu: 5.75 ± 0.09	1.631AlaMet: 1.631 ± 0.04	3.04AlaAsn: 3.04 ± 0.065	1.361AlaPro: 1.361 ± 0.039	1.35AlaGln: 1.35 ± 0.039	1.787AlaArg: 1.787 ± 0.043	3.224AlaSer: 3.224 ± 0.062	3.142AlaThr: 3.142 ± 0.071	3.979AlaVal: 3.979 ± 0.074	0.388AlaTrp: 0.388 ± 0.024	2.189AlaTyr: 2.189 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.57CysAla: 0.57 ± 0.027	0.21CysCys: 0.21 ± 0.022	0.689CysAsp: 0.689 ± 0.027	0.79CysGlu: 0.79 ± 0.033	0.479CysPhe: 0.479 ± 0.023	1.078CysGly: 1.078 ± 0.039	0.213CysHis: 0.213 ± 0.016	1.167CysIle: 1.167 ± 0.037	0.995CysLys: 0.995 ± 0.035	0.809CysLeu: 0.809 ± 0.029	0.265CysMet: 0.265 ± 0.015	0.787CysAsn: 0.787 ± 0.034	0.46CysPro: 0.46 ± 0.028	0.212CysGln: 0.212 ± 0.014	0.378CysArg: 0.378 ± 0.02	0.722CysSer: 0.722 ± 0.032	0.615CysThr: 0.615 ± 0.024	0.632CysVal: 0.632 ± 0.027	0.062CysTrp: 0.062 ± 0.008	0.454CysTyr: 0.454 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.702AspAla: 2.702 ± 0.061	0.539AspCys: 0.539 ± 0.022	2.993AspAsp: 2.993 ± 0.064	4.983AspGlu: 4.983 ± 0.074	2.681AspPhe: 2.681 ± 0.053	3.644AspGly: 3.644 ± 0.065	0.534AspHis: 0.534 ± 0.025	6.321AspIle: 6.321 ± 0.088	5.292AspLys: 5.292 ± 0.085	4.824AspLeu: 4.824 ± 0.072	1.384AspMet: 1.384 ± 0.038	3.743AspAsn: 3.743 ± 0.07	1.166AspPro: 1.166 ± 0.036	0.69AspGln: 0.69 ± 0.027	1.81AspArg: 1.81 ± 0.043	3.294AspSer: 3.294 ± 0.05	2.608AspThr: 2.608 ± 0.055	3.576AspVal: 3.576 ± 0.055	0.345AspTrp: 0.345 ± 0.019	2.779AspTyr: 2.779 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.631GluAla: 4.631 ± 0.085	0.779GluCys: 0.779 ± 0.033	4.546GluAsp: 4.546 ± 0.068	7.932GluGlu: 7.932 ± 0.107	3.289GluPhe: 3.289 ± 0.066	4.448GluGly: 4.448 ± 0.07	0.841GluHis: 0.841 ± 0.028	7.612GluIle: 7.612 ± 0.1	7.424GluLys: 7.424 ± 0.122	7.217GluLeu: 7.217 ± 0.098	1.968GluMet: 1.968 ± 0.046	5.912GluAsn: 5.912 ± 0.093	1.356GluPro: 1.356 ± 0.038	1.596GluGln: 1.596 ± 0.041	2.527GluArg: 2.527 ± 0.056	3.855GluSer: 3.855 ± 0.064	3.017GluThr: 3.017 ± 0.062	5.676GluVal: 5.676 ± 0.083	0.49GluTrp: 0.49 ± 0.021	3.451GluTyr: 3.451 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.245PheAla: 2.245 ± 0.055	0.505PheCys: 0.505 ± 0.023	2.62PheAsp: 2.62 ± 0.055	2.828PheGlu: 2.828 ± 0.061	1.848PhePhe: 1.848 ± 0.051	2.828PheGly: 2.828 ± 0.054	0.45PheHis: 0.45 ± 0.022	4.816PheIle: 4.816 ± 0.086	3.923PheLys: 3.923 ± 0.068	3.653PheLeu: 3.653 ± 0.076	1.156PheMet: 1.156 ± 0.032	3.195PheAsn: 3.195 ± 0.06	1.062PhePro: 1.062 ± 0.035	0.777PheGln: 0.777 ± 0.029	1.25PheArg: 1.25 ± 0.033	2.868PheSer: 2.868 ± 0.066	2.457PheThr: 2.457 ± 0.057	2.513PheVal: 2.513 ± 0.051	0.312PheTrp: 0.312 ± 0.019	1.788PheTyr: 1.788 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.043GlyAla: 4.043 ± 0.085	0.911GlyCys: 0.911 ± 0.039	3.267GlyAsp: 3.267 ± 0.067	4.647GlyGlu: 4.647 ± 0.077	2.956GlyPhe: 2.956 ± 0.058	4.266GlyGly: 4.266 ± 0.088	0.919GlyHis: 0.919 ± 0.031	6.642GlyIle: 6.642 ± 0.108	5.318GlyLys: 5.318 ± 0.074	5.352GlyLeu: 5.352 ± 0.071	1.615GlyMet: 1.615 ± 0.043	3.624GlyAsn: 3.624 ± 0.071	1.152GlyPro: 1.152 ± 0.04	1.524GlyGln: 1.524 ± 0.038	2.194GlyArg: 2.194 ± 0.049	3.608GlySer: 3.608 ± 0.073	3.505GlyThr: 3.505 ± 0.063	4.846GlyVal: 4.846 ± 0.075	0.485GlyTrp: 0.485 ± 0.022	3.056GlyTyr: 3.056 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.599HisAla: 0.599 ± 0.025	0.199HisCys: 0.199 ± 0.014	0.614HisAsp: 0.614 ± 0.025	0.821HisGlu: 0.821 ± 0.032	0.513HisPhe: 0.513 ± 0.025	0.923HisGly: 0.923 ± 0.032	0.264HisHis: 0.264 ± 0.018	1.244HisIle: 1.244 ± 0.038	1.001HisLys: 1.001 ± 0.039	1.07HisLeu: 1.07 ± 0.039	0.324HisMet: 0.324 ± 0.017	0.782HisAsn: 0.782 ± 0.029	0.529HisPro: 0.529 ± 0.024	0.305HisGln: 0.305 ± 0.017	0.503HisArg: 0.503 ± 0.024	0.794HisSer: 0.794 ± 0.027	0.614HisThr: 0.614 ± 0.024	0.658HisVal: 0.658 ± 0.032	0.11HisTrp: 0.11 ± 0.012	0.551HisTyr: 0.551 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.966IleAla: 5.966 ± 0.089	1.234IleCys: 1.234 ± 0.044	6.064IleAsp: 6.064 ± 0.074	7.47IleGlu: 7.47 ± 0.113	4.228IlePhe: 4.228 ± 0.082	6.172IleGly: 6.172 ± 0.094	1.151IleHis: 1.151 ± 0.028	9.878IleIle: 9.878 ± 0.173	8.882IleLys: 8.882 ± 0.113	9.065IleLeu: 9.065 ± 0.143	2.333IleMet: 2.333 ± 0.05	7.318IleAsn: 7.318 ± 0.11	3.12IlePro: 3.12 ± 0.059	2.028IleGln: 2.028 ± 0.041	3.024IleArg: 3.024 ± 0.058	7.047IleSer: 7.047 ± 0.092	5.161IleThr: 5.161 ± 0.071	6.27IleVal: 6.27 ± 0.076	0.641IleTrp: 0.641 ± 0.028	3.948IleTyr: 3.948 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.748LysAla: 4.748 ± 0.072	0.918LysCys: 0.918 ± 0.036	5.37LysAsp: 5.37 ± 0.067	9.009LysGlu: 9.009 ± 0.13	3.366LysPhe: 3.366 ± 0.059	4.856LysGly: 4.856 ± 0.088	1.002LysHis: 1.002 ± 0.038	8.121LysIle: 8.121 ± 0.1	7.611LysLys: 7.611 ± 0.121	7.303LysLeu: 7.303 ± 0.095	2.264LysMet: 2.264 ± 0.051	6.401LysAsn: 6.401 ± 0.099	1.895LysPro: 1.895 ± 0.044	1.792LysGln: 1.792 ± 0.04	2.974LysArg: 2.974 ± 0.062	5.083LysSer: 5.083 ± 0.074	3.796LysThr: 3.796 ± 0.07	5.96LysVal: 5.96 ± 0.079	0.617LysTrp: 0.617 ± 0.025	4.293LysTyr: 4.293 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	5.201LeuAla: 5.201 ± 0.085	1.045LeuCys: 1.045 ± 0.032	5.142LeuAsp: 5.142 ± 0.065	6.705LeuGlu: 6.705 ± 0.095	3.609LeuPhe: 3.609 ± 0.078	5.927LeuGly: 5.927 ± 0.08	1.034LeuHis: 1.034 ± 0.026	8.429LeuIle: 8.429 ± 0.118	7.988LeuLys: 7.988 ± 0.101	7.498LeuLeu: 7.498 ± 0.124	2.183LeuMet: 2.183 ± 0.045	6.334LeuAsn: 6.334 ± 0.094	2.716LeuPro: 2.716 ± 0.054	1.922LeuGln: 1.922 ± 0.052	3.025LeuArg: 3.025 ± 0.054	6.367LeuSer: 6.367 ± 0.109	4.485LeuThr: 4.485 ± 0.071	5.461LeuVal: 5.461 ± 0.075	0.554LeuTrp: 0.554 ± 0.027	3.125LeuTyr: 3.125 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.765MetAla: 1.765 ± 0.043	0.25MetCys: 0.25 ± 0.014	1.444MetAsp: 1.444 ± 0.041	1.817MetGlu: 1.817 ± 0.044	0.96MetPhe: 0.96 ± 0.029	1.679MetGly: 1.679 ± 0.044	0.325MetHis: 0.325 ± 0.017	2.248MetIle: 2.248 ± 0.045	2.403MetLys: 2.403 ± 0.053	2.147MetLeu: 2.147 ± 0.05	0.69MetMet: 0.69 ± 0.03	1.702MetAsn: 1.702 ± 0.044	0.842MetPro: 0.842 ± 0.031	0.668MetGln: 0.668 ± 0.022	0.83MetArg: 0.83 ± 0.029	1.551MetSer: 1.551 ± 0.044	1.222MetThr: 1.222 ± 0.035	1.485MetVal: 1.485 ± 0.04	0.191MetTrp: 0.191 ± 0.016	0.918MetTyr: 0.918 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.066	0.769AsnCys: 0.769 ± 0.031	3.692AsnAsp: 3.692 ± 0.065	5.327AsnGlu: 5.327 ± 0.082	2.752AsnPhe: 2.752 ± 0.053	4.327AsnGly: 4.327 ± 0.082	0.752AsnHis: 0.752 ± 0.028	7.709AsnIle: 7.709 ± 0.11	6.705AsnLys: 6.705 ± 0.1	5.853AsnLeu: 5.853 ± 0.078	1.677AsnMet: 1.677 ± 0.039	5.578AsnAsn: 5.578 ± 0.106	2.103AsnPro: 2.103 ± 0.043	1.183AsnGln: 1.183 ± 0.034	2.039AsnArg: 2.039 ± 0.048	4.53AsnSer: 4.53 ± 0.077	3.313AsnThr: 3.313 ± 0.067	3.842AsnVal: 3.842 ± 0.065	0.482AsnTrp: 0.482 ± 0.022	3.076AsnTyr: 3.076 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	1.362ProAla: 1.362 ± 0.039	0.32ProCys: 0.32 ± 0.018	1.204ProAsp: 1.204 ± 0.035	2.048ProGlu: 2.048 ± 0.052	1.338ProPhe: 1.338 ± 0.035	1.559ProGly: 1.559 ± 0.05	0.455ProHis: 0.455 ± 0.023	2.632ProIle: 2.632 ± 0.06	1.951ProLys: 1.951 ± 0.045	2.305ProLeu: 2.305 ± 0.049	0.658ProMet: 0.658 ± 0.024	1.619ProAsn: 1.619 ± 0.043	0.53ProPro: 0.53 ± 0.023	0.757ProGln: 0.757 ± 0.028	0.76ProArg: 0.76 ± 0.028	1.71ProSer: 1.71 ± 0.038	1.489ProThr: 1.489 ± 0.046	1.876ProVal: 1.876 ± 0.043	0.251ProTrp: 0.251 ± 0.018	1.208ProTyr: 1.208 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.275GlnAla: 1.275 ± 0.038	0.245GlnCys: 0.245 ± 0.015	1.067GlnAsp: 1.067 ± 0.032	1.665GlnGlu: 1.665 ± 0.04	0.857GlnPhe: 0.857 ± 0.028	1.552GlnGly: 1.552 ± 0.048	0.266GlnHis: 0.266 ± 0.017	1.925GlnIle: 1.925 ± 0.045	1.61GlnLys: 1.61 ± 0.048	1.919GlnLeu: 1.919 ± 0.041	0.605GlnMet: 0.605 ± 0.025	1.258GlnAsn: 1.258 ± 0.04	0.48GlnPro: 0.48 ± 0.024	0.537GlnGln: 0.537 ± 0.028	0.838GlnArg: 0.838 ± 0.031	1.252GlnSer: 1.252 ± 0.035	0.95GlnThr: 0.95 ± 0.035	1.377GlnVal: 1.377 ± 0.036	0.202GlnTrp: 0.202 ± 0.015	1.048GlnTyr: 1.048 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.759ArgAla: 1.759 ± 0.042	0.447ArgCys: 0.447 ± 0.022	1.866ArgAsp: 1.866 ± 0.041	3.019ArgGlu: 3.019 ± 0.052	1.405ArgPhe: 1.405 ± 0.042	2.035ArgGly: 2.035 ± 0.048	0.414ArgHis: 0.414 ± 0.021	2.98ArgIle: 2.98 ± 0.057	2.744ArgLys: 2.744 ± 0.057	2.766ArgLeu: 2.766 ± 0.055	0.891ArgMet: 0.891 ± 0.031	2.013ArgAsn: 2.013 ± 0.046	0.771ArgPro: 0.771 ± 0.028	0.813ArgGln: 0.813 ± 0.026	1.374ArgArg: 1.374 ± 0.042	1.586ArgSer: 1.586 ± 0.038	1.451ArgThr: 1.451 ± 0.037	2.348ArgVal: 2.348 ± 0.05	0.259ArgTrp: 0.259 ± 0.016	1.487ArgTyr: 1.487 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.13SerAla: 3.13 ± 0.065	0.637SerCys: 0.637 ± 0.029	3.303SerAsp: 3.303 ± 0.06	4.228SerGlu: 4.228 ± 0.067	2.957SerPhe: 2.957 ± 0.054	4.152SerGly: 4.152 ± 0.062	0.859SerHis: 0.859 ± 0.033	6.545SerIle: 6.545 ± 0.101	5.679SerLys: 5.679 ± 0.081	6.015SerLeu: 6.015 ± 0.087	1.504SerMet: 1.504 ± 0.034	4.502SerAsn: 4.502 ± 0.086	1.528SerPro: 1.528 ± 0.04	1.415SerGln: 1.415 ± 0.041	1.915SerArg: 1.915 ± 0.041	4.161SerSer: 4.161 ± 0.091	3.41SerThr: 3.41 ± 0.063	3.669SerVal: 3.669 ± 0.071	0.416SerTrp: 0.416 ± 0.025	2.644SerTyr: 2.644 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	2.997ThrAla: 2.997 ± 0.07	0.508ThrCys: 0.508 ± 0.023	2.516ThrAsp: 2.516 ± 0.056	3.243ThrGlu: 3.243 ± 0.063	2.28ThrPhe: 2.28 ± 0.054	3.541ThrGly: 3.541 ± 0.069	0.709ThrHis: 0.709 ± 0.027	5.107ThrIle: 5.107 ± 0.083	3.505ThrLys: 3.505 ± 0.058	5.004ThrLeu: 5.004 ± 0.077	1.185ThrMet: 1.185 ± 0.034	3.06ThrAsn: 3.06 ± 0.062	1.799ThrPro: 1.799 ± 0.043	1.053ThrGln: 1.053 ± 0.035	1.475ThrArg: 1.475 ± 0.036	3.272ThrSer: 3.272 ± 0.067	2.913ThrThr: 2.913 ± 0.06	3.568ThrVal: 3.568 ± 0.072	0.418ThrTrp: 0.418 ± 0.026	2.026ThrTyr: 2.026 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.074ValAla: 4.074 ± 0.075	0.761ValCys: 0.761 ± 0.028	3.972ValAsp: 3.972 ± 0.063	4.727ValGlu: 4.727 ± 0.083	2.809ValPhe: 2.809 ± 0.059	4.129ValGly: 4.129 ± 0.069	0.792ValHis: 0.792 ± 0.03	6.49ValIle: 6.49 ± 0.076	5.366ValLys: 5.366 ± 0.069	5.88ValLeu: 5.88 ± 0.082	1.608ValMet: 1.608 ± 0.043	4.272ValAsn: 4.272 ± 0.079	1.804ValPro: 1.804 ± 0.045	1.281ValGln: 1.281 ± 0.041	2.03ValArg: 2.03 ± 0.048	4.356ValSer: 4.356 ± 0.072	3.394ValThr: 3.394 ± 0.058	4.765ValVal: 4.765 ± 0.084	0.401ValTrp: 0.401 ± 0.018	2.413ValTyr: 2.413 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.379TrpAla: 0.379 ± 0.018	0.085TrpCys: 0.085 ± 0.008	0.378TrpAsp: 0.378 ± 0.022	0.471TrpGlu: 0.471 ± 0.024	0.311TrpPhe: 0.311 ± 0.02	0.506TrpGly: 0.506 ± 0.025	0.13TrpHis: 0.13 ± 0.011	0.707TrpIle: 0.707 ± 0.029	0.453TrpLys: 0.453 ± 0.021	0.576TrpLeu: 0.576 ± 0.026	0.17TrpMet: 0.17 ± 0.013	0.496TrpAsn: 0.496 ± 0.026	0.165TrpPro: 0.165 ± 0.013	0.228TrpGln: 0.228 ± 0.016	0.267TrpArg: 0.267 ± 0.016	0.475TrpSer: 0.475 ± 0.027	0.365TrpThr: 0.365 ± 0.022	0.464TrpVal: 0.464 ± 0.029	0.075TrpTrp: 0.075 ± 0.009	0.285TrpTyr: 0.285 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.969TyrAla: 1.969 ± 0.046	0.56TyrCys: 0.56 ± 0.024	2.604TyrAsp: 2.604 ± 0.054	3.183TyrGlu: 3.183 ± 0.06	1.95TyrPhe: 1.95 ± 0.048	2.643TyrGly: 2.643 ± 0.052	0.541TyrHis: 0.541 ± 0.025	4.306TyrIle: 4.306 ± 0.066	3.829TyrLys: 3.829 ± 0.072	3.746TyrLeu: 3.746 ± 0.074	1.021TyrMet: 1.021 ± 0.034	3.129TyrAsn: 3.129 ± 0.056	1.193TyrPro: 1.193 ± 0.036	0.798TyrGln: 0.798 ± 0.03	1.426TyrArg: 1.426 ± 0.04	2.914TyrSer: 2.914 ± 0.05	2.274TyrThr: 2.274 ± 0.055	2.361TyrVal: 2.361 ± 0.047	0.291TyrTrp: 0.291 ± 0.016	2.055TyrTyr: 2.055 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3453 proteins (1020863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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