Amino acid dipepetide frequency for Chitinophaga jiangningensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.581AlaAla: 9.581 ± 0.088
0.773AlaCys: 0.773 ± 0.021
4.848AlaAsp: 4.848 ± 0.055
4.246AlaGlu: 4.246 ± 0.056
3.506AlaPhe: 3.506 ± 0.043
6.899AlaGly: 6.899 ± 0.075
1.396AlaHis: 1.396 ± 0.027
5.321AlaIle: 5.321 ± 0.052
4.183AlaLys: 4.183 ± 0.057
7.369AlaLeu: 7.369 ± 0.072
2.127AlaMet: 2.127 ± 0.032
4.083AlaAsn: 4.083 ± 0.052
3.193AlaPro: 3.193 ± 0.052
3.226AlaGln: 3.226 ± 0.038
3.203AlaArg: 3.203 ± 0.044
4.764AlaSer: 4.764 ± 0.055
5.655AlaThr: 5.655 ± 0.093
5.78AlaVal: 5.78 ± 0.065
1.02AlaTrp: 1.02 ± 0.023
3.212AlaTyr: 3.212 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.569CysAla: 0.569 ± 0.017
0.182CysCys: 0.182 ± 0.01
0.368CysAsp: 0.368 ± 0.015
0.39CysGlu: 0.39 ± 0.015
0.391CysPhe: 0.391 ± 0.014
0.627CysGly: 0.627 ± 0.023
0.192CysHis: 0.192 ± 0.012
0.587CysIle: 0.587 ± 0.018
0.454CysLys: 0.454 ± 0.016
0.783CysLeu: 0.783 ± 0.019
0.233CysMet: 0.233 ± 0.011
0.428CysAsn: 0.428 ± 0.021
0.334CysPro: 0.334 ± 0.015
0.273CysGln: 0.273 ± 0.011
0.383CysArg: 0.383 ± 0.013
0.517CysSer: 0.517 ± 0.017
0.516CysThr: 0.516 ± 0.026
0.438CysVal: 0.438 ± 0.016
0.126CysTrp: 0.126 ± 0.007
0.345CysTyr: 0.345 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.42AspAla: 4.42 ± 0.051
0.401AspCys: 0.401 ± 0.017
2.25AspAsp: 2.25 ± 0.04
2.787AspGlu: 2.787 ± 0.043
2.66AspPhe: 2.66 ± 0.037
3.814AspGly: 3.814 ± 0.054
0.968AspHis: 0.968 ± 0.024
3.73AspIle: 3.73 ± 0.046
3.521AspLys: 3.521 ± 0.054
4.545AspLeu: 4.545 ± 0.045
1.256AspMet: 1.256 ± 0.026
2.741AspAsn: 2.741 ± 0.042
2.332AspPro: 2.332 ± 0.037
1.86AspGln: 1.86 ± 0.029
2.011AspArg: 2.011 ± 0.03
2.987AspSer: 2.987 ± 0.043
2.936AspThr: 2.936 ± 0.049
3.349AspVal: 3.349 ± 0.045
0.77AspTrp: 0.77 ± 0.02
2.57AspTyr: 2.57 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
4.337GluAla: 4.337 ± 0.054
0.316GluCys: 0.316 ± 0.013
2.486GluAsp: 2.486 ± 0.042
3.366GluGlu: 3.366 ± 0.055
2.069GluPhe: 2.069 ± 0.033
3.214GluGly: 3.214 ± 0.042
1.022GluHis: 1.022 ± 0.023
3.644GluIle: 3.644 ± 0.05
4.231GluLys: 4.231 ± 0.058
5.19GluLeu: 5.19 ± 0.06
1.528GluMet: 1.528 ± 0.033
2.738GluAsn: 2.738 ± 0.04
1.613GluPro: 1.613 ± 0.027
2.515GluGln: 2.515 ± 0.042
2.39GluArg: 2.39 ± 0.031
2.506GluSer: 2.506 ± 0.034
2.555GluThr: 2.555 ± 0.032
3.744GluVal: 3.744 ± 0.045
0.705GluTrp: 0.705 ± 0.019
1.87GluTyr: 1.87 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.326PheAla: 3.326 ± 0.041
0.421PheCys: 0.421 ± 0.014
2.54PheAsp: 2.54 ± 0.036
2.31PheGlu: 2.31 ± 0.033
2.161PhePhe: 2.161 ± 0.039
3.091PheGly: 3.091 ± 0.043
0.868PheHis: 0.868 ± 0.02
2.773PheIle: 2.773 ± 0.036
2.441PheLys: 2.441 ± 0.036
3.992PheLeu: 3.992 ± 0.058
1.158PheMet: 1.158 ± 0.027
2.755PheAsn: 2.755 ± 0.043
1.811PhePro: 1.811 ± 0.028
1.475PheGln: 1.475 ± 0.024
2.167PheArg: 2.167 ± 0.034
3.304PheSer: 3.304 ± 0.045
3.183PheThr: 3.183 ± 0.043
2.604PheVal: 2.604 ± 0.042
0.541PheTrp: 0.541 ± 0.019
1.943PheTyr: 1.943 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.427GlyAla: 5.427 ± 0.065
0.631GlyCys: 0.631 ± 0.028
3.475GlyAsp: 3.475 ± 0.045
3.292GlyGlu: 3.292 ± 0.038
3.378GlyPhe: 3.378 ± 0.044
5.263GlyGly: 5.263 ± 0.077
1.264GlyHis: 1.264 ± 0.029
5.152GlyIle: 5.152 ± 0.064
5.004GlyLys: 5.004 ± 0.049
6.116GlyLeu: 6.116 ± 0.064
1.906GlyMet: 1.906 ± 0.029
4.169GlyAsn: 4.169 ± 0.065
1.874GlyPro: 1.874 ± 0.045
2.488GlyGln: 2.488 ± 0.036
2.946GlyArg: 2.946 ± 0.046
4.357GlySer: 4.357 ± 0.052
4.934GlyThr: 4.934 ± 0.087
4.682GlyVal: 4.682 ± 0.055
1.066GlyTrp: 1.066 ± 0.026
3.368GlyTyr: 3.368 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.378HisAla: 1.378 ± 0.029
0.199HisCys: 0.199 ± 0.009
0.891HisAsp: 0.891 ± 0.023
0.952HisGlu: 0.952 ± 0.023
1.134HisPhe: 1.134 ± 0.025
1.239HisGly: 1.239 ± 0.027
0.632HisHis: 0.632 ± 0.02
1.322HisIle: 1.322 ± 0.025
0.969HisLys: 0.969 ± 0.026
2.055HisLeu: 2.055 ± 0.031
0.442HisMet: 0.442 ± 0.015
0.925HisAsn: 0.925 ± 0.021
1.12HisPro: 1.12 ± 0.025
0.885HisGln: 0.885 ± 0.025
0.874HisArg: 0.874 ± 0.022
1.025HisSer: 1.025 ± 0.024
1.207HisThr: 1.207 ± 0.022
1.018HisVal: 1.018 ± 0.022
0.304HisTrp: 0.304 ± 0.014
0.923HisTyr: 0.923 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.562IleAla: 5.562 ± 0.06
0.668IleCys: 0.668 ± 0.02
3.424IleAsp: 3.424 ± 0.044
2.925IleGlu: 2.925 ± 0.042
2.679IlePhe: 2.679 ± 0.038
4.405IleGly: 4.405 ± 0.052
1.376IleHis: 1.376 ± 0.029
4.225IleIle: 4.225 ± 0.057
3.483IleLys: 3.483 ± 0.047
5.44IleLeu: 5.44 ± 0.061
1.33IleMet: 1.33 ± 0.026
3.639IleAsn: 3.639 ± 0.044
3.211IlePro: 3.211 ± 0.044
2.316IleGln: 2.316 ± 0.036
3.37IleArg: 3.37 ± 0.041
4.612IleSer: 4.612 ± 0.052
4.853IleThr: 4.853 ± 0.072
3.856IleVal: 3.856 ± 0.05
0.702IleTrp: 0.702 ± 0.02
2.487IleTyr: 2.487 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.969LysAla: 4.969 ± 0.053
0.307LysCys: 0.307 ± 0.014
3.653LysAsp: 3.653 ± 0.051
3.869LysGlu: 3.869 ± 0.059
2.116LysPhe: 2.116 ± 0.033
4.288LysGly: 4.288 ± 0.057
1.083LysHis: 1.083 ± 0.028
3.708LysIle: 3.708 ± 0.046
4.231LysLys: 4.231 ± 0.061
5.181LysLeu: 5.181 ± 0.054
1.733LysMet: 1.733 ± 0.028
3.204LysAsn: 3.204 ± 0.039
2.619LysPro: 2.619 ± 0.041
2.628LysGln: 2.628 ± 0.042
2.444LysArg: 2.444 ± 0.036
3.305LysSer: 3.305 ± 0.041
3.365LysThr: 3.365 ± 0.04
4.111LysVal: 4.111 ± 0.046
0.77LysTrp: 0.77 ± 0.02
2.54LysTyr: 2.54 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
7.29LeuAla: 7.29 ± 0.065
0.814LeuCys: 0.814 ± 0.018
4.667LeuAsp: 4.667 ± 0.053
4.884LeuGlu: 4.884 ± 0.053
4.213LeuPhe: 4.213 ± 0.054
5.718LeuGly: 5.718 ± 0.061
2.093LeuHis: 2.093 ± 0.043
5.405LeuIle: 5.405 ± 0.064
5.82LeuLys: 5.82 ± 0.06
10.206LeuLeu: 10.206 ± 0.104
2.269LeuMet: 2.269 ± 0.034
4.698LeuAsn: 4.698 ± 0.05
4.654LeuPro: 4.654 ± 0.048
4.875LeuGln: 4.875 ± 0.051
4.259LeuArg: 4.259 ± 0.043
6.207LeuSer: 6.207 ± 0.059
5.754LeuThr: 5.754 ± 0.059
5.612LeuVal: 5.612 ± 0.059
0.97LeuTrp: 0.97 ± 0.025
3.438LeuTyr: 3.438 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.122MetAla: 2.122 ± 0.033
0.135MetCys: 0.135 ± 0.008
1.331MetAsp: 1.331 ± 0.028
1.552MetGlu: 1.552 ± 0.029
0.793MetPhe: 0.793 ± 0.019
1.596MetGly: 1.596 ± 0.03
0.546MetHis: 0.546 ± 0.016
1.4MetIle: 1.4 ± 0.027
1.983MetLys: 1.983 ± 0.035
2.411MetLeu: 2.411 ± 0.036
0.674MetMet: 0.674 ± 0.017
1.324MetAsn: 1.324 ± 0.026
1.267MetPro: 1.267 ± 0.024
1.259MetGln: 1.259 ± 0.024
1.153MetArg: 1.153 ± 0.024
1.356MetSer: 1.356 ± 0.027
1.234MetThr: 1.234 ± 0.023
1.575MetVal: 1.575 ± 0.028
0.217MetTrp: 0.217 ± 0.011
0.784MetTyr: 0.784 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
4.261AsnAla: 4.261 ± 0.051
0.395AsnCys: 0.395 ± 0.015
2.617AsnAsp: 2.617 ± 0.035
2.543AsnGlu: 2.543 ± 0.034
2.365AsnPhe: 2.365 ± 0.034
4.367AsnGly: 4.367 ± 0.066
0.866AsnHis: 0.866 ± 0.026
3.946AsnIle: 3.946 ± 0.048
3.097AsnLys: 3.097 ± 0.038
4.455AsnLeu: 4.455 ± 0.048
1.228AsnMet: 1.228 ± 0.022
3.304AsnAsn: 3.304 ± 0.058
2.706AsnPro: 2.706 ± 0.039
1.879AsnGln: 1.879 ± 0.029
2.375AsnArg: 2.375 ± 0.037
3.096AsnSer: 3.096 ± 0.043
3.645AsnThr: 3.645 ± 0.065
3.263AsnVal: 3.263 ± 0.051
0.766AsnTrp: 0.766 ± 0.022
2.475AsnTyr: 2.475 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.849ProAla: 4.849 ± 0.061
0.237ProCys: 0.237 ± 0.011
2.824ProAsp: 2.824 ± 0.038
2.93ProGlu: 2.93 ± 0.044
1.942ProPhe: 1.942 ± 0.033
3.623ProGly: 3.623 ± 0.047
0.711ProHis: 0.711 ± 0.018
2.059ProIle: 2.059 ± 0.033
1.955ProLys: 1.955 ± 0.037
3.73ProLeu: 3.73 ± 0.042
0.928ProMet: 0.928 ± 0.02
1.893ProAsn: 1.893 ± 0.035
1.401ProPro: 1.401 ± 0.03
1.626ProGln: 1.626 ± 0.031
1.294ProArg: 1.294 ± 0.024
2.231ProSer: 2.231 ± 0.039
2.141ProThr: 2.141 ± 0.037
4.017ProVal: 4.017 ± 0.053
0.525ProTrp: 0.525 ± 0.016
1.741ProTyr: 1.741 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.157GlnAla: 3.157 ± 0.036
0.221GlnCys: 0.221 ± 0.011
1.792GlnAsp: 1.792 ± 0.028
2.353GlnGlu: 2.353 ± 0.04
1.739GlnPhe: 1.739 ± 0.029
2.303GlnGly: 2.303 ± 0.038
1.086GlnHis: 1.086 ± 0.025
2.134GlnIle: 2.134 ± 0.032
2.171GlnLys: 2.171 ± 0.038
4.958GlnLeu: 4.958 ± 0.062
0.975GlnMet: 0.975 ± 0.02
1.696GlnAsn: 1.696 ± 0.035
2.028GlnPro: 2.028 ± 0.035
3.244GlnGln: 3.244 ± 0.056
1.914GlnArg: 1.914 ± 0.033
2.197GlnSer: 2.197 ± 0.037
2.165GlnThr: 2.165 ± 0.035
2.867GlnVal: 2.867 ± 0.034
0.586GlnTrp: 0.586 ± 0.016
1.819GlnTyr: 1.819 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.809ArgAla: 2.809 ± 0.035
0.287ArgCys: 0.287 ± 0.012
2.077ArgAsp: 2.077 ± 0.03
2.57ArgGlu: 2.57 ± 0.046
2.242ArgPhe: 2.242 ± 0.033
2.338ArgGly: 2.338 ± 0.04
0.884ArgHis: 0.884 ± 0.02
3.211ArgIle: 3.211 ± 0.041
2.993ArgLys: 2.993 ± 0.04
4.22ArgLeu: 4.22 ± 0.055
1.276ArgMet: 1.276 ± 0.027
2.521ArgAsn: 2.521 ± 0.038
1.591ArgPro: 1.591 ± 0.032
1.938ArgGln: 1.938 ± 0.035
1.951ArgArg: 1.951 ± 0.032
2.334ArgSer: 2.334 ± 0.04
2.343ArgThr: 2.343 ± 0.033
2.648ArgVal: 2.648 ± 0.034
0.742ArgTrp: 0.742 ± 0.019
2.138ArgTyr: 2.138 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.894SerAla: 4.894 ± 0.049
0.612SerCys: 0.612 ± 0.019
2.832SerAsp: 2.832 ± 0.034
2.526SerGlu: 2.526 ± 0.035
3.126SerPhe: 3.126 ± 0.042
5.001SerGly: 5.001 ± 0.063
1.071SerHis: 1.071 ± 0.023
4.062SerIle: 4.062 ± 0.049
3.042SerLys: 3.042 ± 0.039
5.85SerLeu: 5.85 ± 0.059
1.439SerMet: 1.439 ± 0.023
3.184SerAsn: 3.184 ± 0.045
2.462SerPro: 2.462 ± 0.037
2.001SerGln: 2.001 ± 0.03
2.694SerArg: 2.694 ± 0.037
3.81SerSer: 3.81 ± 0.052
3.714SerThr: 3.714 ± 0.048
3.964SerVal: 3.964 ± 0.048
0.94SerTrp: 0.94 ± 0.023
2.711SerTyr: 2.711 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.013ThrAla: 6.013 ± 0.092
0.455ThrCys: 0.455 ± 0.022
3.542ThrAsp: 3.542 ± 0.051
2.714ThrGlu: 2.714 ± 0.041
2.767ThrPhe: 2.767 ± 0.039
5.504ThrGly: 5.504 ± 0.084
1.064ThrHis: 1.064 ± 0.021
4.327ThrIle: 4.327 ± 0.066
2.913ThrLys: 2.913 ± 0.044
5.826ThrLeu: 5.826 ± 0.058
1.196ThrMet: 1.196 ± 0.023
3.065ThrAsn: 3.065 ± 0.055
3.191ThrPro: 3.191 ± 0.045
1.957ThrGln: 1.957 ± 0.034
2.405ThrArg: 2.405 ± 0.033
3.661ThrSer: 3.661 ± 0.058
4.325ThrThr: 4.325 ± 0.075
4.646ThrVal: 4.646 ± 0.092
0.901ThrTrp: 0.901 ± 0.034
2.615ThrTyr: 2.615 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.367ValAla: 5.367 ± 0.056
0.578ValCys: 0.578 ± 0.018
3.197ValAsp: 3.197 ± 0.038
3.051ValGlu: 3.051 ± 0.044
2.837ValPhe: 2.837 ± 0.041
3.72ValGly: 3.72 ± 0.053
1.173ValHis: 1.173 ± 0.026
4.46ValIle: 4.46 ± 0.051
4.37ValLys: 4.37 ± 0.051
6.223ValLeu: 6.223 ± 0.059
1.699ValMet: 1.699 ± 0.028
3.806ValAsn: 3.806 ± 0.054
3.004ValPro: 3.004 ± 0.04
2.461ValGln: 2.461 ± 0.039
2.667ValArg: 2.667 ± 0.034
4.328ValSer: 4.328 ± 0.056
4.813ValThr: 4.813 ± 0.084
4.6ValVal: 4.6 ± 0.06
0.754ValTrp: 0.754 ± 0.02
2.633ValTyr: 2.633 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.872TrpAla: 0.872 ± 0.023
0.125TrpCys: 0.125 ± 0.008
0.692TrpAsp: 0.692 ± 0.017
0.752TrpGlu: 0.752 ± 0.019
0.559TrpPhe: 0.559 ± 0.017
0.878TrpGly: 0.878 ± 0.023
0.311TrpHis: 0.311 ± 0.012
0.748TrpIle: 0.748 ± 0.021
0.903TrpLys: 0.903 ± 0.022
1.364TrpLeu: 1.364 ± 0.03
0.405TrpMet: 0.405 ± 0.014
0.771TrpAsn: 0.771 ± 0.02
0.404TrpPro: 0.404 ± 0.015
0.73TrpGln: 0.73 ± 0.018
0.589TrpArg: 0.589 ± 0.017
0.746TrpSer: 0.746 ± 0.024
0.797TrpThr: 0.797 ± 0.029
0.743TrpVal: 0.743 ± 0.019
0.263TrpTrp: 0.263 ± 0.012
0.6TrpTyr: 0.6 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.183TyrAla: 3.183 ± 0.041
0.379TyrCys: 0.379 ± 0.014
2.402TyrAsp: 2.402 ± 0.04
2.026TyrGlu: 2.026 ± 0.033
2.187TyrPhe: 2.187 ± 0.031
2.906TyrGly: 2.906 ± 0.041
0.889TyrHis: 0.889 ± 0.023
2.349TyrIle: 2.349 ± 0.034
2.36TyrLys: 2.36 ± 0.036
3.935TyrLeu: 3.935 ± 0.048
0.911TyrMet: 0.911 ± 0.02
2.705TyrAsn: 2.705 ± 0.043
1.838TyrPro: 1.838 ± 0.03
1.767TyrGln: 1.767 ± 0.031
2.025TyrArg: 2.025 ± 0.03
2.594TyrSer: 2.594 ± 0.044
2.955TyrThr: 2.955 ± 0.058
2.221TyrVal: 2.221 ± 0.033
0.58TyrTrp: 0.58 ± 0.017
2.087TyrTyr: 2.087 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5782 proteins (2166146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski