Amino acid dipepetide frequency for Frateuria terrea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.713AlaAla: 17.713 ± 0.192	1.37AlaCys: 1.37 ± 0.043	6.987AlaAsp: 6.987 ± 0.084	6.588AlaGlu: 6.588 ± 0.1	4.083AlaPhe: 4.083 ± 0.064	11.355AlaGly: 11.355 ± 0.127	3.144AlaHis: 3.144 ± 0.055	5.425AlaIle: 5.425 ± 0.085	3.285AlaLys: 3.285 ± 0.071	15.714AlaLeu: 15.714 ± 0.169	3.517AlaMet: 3.517 ± 0.064	2.886AlaAsn: 2.886 ± 0.059	6.514AlaPro: 6.514 ± 0.095	5.543AlaGln: 5.543 ± 0.076	10.281AlaArg: 10.281 ± 0.104	6.839AlaSer: 6.839 ± 0.083	6.257AlaThr: 6.257 ± 0.094	8.787AlaVal: 8.787 ± 0.097	2.243AlaTrp: 2.243 ± 0.046	2.609AlaTyr: 2.609 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.034	0.106CysCys: 0.106 ± 0.011	0.482CysAsp: 0.482 ± 0.024	0.468CysGlu: 0.468 ± 0.022	0.313CysPhe: 0.313 ± 0.015	0.952CysGly: 0.952 ± 0.033	0.292CysHis: 0.292 ± 0.02	0.363CysIle: 0.363 ± 0.018	0.155CysLys: 0.155 ± 0.013	0.863CysLeu: 0.863 ± 0.031	0.182CysMet: 0.182 ± 0.012	0.198CysAsn: 0.198 ± 0.014	0.428CysPro: 0.428 ± 0.02	0.24CysGln: 0.24 ± 0.016	0.624CysArg: 0.624 ± 0.024	0.458CysSer: 0.458 ± 0.022	0.436CysThr: 0.436 ± 0.02	0.669CysVal: 0.669 ± 0.025	0.141CysTrp: 0.141 ± 0.013	0.236CysTyr: 0.236 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.06AspAla: 8.06 ± 0.09	0.444AspCys: 0.444 ± 0.022	3.145AspAsp: 3.145 ± 0.063	3.294AspGlu: 3.294 ± 0.062	2.127AspPhe: 2.127 ± 0.047	5.356AspGly: 5.356 ± 0.083	1.27AspHis: 1.27 ± 0.038	2.207AspIle: 2.207 ± 0.05	1.529AspLys: 1.529 ± 0.045	5.563AspLeu: 5.563 ± 0.085	1.116AspMet: 1.116 ± 0.032	1.329AspAsn: 1.329 ± 0.04	3.607AspPro: 3.607 ± 0.059	1.845AspGln: 1.845 ± 0.041	4.005AspArg: 4.005 ± 0.063	2.247AspSer: 2.247 ± 0.046	2.773AspThr: 2.773 ± 0.058	4.165AspVal: 4.165 ± 0.057	1.082AspTrp: 1.082 ± 0.029	1.779AspTyr: 1.779 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.863GluAla: 6.863 ± 0.103	0.358GluCys: 0.358 ± 0.017	2.381GluAsp: 2.381 ± 0.051	2.42GluGlu: 2.42 ± 0.059	1.47GluPhe: 1.47 ± 0.035	4.11GluGly: 4.11 ± 0.081	1.599GluHis: 1.599 ± 0.044	2.099GluIle: 2.099 ± 0.054	1.479GluLys: 1.479 ± 0.044	6.271GluLeu: 6.271 ± 0.09	0.987GluMet: 0.987 ± 0.03	1.067GluAsn: 1.067 ± 0.033	2.699GluPro: 2.699 ± 0.056	2.701GluGln: 2.701 ± 0.057	5.267GluArg: 5.267 ± 0.085	2.25GluSer: 2.25 ± 0.048	2.269GluThr: 2.269 ± 0.048	3.822GluVal: 3.822 ± 0.072	0.632GluTrp: 0.632 ± 0.026	1.025GluTyr: 1.025 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.304PheAla: 4.304 ± 0.063	0.339PheCys: 0.339 ± 0.018	2.557PheAsp: 2.557 ± 0.042	1.881PheGlu: 1.881 ± 0.042	1.189PhePhe: 1.189 ± 0.039	3.313PheGly: 3.313 ± 0.055	0.807PheHis: 0.807 ± 0.024	1.164PheIle: 1.164 ± 0.031	0.834PheLys: 0.834 ± 0.03	3.045PheLeu: 3.045 ± 0.051	0.641PheMet: 0.641 ± 0.022	1.006PheAsn: 1.006 ± 0.031	1.466PhePro: 1.466 ± 0.037	1.007PheGln: 1.007 ± 0.029	2.136PheArg: 2.136 ± 0.044	1.801PheSer: 1.801 ± 0.052	1.719PheThr: 1.719 ± 0.039	2.657PheVal: 2.657 ± 0.05	0.46PheTrp: 0.46 ± 0.023	0.903PheTyr: 0.903 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.465GlyAla: 9.465 ± 0.108	0.85GlyCys: 0.85 ± 0.032	4.642GlyAsp: 4.642 ± 0.077	4.884GlyGlu: 4.884 ± 0.071	3.233GlyPhe: 3.233 ± 0.054	7.168GlyGly: 7.168 ± 0.136	2.285GlyHis: 2.285 ± 0.04	3.822GlyIle: 3.822 ± 0.072	3.151GlyLys: 3.151 ± 0.073	8.755GlyLeu: 8.755 ± 0.099	2.414GlyMet: 2.414 ± 0.048	2.37GlyAsn: 2.37 ± 0.064	3.292GlyPro: 3.292 ± 0.056	3.348GlyGln: 3.348 ± 0.056	6.369GlyArg: 6.369 ± 0.083	4.836GlySer: 4.836 ± 0.083	4.708GlyThr: 4.708 ± 0.116	6.559GlyVal: 6.559 ± 0.08	1.72GlyTrp: 1.72 ± 0.042	2.523GlyTyr: 2.523 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	3.65HisAla: 3.65 ± 0.059	0.284HisCys: 0.284 ± 0.016	1.51HisAsp: 1.51 ± 0.039	1.269HisGlu: 1.269 ± 0.034	0.902HisPhe: 0.902 ± 0.026	2.632HisGly: 2.632 ± 0.053	0.701HisHis: 0.701 ± 0.025	0.801HisIle: 0.801 ± 0.025	0.529HisLys: 0.529 ± 0.025	2.446HisLeu: 2.446 ± 0.043	0.565HisMet: 0.565 ± 0.024	0.507HisAsn: 0.507 ± 0.024	1.725HisPro: 1.725 ± 0.043	0.75HisGln: 0.75 ± 0.028	1.901HisArg: 1.901 ± 0.049	1.065HisSer: 1.065 ± 0.032	1.144HisThr: 1.144 ± 0.032	1.838HisVal: 1.838 ± 0.042	0.495HisTrp: 0.495 ± 0.021	0.72HisTyr: 0.72 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.718IleAla: 5.718 ± 0.075	0.355IleCys: 0.355 ± 0.016	3.155IleAsp: 3.155 ± 0.059	2.823IleGlu: 2.823 ± 0.053	1.043IlePhe: 1.043 ± 0.032	4.123IleGly: 4.123 ± 0.062	0.886IleHis: 0.886 ± 0.026	1.139IleIle: 1.139 ± 0.035	1.121IleLys: 1.121 ± 0.038	2.851IleLeu: 2.851 ± 0.054	0.514IleMet: 0.514 ± 0.021	1.192IleAsn: 1.192 ± 0.031	1.897IlePro: 1.897 ± 0.041	1.073IleGln: 1.073 ± 0.03	2.551IleArg: 2.551 ± 0.052	2.029IleSer: 2.029 ± 0.043	2.094IleThr: 2.094 ± 0.048	3.027IleVal: 3.027 ± 0.054	0.411IleTrp: 0.411 ± 0.022	0.917IleTyr: 0.917 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.453LysAla: 3.453 ± 0.087	0.119LysCys: 0.119 ± 0.01	1.416LysAsp: 1.416 ± 0.038	1.189LysGlu: 1.189 ± 0.042	0.7LysPhe: 0.7 ± 0.027	2.102LysGly: 2.102 ± 0.053	0.668LysHis: 0.668 ± 0.028	1.022LysIle: 1.022 ± 0.032	1.02LysLys: 1.02 ± 0.053	3.186LysLeu: 3.186 ± 0.056	0.564LysMet: 0.564 ± 0.02	0.667LysAsn: 0.667 ± 0.028	1.952LysPro: 1.952 ± 0.043	1.166LysGln: 1.166 ± 0.037	2.055LysArg: 2.055 ± 0.05	1.303LysSer: 1.303 ± 0.036	1.374LysThr: 1.374 ± 0.035	2.168LysVal: 2.168 ± 0.047	0.281LysTrp: 0.281 ± 0.018	0.561LysTyr: 0.561 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.692LeuAla: 16.692 ± 0.165	1.01LeuCys: 1.01 ± 0.03	7.0LeuAsp: 7.0 ± 0.091	5.485LeuGlu: 5.485 ± 0.094	3.421LeuPhe: 3.421 ± 0.064	9.387LeuGly: 9.387 ± 0.103	2.7LeuHis: 2.7 ± 0.049	3.734LeuIle: 3.734 ± 0.057	3.279LeuLys: 3.279 ± 0.06	12.403LeuLeu: 12.403 ± 0.167	2.003LeuMet: 2.003 ± 0.051	2.269LeuAsn: 2.269 ± 0.05	6.8LeuPro: 6.8 ± 0.09	3.516LeuGln: 3.516 ± 0.058	8.722LeuArg: 8.722 ± 0.11	5.721LeuSer: 5.721 ± 0.073	5.038LeuThr: 5.038 ± 0.093	8.026LeuVal: 8.026 ± 0.101	1.486LeuTrp: 1.486 ± 0.038	2.285LeuTyr: 2.285 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.764MetAla: 2.764 ± 0.052	0.135MetCys: 0.135 ± 0.012	1.172MetAsp: 1.172 ± 0.035	0.91MetGlu: 0.91 ± 0.029	0.634MetPhe: 0.634 ± 0.026	1.583MetGly: 1.583 ± 0.047	0.606MetHis: 0.606 ± 0.024	0.8MetIle: 0.8 ± 0.03	0.766MetLys: 0.766 ± 0.024	2.546MetLeu: 2.546 ± 0.047	0.398MetMet: 0.398 ± 0.023	0.712MetAsn: 0.712 ± 0.026	1.516MetPro: 1.516 ± 0.038	0.938MetGln: 0.938 ± 0.03	1.78MetArg: 1.78 ± 0.039	1.383MetSer: 1.383 ± 0.031	1.241MetThr: 1.241 ± 0.033	1.502MetVal: 1.502 ± 0.036	0.207MetTrp: 0.207 ± 0.012	0.382MetTyr: 0.382 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.107AsnAla: 3.107 ± 0.054	0.198AsnCys: 0.198 ± 0.014	1.368AsnAsp: 1.368 ± 0.039	1.134AsnGlu: 1.134 ± 0.037	0.836AsnPhe: 0.836 ± 0.027	2.253AsnGly: 2.253 ± 0.057	0.55AsnHis: 0.55 ± 0.025	0.941AsnIle: 0.941 ± 0.031	0.561AsnLys: 0.561 ± 0.022	2.657AsnLeu: 2.657 ± 0.061	0.419AsnMet: 0.419 ± 0.019	0.629AsnAsn: 0.629 ± 0.027	1.677AsnPro: 1.677 ± 0.044	0.802AsnGln: 0.802 ± 0.03	1.65AsnArg: 1.65 ± 0.042	1.001AsnSer: 1.001 ± 0.032	1.251AsnThr: 1.251 ± 0.042	1.79AsnVal: 1.79 ± 0.042	0.399AsnTrp: 0.399 ± 0.022	0.675AsnTyr: 0.675 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.802ProAla: 7.802 ± 0.099	0.395ProCys: 0.395 ± 0.02	3.548ProAsp: 3.548 ± 0.065	3.046ProGlu: 3.046 ± 0.062	1.786ProPhe: 1.786 ± 0.043	5.15ProGly: 5.15 ± 0.067	1.321ProHis: 1.321 ± 0.037	1.837ProIle: 1.837 ± 0.036	1.334ProLys: 1.334 ± 0.039	5.61ProLeu: 5.61 ± 0.081	1.362ProMet: 1.362 ± 0.031	1.198ProAsn: 1.198 ± 0.039	3.287ProPro: 3.287 ± 0.082	2.218ProGln: 2.218 ± 0.047	3.686ProArg: 3.686 ± 0.065	2.769ProSer: 2.769 ± 0.05	2.502ProThr: 2.502 ± 0.046	4.254ProVal: 4.254 ± 0.066	0.927ProTrp: 0.927 ± 0.034	1.277ProTyr: 1.277 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.658GlnAla: 5.658 ± 0.079	0.246GlnCys: 0.246 ± 0.015	1.579GlnAsp: 1.579 ± 0.042	1.387GlnGlu: 1.387 ± 0.04	1.104GlnPhe: 1.104 ± 0.034	3.01GlnGly: 3.01 ± 0.057	0.974GlnHis: 0.974 ± 0.026	1.418GlnIle: 1.418 ± 0.038	0.9GlnLys: 0.9 ± 0.028	4.484GlnLeu: 4.484 ± 0.068	0.815GlnMet: 0.815 ± 0.029	0.716GlnAsn: 0.716 ± 0.028	2.39GlnPro: 2.39 ± 0.048	1.841GlnGln: 1.841 ± 0.047	3.467GlnArg: 3.467 ± 0.071	1.81GlnSer: 1.81 ± 0.04	1.613GlnThr: 1.613 ± 0.045	3.079GlnVal: 3.079 ± 0.054	0.615GlnTrp: 0.615 ± 0.024	0.812GlnTyr: 0.812 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.978ArgAla: 8.978 ± 0.112	0.652ArgCys: 0.652 ± 0.025	4.138ArgAsp: 4.138 ± 0.067	4.82ArgGlu: 4.82 ± 0.079	2.861ArgPhe: 2.861 ± 0.055	5.471ArgGly: 5.471 ± 0.067	2.295ArgHis: 2.295 ± 0.046	3.456ArgIle: 3.456 ± 0.055	2.07ArgLys: 2.07 ± 0.05	9.079ArgLeu: 9.079 ± 0.119	1.964ArgMet: 1.964 ± 0.042	1.804ArgAsn: 1.804 ± 0.038	3.741ArgPro: 3.741 ± 0.065	3.309ArgGln: 3.309 ± 0.064	6.456ArgArg: 6.456 ± 0.097	3.624ArgSer: 3.624 ± 0.064	3.382ArgThr: 3.382 ± 0.056	5.52ArgVal: 5.52 ± 0.074	1.529ArgTrp: 1.529 ± 0.038	2.249ArgTyr: 2.249 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.012SerAla: 6.012 ± 0.083	0.395SerCys: 0.395 ± 0.017	2.648SerAsp: 2.648 ± 0.048	2.371SerGlu: 2.371 ± 0.05	1.888SerPhe: 1.888 ± 0.043	5.015SerGly: 5.015 ± 0.104	1.292SerHis: 1.292 ± 0.034	2.122SerIle: 2.122 ± 0.036	1.248SerLys: 1.248 ± 0.043	5.507SerLeu: 5.507 ± 0.075	1.225SerMet: 1.225 ± 0.036	1.314SerAsn: 1.314 ± 0.039	2.825SerPro: 2.825 ± 0.052	1.735SerGln: 1.735 ± 0.043	3.556SerArg: 3.556 ± 0.06	2.772SerSer: 2.772 ± 0.071	2.615SerThr: 2.615 ± 0.056	3.551SerVal: 3.551 ± 0.056	0.793SerTrp: 0.793 ± 0.029	1.348SerTyr: 1.348 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.791ThrAla: 5.791 ± 0.065	0.384ThrCys: 0.384 ± 0.019	2.596ThrAsp: 2.596 ± 0.066	2.076ThrGlu: 2.076 ± 0.04	1.607ThrPhe: 1.607 ± 0.04	4.549ThrGly: 4.549 ± 0.083	1.206ThrHis: 1.206 ± 0.032	2.074ThrIle: 2.074 ± 0.048	0.928ThrLys: 0.928 ± 0.03	6.312ThrLeu: 6.312 ± 0.117	0.898ThrMet: 0.898 ± 0.028	1.018ThrAsn: 1.018 ± 0.032	3.333ThrPro: 3.333 ± 0.057	1.641ThrGln: 1.641 ± 0.035	3.514ThrArg: 3.514 ± 0.055	2.39ThrSer: 2.39 ± 0.062	2.478ThrThr: 2.478 ± 0.067	4.02ThrVal: 4.02 ± 0.076	0.7ThrTrp: 0.7 ± 0.027	1.135ThrTyr: 1.135 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.614ValAla: 9.614 ± 0.101	0.66ValCys: 0.66 ± 0.027	4.498ValAsp: 4.498 ± 0.067	4.063ValGlu: 4.063 ± 0.074	2.514ValPhe: 2.514 ± 0.052	5.635ValGly: 5.635 ± 0.069	1.792ValHis: 1.792 ± 0.042	3.145ValIle: 3.145 ± 0.061	1.767ValLys: 1.767 ± 0.039	8.627ValLeu: 8.627 ± 0.096	1.576ValMet: 1.576 ± 0.041	1.884ValAsn: 1.884 ± 0.051	4.104ValPro: 4.104 ± 0.068	2.528ValGln: 2.528 ± 0.049	5.663ValArg: 5.663 ± 0.092	3.89ValSer: 3.89 ± 0.067	3.823ValThr: 3.823 ± 0.085	5.926ValVal: 5.926 ± 0.076	0.91ValTrp: 0.91 ± 0.032	1.623ValTyr: 1.623 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.322TrpAla: 1.322 ± 0.034	0.164TrpCys: 0.164 ± 0.013	0.703TrpAsp: 0.703 ± 0.023	0.545TrpGlu: 0.545 ± 0.024	0.599TrpPhe: 0.599 ± 0.024	0.967TrpGly: 0.967 ± 0.03	0.492TrpHis: 0.492 ± 0.023	0.683TrpIle: 0.683 ± 0.023	0.444TrpLys: 0.444 ± 0.021	2.434TrpLeu: 2.434 ± 0.052	0.42TrpMet: 0.42 ± 0.023	0.52TrpAsn: 0.52 ± 0.021	0.838TrpPro: 0.838 ± 0.031	0.809TrpGln: 0.809 ± 0.028	1.499TrpArg: 1.499 ± 0.046	0.923TrpSer: 0.923 ± 0.027	0.724TrpThr: 0.724 ± 0.029	0.986TrpVal: 0.986 ± 0.034	0.307TrpTrp: 0.307 ± 0.019	0.379TrpTyr: 0.379 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.1TyrAla: 3.1 ± 0.062	0.219TyrCys: 0.219 ± 0.014	1.421TyrAsp: 1.421 ± 0.037	1.115TyrGlu: 1.115 ± 0.03	0.919TyrPhe: 0.919 ± 0.03	2.264TyrGly: 2.264 ± 0.052	0.553TyrHis: 0.553 ± 0.022	0.667TyrIle: 0.667 ± 0.027	0.563TyrLys: 0.563 ± 0.022	2.625TyrLeu: 2.625 ± 0.056	0.396TyrMet: 0.396 ± 0.02	0.609TyrAsn: 0.609 ± 0.029	1.216TyrPro: 1.216 ± 0.036	0.908TyrGln: 0.908 ± 0.031	2.217TyrArg: 2.217 ± 0.047	1.12TyrSer: 1.12 ± 0.034	1.208TyrThr: 1.208 ± 0.037	1.898TyrVal: 1.898 ± 0.042	0.419TyrTrp: 0.419 ± 0.021	0.73TyrTyr: 0.73 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3427 proteins (1139055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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