Amino acid dipepetide frequency for Aquimarina sp. RZ0

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.625AlaAla: 3.625 ± 0.061
0.522AlaCys: 0.522 ± 0.019
2.97AlaAsp: 2.97 ± 0.047
3.216AlaGlu: 3.216 ± 0.057
2.849AlaPhe: 2.849 ± 0.046
3.793AlaGly: 3.793 ± 0.063
1.011AlaHis: 1.011 ± 0.023
5.283AlaIle: 5.283 ± 0.058
4.059AlaLys: 4.059 ± 0.061
5.347AlaLeu: 5.347 ± 0.06
1.231AlaMet: 1.231 ± 0.029
3.206AlaAsn: 3.206 ± 0.043
1.78AlaPro: 1.78 ± 0.032
2.075AlaGln: 2.075 ± 0.042
1.857AlaArg: 1.857 ± 0.038
4.086AlaSer: 4.086 ± 0.055
3.739AlaThr: 3.739 ± 0.073
3.489AlaVal: 3.489 ± 0.05
0.519AlaTrp: 0.519 ± 0.017
2.323AlaTyr: 2.323 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.428CysAla: 0.428 ± 0.014
0.121CysCys: 0.121 ± 0.007
0.445CysAsp: 0.445 ± 0.022
0.458CysGlu: 0.458 ± 0.016
0.428CysPhe: 0.428 ± 0.015
0.579CysGly: 0.579 ± 0.021
0.179CysHis: 0.179 ± 0.01
0.702CysIle: 0.702 ± 0.022
0.526CysLys: 0.526 ± 0.017
0.649CysLeu: 0.649 ± 0.02
0.14CysMet: 0.14 ± 0.008
0.477CysAsn: 0.477 ± 0.017
0.294CysPro: 0.294 ± 0.015
0.253CysGln: 0.253 ± 0.011
0.245CysArg: 0.245 ± 0.01
0.643CysSer: 0.643 ± 0.022
0.481CysThr: 0.481 ± 0.016
0.428CysVal: 0.428 ± 0.015
0.078CysTrp: 0.078 ± 0.006
0.368CysTyr: 0.368 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.423AspAla: 3.423 ± 0.049
0.449AspCys: 0.449 ± 0.018
3.067AspAsp: 3.067 ± 0.062
3.295AspGlu: 3.295 ± 0.051
3.735AspPhe: 3.735 ± 0.058
3.991AspGly: 3.991 ± 0.092
1.074AspHis: 1.074 ± 0.024
5.296AspIle: 5.296 ± 0.056
3.913AspLys: 3.913 ± 0.059
5.098AspLeu: 5.098 ± 0.057
1.053AspMet: 1.053 ± 0.025
3.333AspAsn: 3.333 ± 0.06
2.131AspPro: 2.131 ± 0.045
2.124AspGln: 2.124 ± 0.036
2.02AspArg: 2.02 ± 0.037
3.362AspSer: 3.362 ± 0.054
3.563AspThr: 3.563 ± 0.074
3.293AspVal: 3.293 ± 0.048
0.808AspTrp: 0.808 ± 0.023
2.595AspTyr: 2.595 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
3.769GluAla: 3.769 ± 0.054
0.37GluCys: 0.37 ± 0.017
3.577GluAsp: 3.577 ± 0.046
5.042GluGlu: 5.042 ± 0.073
2.869GluPhe: 2.869 ± 0.039
3.565GluGly: 3.565 ± 0.047
1.075GluHis: 1.075 ± 0.025
5.912GluIle: 5.912 ± 0.069
5.84GluLys: 5.84 ± 0.082
6.072GluLeu: 6.072 ± 0.077
1.322GluMet: 1.322 ± 0.029
4.664GluAsn: 4.664 ± 0.06
1.425GluPro: 1.425 ± 0.029
2.262GluGln: 2.262 ± 0.039
2.333GluArg: 2.333 ± 0.038
3.47GluSer: 3.47 ± 0.046
3.521GluThr: 3.521 ± 0.046
4.073GluVal: 4.073 ± 0.049
0.582GluTrp: 0.582 ± 0.018
2.66GluTyr: 2.66 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
2.545PheAla: 2.545 ± 0.041
0.465PheCys: 0.465 ± 0.016
3.443PheAsp: 3.443 ± 0.051
3.207PheGlu: 3.207 ± 0.048
2.84PhePhe: 2.84 ± 0.047
3.382PheGly: 3.382 ± 0.05
0.782PheHis: 0.782 ± 0.019
4.126PheIle: 4.126 ± 0.042
3.484PheLys: 3.484 ± 0.043
4.549PheLeu: 4.549 ± 0.065
1.043PheMet: 1.043 ± 0.028
3.154PheAsn: 3.154 ± 0.042
1.697PhePro: 1.697 ± 0.032
1.498PheGln: 1.498 ± 0.031
1.854PheArg: 1.854 ± 0.027
4.227PheSer: 4.227 ± 0.05
3.244PheThr: 3.244 ± 0.047
2.787PheVal: 2.787 ± 0.038
0.593PheTrp: 0.593 ± 0.019
2.19PheTyr: 2.19 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
3.97GlyAla: 3.97 ± 0.107
0.6GlyCys: 0.6 ± 0.018
3.64GlyAsp: 3.64 ± 0.06
3.576GlyGlu: 3.576 ± 0.045
3.586GlyPhe: 3.586 ± 0.052
4.637GlyGly: 4.637 ± 0.072
1.076GlyHis: 1.076 ± 0.024
5.817GlyIle: 5.817 ± 0.07
4.552GlyLys: 4.552 ± 0.061
5.261GlyLeu: 5.261 ± 0.055
1.412GlyMet: 1.412 ± 0.031
4.104GlyAsn: 4.104 ± 0.068
1.269GlyPro: 1.269 ± 0.028
1.813GlyGln: 1.813 ± 0.034
2.162GlyArg: 2.162 ± 0.037
4.26GlySer: 4.26 ± 0.06
4.206GlyThr: 4.206 ± 0.063
4.41GlyVal: 4.41 ± 0.064
0.747GlyTrp: 0.747 ± 0.018
2.814GlyTyr: 2.814 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
0.868HisAla: 0.868 ± 0.023
0.206HisCys: 0.206 ± 0.011
0.763HisAsp: 0.763 ± 0.021
0.864HisGlu: 0.864 ± 0.022
1.026HisPhe: 1.026 ± 0.02
1.025HisGly: 1.025 ± 0.028
0.498HisHis: 0.498 ± 0.018
1.647HisIle: 1.647 ± 0.034
1.431HisLys: 1.431 ± 0.028
1.665HisLeu: 1.665 ± 0.029
0.354HisMet: 0.354 ± 0.014
0.985HisAsn: 0.985 ± 0.021
0.815HisPro: 0.815 ± 0.021
0.81HisGln: 0.81 ± 0.024
0.693HisArg: 0.693 ± 0.018
1.14HisSer: 1.14 ± 0.024
1.151HisThr: 1.151 ± 0.026
0.794HisVal: 0.794 ± 0.022
0.243HisTrp: 0.243 ± 0.012
0.816HisTyr: 0.816 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.461IleAla: 5.461 ± 0.065
0.722IleCys: 0.722 ± 0.02
5.54IleAsp: 5.54 ± 0.063
5.965IleGlu: 5.965 ± 0.062
3.716IlePhe: 3.716 ± 0.052
5.273IleGly: 5.273 ± 0.06
1.636IleHis: 1.636 ± 0.029
6.761IleIle: 6.761 ± 0.064
6.617IleLys: 6.617 ± 0.064
7.486IleLeu: 7.486 ± 0.075
1.342IleMet: 1.342 ± 0.03
5.397IleAsn: 5.397 ± 0.061
3.502IlePro: 3.502 ± 0.044
2.962IleGln: 2.962 ± 0.046
3.026IleArg: 3.026 ± 0.044
6.575IleSer: 6.575 ± 0.067
5.676IleThr: 5.676 ± 0.067
4.784IleVal: 4.784 ± 0.058
0.794IleTrp: 0.794 ± 0.023
3.081IleTyr: 3.081 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.217LysAla: 4.217 ± 0.061
0.355LysCys: 0.355 ± 0.014
4.272LysAsp: 4.272 ± 0.058
6.583LysGlu: 6.583 ± 0.085
2.715LysPhe: 2.715 ± 0.05
4.492LysGly: 4.492 ± 0.053
1.289LysHis: 1.289 ± 0.03
6.71LysIle: 6.71 ± 0.077
7.875LysLys: 7.875 ± 0.093
6.308LysLeu: 6.308 ± 0.066
1.732LysMet: 1.732 ± 0.031
5.769LysAsn: 5.769 ± 0.071
2.264LysPro: 2.264 ± 0.038
2.594LysGln: 2.594 ± 0.043
2.908LysArg: 2.908 ± 0.044
4.623LysSer: 4.623 ± 0.054
4.794LysThr: 4.794 ± 0.049
4.357LysVal: 4.357 ± 0.047
0.781LysTrp: 0.781 ± 0.022
2.956LysTyr: 2.956 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
4.91LeuAla: 4.91 ± 0.06
0.72LeuCys: 0.72 ± 0.019
5.247LeuAsp: 5.247 ± 0.068
5.938LeuGlu: 5.938 ± 0.066
4.726LeuPhe: 4.726 ± 0.06
5.562LeuGly: 5.562 ± 0.06
1.586LeuHis: 1.586 ± 0.033
7.214LeuIle: 7.214 ± 0.078
7.335LeuLys: 7.335 ± 0.074
8.544LeuLeu: 8.544 ± 0.091
1.842LeuMet: 1.842 ± 0.03
5.016LeuAsn: 5.016 ± 0.06
3.313LeuPro: 3.313 ± 0.041
3.404LeuGln: 3.404 ± 0.055
3.18LeuArg: 3.18 ± 0.045
6.974LeuSer: 6.974 ± 0.069
5.028LeuThr: 5.028 ± 0.054
4.896LeuVal: 4.896 ± 0.058
0.872LeuTrp: 0.872 ± 0.025
3.363LeuTyr: 3.363 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
1.285MetAla: 1.285 ± 0.025
0.128MetCys: 0.128 ± 0.008
1.069MetAsp: 1.069 ± 0.024
1.173MetGlu: 1.173 ± 0.028
0.742MetPhe: 0.742 ± 0.02
1.217MetGly: 1.217 ± 0.031
0.362MetHis: 0.362 ± 0.016
1.666MetIle: 1.666 ± 0.029
1.944MetLys: 1.944 ± 0.033
1.714MetLeu: 1.714 ± 0.037
0.498MetMet: 0.498 ± 0.019
1.289MetAsn: 1.289 ± 0.024
0.732MetPro: 0.732 ± 0.021
0.683MetGln: 0.683 ± 0.02
0.779MetArg: 0.779 ± 0.022
1.272MetSer: 1.272 ± 0.027
1.086MetThr: 1.086 ± 0.023
1.113MetVal: 1.113 ± 0.029
0.158MetTrp: 0.158 ± 0.01
0.726MetTyr: 0.726 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.525AsnAla: 3.525 ± 0.045
0.488AsnCys: 0.488 ± 0.018
3.597AsnAsp: 3.597 ± 0.051
3.549AsnGlu: 3.549 ± 0.047
3.158AsnPhe: 3.158 ± 0.048
4.256AsnGly: 4.256 ± 0.07
1.16AsnHis: 1.16 ± 0.025
5.248AsnIle: 5.248 ± 0.064
4.507AsnLys: 4.507 ± 0.064
5.321AsnLeu: 5.321 ± 0.066
1.176AsnMet: 1.176 ± 0.025
4.269AsnAsn: 4.269 ± 0.071
2.84AsnPro: 2.84 ± 0.039
2.458AsnGln: 2.458 ± 0.044
2.399AsnArg: 2.399 ± 0.034
4.127AsnSer: 4.127 ± 0.049
4.394AsnThr: 4.394 ± 0.063
3.24AsnVal: 3.24 ± 0.048
0.835AsnTrp: 0.835 ± 0.022
2.693AsnTyr: 2.693 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
1.784ProAla: 1.784 ± 0.036
0.21ProCys: 0.21 ± 0.012
2.351ProAsp: 2.351 ± 0.047
2.733ProGlu: 2.733 ± 0.042
1.807ProPhe: 1.807 ± 0.03
2.082ProGly: 2.082 ± 0.042
0.548ProHis: 0.548 ± 0.016
2.847ProIle: 2.847 ± 0.04
2.374ProLys: 2.374 ± 0.04
2.8ProLeu: 2.8 ± 0.035
0.61ProMet: 0.61 ± 0.019
2.281ProAsn: 2.281 ± 0.042
0.927ProPro: 0.927 ± 0.028
1.065ProGln: 1.065 ± 0.023
0.96ProArg: 0.96 ± 0.024
2.292ProSer: 2.292 ± 0.04
2.002ProThr: 2.002 ± 0.04
2.269ProVal: 2.269 ± 0.044
0.368ProTrp: 0.368 ± 0.014
1.329ProTyr: 1.329 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
1.78GlnAla: 1.78 ± 0.034
0.234GlnCys: 0.234 ± 0.013
1.739GlnAsp: 1.739 ± 0.028
2.632GlnGlu: 2.632 ± 0.043
1.597GlnPhe: 1.597 ± 0.032
2.052GlnGly: 2.052 ± 0.068
0.612GlnHis: 0.612 ± 0.018
2.758GlnIle: 2.758 ± 0.039
3.15GlnLys: 3.15 ± 0.052
3.468GlnLeu: 3.468 ± 0.05
0.73GlnMet: 0.73 ± 0.019
2.32GlnAsn: 2.32 ± 0.042
0.977GlnPro: 0.977 ± 0.022
1.505GlnGln: 1.505 ± 0.033
1.271GlnArg: 1.271 ± 0.027
2.084GlnSer: 2.084 ± 0.03
1.838GlnThr: 1.838 ± 0.029
1.969GlnVal: 1.969 ± 0.034
0.424GlnTrp: 0.424 ± 0.016
1.507GlnTyr: 1.507 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
1.909ArgAla: 1.909 ± 0.036
0.236ArgCys: 0.236 ± 0.011
1.921ArgAsp: 1.921 ± 0.033
2.202ArgGlu: 2.202 ± 0.036
1.95ArgPhe: 1.95 ± 0.031
2.023ArgGly: 2.023 ± 0.03
0.591ArgHis: 0.591 ± 0.016
3.267ArgIle: 3.267 ± 0.047
2.946ArgLys: 2.946 ± 0.044
3.382ArgLeu: 3.382 ± 0.051
0.831ArgMet: 0.831 ± 0.022
2.304ArgAsn: 2.304 ± 0.038
1.073ArgPro: 1.073 ± 0.024
1.089ArgGln: 1.089 ± 0.025
1.34ArgArg: 1.34 ± 0.029
2.192ArgSer: 2.192 ± 0.037
1.889ArgThr: 1.889 ± 0.033
2.096ArgVal: 2.096 ± 0.037
0.461ArgTrp: 0.461 ± 0.015
1.668ArgTyr: 1.668 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
3.465SerAla: 3.465 ± 0.045
0.77SerCys: 0.77 ± 0.026
3.896SerAsp: 3.896 ± 0.064
4.138SerGlu: 4.138 ± 0.05
4.125SerPhe: 4.125 ± 0.043
5.049SerGly: 5.049 ± 0.06
1.11SerHis: 1.11 ± 0.027
6.149SerIle: 6.149 ± 0.068
5.03SerLys: 5.03 ± 0.059
6.286SerLeu: 6.286 ± 0.071
1.261SerMet: 1.261 ± 0.027
4.238SerAsn: 4.238 ± 0.057
2.155SerPro: 2.155 ± 0.035
2.227SerGln: 2.227 ± 0.034
2.319SerArg: 2.319 ± 0.037
4.812SerSer: 4.812 ± 0.068
3.735SerThr: 3.735 ± 0.054
3.925SerVal: 3.925 ± 0.051
0.762SerTrp: 0.762 ± 0.023
3.009SerTyr: 3.009 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
3.688ThrAla: 3.688 ± 0.058
0.369ThrCys: 0.369 ± 0.014
3.593ThrAsp: 3.593 ± 0.065
3.508ThrGlu: 3.508 ± 0.051
3.062ThrPhe: 3.062 ± 0.039
4.326ThrGly: 4.326 ± 0.103
1.095ThrHis: 1.095 ± 0.027
5.916ThrIle: 5.916 ± 0.061
4.104ThrLys: 4.104 ± 0.05
5.305ThrLeu: 5.305 ± 0.047
0.955ThrMet: 0.955 ± 0.021
3.706ThrAsn: 3.706 ± 0.055
2.667ThrPro: 2.667 ± 0.037
1.957ThrGln: 1.957 ± 0.032
1.889ThrArg: 1.889 ± 0.031
4.311ThrSer: 4.311 ± 0.054
3.967ThrThr: 3.967 ± 0.06
3.68ThrVal: 3.68 ± 0.067
0.626ThrTrp: 0.626 ± 0.02
2.598ThrTyr: 2.598 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
3.546ValAla: 3.546 ± 0.045
0.486ValCys: 0.486 ± 0.017
3.403ValAsp: 3.403 ± 0.052
3.242ValGlu: 3.242 ± 0.046
3.241ValPhe: 3.241 ± 0.049
3.385ValGly: 3.385 ± 0.05
1.002ValHis: 1.002 ± 0.023
4.93ValIle: 4.93 ± 0.059
3.864ValLys: 3.864 ± 0.049
5.661ValLeu: 5.661 ± 0.066
1.161ValMet: 1.161 ± 0.027
3.378ValAsn: 3.378 ± 0.052
2.053ValPro: 2.053 ± 0.036
1.748ValGln: 1.748 ± 0.03
1.939ValArg: 1.939 ± 0.034
4.629ValSer: 4.629 ± 0.06
3.787ValThr: 3.787 ± 0.061
3.684ValVal: 3.684 ± 0.056
0.586ValTrp: 0.586 ± 0.018
2.314ValTyr: 2.314 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.549TrpAla: 0.549 ± 0.017
0.11TrpCys: 0.11 ± 0.008
0.663TrpAsp: 0.663 ± 0.022
0.708TrpGlu: 0.708 ± 0.02
0.567TrpPhe: 0.567 ± 0.018
0.689TrpGly: 0.689 ± 0.018
0.224TrpHis: 0.224 ± 0.012
0.883TrpIle: 0.883 ± 0.021
0.881TrpLys: 0.881 ± 0.024
0.953TrpLeu: 0.953 ± 0.021
0.283TrpMet: 0.283 ± 0.014
0.785TrpAsn: 0.785 ± 0.023
0.231TrpPro: 0.231 ± 0.012
0.423TrpGln: 0.423 ± 0.016
0.43TrpArg: 0.43 ± 0.015
0.727TrpSer: 0.727 ± 0.023
0.563TrpThr: 0.563 ± 0.019
0.627TrpVal: 0.627 ± 0.02
0.165TrpTrp: 0.165 ± 0.01
0.45TrpTyr: 0.45 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.232TyrAla: 2.232 ± 0.036
0.361TyrCys: 0.361 ± 0.013
2.427TyrAsp: 2.427 ± 0.036
2.376TyrGlu: 2.376 ± 0.036
2.373TyrPhe: 2.373 ± 0.038
2.531TyrGly: 2.531 ± 0.04
0.882TyrHis: 0.882 ± 0.021
3.186TyrIle: 3.186 ± 0.043
3.162TyrLys: 3.162 ± 0.05
3.801TyrLeu: 3.801 ± 0.05
0.658TyrMet: 0.658 ± 0.02
2.565TyrAsn: 2.565 ± 0.042
1.495TyrPro: 1.495 ± 0.03
1.694TyrGln: 1.694 ± 0.034
1.767TyrArg: 1.767 ± 0.031
2.655TyrSer: 2.655 ± 0.039
2.658TyrThr: 2.658 ± 0.04
2.126TyrVal: 2.126 ± 0.038
0.51TyrTrp: 0.51 ± 0.019
1.953TyrTyr: 1.953 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5315 proteins (1900794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski