Amino acid dipepetide frequency for Oceanospirillales bacterium LUC14_002_19_P2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.519AlaAla: 8.519 ± 0.124	1.237AlaCys: 1.237 ± 0.047	5.374AlaAsp: 5.374 ± 0.095	5.794AlaGlu: 5.794 ± 0.092	3.437AlaPhe: 3.437 ± 0.083	7.569AlaGly: 7.569 ± 0.169	1.723AlaHis: 1.723 ± 0.048	5.898AlaIle: 5.898 ± 0.085	3.237AlaLys: 3.237 ± 0.073	10.14AlaLeu: 10.14 ± 0.138	3.034AlaMet: 3.034 ± 0.069	2.878AlaAsn: 2.878 ± 0.069	3.208AlaPro: 3.208 ± 0.076	3.272AlaGln: 3.272 ± 0.062	5.302AlaArg: 5.302 ± 0.085	5.55AlaSer: 5.55 ± 0.105	4.693AlaThr: 4.693 ± 0.087	6.614AlaVal: 6.614 ± 0.096	1.221AlaTrp: 1.221 ± 0.043	2.304AlaTyr: 2.304 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.036	0.194CysCys: 0.194 ± 0.017	0.624CysAsp: 0.624 ± 0.026	0.601CysGlu: 0.601 ± 0.028	0.454CysPhe: 0.454 ± 0.023	0.961CysGly: 0.961 ± 0.036	0.363CysHis: 0.363 ± 0.023	0.608CysIle: 0.608 ± 0.032	0.356CysLys: 0.356 ± 0.021	1.22CysLeu: 1.22 ± 0.043	0.267CysMet: 0.267 ± 0.016	0.387CysAsn: 0.387 ± 0.021	0.581CysPro: 0.581 ± 0.027	0.534CysGln: 0.534 ± 0.024	0.815CysArg: 0.815 ± 0.03	0.76CysSer: 0.76 ± 0.032	0.479CysThr: 0.479 ± 0.024	0.686CysVal: 0.686 ± 0.034	0.153CysTrp: 0.153 ± 0.015	0.35CysTyr: 0.35 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.129AspAla: 5.129 ± 0.095	0.654AspCys: 0.654 ± 0.03	3.693AspAsp: 3.693 ± 0.109	3.853AspGlu: 3.853 ± 0.066	2.259AspPhe: 2.259 ± 0.057	4.274AspGly: 4.274 ± 0.122	1.363AspHis: 1.363 ± 0.047	3.947AspIle: 3.947 ± 0.071	2.438AspLys: 2.438 ± 0.057	5.372AspLeu: 5.372 ± 0.083	1.59AspMet: 1.59 ± 0.036	2.446AspAsn: 2.446 ± 0.079	2.482AspPro: 2.482 ± 0.057	2.535AspGln: 2.535 ± 0.068	3.435AspArg: 3.435 ± 0.06	3.354AspSer: 3.354 ± 0.081	3.223AspThr: 3.223 ± 0.139	3.987AspVal: 3.987 ± 0.088	0.93AspTrp: 0.93 ± 0.032	1.981AspTyr: 1.981 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.031GluAla: 6.031 ± 0.094	0.548GluCys: 0.548 ± 0.025	2.986GluAsp: 2.986 ± 0.065	3.872GluGlu: 3.872 ± 0.098	1.865GluPhe: 1.865 ± 0.05	4.094GluGly: 4.094 ± 0.079	1.602GluHis: 1.602 ± 0.043	3.328GluIle: 3.328 ± 0.07	3.331GluLys: 3.331 ± 0.078	6.276GluLeu: 6.276 ± 0.095	1.545GluMet: 1.545 ± 0.045	2.357GluAsn: 2.357 ± 0.052	2.502GluPro: 2.502 ± 0.055	3.883GluGln: 3.883 ± 0.072	3.885GluArg: 3.885 ± 0.079	3.728GluSer: 3.728 ± 0.071	3.772GluThr: 3.772 ± 0.066	3.892GluVal: 3.892 ± 0.068	0.727GluTrp: 0.727 ± 0.03	1.576GluTyr: 1.576 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.977PheAla: 2.977 ± 0.063	0.468PheCys: 0.468 ± 0.022	2.404PheAsp: 2.404 ± 0.054	2.072PheGlu: 2.072 ± 0.049	1.502PhePhe: 1.502 ± 0.045	2.861PheGly: 2.861 ± 0.062	0.826PheHis: 0.826 ± 0.035	2.166PheIle: 2.166 ± 0.045	1.235PheLys: 1.235 ± 0.047	3.53PheLeu: 3.53 ± 0.066	1.022PheMet: 1.022 ± 0.035	1.558PheAsn: 1.558 ± 0.047	1.467PhePro: 1.467 ± 0.043	1.378PheGln: 1.378 ± 0.039	2.104PheArg: 2.104 ± 0.051	2.864PheSer: 2.864 ± 0.061	2.228PheThr: 2.228 ± 0.051	2.407PheVal: 2.407 ± 0.063	0.543PheTrp: 0.543 ± 0.027	1.231PheTyr: 1.231 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.709GlyAla: 5.709 ± 0.129	1.097GlyCys: 1.097 ± 0.036	4.149GlyAsp: 4.149 ± 0.145	4.485GlyGlu: 4.485 ± 0.066	3.164GlyPhe: 3.164 ± 0.062	5.491GlyGly: 5.491 ± 0.17	1.818GlyHis: 1.818 ± 0.038	4.956GlyIle: 4.956 ± 0.075	3.651GlyLys: 3.651 ± 0.066	7.623GlyLeu: 7.623 ± 0.109	2.372GlyMet: 2.372 ± 0.054	2.851GlyAsn: 2.851 ± 0.09	1.905GlyPro: 1.905 ± 0.055	3.272GlyGln: 3.272 ± 0.063	4.172GlyArg: 4.172 ± 0.08	4.461GlySer: 4.461 ± 0.145	3.874GlyThr: 3.874 ± 0.11	5.368GlyVal: 5.368 ± 0.105	1.106GlyTrp: 1.106 ± 0.041	2.486GlyTyr: 2.486 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.82HisAla: 1.82 ± 0.043	0.388HisCys: 0.388 ± 0.023	1.251HisAsp: 1.251 ± 0.044	1.297HisGlu: 1.297 ± 0.039	1.084HisPhe: 1.084 ± 0.037	1.676HisGly: 1.676 ± 0.045	0.734HisHis: 0.734 ± 0.034	1.33HisIle: 1.33 ± 0.044	0.797HisLys: 0.797 ± 0.034	2.3HisLeu: 2.3 ± 0.053	0.57HisMet: 0.57 ± 0.024	0.809HisAsn: 0.809 ± 0.034	1.321HisPro: 1.321 ± 0.046	1.124HisGln: 1.124 ± 0.039	1.398HisArg: 1.398 ± 0.046	1.274HisSer: 1.274 ± 0.038	1.211HisThr: 1.211 ± 0.039	1.316HisVal: 1.316 ± 0.04	0.373HisTrp: 0.373 ± 0.022	0.912HisTyr: 0.912 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.88IleAla: 5.88 ± 0.088	0.646IleCys: 0.646 ± 0.027	3.769IleAsp: 3.769 ± 0.075	3.585IleGlu: 3.585 ± 0.068	1.635IlePhe: 1.635 ± 0.044	4.367IleGly: 4.367 ± 0.082	1.332IleHis: 1.332 ± 0.04	3.086IleIle: 3.086 ± 0.066	2.262IleLys: 2.262 ± 0.058	5.156IleLeu: 5.156 ± 0.083	1.264IleMet: 1.264 ± 0.039	2.569IleAsn: 2.569 ± 0.052	2.905IlePro: 2.905 ± 0.068	2.234IleGln: 2.234 ± 0.052	3.967IleArg: 3.967 ± 0.072	3.637IleSer: 3.637 ± 0.059	3.709IleThr: 3.709 ± 0.089	3.608IleVal: 3.608 ± 0.064	0.592IleTrp: 0.592 ± 0.029	1.475IleTyr: 1.475 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.228LysAla: 4.228 ± 0.084	0.246LysCys: 0.246 ± 0.017	2.224LysAsp: 2.224 ± 0.054	2.461LysGlu: 2.461 ± 0.061	0.915LysPhe: 0.915 ± 0.034	2.981LysGly: 2.981 ± 0.071	0.936LysHis: 0.936 ± 0.032	1.945LysIle: 1.945 ± 0.055	2.087LysLys: 2.087 ± 0.066	3.994LysLeu: 3.994 ± 0.076	0.952LysMet: 0.952 ± 0.037	1.446LysAsn: 1.446 ± 0.045	2.311LysPro: 2.311 ± 0.056	2.084LysGln: 2.084 ± 0.05	2.424LysArg: 2.424 ± 0.06	2.217LysSer: 2.217 ± 0.051	2.714LysThr: 2.714 ± 0.057	2.893LysVal: 2.893 ± 0.066	0.372LysTrp: 0.372 ± 0.019	0.979LysTyr: 0.979 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	10.421LeuAla: 10.421 ± 0.137	1.198LeuCys: 1.198 ± 0.037	6.189LeuAsp: 6.189 ± 0.089	6.516LeuGlu: 6.516 ± 0.096	4.09LeuPhe: 4.09 ± 0.082	7.264LeuGly: 7.264 ± 0.096	2.164LeuHis: 2.164 ± 0.06	5.612LeuIle: 5.612 ± 0.086	4.918LeuLys: 4.918 ± 0.078	11.477LeuLeu: 11.477 ± 0.17	2.926LeuMet: 2.926 ± 0.062	3.934LeuAsn: 3.934 ± 0.07	5.25LeuPro: 5.25 ± 0.09	4.251LeuGln: 4.251 ± 0.08	5.565LeuArg: 5.565 ± 0.085	7.532LeuSer: 7.532 ± 0.1	6.103LeuThr: 6.103 ± 0.092	7.327LeuVal: 7.327 ± 0.104	1.184LeuTrp: 1.184 ± 0.04	2.637LeuTyr: 2.637 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.997MetAla: 2.997 ± 0.057	0.173MetCys: 0.173 ± 0.014	1.544MetAsp: 1.544 ± 0.041	1.554MetGlu: 1.554 ± 0.042	0.711MetPhe: 0.711 ± 0.033	1.973MetGly: 1.973 ± 0.052	0.527MetHis: 0.527 ± 0.025	1.471MetIle: 1.471 ± 0.042	1.232MetLys: 1.232 ± 0.038	2.726MetLeu: 2.726 ± 0.064	0.736MetMet: 0.736 ± 0.032	0.972MetAsn: 0.972 ± 0.029	1.496MetPro: 1.496 ± 0.041	1.096MetGln: 1.096 ± 0.038	1.333MetArg: 1.333 ± 0.046	1.876MetSer: 1.876 ± 0.055	1.898MetThr: 1.898 ± 0.043	1.996MetVal: 1.996 ± 0.05	0.17MetTrp: 0.17 ± 0.011	0.412MetTyr: 0.412 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.066	0.359AsnCys: 0.359 ± 0.02	2.306AsnAsp: 2.306 ± 0.09	1.915AsnGlu: 1.915 ± 0.046	1.098AsnPhe: 1.098 ± 0.038	2.924AsnGly: 2.924 ± 0.078	0.912AsnHis: 0.912 ± 0.033	2.055AsnIle: 2.055 ± 0.05	1.397AsnLys: 1.397 ± 0.043	3.645AsnLeu: 3.645 ± 0.062	0.836AsnMet: 0.836 ± 0.028	1.608AsnAsn: 1.608 ± 0.053	2.191AsnPro: 2.191 ± 0.049	1.678AsnGln: 1.678 ± 0.046	2.475AsnArg: 2.475 ± 0.054	1.914AsnSer: 1.914 ± 0.049	2.275AsnThr: 2.275 ± 0.066	2.169AsnVal: 2.169 ± 0.066	0.456AsnTrp: 0.456 ± 0.022	1.005AsnTyr: 1.005 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.276ProAla: 4.276 ± 0.09	0.423ProCys: 0.423 ± 0.022	3.438ProAsp: 3.438 ± 0.073	4.003ProGlu: 4.003 ± 0.077	1.713ProPhe: 1.713 ± 0.046	3.443ProGly: 3.443 ± 0.078	0.854ProHis: 0.854 ± 0.029	1.894ProIle: 1.894 ± 0.058	1.434ProLys: 1.434 ± 0.042	4.595ProLeu: 4.595 ± 0.083	1.103ProMet: 1.103 ± 0.035	1.32ProAsn: 1.32 ± 0.041	1.549ProPro: 1.549 ± 0.054	1.526ProGln: 1.526 ± 0.045	1.856ProArg: 1.856 ± 0.049	2.429ProSer: 2.429 ± 0.058	1.978ProThr: 1.978 ± 0.047	4.39ProVal: 4.39 ± 0.089	0.611ProTrp: 0.611 ± 0.027	1.164ProTyr: 1.164 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.624GlnAla: 4.624 ± 0.088	0.419GlnCys: 0.419 ± 0.026	2.069GlnAsp: 2.069 ± 0.048	2.492GlnGlu: 2.492 ± 0.055	1.485GlnPhe: 1.485 ± 0.043	3.045GlnGly: 3.045 ± 0.062	1.119GlnHis: 1.119 ± 0.042	2.186GlnIle: 2.186 ± 0.047	1.808GlnLys: 1.808 ± 0.054	4.989GlnLeu: 4.989 ± 0.09	1.162GlnMet: 1.162 ± 0.042	1.301GlnAsn: 1.301 ± 0.035	2.171GlnPro: 2.171 ± 0.067	2.895GlnGln: 2.895 ± 0.08	2.645GlnArg: 2.645 ± 0.065	2.583GlnSer: 2.583 ± 0.049	2.301GlnThr: 2.301 ± 0.046	3.178GlnVal: 3.178 ± 0.068	0.659GlnTrp: 0.659 ± 0.029	1.116GlnTyr: 1.116 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.287ArgAla: 4.287 ± 0.083	0.629ArgCys: 0.629 ± 0.031	3.357ArgAsp: 3.357 ± 0.071	4.125ArgGlu: 4.125 ± 0.073	2.687ArgPhe: 2.687 ± 0.059	3.092ArgGly: 3.092 ± 0.068	1.652ArgHis: 1.652 ± 0.043	3.69ArgIle: 3.69 ± 0.077	2.654ArgLys: 2.654 ± 0.061	6.919ArgLeu: 6.919 ± 0.114	1.617ArgMet: 1.617 ± 0.046	2.239ArgAsn: 2.239 ± 0.049	2.221ArgPro: 2.221 ± 0.059	3.303ArgGln: 3.303 ± 0.076	3.73ArgArg: 3.73 ± 0.084	3.141ArgSer: 3.141 ± 0.068	2.707ArgThr: 2.707 ± 0.054	3.819ArgVal: 3.819 ± 0.061	0.826ArgTrp: 0.826 ± 0.035	2.148ArgTyr: 2.148 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.292SerAla: 5.292 ± 0.099	0.656SerCys: 0.656 ± 0.027	3.832SerAsp: 3.832 ± 0.099	3.69SerGlu: 3.69 ± 0.068	2.309SerPhe: 2.309 ± 0.048	5.59SerGly: 5.59 ± 0.121	1.493SerHis: 1.493 ± 0.045	3.341SerIle: 3.341 ± 0.073	2.024SerLys: 2.024 ± 0.056	7.074SerLeu: 7.074 ± 0.101	1.628SerMet: 1.628 ± 0.044	2.012SerAsn: 2.012 ± 0.063	2.657SerPro: 2.657 ± 0.06	2.537SerGln: 2.537 ± 0.05	3.723SerArg: 3.723 ± 0.072	3.817SerSer: 3.817 ± 0.084	3.052SerThr: 3.052 ± 0.066	4.398SerVal: 4.398 ± 0.088	0.813SerTrp: 0.813 ± 0.031	1.58SerTyr: 1.58 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.148ThrAla: 5.148 ± 0.093	0.564ThrCys: 0.564 ± 0.026	3.28ThrAsp: 3.28 ± 0.11	3.15ThrGlu: 3.15 ± 0.065	2.005ThrPhe: 2.005 ± 0.056	5.085ThrGly: 5.085 ± 0.105	1.167ThrHis: 1.167 ± 0.038	3.38ThrIle: 3.38 ± 0.095	1.364ThrLys: 1.364 ± 0.042	7.141ThrLeu: 7.141 ± 0.12	1.205ThrMet: 1.205 ± 0.038	1.616ThrAsn: 1.616 ± 0.045	3.011ThrPro: 3.011 ± 0.063	1.854ThrGln: 1.854 ± 0.05	3.153ThrArg: 3.153 ± 0.06	3.105ThrSer: 3.105 ± 0.075	3.15ThrThr: 3.15 ± 0.104	4.416ThrVal: 4.416 ± 0.119	0.673ThrTrp: 0.673 ± 0.033	1.323ThrTyr: 1.323 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.576ValAla: 6.576 ± 0.1	0.789ValCys: 0.789 ± 0.031	4.245ValAsp: 4.245 ± 0.084	4.246ValGlu: 4.246 ± 0.073	2.728ValPhe: 2.728 ± 0.061	4.353ValGly: 4.353 ± 0.093	1.319ValHis: 1.319 ± 0.04	4.757ValIle: 4.757 ± 0.085	2.769ValLys: 2.769 ± 0.068	7.187ValLeu: 7.187 ± 0.101	2.101ValMet: 2.101 ± 0.049	2.761ValAsn: 2.761 ± 0.066	2.881ValPro: 2.881 ± 0.061	2.362ValGln: 2.362 ± 0.046	3.854ValArg: 3.854 ± 0.073	4.819ValSer: 4.819 ± 0.095	4.401ValThr: 4.401 ± 0.104	5.299ValVal: 5.299 ± 0.08	0.808ValTrp: 0.808 ± 0.033	1.852ValTyr: 1.852 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.78TrpAla: 0.78 ± 0.03	0.183TrpCys: 0.183 ± 0.016	0.602TrpAsp: 0.602 ± 0.026	0.609TrpGlu: 0.609 ± 0.027	0.574TrpPhe: 0.574 ± 0.027	0.818TrpGly: 0.818 ± 0.032	0.399TrpHis: 0.399 ± 0.023	0.643TrpIle: 0.643 ± 0.026	0.487TrpLys: 0.487 ± 0.027	1.99TrpLeu: 1.99 ± 0.059	0.368TrpMet: 0.368 ± 0.018	0.473TrpAsn: 0.473 ± 0.026	0.544TrpPro: 0.544 ± 0.028	0.921TrpGln: 0.921 ± 0.034	0.873TrpArg: 0.873 ± 0.036	0.767TrpSer: 0.767 ± 0.031	0.497TrpThr: 0.497 ± 0.023	0.73TrpVal: 0.73 ± 0.027	0.2TrpTrp: 0.2 ± 0.017	0.4TrpTyr: 0.4 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.187TyrAla: 2.187 ± 0.044	0.392TyrCys: 0.392 ± 0.02	1.61TyrAsp: 1.61 ± 0.049	1.481TyrGlu: 1.481 ± 0.045	1.126TyrPhe: 1.126 ± 0.043	2.148TyrGly: 2.148 ± 0.05	0.683TyrHis: 0.683 ± 0.025	1.387TyrIle: 1.387 ± 0.038	0.929TyrLys: 0.929 ± 0.033	3.202TyrLeu: 3.202 ± 0.07	0.597TyrMet: 0.597 ± 0.027	0.936TyrAsn: 0.936 ± 0.035	1.345TyrPro: 1.345 ± 0.046	1.51TyrGln: 1.51 ± 0.043	2.135TyrArg: 2.135 ± 0.057	1.688TyrSer: 1.688 ± 0.044	1.523TyrThr: 1.523 ± 0.047	1.614TyrVal: 1.614 ± 0.043	0.438TyrTrp: 0.438 ± 0.02	0.849TyrTyr: 0.849 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2898 proteins (894931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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