Amino acid dipepetide frequency for Pneumocystis jirovecii (strain SE8) (Human pneumocystis pneumonia agent)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.736AlaAla: 2.736 ± 0.068	0.856AlaCys: 0.856 ± 0.023	1.958AlaAsp: 1.958 ± 0.045	2.724AlaGlu: 2.724 ± 0.047	2.369AlaPhe: 2.369 ± 0.041	2.123AlaGly: 2.123 ± 0.052	0.994AlaHis: 0.994 ± 0.025	3.915AlaIle: 3.915 ± 0.062	3.32AlaLys: 3.32 ± 0.05	5.228AlaLeu: 5.228 ± 0.071	1.105AlaMet: 1.105 ± 0.037	2.138AlaAsn: 2.138 ± 0.038	1.609AlaPro: 1.609 ± 0.04	1.708AlaGln: 1.708 ± 0.037	2.175AlaArg: 2.175 ± 0.047	3.975AlaSer: 3.975 ± 0.057	2.374AlaThr: 2.374 ± 0.052	2.559AlaVal: 2.559 ± 0.048	0.572AlaTrp: 0.572 ± 0.024	1.714AlaTyr: 1.714 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.676CysAla: 0.676 ± 0.023	0.278CysCys: 0.278 ± 0.013	0.739CysAsp: 0.739 ± 0.023	0.812CysGlu: 0.812 ± 0.029	0.918CysPhe: 0.918 ± 0.024	0.863CysGly: 0.863 ± 0.027	0.407CysHis: 0.407 ± 0.016	1.493CysIle: 1.493 ± 0.04	1.059CysLys: 1.059 ± 0.026	1.711CysLeu: 1.711 ± 0.041	0.315CysMet: 0.315 ± 0.015	0.758CysAsn: 0.758 ± 0.025	0.609CysPro: 0.609 ± 0.024	0.52CysGln: 0.52 ± 0.02	0.662CysArg: 0.662 ± 0.024	1.345CysSer: 1.345 ± 0.035	0.761CysThr: 0.761 ± 0.024	0.798CysVal: 0.798 ± 0.023	0.162CysTrp: 0.162 ± 0.011	0.521CysTyr: 0.521 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.516AspAla: 2.516 ± 0.045	0.708AspCys: 0.708 ± 0.024	3.516AspAsp: 3.516 ± 0.079	3.895AspGlu: 3.895 ± 0.061	2.812AspPhe: 2.812 ± 0.047	2.326AspGly: 2.326 ± 0.049	1.073AspHis: 1.073 ± 0.027	5.467AspIle: 5.467 ± 0.063	3.722AspLys: 3.722 ± 0.054	5.251AspLeu: 5.251 ± 0.064	1.225AspMet: 1.225 ± 0.029	2.923AspAsn: 2.923 ± 0.058	2.169AspPro: 2.169 ± 0.037	1.72AspGln: 1.72 ± 0.037	1.983AspArg: 1.983 ± 0.045	4.312AspSer: 4.312 ± 0.062	2.834AspThr: 2.834 ± 0.043	3.054AspVal: 3.054 ± 0.046	0.621AspTrp: 0.621 ± 0.024	2.018AspTyr: 2.018 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	3.287GluAla: 3.287 ± 0.067	0.886GluCys: 0.886 ± 0.028	3.518GluAsp: 3.518 ± 0.054	5.389GluGlu: 5.389 ± 0.092	2.791GluPhe: 2.791 ± 0.043	2.487GluGly: 2.487 ± 0.043	1.424GluHis: 1.424 ± 0.032	5.763GluIle: 5.763 ± 0.076	7.155GluLys: 7.155 ± 0.107	6.111GluLeu: 6.111 ± 0.074	1.594GluMet: 1.594 ± 0.031	5.402GluAsn: 5.402 ± 0.075	1.771GluPro: 1.771 ± 0.04	2.338GluGln: 2.338 ± 0.041	3.165GluArg: 3.165 ± 0.055	4.801GluSer: 4.801 ± 0.076	3.843GluThr: 3.843 ± 0.05	2.799GluVal: 2.799 ± 0.045	0.784GluTrp: 0.784 ± 0.024	2.513GluTyr: 2.513 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	1.861PheAla: 1.861 ± 0.039	0.852PheCys: 0.852 ± 0.028	2.708PheAsp: 2.708 ± 0.042	2.929PheGlu: 2.929 ± 0.052	2.638PhePhe: 2.638 ± 0.054	2.267PheGly: 2.267 ± 0.045	1.151PheHis: 1.151 ± 0.028	3.62PheIle: 3.62 ± 0.061	3.191PheLys: 3.191 ± 0.051	4.953PheLeu: 4.953 ± 0.069	0.991PheMet: 0.991 ± 0.028	2.535PheAsn: 2.535 ± 0.042	1.963PhePro: 1.963 ± 0.038	1.984PheGln: 1.984 ± 0.043	1.96PheArg: 1.96 ± 0.036	5.135PheSer: 5.135 ± 0.068	2.097PheThr: 2.097 ± 0.04	2.468PheVal: 2.468 ± 0.047	0.57PheTrp: 0.57 ± 0.025	1.808PheTyr: 1.808 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	2.034GlyAla: 2.034 ± 0.042	0.728GlyCys: 0.728 ± 0.025	2.151GlyAsp: 2.151 ± 0.044	2.372GlyGlu: 2.372 ± 0.051	2.303GlyPhe: 2.303 ± 0.043	2.512GlyGly: 2.512 ± 0.065	1.167GlyHis: 1.167 ± 0.032	3.94GlyIle: 3.94 ± 0.055	3.538GlyLys: 3.538 ± 0.058	4.164GlyLeu: 4.164 ± 0.061	0.986GlyMet: 0.986 ± 0.031	2.347GlyAsn: 2.347 ± 0.046	1.355GlyPro: 1.355 ± 0.035	1.415GlyGln: 1.415 ± 0.034	2.18GlyArg: 2.18 ± 0.047	3.576GlySer: 3.576 ± 0.057	2.513GlyThr: 2.513 ± 0.047	2.554GlyVal: 2.554 ± 0.054	0.635GlyTrp: 0.635 ± 0.024	1.787GlyTyr: 1.787 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.072HisAla: 1.072 ± 0.026	0.368HisCys: 0.368 ± 0.015	1.188HisAsp: 1.188 ± 0.028	1.465HisGlu: 1.465 ± 0.031	1.145HisPhe: 1.145 ± 0.03	1.09HisGly: 1.09 ± 0.031	0.592HisHis: 0.592 ± 0.021	1.967HisIle: 1.967 ± 0.038	1.548HisLys: 1.548 ± 0.032	2.406HisLeu: 2.406 ± 0.041	0.488HisMet: 0.488 ± 0.016	1.195HisAsn: 1.195 ± 0.03	1.137HisPro: 1.137 ± 0.032	0.871HisGln: 0.871 ± 0.026	1.047HisArg: 1.047 ± 0.027	1.934HisSer: 1.934 ± 0.043	1.161HisThr: 1.161 ± 0.034	1.277HisVal: 1.277 ± 0.029	0.26HisTrp: 0.26 ± 0.015	0.811HisTyr: 0.811 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.843IleAla: 3.843 ± 0.059	1.442IleCys: 1.442 ± 0.036	4.673IleAsp: 4.673 ± 0.057	5.577IleGlu: 5.577 ± 0.082	4.074IlePhe: 4.074 ± 0.059	3.485IleGly: 3.485 ± 0.054	2.049IleHis: 2.049 ± 0.039	6.546IleIle: 6.546 ± 0.104	6.175IleLys: 6.175 ± 0.076	8.414IleLeu: 8.414 ± 0.092	1.712IleMet: 1.712 ± 0.037	4.844IleAsn: 4.844 ± 0.07	3.516IlePro: 3.516 ± 0.051	3.345IleGln: 3.345 ± 0.057	3.603IleArg: 3.603 ± 0.055	7.843IleSer: 7.843 ± 0.074	3.836IleThr: 3.836 ± 0.056	4.153IleVal: 4.153 ± 0.054	0.935IleTrp: 0.935 ± 0.03	3.201IleTyr: 3.201 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	3.524LysAla: 3.524 ± 0.064	1.023LysCys: 1.023 ± 0.031	4.565LysAsp: 4.565 ± 0.059	6.382LysGlu: 6.382 ± 0.083	2.849LysPhe: 2.849 ± 0.05	2.924LysGly: 2.924 ± 0.047	1.958LysHis: 1.958 ± 0.034	6.831LysIle: 6.831 ± 0.075	8.446LysLys: 8.446 ± 0.128	6.725LysLeu: 6.725 ± 0.07	1.795LysMet: 1.795 ± 0.035	6.242LysAsn: 6.242 ± 0.081	2.475LysPro: 2.475 ± 0.045	3.039LysGln: 3.039 ± 0.053	3.863LysArg: 3.863 ± 0.057	5.85LysSer: 5.85 ± 0.072	4.773LysThr: 4.773 ± 0.064	3.526LysVal: 3.526 ± 0.061	0.805LysTrp: 0.805 ± 0.023	3.165LysTyr: 3.165 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	4.53LeuAla: 4.53 ± 0.071	1.627LeuCys: 1.627 ± 0.035	5.461LeuAsp: 5.461 ± 0.063	7.131LeuGlu: 7.131 ± 0.096	4.575LeuPhe: 4.575 ± 0.061	4.242LeuGly: 4.242 ± 0.061	2.225LeuHis: 2.225 ± 0.042	6.733LeuIle: 6.733 ± 0.075	8.385LeuLys: 8.385 ± 0.076	9.39LeuLeu: 9.39 ± 0.112	1.856LeuMet: 1.856 ± 0.032	5.906LeuAsn: 5.906 ± 0.078	3.878LeuPro: 3.878 ± 0.058	3.907LeuGln: 3.907 ± 0.066	4.697LeuArg: 4.697 ± 0.058	9.317LeuSer: 9.317 ± 0.088	4.545LeuThr: 4.545 ± 0.064	4.609LeuVal: 4.609 ± 0.063	1.153LeuTrp: 1.153 ± 0.028	3.549LeuTyr: 3.549 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.121MetAla: 1.121 ± 0.028	0.282MetCys: 0.282 ± 0.013	1.3MetAsp: 1.3 ± 0.035	1.509MetGlu: 1.509 ± 0.035	0.924MetPhe: 0.924 ± 0.024	1.062MetGly: 1.062 ± 0.028	0.523MetHis: 0.523 ± 0.019	1.635MetIle: 1.635 ± 0.035	1.753MetLys: 1.753 ± 0.039	2.05MetLeu: 2.05 ± 0.042	0.463MetMet: 0.463 ± 0.022	1.295MetAsn: 1.295 ± 0.033	0.829MetPro: 0.829 ± 0.019	0.837MetGln: 0.837 ± 0.027	0.922MetArg: 0.922 ± 0.023	1.861MetSer: 1.861 ± 0.038	1.143MetThr: 1.143 ± 0.03	1.12MetVal: 1.12 ± 0.03	0.16MetTrp: 0.16 ± 0.011	0.623MetTyr: 0.623 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.679AsnAla: 2.679 ± 0.044	0.81AsnCys: 0.81 ± 0.026	3.525AsnAsp: 3.525 ± 0.054	4.154AsnGlu: 4.154 ± 0.06	2.73AsnPhe: 2.73 ± 0.046	2.469AsnGly: 2.469 ± 0.045	1.287AsnHis: 1.287 ± 0.03	6.224AsnIle: 6.224 ± 0.087	4.661AsnLys: 4.661 ± 0.067	5.225AsnLeu: 5.225 ± 0.068	1.453AsnMet: 1.453 ± 0.033	4.093AsnAsn: 4.093 ± 0.073	2.264AsnPro: 2.264 ± 0.048	2.145AsnGln: 2.145 ± 0.044	2.052AsnArg: 2.052 ± 0.043	5.027AsnSer: 5.027 ± 0.076	3.726AsnThr: 3.726 ± 0.067	3.047AsnVal: 3.047 ± 0.047	0.582AsnTrp: 0.582 ± 0.02	2.203AsnTyr: 2.203 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.482ProAla: 1.482 ± 0.035	0.528ProCys: 0.528 ± 0.02	1.954ProAsp: 1.954 ± 0.038	2.67ProGlu: 2.67 ± 0.053	1.919ProPhe: 1.919 ± 0.035	1.711ProGly: 1.711 ± 0.041	0.837ProHis: 0.837 ± 0.026	3.018ProIle: 3.018 ± 0.046	2.698ProLys: 2.698 ± 0.049	3.849ProLeu: 3.849 ± 0.055	0.702ProMet: 0.702 ± 0.023	2.009ProAsn: 2.009 ± 0.041	1.983ProPro: 1.983 ± 0.067	1.337ProGln: 1.337 ± 0.032	1.525ProArg: 1.525 ± 0.038	3.611ProSer: 3.611 ± 0.05	1.961ProThr: 1.961 ± 0.041	2.141ProVal: 2.141 ± 0.041	0.405ProTrp: 0.405 ± 0.016	1.518ProTyr: 1.518 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.807GlnAla: 1.807 ± 0.036	0.522GlnCys: 0.522 ± 0.022	1.851GlnAsp: 1.851 ± 0.038	2.859GlnGlu: 2.859 ± 0.048	1.51GlnPhe: 1.51 ± 0.031	1.48GlnGly: 1.48 ± 0.03	0.868GlnHis: 0.868 ± 0.026	2.915GlnIle: 2.915 ± 0.048	3.649GlnLys: 3.649 ± 0.053	3.515GlnLeu: 3.515 ± 0.055	0.806GlnMet: 0.806 ± 0.025	2.707GlnAsn: 2.707 ± 0.056	1.221GlnPro: 1.221 ± 0.033	1.738GlnGln: 1.738 ± 0.044	1.855GlnArg: 1.855 ± 0.038	2.733GlnSer: 2.733 ± 0.051	2.098GlnThr: 2.098 ± 0.041	1.704GlnVal: 1.704 ± 0.037	0.431GlnTrp: 0.431 ± 0.018	1.35GlnTyr: 1.35 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.209ArgAla: 2.209 ± 0.043	0.664ArgCys: 0.664 ± 0.019	2.174ArgAsp: 2.174 ± 0.039	2.826ArgGlu: 2.826 ± 0.049	2.068ArgPhe: 2.068 ± 0.039	1.917ArgGly: 1.917 ± 0.047	1.049ArgHis: 1.049 ± 0.029	3.752ArgIle: 3.752 ± 0.049	3.911ArgLys: 3.911 ± 0.057	4.515ArgLeu: 4.515 ± 0.063	1.003ArgMet: 1.003 ± 0.03	2.455ArgAsn: 2.455 ± 0.041	1.567ArgPro: 1.567 ± 0.034	1.83ArgGln: 1.83 ± 0.04	2.722ArgArg: 2.722 ± 0.05	3.342ArgSer: 3.342 ± 0.066	2.227ArgThr: 2.227 ± 0.047	2.319ArgVal: 2.319 ± 0.045	0.534ArgTrp: 0.534 ± 0.022	1.625ArgTyr: 1.625 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.599SerAla: 3.599 ± 0.054	1.298SerCys: 1.298 ± 0.03	4.469SerAsp: 4.469 ± 0.069	5.618SerGlu: 5.618 ± 0.069	4.49SerPhe: 4.49 ± 0.063	4.002SerGly: 4.002 ± 0.063	1.855SerHis: 1.855 ± 0.041	7.107SerIle: 7.107 ± 0.09	6.749SerLys: 6.749 ± 0.081	8.892SerLeu: 8.892 ± 0.094	1.736SerMet: 1.736 ± 0.033	5.097SerAsn: 5.097 ± 0.082	3.335SerPro: 3.335 ± 0.069	3.29SerGln: 3.29 ± 0.057	3.727SerArg: 3.727 ± 0.059	8.746SerSer: 8.746 ± 0.11	4.641SerThr: 4.641 ± 0.056	4.411SerVal: 4.411 ± 0.06	0.878SerTrp: 0.878 ± 0.028	3.034SerTyr: 3.034 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	2.479ThrAla: 2.479 ± 0.042	0.846ThrCys: 0.846 ± 0.028	2.552ThrAsp: 2.552 ± 0.044	3.187ThrGlu: 3.187 ± 0.048	2.515ThrPhe: 2.515 ± 0.042	2.568ThrGly: 2.568 ± 0.052	1.252ThrHis: 1.252 ± 0.028	4.194ThrIle: 4.194 ± 0.066	3.698ThrLys: 3.698 ± 0.062	5.355ThrLeu: 5.355 ± 0.068	1.05ThrMet: 1.05 ± 0.027	2.955ThrAsn: 2.955 ± 0.053	2.37ThrPro: 2.37 ± 0.046	1.968ThrGln: 1.968 ± 0.036	2.182ThrArg: 2.182 ± 0.039	4.878ThrSer: 4.878 ± 0.07	2.678ThrThr: 2.678 ± 0.049	2.876ThrVal: 2.876 ± 0.052	0.538ThrTrp: 0.538 ± 0.016	1.891ThrTyr: 1.891 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	2.49ValAla: 2.49 ± 0.041	0.875ValCys: 0.875 ± 0.028	2.887ValAsp: 2.887 ± 0.052	3.293ValGlu: 3.293 ± 0.051	2.765ValPhe: 2.765 ± 0.043	2.269ValGly: 2.269 ± 0.044	1.133ValHis: 1.133 ± 0.03	3.896ValIle: 3.896 ± 0.052	3.532ValLys: 3.532 ± 0.052	5.392ValLeu: 5.392 ± 0.073	1.007ValMet: 1.007 ± 0.029	2.626ValAsn: 2.626 ± 0.043	2.119ValPro: 2.119 ± 0.038	1.874ValGln: 1.874 ± 0.04	2.176ValArg: 2.176 ± 0.045	4.743ValSer: 4.743 ± 0.068	2.366ValThr: 2.366 ± 0.043	2.852ValVal: 2.852 ± 0.059	0.565ValTrp: 0.565 ± 0.019	1.871ValTyr: 1.871 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.019	0.19TrpCys: 0.19 ± 0.012	0.74TrpAsp: 0.74 ± 0.024	0.7TrpGlu: 0.7 ± 0.024	0.441TrpPhe: 0.441 ± 0.019	0.529TrpGly: 0.529 ± 0.022	0.24TrpHis: 0.24 ± 0.014	0.996TrpIle: 0.996 ± 0.03	1.002TrpLys: 1.002 ± 0.028	0.928TrpLeu: 0.928 ± 0.028	0.266TrpMet: 0.266 ± 0.013	0.69TrpAsn: 0.69 ± 0.022	0.329TrpPro: 0.329 ± 0.017	0.357TrpGln: 0.357 ± 0.017	0.57TrpArg: 0.57 ± 0.02	0.851TrpSer: 0.851 ± 0.023	0.561TrpThr: 0.561 ± 0.02	0.622TrpVal: 0.622 ± 0.022	0.152TrpTrp: 0.152 ± 0.011	0.36TrpTyr: 0.36 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.667TyrAla: 1.667 ± 0.033	0.626TyrCys: 0.626 ± 0.022	2.213TyrAsp: 2.213 ± 0.038	2.33TyrGlu: 2.33 ± 0.046	1.842TyrPhe: 1.842 ± 0.037	1.934TyrGly: 1.934 ± 0.04	0.937TyrHis: 0.937 ± 0.026	3.256TyrIle: 3.256 ± 0.051	2.568TyrLys: 2.568 ± 0.043	3.643TyrLeu: 3.643 ± 0.059	0.857TyrMet: 0.857 ± 0.025	2.141TyrAsn: 2.141 ± 0.045	1.357TyrPro: 1.357 ± 0.033	1.395TyrGln: 1.395 ± 0.033	1.643TyrArg: 1.643 ± 0.036	3.096TyrSer: 3.096 ± 0.052	1.895TyrThr: 1.895 ± 0.039	1.842TyrVal: 1.842 ± 0.037	0.322TyrTrp: 0.322 ± 0.015	1.46TyrTyr: 1.46 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3419 proteins (1381820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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