Amino acid dipepetide frequency for Streptomyces collinus (strain DSM 40733 / Tue 365)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.647AlaAla: 22.647 ± 0.177	1.104AlaCys: 1.104 ± 0.025	8.518AlaAsp: 8.518 ± 0.075	9.014AlaGlu: 9.014 ± 0.102	3.493AlaPhe: 3.493 ± 0.047	13.962AlaGly: 13.962 ± 0.103	3.176AlaHis: 3.176 ± 0.039	3.027AlaIle: 3.027 ± 0.045	2.708AlaLys: 2.708 ± 0.051	15.105AlaLeu: 15.105 ± 0.113	2.336AlaMet: 2.336 ± 0.035	1.785AlaAsn: 1.785 ± 0.029	7.645AlaPro: 7.645 ± 0.091	3.732AlaGln: 3.732 ± 0.051	11.207AlaArg: 11.207 ± 0.088	5.712AlaSer: 5.712 ± 0.065	6.967AlaThr: 6.967 ± 0.062	12.698AlaVal: 12.698 ± 0.093	1.901AlaTrp: 1.901 ± 0.03	2.778AlaTyr: 2.778 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.181CysAla: 1.181 ± 0.026	0.095CysCys: 0.095 ± 0.008	0.458CysAsp: 0.458 ± 0.014	0.394CysGlu: 0.394 ± 0.013	0.221CysPhe: 0.221 ± 0.01	0.977CysGly: 0.977 ± 0.022	0.213CysHis: 0.213 ± 0.011	0.152CysIle: 0.152 ± 0.007	0.107CysLys: 0.107 ± 0.007	0.789CysLeu: 0.789 ± 0.02	0.125CysMet: 0.125 ± 0.007	0.134CysAsn: 0.134 ± 0.008	0.493CysPro: 0.493 ± 0.014	0.16CysGln: 0.16 ± 0.008	0.628CysArg: 0.628 ± 0.019	0.421CysSer: 0.421 ± 0.012	0.507CysThr: 0.507 ± 0.016	0.686CysVal: 0.686 ± 0.016	0.122CysTrp: 0.122 ± 0.008	0.143CysTyr: 0.143 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.771AspAla: 7.771 ± 0.07	0.434AspCys: 0.434 ± 0.014	3.63AspAsp: 3.63 ± 0.045	3.728AspGlu: 3.728 ± 0.044	1.627AspPhe: 1.627 ± 0.032	6.557AspGly: 6.557 ± 0.066	1.472AspHis: 1.472 ± 0.03	1.692AspIle: 1.692 ± 0.029	1.142AspLys: 1.142 ± 0.028	6.376AspLeu: 6.376 ± 0.062	0.809AspMet: 0.809 ± 0.019	0.898AspAsn: 0.898 ± 0.02	4.666AspPro: 4.666 ± 0.048	1.472AspGln: 1.472 ± 0.03	5.118AspArg: 5.118 ± 0.061	2.388AspSer: 2.388 ± 0.036	3.268AspThr: 3.268 ± 0.04	4.757AspVal: 4.757 ± 0.044	1.018AspTrp: 1.018 ± 0.023	1.088AspTyr: 1.088 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.415GluAla: 7.415 ± 0.087	0.362GluCys: 0.362 ± 0.013	2.807GluAsp: 2.807 ± 0.043	3.566GluGlu: 3.566 ± 0.059	1.387GluPhe: 1.387 ± 0.027	4.164GluGly: 4.164 ± 0.049	1.512GluHis: 1.512 ± 0.027	2.09GluIle: 2.09 ± 0.04	1.333GluLys: 1.333 ± 0.033	6.644GluLeu: 6.644 ± 0.067	0.836GluMet: 0.836 ± 0.021	0.955GluAsn: 0.955 ± 0.025	3.505GluPro: 3.505 ± 0.047	2.107GluGln: 2.107 ± 0.038	5.696GluArg: 5.696 ± 0.069	2.366GluSer: 2.366 ± 0.034	2.817GluThr: 2.817 ± 0.042	4.415GluVal: 4.415 ± 0.053	0.736GluTrp: 0.736 ± 0.016	1.041GluTyr: 1.041 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.668PheAla: 3.668 ± 0.049	0.275PheCys: 0.275 ± 0.012	1.878PheAsp: 1.878 ± 0.033	1.414PheGlu: 1.414 ± 0.029	0.878PhePhe: 0.878 ± 0.023	3.059PheGly: 3.059 ± 0.046	0.624PheHis: 0.624 ± 0.021	0.581PheIle: 0.581 ± 0.017	0.498PheLys: 0.498 ± 0.017	2.64PheLeu: 2.64 ± 0.039	0.377PheMet: 0.377 ± 0.013	0.534PheAsn: 0.534 ± 0.016	1.379PhePro: 1.379 ± 0.026	0.657PheGln: 0.657 ± 0.019	1.87PheArg: 1.87 ± 0.025	1.395PheSer: 1.395 ± 0.027	1.953PheThr: 1.953 ± 0.03	2.22PheVal: 2.22 ± 0.033	0.402PheTrp: 0.402 ± 0.015	0.563PheTyr: 0.563 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.62GlyAla: 11.62 ± 0.101	0.858GlyCys: 0.858 ± 0.022	5.36GlyAsp: 5.36 ± 0.059	5.099GlyGlu: 5.099 ± 0.058	2.881GlyPhe: 2.881 ± 0.04	9.249GlyGly: 9.249 ± 0.099	2.586GlyHis: 2.586 ± 0.028	3.196GlyIle: 3.196 ± 0.041	2.288GlyLys: 2.288 ± 0.041	9.587GlyLeu: 9.587 ± 0.079	1.925GlyMet: 1.925 ± 0.028	1.704GlyAsn: 1.704 ± 0.035	5.597GlyPro: 5.597 ± 0.054	2.647GlyGln: 2.647 ± 0.048	8.438GlyArg: 8.438 ± 0.076	5.327GlySer: 5.327 ± 0.049	6.747GlyThr: 6.747 ± 0.06	7.78GlyVal: 7.78 ± 0.071	1.688GlyTrp: 1.688 ± 0.034	2.303GlyTyr: 2.303 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.862HisAla: 2.862 ± 0.04	0.222HisCys: 0.222 ± 0.01	1.414HisAsp: 1.414 ± 0.029	1.248HisGlu: 1.248 ± 0.024	0.637HisPhe: 0.637 ± 0.018	2.621HisGly: 2.621 ± 0.032	0.739HisHis: 0.739 ± 0.022	0.612HisIle: 0.612 ± 0.017	0.369HisLys: 0.369 ± 0.012	2.53HisLeu: 2.53 ± 0.039	0.345HisMet: 0.345 ± 0.013	0.351HisAsn: 0.351 ± 0.012	1.932HisPro: 1.932 ± 0.029	0.625HisGln: 0.625 ± 0.017	2.281HisArg: 2.281 ± 0.035	0.976HisSer: 0.976 ± 0.019	1.45HisThr: 1.45 ± 0.028	1.791HisVal: 1.791 ± 0.03	0.395HisTrp: 0.395 ± 0.013	0.476HisTyr: 0.476 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.324IleAla: 4.324 ± 0.057	0.263IleCys: 0.263 ± 0.012	1.977IleAsp: 1.977 ± 0.034	1.773IleGlu: 1.773 ± 0.031	0.596IlePhe: 0.596 ± 0.017	3.304IleGly: 3.304 ± 0.046	0.552IleHis: 0.552 ± 0.015	0.757IleIle: 0.757 ± 0.021	0.661IleLys: 0.661 ± 0.022	2.19IleLeu: 2.19 ± 0.039	0.388IleMet: 0.388 ± 0.014	0.616IleAsn: 0.616 ± 0.017	1.583IlePro: 1.583 ± 0.028	0.666IleGln: 0.666 ± 0.018	2.064IleArg: 2.064 ± 0.031	1.431IleSer: 1.431 ± 0.029	1.984IleThr: 1.984 ± 0.032	2.509IleVal: 2.509 ± 0.04	0.339IleTrp: 0.339 ± 0.012	0.468IleTyr: 0.468 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.878LysAla: 2.878 ± 0.057	0.112LysCys: 0.112 ± 0.008	1.311LysAsp: 1.311 ± 0.034	1.113LysGlu: 1.113 ± 0.029	0.415LysPhe: 0.415 ± 0.016	1.783LysGly: 1.783 ± 0.036	0.399LysHis: 0.399 ± 0.015	0.797LysIle: 0.797 ± 0.021	0.809LysLys: 0.809 ± 0.028	1.873LysLeu: 1.873 ± 0.038	0.367LysMet: 0.367 ± 0.013	0.494LysAsn: 0.494 ± 0.018	1.244LysPro: 1.244 ± 0.033	0.672LysGln: 0.672 ± 0.021	1.349LysArg: 1.349 ± 0.027	1.032LysSer: 1.032 ± 0.025	1.186LysThr: 1.186 ± 0.029	1.845LysVal: 1.845 ± 0.032	0.251LysTrp: 0.251 ± 0.011	0.443LysTyr: 0.443 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.54LeuAla: 15.54 ± 0.1	0.888LeuCys: 0.888 ± 0.021	6.847LeuAsp: 6.847 ± 0.071	4.621LeuGlu: 4.621 ± 0.056	2.578LeuPhe: 2.578 ± 0.037	9.485LeuGly: 9.485 ± 0.08	2.399LeuHis: 2.399 ± 0.036	2.953LeuIle: 2.953 ± 0.045	1.99LeuLys: 1.99 ± 0.034	11.547LeuLeu: 11.547 ± 0.101	1.609LeuMet: 1.609 ± 0.029	1.59LeuAsn: 1.59 ± 0.033	6.7LeuPro: 6.7 ± 0.07	2.157LeuGln: 2.157 ± 0.033	9.044LeuArg: 9.044 ± 0.078	5.072LeuSer: 5.072 ± 0.049	7.023LeuThr: 7.023 ± 0.071	9.109LeuVal: 9.109 ± 0.083	1.334LeuTrp: 1.334 ± 0.029	1.886LeuTyr: 1.886 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.033	0.136MetCys: 0.136 ± 0.007	0.827MetAsp: 0.827 ± 0.02	0.721MetGlu: 0.721 ± 0.023	0.435MetPhe: 0.435 ± 0.015	1.246MetGly: 1.246 ± 0.026	0.338MetHis: 0.338 ± 0.012	0.616MetIle: 0.616 ± 0.016	0.379MetLys: 0.379 ± 0.014	1.604MetLeu: 1.604 ± 0.029	0.251MetMet: 0.251 ± 0.012	0.402MetAsn: 0.402 ± 0.014	1.055MetPro: 1.055 ± 0.02	0.417MetGln: 0.417 ± 0.014	1.355MetArg: 1.355 ± 0.026	1.259MetSer: 1.259 ± 0.027	1.474MetThr: 1.474 ± 0.025	1.236MetVal: 1.236 ± 0.024	0.215MetTrp: 0.215 ± 0.011	0.309MetTyr: 0.309 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.065AsnAla: 2.065 ± 0.036	0.163AsnCys: 0.163 ± 0.008	0.889AsnAsp: 0.889 ± 0.022	0.735AsnGlu: 0.735 ± 0.017	0.447AsnPhe: 0.447 ± 0.013	1.79AsnGly: 1.79 ± 0.036	0.393AsnHis: 0.393 ± 0.014	0.592AsnIle: 0.592 ± 0.015	0.371AsnLys: 0.371 ± 0.014	1.523AsnLeu: 1.523 ± 0.029	0.286AsnMet: 0.286 ± 0.012	0.394AsnAsn: 0.394 ± 0.017	1.286AsnPro: 1.286 ± 0.026	0.482AsnGln: 0.482 ± 0.015	1.189AsnArg: 1.189 ± 0.027	0.835AsnSer: 0.835 ± 0.021	1.027AsnThr: 1.027 ± 0.022	1.33AsnVal: 1.33 ± 0.028	0.252AsnTrp: 0.252 ± 0.011	0.368AsnTyr: 0.368 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.716ProAla: 9.716 ± 0.111	0.38ProCys: 0.38 ± 0.012	4.59ProAsp: 4.59 ± 0.05	4.261ProGlu: 4.261 ± 0.045	1.527ProPhe: 1.527 ± 0.028	7.32ProGly: 7.32 ± 0.074	1.512ProHis: 1.512 ± 0.028	1.093ProIle: 1.093 ± 0.023	1.075ProLys: 1.075 ± 0.023	5.6ProLeu: 5.6 ± 0.063	0.932ProMet: 0.932 ± 0.025	0.796ProAsn: 0.796 ± 0.022	3.659ProPro: 3.659 ± 0.062	1.707ProGln: 1.707 ± 0.037	4.216ProArg: 4.216 ± 0.047	3.042ProSer: 3.042 ± 0.041	3.027ProThr: 3.027 ± 0.042	5.733ProVal: 5.733 ± 0.059	0.897ProTrp: 0.897 ± 0.023	1.478ProTyr: 1.478 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.714GlnAla: 3.714 ± 0.056	0.163GlnCys: 0.163 ± 0.008	1.411GlnAsp: 1.411 ± 0.026	1.373GlnGlu: 1.373 ± 0.028	0.646GlnPhe: 0.646 ± 0.017	2.299GlnGly: 2.299 ± 0.035	0.64GlnHis: 0.64 ± 0.017	1.02GlnIle: 1.02 ± 0.021	0.601GlnLys: 0.601 ± 0.019	2.867GlnLeu: 2.867 ± 0.041	0.449GlnMet: 0.449 ± 0.015	0.449GlnAsn: 0.449 ± 0.017	1.667GlnPro: 1.667 ± 0.044	1.186GlnGln: 1.186 ± 0.035	2.31GlnArg: 2.31 ± 0.036	1.234GlnSer: 1.234 ± 0.026	1.293GlnThr: 1.293 ± 0.027	2.375GlnVal: 2.375 ± 0.039	0.434GlnTrp: 0.434 ± 0.013	0.593GlnTyr: 0.593 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.566ArgAla: 10.566 ± 0.08	0.614ArgCys: 0.614 ± 0.017	4.493ArgAsp: 4.493 ± 0.05	4.831ArgGlu: 4.831 ± 0.052	2.381ArgPhe: 2.381 ± 0.034	6.141ArgGly: 6.141 ± 0.058	2.314ArgHis: 2.314 ± 0.033	3.04ArgIle: 3.04 ± 0.04	1.585ArgLys: 1.585 ± 0.034	9.468ArgLeu: 9.468 ± 0.089	1.696ArgMet: 1.696 ± 0.025	1.255ArgAsn: 1.255 ± 0.027	5.515ArgPro: 5.515 ± 0.064	2.315ArgGln: 2.315 ± 0.033	8.273ArgArg: 8.273 ± 0.085	3.939ArgSer: 3.939 ± 0.04	5.715ArgThr: 5.715 ± 0.065	6.127ArgVal: 6.127 ± 0.067	1.408ArgTrp: 1.408 ± 0.029	1.787ArgTyr: 1.787 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.694SerAla: 6.694 ± 0.061	0.4SerCys: 0.4 ± 0.016	2.479SerAsp: 2.479 ± 0.038	2.13SerGlu: 2.13 ± 0.039	1.477SerPhe: 1.477 ± 0.026	6.003SerGly: 6.003 ± 0.065	0.961SerHis: 0.961 ± 0.022	1.209SerIle: 1.209 ± 0.028	0.931SerLys: 0.931 ± 0.024	4.687SerLeu: 4.687 ± 0.049	0.982SerMet: 0.982 ± 0.023	0.792SerAsn: 0.792 ± 0.022	3.012SerPro: 3.012 ± 0.04	1.117SerGln: 1.117 ± 0.025	3.628SerArg: 3.628 ± 0.043	2.591SerSer: 2.591 ± 0.047	2.839SerThr: 2.839 ± 0.041	4.081SerVal: 4.081 ± 0.045	0.826SerTrp: 0.826 ± 0.019	1.189SerTyr: 1.189 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.271ThrAla: 9.271 ± 0.076	0.428ThrCys: 0.428 ± 0.015	3.615ThrAsp: 3.615 ± 0.039	3.248ThrGlu: 3.248 ± 0.044	1.569ThrPhe: 1.569 ± 0.027	7.088ThrGly: 7.088 ± 0.063	1.235ThrHis: 1.235 ± 0.022	1.461ThrIle: 1.461 ± 0.031	1.067ThrLys: 1.067 ± 0.028	5.696ThrLeu: 5.696 ± 0.049	0.861ThrMet: 0.861 ± 0.019	0.906ThrAsn: 0.906 ± 0.019	4.151ThrPro: 4.151 ± 0.052	1.311ThrGln: 1.311 ± 0.025	4.047ThrArg: 4.047 ± 0.045	2.961ThrSer: 2.961 ± 0.045	3.737ThrThr: 3.737 ± 0.052	6.194ThrVal: 6.194 ± 0.061	0.901ThrTrp: 0.901 ± 0.021	1.315ThrTyr: 1.315 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.906ValAla: 10.906 ± 0.087	0.792ValCys: 0.792 ± 0.023	5.015ValAsp: 5.015 ± 0.059	4.588ValGlu: 4.588 ± 0.054	2.493ValPhe: 2.493 ± 0.036	6.503ValGly: 6.503 ± 0.062	2.05ValHis: 2.05 ± 0.027	2.588ValIle: 2.588 ± 0.041	1.718ValLys: 1.718 ± 0.032	9.816ValLeu: 9.816 ± 0.086	1.357ValMet: 1.357 ± 0.028	1.613ValAsn: 1.613 ± 0.028	5.635ValPro: 5.635 ± 0.057	2.109ValGln: 2.109 ± 0.031	7.577ValArg: 7.577 ± 0.075	4.243ValSer: 4.243 ± 0.045	5.805ValThr: 5.805 ± 0.062	8.221ValVal: 8.221 ± 0.079	1.173ValTrp: 1.173 ± 0.02	1.559ValTyr: 1.559 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.687TrpAla: 1.687 ± 0.036	0.144TrpCys: 0.144 ± 0.008	0.849TrpAsp: 0.849 ± 0.021	0.677TrpGlu: 0.677 ± 0.017	0.535TrpPhe: 0.535 ± 0.015	1.038TrpGly: 1.038 ± 0.023	0.373TrpHis: 0.373 ± 0.013	0.52TrpIle: 0.52 ± 0.014	0.345TrpLys: 0.345 ± 0.013	1.762TrpLeu: 1.762 ± 0.032	0.272TrpMet: 0.272 ± 0.01	0.371TrpAsn: 0.371 ± 0.014	0.792TrpPro: 0.792 ± 0.02	0.61TrpGln: 0.61 ± 0.017	1.372TrpArg: 1.372 ± 0.024	0.896TrpSer: 0.896 ± 0.019	1.043TrpThr: 1.043 ± 0.024	0.965TrpVal: 0.965 ± 0.024	0.345TrpTrp: 0.345 ± 0.014	0.368TrpTyr: 0.368 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.82TyrAla: 2.82 ± 0.035	0.173TyrCys: 0.173 ± 0.009	1.544TyrAsp: 1.544 ± 0.027	1.218TyrGlu: 1.218 ± 0.024	0.644TyrPhe: 0.644 ± 0.019	2.291TyrGly: 2.291 ± 0.04	0.386TyrHis: 0.386 ± 0.014	0.446TyrIle: 0.446 ± 0.017	0.396TyrLys: 0.396 ± 0.015	2.067TyrLeu: 2.067 ± 0.031	0.242TyrMet: 0.242 ± 0.01	0.38TyrAsn: 0.38 ± 0.014	1.048TyrPro: 1.048 ± 0.025	0.577TyrGln: 0.577 ± 0.019	1.801TyrArg: 1.801 ± 0.031	0.905TyrSer: 0.905 ± 0.023	1.199TyrThr: 1.199 ± 0.027	1.689TyrVal: 1.689 ± 0.029	0.33TyrTrp: 0.33 ± 0.011	0.422TyrTyr: 0.422 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6682 proteins (2231205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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