Amino acid dipepetide frequency for Circoviridae 4 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.534AlaAla: 3.534 ± 2.28
0.0AlaCys: 0.0 ± 0.0
4.711AlaAsp: 4.711 ± 3.039
5.889AlaGlu: 5.889 ± 1.933
0.0AlaPhe: 0.0 ± 0.0
10.601AlaGly: 10.601 ± 2.696
0.0AlaHis: 0.0 ± 0.0
2.356AlaIle: 2.356 ± 0.827
0.0AlaLys: 0.0 ± 0.0
5.889AlaLeu: 5.889 ± 1.943
1.178AlaMet: 1.178 ± 1.015
2.356AlaAsn: 2.356 ± 2.514
2.356AlaPro: 2.356 ± 1.52
2.356AlaGln: 2.356 ± 1.52
8.245AlaArg: 8.245 ± 2.747
4.711AlaSer: 4.711 ± 2.66
7.067AlaThr: 7.067 ± 3.109
8.245AlaVal: 8.245 ± 0.573
0.0AlaTrp: 0.0 ± 0.0
1.178AlaTyr: 1.178 ± 1.257
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.178CysAsp: 1.178 ± 0.76
1.178CysGlu: 1.178 ± 1.015
1.178CysPhe: 1.178 ± 0.76
1.178CysGly: 1.178 ± 1.257
1.178CysHis: 1.178 ± 0.76
1.178CysIle: 1.178 ± 0.76
0.0CysLys: 0.0 ± 0.0
2.356CysLeu: 2.356 ± 1.339
0.0CysMet: 0.0 ± 0.649
1.178CysAsn: 1.178 ± 1.015
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.178CysArg: 1.178 ± 0.76
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.711AspAla: 4.711 ± 1.859
1.178AspCys: 1.178 ± 0.76
5.889AspAsp: 5.889 ± 0.985
3.534AspGlu: 3.534 ± 0.603
3.534AspPhe: 3.534 ± 1.313
5.889AspGly: 5.889 ± 3.799
2.356AspHis: 2.356 ± 1.036
3.534AspIle: 3.534 ± 2.175
2.356AspLys: 2.356 ± 2.03
4.711AspLeu: 4.711 ± 1.878
0.0AspMet: 0.0 ± 0.0
4.711AspAsn: 4.711 ± 1.878
4.711AspPro: 4.711 ± 3.039
1.178AspGln: 1.178 ± 1.257
2.356AspArg: 2.356 ± 0.827
4.711AspSer: 4.711 ± 0.299
5.889AspThr: 5.889 ± 3.269
1.178AspVal: 1.178 ± 0.76
1.178AspTrp: 1.178 ± 1.015
4.711AspTyr: 4.711 ± 2.073
0.0AspXaa: 0.0 ± 0.0
Glu
5.889GluAla: 5.889 ± 2.24
2.356GluCys: 2.356 ± 1.036
3.534GluAsp: 3.534 ± 1.222
8.245GluGlu: 8.245 ± 2.489
1.178GluPhe: 1.178 ± 1.015
8.245GluGly: 8.245 ± 2.357
2.356GluHis: 2.356 ± 1.036
3.534GluIle: 3.534 ± 2.016
2.356GluLys: 2.356 ± 1.52
3.534GluLeu: 3.534 ± 2.391
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
1.178GluPro: 1.178 ± 0.76
1.178GluGln: 1.178 ± 0.76
4.711GluArg: 4.711 ± 0.299
4.711GluSer: 4.711 ± 2.678
1.178GluThr: 1.178 ± 0.76
3.534GluVal: 3.534 ± 2.016
1.178GluTrp: 1.178 ± 0.76
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
4.711PheAla: 4.711 ± 0.299
0.0PheCys: 0.0 ± 0.0
3.534PheAsp: 3.534 ± 0.603
3.534PheGlu: 3.534 ± 0.603
1.178PhePhe: 1.178 ± 1.257
0.0PheGly: 0.0 ± 0.0
2.356PheHis: 2.356 ± 1.339
1.178PheIle: 1.178 ± 1.257
0.0PheLys: 0.0 ± 0.0
4.711PheLeu: 4.711 ± 0.299
0.0PheMet: 0.0 ± 0.0
4.711PheAsn: 4.711 ± 1.309
1.178PhePro: 1.178 ± 0.76
1.178PheGln: 1.178 ± 1.257
1.178PheArg: 1.178 ± 1.015
1.178PheSer: 1.178 ± 1.257
2.356PheThr: 2.356 ± 0.827
2.356PheVal: 2.356 ± 0.827
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.711GlyAla: 4.711 ± 2.66
1.178GlyCys: 1.178 ± 0.76
4.711GlyAsp: 4.711 ± 3.039
5.889GlyGlu: 5.889 ± 2.24
3.534GlyPhe: 3.534 ± 2.175
9.423GlyGly: 9.423 ± 3.718
2.356GlyHis: 2.356 ± 0.827
1.178GlyIle: 1.178 ± 0.76
2.356GlyLys: 2.356 ± 1.52
4.711GlyLeu: 4.711 ± 0.299
1.178GlyMet: 1.178 ± 0.79
5.889GlyAsn: 5.889 ± 3.666
4.711GlyPro: 4.711 ± 1.859
2.356GlyGln: 2.356 ± 1.52
7.067GlyArg: 7.067 ± 1.732
5.889GlySer: 5.889 ± 0.985
8.245GlyThr: 8.245 ± 3.27
5.889GlyVal: 5.889 ± 2.24
3.534GlyTrp: 3.534 ± 2.28
4.711GlyTyr: 4.711 ± 1.309
0.0GlyXaa: 0.0 ± 0.0
His
1.178HisAla: 1.178 ± 0.76
1.178HisCys: 1.178 ± 1.015
0.0HisAsp: 0.0 ± 0.0
1.178HisGlu: 1.178 ± 1.257
0.0HisPhe: 0.0 ± 0.0
2.356HisGly: 2.356 ± 1.52
1.178HisHis: 1.178 ± 0.76
1.178HisIle: 1.178 ± 1.257
1.178HisLys: 1.178 ± 1.015
2.356HisLeu: 2.356 ± 1.52
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.356HisPro: 2.356 ± 1.52
1.178HisGln: 1.178 ± 1.257
1.178HisArg: 1.178 ± 0.76
0.0HisSer: 0.0 ± 0.0
1.178HisThr: 1.178 ± 0.76
2.356HisVal: 2.356 ± 1.036
2.356HisTrp: 2.356 ± 1.339
1.178HisTyr: 1.178 ± 1.015
0.0HisXaa: 0.0 ± 0.0
Ile
3.534IleAla: 3.534 ± 1.688
0.0IleCys: 0.0 ± 0.0
3.534IleAsp: 3.534 ± 0.603
1.178IleGlu: 1.178 ± 1.257
2.356IlePhe: 2.356 ± 1.52
2.356IleGly: 2.356 ± 2.514
2.356IleHis: 2.356 ± 0.827
1.178IleIle: 1.178 ± 0.76
1.178IleLys: 1.178 ± 0.76
3.534IleLeu: 3.534 ± 2.391
0.0IleMet: 0.0 ± 0.0
2.356IleAsn: 2.356 ± 1.339
2.356IlePro: 2.356 ± 2.03
0.0IleGln: 0.0 ± 0.0
3.534IleArg: 3.534 ± 2.016
3.534IleSer: 3.534 ± 0.603
2.356IleThr: 2.356 ± 1.52
2.356IleVal: 2.356 ± 1.339
0.0IleTrp: 0.0 ± 0.0
1.178IleTyr: 1.178 ± 1.257
0.0IleXaa: 0.0 ± 0.0
Lys
2.356LysAla: 2.356 ± 1.52
0.0LysCys: 0.0 ± 0.0
1.178LysAsp: 1.178 ± 1.015
1.178LysGlu: 1.178 ± 0.76
2.356LysPhe: 2.356 ± 1.339
2.356LysGly: 2.356 ± 1.52
4.711LysHis: 4.711 ± 3.039
1.178LysIle: 1.178 ± 1.257
1.178LysLys: 1.178 ± 1.015
1.178LysLeu: 1.178 ± 0.76
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
0.0LysPro: 0.0 ± 0.0
2.356LysGln: 2.356 ± 0.827
3.534LysArg: 3.534 ± 1.222
3.534LysSer: 3.534 ± 1.688
1.178LysThr: 1.178 ± 1.015
4.711LysVal: 4.711 ± 1.654
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
1.178LeuAla: 1.178 ± 0.76
1.178LeuCys: 1.178 ± 0.76
12.956LeuAsp: 12.956 ± 1.91
4.711LeuGlu: 4.711 ± 1.878
1.178LeuPhe: 1.178 ± 0.76
1.178LeuGly: 1.178 ± 1.257
0.0LeuHis: 0.0 ± 0.0
4.711LeuIle: 4.711 ± 1.309
3.534LeuLys: 3.534 ± 0.603
11.779LeuLeu: 11.779 ± 4.738
1.178LeuMet: 1.178 ± 0.76
1.178LeuAsn: 1.178 ± 1.015
7.067LeuPro: 7.067 ± 1.206
3.534LeuGln: 3.534 ± 1.222
3.534LeuArg: 3.534 ± 2.175
4.711LeuSer: 4.711 ± 0.299
4.711LeuThr: 4.711 ± 1.79
3.534LeuVal: 3.534 ± 0.603
0.0LeuTrp: 0.0 ± 0.0
1.178LeuTyr: 1.178 ± 1.015
0.0LeuXaa: 0.0 ± 0.0
Met
1.178MetAla: 1.178 ± 1.015
0.0MetCys: 0.0 ± 0.0
1.178MetAsp: 1.178 ± 0.76
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.178MetGly: 1.178 ± 1.015
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.356MetLeu: 2.356 ± 0.827
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.356MetPro: 2.356 ± 0.827
0.0MetGln: 0.0 ± 0.0
1.178MetArg: 1.178 ± 1.015
2.356MetSer: 2.356 ± 1.036
0.0MetThr: 0.0 ± 0.0
2.356MetVal: 2.356 ± 1.036
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.178AsnAla: 1.178 ± 1.257
0.0AsnCys: 0.0 ± 0.0
4.711AsnAsp: 4.711 ± 1.309
3.534AsnGlu: 3.534 ± 1.688
1.178AsnPhe: 1.178 ± 1.015
5.889AsnGly: 5.889 ± 2.263
1.178AsnHis: 1.178 ± 1.257
1.178AsnIle: 1.178 ± 1.015
2.356AsnLys: 2.356 ± 0.827
4.711AsnLeu: 4.711 ± 2.898
2.356AsnMet: 2.356 ± 1.167
4.711AsnAsn: 4.711 ± 2.898
1.178AsnPro: 1.178 ± 0.76
1.178AsnGln: 1.178 ± 1.257
2.356AsnArg: 2.356 ± 2.03
3.534AsnSer: 3.534 ± 1.688
2.356AsnThr: 2.356 ± 1.036
1.178AsnVal: 1.178 ± 0.76
0.0AsnTrp: 0.0 ± 0.0
1.178AsnTyr: 1.178 ± 1.257
0.0AsnXaa: 0.0 ± 0.0
Pro
4.711ProAla: 4.711 ± 1.878
0.0ProCys: 0.0 ± 0.0
2.356ProAsp: 2.356 ± 1.52
3.534ProGlu: 3.534 ± 1.313
0.0ProPhe: 0.0 ± 0.0
7.067ProGly: 7.067 ± 1.206
0.0ProHis: 0.0 ± 0.0
3.534ProIle: 3.534 ± 2.391
0.0ProLys: 0.0 ± 0.0
2.356ProLeu: 2.356 ± 1.52
1.178ProMet: 1.178 ± 0.76
1.178ProAsn: 1.178 ± 1.015
14.134ProPro: 14.134 ± 9.118
5.889ProGln: 5.889 ± 2.564
1.178ProArg: 1.178 ± 0.76
5.889ProSer: 5.889 ± 1.943
4.711ProThr: 4.711 ± 3.039
4.711ProVal: 4.711 ± 0.299
0.0ProTrp: 0.0 ± 0.0
1.178ProTyr: 1.178 ± 0.76
0.0ProXaa: 0.0 ± 0.0
Gln
5.889GlnAla: 5.889 ± 0.985
1.178GlnCys: 1.178 ± 1.015
1.178GlnAsp: 1.178 ± 0.76
2.356GlnGlu: 2.356 ± 1.52
2.356GlnPhe: 2.356 ± 1.339
3.534GlnGly: 3.534 ± 1.222
0.0GlnHis: 0.0 ± 0.0
2.356GlnIle: 2.356 ± 1.036
1.178GlnLys: 1.178 ± 0.76
1.178GlnLeu: 1.178 ± 0.76
0.0GlnMet: 0.0 ± 0.0
1.178GlnAsn: 1.178 ± 1.015
3.534GlnPro: 3.534 ± 2.28
2.356GlnGln: 2.356 ± 1.52
8.245GlnArg: 8.245 ± 3.15
2.356GlnSer: 2.356 ± 2.03
2.356GlnThr: 2.356 ± 2.03
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.356ArgAla: 2.356 ± 2.03
1.178ArgCys: 1.178 ± 1.015
2.356ArgAsp: 2.356 ± 0.827
0.0ArgGlu: 0.0 ± 0.0
8.245ArgPhe: 8.245 ± 3.27
5.889ArgGly: 5.889 ± 2.564
1.178ArgHis: 1.178 ± 1.015
3.534ArgIle: 3.534 ± 0.603
5.889ArgLys: 5.889 ± 1.943
1.178ArgLeu: 1.178 ± 0.76
1.178ArgMet: 1.178 ± 0.76
0.0ArgAsn: 0.0 ± 0.0
4.711ArgPro: 4.711 ± 0.299
0.0ArgGln: 0.0 ± 0.0
5.889ArgArg: 5.889 ± 3.034
4.711ArgSer: 4.711 ± 2.66
5.889ArgThr: 5.889 ± 0.985
8.245ArgVal: 8.245 ± 0.573
2.356ArgTrp: 2.356 ± 0.827
5.889ArgTyr: 5.889 ± 0.717
0.0ArgXaa: 0.0 ± 0.0
Ser
2.356SerAla: 2.356 ± 1.52
0.0SerCys: 0.0 ± 0.0
4.711SerAsp: 4.711 ± 2.073
7.067SerGlu: 7.067 ± 2.515
1.178SerPhe: 1.178 ± 1.015
5.889SerGly: 5.889 ± 1.943
0.0SerHis: 0.0 ± 0.0
2.356SerIle: 2.356 ± 2.03
3.534SerLys: 3.534 ± 0.603
4.711SerLeu: 4.711 ± 3.398
1.178SerMet: 1.178 ± 1.015
8.245SerAsn: 8.245 ± 2.747
2.356SerPro: 2.356 ± 1.036
7.067SerGln: 7.067 ± 3.254
5.889SerArg: 5.889 ± 1.943
9.423SerSer: 9.423 ± 1.036
3.534SerThr: 3.534 ± 3.044
3.534SerVal: 3.534 ± 2.175
0.0SerTrp: 0.0 ± 0.0
2.356SerTyr: 2.356 ± 0.827
0.0SerXaa: 0.0 ± 0.0
Thr
11.779ThrAla: 11.779 ± 1.435
1.178ThrCys: 1.178 ± 0.76
4.711ThrAsp: 4.711 ± 3.398
3.534ThrGlu: 3.534 ± 2.016
2.356ThrPhe: 2.356 ± 1.036
10.601ThrGly: 10.601 ± 3.086
0.0ThrHis: 0.0 ± 0.0
1.178ThrIle: 1.178 ± 1.015
0.0ThrLys: 0.0 ± 0.0
4.711ThrLeu: 4.711 ± 1.654
0.0ThrMet: 0.0 ± 0.0
3.534ThrAsn: 3.534 ± 1.688
3.534ThrPro: 3.534 ± 1.313
2.356ThrGln: 2.356 ± 1.52
2.356ThrArg: 2.356 ± 1.036
7.067ThrSer: 7.067 ± 2.515
8.245ThrThr: 8.245 ± 1.767
4.711ThrVal: 4.711 ± 0.299
1.178ThrTrp: 1.178 ± 0.76
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
7.067ValAla: 7.067 ± 4.285
0.0ValCys: 0.0 ± 0.0
2.356ValAsp: 2.356 ± 1.036
1.178ValGlu: 1.178 ± 0.76
3.534ValPhe: 3.534 ± 1.688
4.711ValGly: 4.711 ± 0.299
1.178ValHis: 1.178 ± 0.76
2.356ValIle: 2.356 ± 0.827
4.711ValLys: 4.711 ± 1.859
4.711ValLeu: 4.711 ± 2.073
2.356ValMet: 2.356 ± 1.339
1.178ValAsn: 1.178 ± 1.015
3.534ValPro: 3.534 ± 1.313
1.178ValGln: 1.178 ± 1.015
1.178ValArg: 1.178 ± 1.015
4.711ValSer: 4.711 ± 1.79
8.245ValThr: 8.245 ± 2.357
4.711ValVal: 4.711 ± 2.898
2.356ValTrp: 2.356 ± 1.52
3.534ValTyr: 3.534 ± 2.28
0.0ValXaa: 0.0 ± 0.0
Trp
1.178TrpAla: 1.178 ± 1.015
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
1.178TrpHis: 1.178 ± 1.257
1.178TrpIle: 1.178 ± 0.76
0.0TrpLys: 0.0 ± 0.0
1.178TrpLeu: 1.178 ± 0.76
0.0TrpMet: 0.0 ± 0.0
1.178TrpAsn: 1.178 ± 0.76
0.0TrpPro: 0.0 ± 0.0
1.178TrpGln: 1.178 ± 1.015
2.356TrpArg: 2.356 ± 0.827
1.178TrpSer: 1.178 ± 0.76
2.356TrpThr: 2.356 ± 1.52
1.178TrpVal: 1.178 ± 0.76
2.356TrpTrp: 2.356 ± 1.52
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.178TyrAla: 1.178 ± 0.76
2.356TyrCys: 2.356 ± 1.036
3.534TyrAsp: 3.534 ± 0.603
1.178TyrGlu: 1.178 ± 1.257
0.0TyrPhe: 0.0 ± 0.0
1.178TyrGly: 1.178 ± 1.015
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
1.178TyrLys: 1.178 ± 0.76
1.178TyrLeu: 1.178 ± 1.257
1.178TyrMet: 1.178 ± 0.76
2.356TyrAsn: 2.356 ± 2.03
2.356TyrPro: 2.356 ± 1.339
4.711TyrGln: 4.711 ± 3.039
3.534TyrArg: 3.534 ± 1.688
1.178TyrSer: 1.178 ± 1.257
1.178TyrThr: 1.178 ± 1.257
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
3.534TyrTyr: 3.534 ± 0.603
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski