Amino acid dipepetide frequency for Treponema porcinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.989AlaAla: 7.989 ± 0.155	1.105AlaCys: 1.105 ± 0.042	5.127AlaAsp: 5.127 ± 0.109	6.554AlaGlu: 6.554 ± 0.115	3.57AlaPhe: 3.57 ± 0.085	6.411AlaGly: 6.411 ± 0.103	1.094AlaHis: 1.094 ± 0.042	4.141AlaIle: 4.141 ± 0.085	4.87AlaLys: 4.87 ± 0.088	7.126AlaLeu: 7.126 ± 0.12	1.766AlaMet: 1.766 ± 0.048	2.595AlaAsn: 2.595 ± 0.069	2.226AlaPro: 2.226 ± 0.063	2.611AlaGln: 2.611 ± 0.068	3.2AlaArg: 3.2 ± 0.08	4.874AlaSer: 4.874 ± 0.088	2.988AlaThr: 2.988 ± 0.081	7.205AlaVal: 7.205 ± 0.115	0.604AlaTrp: 0.604 ± 0.035	2.519AlaTyr: 2.519 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.521CysAla: 1.521 ± 0.052	0.284CysCys: 0.284 ± 0.021	0.796CysAsp: 0.796 ± 0.033	0.747CysGlu: 0.747 ± 0.033	0.756CysPhe: 0.756 ± 0.037	1.528CysGly: 1.528 ± 0.053	0.238CysHis: 0.238 ± 0.018	1.151CysIle: 1.151 ± 0.044	0.689CysLys: 0.689 ± 0.032	1.11CysLeu: 1.11 ± 0.038	0.34CysMet: 0.34 ± 0.024	0.556CysAsn: 0.556 ± 0.027	0.64CysPro: 0.64 ± 0.037	0.314CysGln: 0.314 ± 0.019	0.873CysArg: 0.873 ± 0.034	1.131CysSer: 1.131 ± 0.041	0.902CysThr: 0.902 ± 0.035	0.983CysVal: 0.983 ± 0.037	0.134CysTrp: 0.134 ± 0.013	0.526CysTyr: 0.526 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.457AspAla: 4.457 ± 0.084	0.829AspCys: 0.829 ± 0.03	3.36AspAsp: 3.36 ± 0.092	4.62AspGlu: 4.62 ± 0.084	3.658AspPhe: 3.658 ± 0.068	4.723AspGly: 4.723 ± 0.109	0.56AspHis: 0.56 ± 0.029	4.3AspIle: 4.3 ± 0.079	3.343AspLys: 3.343 ± 0.081	4.088AspLeu: 4.088 ± 0.085	1.359AspMet: 1.359 ± 0.044	2.199AspAsn: 2.199 ± 0.069	1.549AspPro: 1.549 ± 0.044	0.825AspGln: 0.825 ± 0.039	2.097AspArg: 2.097 ± 0.051	4.205AspSer: 4.205 ± 0.092	2.842AspThr: 2.842 ± 0.072	3.809AspVal: 3.809 ± 0.072	0.669AspTrp: 0.669 ± 0.034	2.452AspTyr: 2.452 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.743GluAla: 4.743 ± 0.089	0.931GluCys: 0.931 ± 0.04	3.4GluAsp: 3.4 ± 0.077	5.544GluGlu: 5.544 ± 0.135	2.806GluPhe: 2.806 ± 0.065	3.353GluGly: 3.353 ± 0.069	1.08GluHis: 1.08 ± 0.045	5.48GluIle: 5.48 ± 0.088	7.496GluLys: 7.496 ± 0.13	6.097GluLeu: 6.097 ± 0.104	1.855GluMet: 1.855 ± 0.051	4.94GluAsn: 4.94 ± 0.091	2.084GluPro: 2.084 ± 0.076	2.681GluGln: 2.681 ± 0.079	3.181GluArg: 3.181 ± 0.083	3.977GluSer: 3.977 ± 0.083	3.849GluThr: 3.849 ± 0.083	3.585GluVal: 3.585 ± 0.074	0.7GluTrp: 0.7 ± 0.033	2.701GluTyr: 2.701 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	3.737PheAla: 3.737 ± 0.086	1.016PheCys: 1.016 ± 0.04	2.94PheAsp: 2.94 ± 0.072	3.009PheGlu: 3.009 ± 0.07	2.786PhePhe: 2.786 ± 0.08	3.254PheGly: 3.254 ± 0.073	0.706PheHis: 0.706 ± 0.031	3.553PheIle: 3.553 ± 0.07	2.591PheLys: 2.591 ± 0.068	4.364PheLeu: 4.364 ± 0.098	1.141PheMet: 1.141 ± 0.039	2.138PheAsn: 2.138 ± 0.065	1.865PhePro: 1.865 ± 0.05	1.162PheGln: 1.162 ± 0.04	2.031PheArg: 2.031 ± 0.048	4.605PheSer: 4.605 ± 0.101	3.058PheThr: 3.058 ± 0.065	3.144PheVal: 3.144 ± 0.073	0.445PheTrp: 0.445 ± 0.027	1.936PheTyr: 1.936 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.036GlyAla: 5.036 ± 0.111	1.098GlyCys: 1.098 ± 0.034	3.147GlyAsp: 3.147 ± 0.076	3.908GlyGlu: 3.908 ± 0.072	3.377GlyPhe: 3.377 ± 0.074	4.624GlyGly: 4.624 ± 0.136	0.954GlyHis: 0.954 ± 0.037	5.854GlyIle: 5.854 ± 0.093	5.605GlyLys: 5.605 ± 0.087	5.238GlyLeu: 5.238 ± 0.101	1.807GlyMet: 1.807 ± 0.06	3.304GlyAsn: 3.304 ± 0.085	1.157GlyPro: 1.157 ± 0.048	1.594GlyGln: 1.594 ± 0.051	2.731GlyArg: 2.731 ± 0.067	4.349GlySer: 4.349 ± 0.094	4.732GlyThr: 4.732 ± 0.131	4.118GlyVal: 4.118 ± 0.087	0.735GlyTrp: 0.735 ± 0.033	2.586GlyTyr: 2.586 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.865HisAla: 0.865 ± 0.033	0.265HisCys: 0.265 ± 0.017	0.751HisAsp: 0.751 ± 0.036	0.823HisGlu: 0.823 ± 0.037	0.894HisPhe: 0.894 ± 0.033	0.986HisGly: 0.986 ± 0.045	0.307HisHis: 0.307 ± 0.022	1.297HisIle: 1.297 ± 0.039	0.918HisLys: 0.918 ± 0.032	1.428HisLeu: 1.428 ± 0.045	0.241HisMet: 0.241 ± 0.015	0.729HisAsn: 0.729 ± 0.029	0.809HisPro: 0.809 ± 0.03	0.411HisGln: 0.411 ± 0.021	0.615HisArg: 0.615 ± 0.028	1.096HisSer: 1.096 ± 0.036	0.889HisThr: 0.889 ± 0.033	0.784HisVal: 0.784 ± 0.034	0.168HisTrp: 0.168 ± 0.015	0.601HisTyr: 0.601 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.727IleAla: 5.727 ± 0.09	1.143IleCys: 1.143 ± 0.046	4.134IleAsp: 4.134 ± 0.081	4.728IleGlu: 4.728 ± 0.087	3.203IlePhe: 3.203 ± 0.074	3.985IleGly: 3.985 ± 0.069	1.117IleHis: 1.117 ± 0.034	5.113IleIle: 5.113 ± 0.111	4.604IleLys: 4.604 ± 0.084	6.314IleLeu: 6.314 ± 0.105	1.53IleMet: 1.53 ± 0.044	3.062IleAsn: 3.062 ± 0.072	3.442IlePro: 3.442 ± 0.063	2.434IleGln: 2.434 ± 0.057	3.226IleArg: 3.226 ± 0.071	5.605IleSer: 5.605 ± 0.091	4.502IleThr: 4.502 ± 0.107	4.454IleVal: 4.454 ± 0.098	0.484IleTrp: 0.484 ± 0.026	2.297IleTyr: 2.297 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.249LysAla: 5.249 ± 0.105	0.775LysCys: 0.775 ± 0.031	4.169LysAsp: 4.169 ± 0.084	5.446LysGlu: 5.446 ± 0.109	2.397LysPhe: 2.397 ± 0.062	3.878LysGly: 3.878 ± 0.069	0.921LysHis: 0.921 ± 0.037	5.8LysIle: 5.8 ± 0.099	6.815LysLys: 6.815 ± 0.102	5.375LysLeu: 5.375 ± 0.085	2.047LysMet: 2.047 ± 0.045	4.972LysAsn: 4.972 ± 0.091	2.239LysPro: 2.239 ± 0.058	2.284LysGln: 2.284 ± 0.055	2.793LysArg: 2.793 ± 0.06	4.553LysSer: 4.553 ± 0.085	4.735LysThr: 4.735 ± 0.085	3.633LysVal: 3.633 ± 0.078	0.623LysTrp: 0.623 ± 0.028	2.691LysTyr: 2.691 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.267LeuAla: 6.267 ± 0.123	1.596LeuCys: 1.596 ± 0.046	4.727LeuAsp: 4.727 ± 0.088	5.837LeuGlu: 5.837 ± 0.114	4.776LeuPhe: 4.776 ± 0.1	5.143LeuGly: 5.143 ± 0.085	1.547LeuHis: 1.547 ± 0.046	5.302LeuIle: 5.302 ± 0.1	6.074LeuLys: 6.074 ± 0.109	7.964LeuLeu: 7.964 ± 0.127	2.02LeuMet: 2.02 ± 0.053	4.116LeuAsn: 4.116 ± 0.091	3.69LeuPro: 3.69 ± 0.072	2.541LeuGln: 2.541 ± 0.061	3.573LeuArg: 3.573 ± 0.08	7.509LeuSer: 7.509 ± 0.108	4.539LeuThr: 4.539 ± 0.083	5.291LeuVal: 5.291 ± 0.093	0.731LeuTrp: 0.731 ± 0.032	3.392LeuTyr: 3.392 ± 0.082	0.0LeuXaa: 0.0 ± 0.0
Met	1.795MetAla: 1.795 ± 0.052	0.293MetCys: 0.293 ± 0.021	1.158MetAsp: 1.158 ± 0.04	1.702MetGlu: 1.702 ± 0.042	0.893MetPhe: 0.893 ± 0.032	1.361MetGly: 1.361 ± 0.047	0.417MetHis: 0.417 ± 0.025	1.736MetIle: 1.736 ± 0.045	2.291MetLys: 2.291 ± 0.056	2.108MetLeu: 2.108 ± 0.06	0.654MetMet: 0.654 ± 0.03	1.496MetAsn: 1.496 ± 0.043	0.95MetPro: 0.95 ± 0.043	0.959MetGln: 0.959 ± 0.035	0.994MetArg: 0.994 ± 0.037	1.55MetSer: 1.55 ± 0.049	1.493MetThr: 1.493 ± 0.052	1.174MetVal: 1.174 ± 0.048	0.134MetTrp: 0.134 ± 0.012	0.751MetTyr: 0.751 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	4.164AsnAla: 4.164 ± 0.083	0.729AsnCys: 0.729 ± 0.032	2.595AsnAsp: 2.595 ± 0.062	3.17AsnGlu: 3.17 ± 0.092	1.993AsnPhe: 1.993 ± 0.054	3.961AsnGly: 3.961 ± 0.094	0.727AsnHis: 0.727 ± 0.035	3.513AsnIle: 3.513 ± 0.076	2.954AsnLys: 2.954 ± 0.07	3.922AsnLeu: 3.922 ± 0.065	1.178AsnMet: 1.178 ± 0.042	2.061AsnAsn: 2.061 ± 0.082	2.479AsnPro: 2.479 ± 0.067	1.391AsnGln: 1.391 ± 0.045	2.114AsnArg: 2.114 ± 0.053	3.274AsnSer: 3.274 ± 0.082	2.601AsnThr: 2.601 ± 0.055	3.117AsnVal: 3.117 ± 0.08	0.501AsnTrp: 0.501 ± 0.027	1.763AsnTyr: 1.763 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	3.051ProAla: 3.051 ± 0.072	0.503ProCys: 0.503 ± 0.028	2.512ProAsp: 2.512 ± 0.059	3.769ProGlu: 3.769 ± 0.074	1.986ProPhe: 1.986 ± 0.05	2.296ProGly: 2.296 ± 0.064	0.541ProHis: 0.541 ± 0.027	1.497ProIle: 1.497 ± 0.043	1.941ProLys: 1.941 ± 0.057	3.215ProLeu: 3.215 ± 0.068	0.62ProMet: 0.62 ± 0.035	1.273ProAsn: 1.273 ± 0.041	1.023ProPro: 1.023 ± 0.042	1.215ProGln: 1.215 ± 0.04	1.104ProArg: 1.104 ± 0.039	2.435ProSer: 2.435 ± 0.072	1.263ProThr: 1.263 ± 0.039	3.619ProVal: 3.619 ± 0.086	0.318ProTrp: 0.318 ± 0.023	1.431ProTyr: 1.431 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.224GlnAla: 2.224 ± 0.055	0.354GlnCys: 0.354 ± 0.02	1.347GlnAsp: 1.347 ± 0.042	2.125GlnGlu: 2.125 ± 0.062	1.493GlnPhe: 1.493 ± 0.047	1.577GlnGly: 1.577 ± 0.043	0.452GlnHis: 0.452 ± 0.023	2.432GlnIle: 2.432 ± 0.057	3.099GlnLys: 3.099 ± 0.076	2.651GlnLeu: 2.651 ± 0.063	0.896GlnMet: 0.896 ± 0.035	2.121GlnAsn: 2.121 ± 0.053	0.943GlnPro: 0.943 ± 0.041	1.114GlnGln: 1.114 ± 0.043	1.18GlnArg: 1.18 ± 0.047	1.804GlnSer: 1.804 ± 0.052	1.781GlnThr: 1.781 ± 0.052	1.537GlnVal: 1.537 ± 0.045	0.24GlnTrp: 0.24 ± 0.02	1.082GlnTyr: 1.082 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.896ArgAla: 2.896 ± 0.067	0.552ArgCys: 0.552 ± 0.031	2.004ArgAsp: 2.004 ± 0.057	2.691ArgGlu: 2.691 ± 0.065	2.122ArgPhe: 2.122 ± 0.049	2.186ArgGly: 2.186 ± 0.058	0.673ArgHis: 0.673 ± 0.033	3.593ArgIle: 3.593 ± 0.074	3.152ArgLys: 3.152 ± 0.072	4.004ArgLeu: 4.004 ± 0.094	1.223ArgMet: 1.223 ± 0.047	2.393ArgAsn: 2.393 ± 0.062	1.354ArgPro: 1.354 ± 0.046	1.512ArgGln: 1.512 ± 0.055	2.273ArgArg: 2.273 ± 0.061	2.309ArgSer: 2.309 ± 0.055	2.719ArgThr: 2.719 ± 0.063	2.193ArgVal: 2.193 ± 0.066	0.397ArgTrp: 0.397 ± 0.024	1.533ArgTyr: 1.533 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.217SerAla: 6.217 ± 0.097	1.113SerCys: 1.113 ± 0.037	4.315SerAsp: 4.315 ± 0.086	4.864SerGlu: 4.864 ± 0.102	4.104SerPhe: 4.104 ± 0.08	5.857SerGly: 5.857 ± 0.122	0.898SerHis: 0.898 ± 0.039	4.436SerIle: 4.436 ± 0.08	3.914SerLys: 3.914 ± 0.082	6.367SerLeu: 6.367 ± 0.108	1.432SerMet: 1.432 ± 0.039	2.574SerAsn: 2.574 ± 0.072	2.264SerPro: 2.264 ± 0.051	2.007SerGln: 2.007 ± 0.059	2.891SerArg: 2.891 ± 0.069	5.544SerSer: 5.544 ± 0.127	3.217SerThr: 3.217 ± 0.084	5.825SerVal: 5.825 ± 0.102	0.753SerTrp: 0.753 ± 0.034	2.81SerTyr: 2.81 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	5.081ThrAla: 5.081 ± 0.092	0.627ThrCys: 0.627 ± 0.028	3.46ThrAsp: 3.46 ± 0.082	4.024ThrGlu: 4.024 ± 0.083	2.646ThrPhe: 2.646 ± 0.071	4.73ThrGly: 4.73 ± 0.109	0.837ThrHis: 0.837 ± 0.031	3.706ThrIle: 3.706 ± 0.094	3.296ThrLys: 3.296 ± 0.075	4.775ThrLeu: 4.775 ± 0.097	1.155ThrMet: 1.155 ± 0.038	2.093ThrAsn: 2.093 ± 0.071	2.273ThrPro: 2.273 ± 0.057	1.64ThrGln: 1.64 ± 0.05	1.77ThrArg: 1.77 ± 0.051	3.369ThrSer: 3.369 ± 0.079	2.728ThrThr: 2.728 ± 0.102	5.232ThrVal: 5.232 ± 0.112	0.436ThrTrp: 0.436 ± 0.026	1.86ThrTyr: 1.86 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.094ValAla: 4.094 ± 0.086	1.3ValCys: 1.3 ± 0.046	3.258ValAsp: 3.258 ± 0.075	3.923ValGlu: 3.923 ± 0.087	3.589ValPhe: 3.589 ± 0.082	3.068ValGly: 3.068 ± 0.079	1.069ValHis: 1.069 ± 0.042	4.946ValIle: 4.946 ± 0.084	4.457ValLys: 4.457 ± 0.079	6.628ValLeu: 6.628 ± 0.104	1.563ValMet: 1.563 ± 0.045	2.92ValAsn: 2.92 ± 0.068	3.052ValPro: 3.052 ± 0.081	2.411ValGln: 2.411 ± 0.058	3.079ValArg: 3.079 ± 0.074	5.733ValSer: 5.733 ± 0.101	4.014ValThr: 4.014 ± 0.12	4.312ValVal: 4.312 ± 0.092	0.629ValTrp: 0.629 ± 0.031	2.541ValTyr: 2.541 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.59TrpAla: 0.59 ± 0.03	0.162TrpCys: 0.162 ± 0.016	0.462TrpAsp: 0.462 ± 0.025	0.586TrpGlu: 0.586 ± 0.032	0.461TrpPhe: 0.461 ± 0.027	0.514TrpGly: 0.514 ± 0.028	0.178TrpHis: 0.178 ± 0.017	0.635TrpIle: 0.635 ± 0.029	0.791TrpLys: 0.791 ± 0.039	0.791TrpLeu: 0.791 ± 0.039	0.212TrpMet: 0.212 ± 0.018	0.715TrpAsn: 0.715 ± 0.034	0.204TrpPro: 0.204 ± 0.018	0.374TrpGln: 0.374 ± 0.025	0.37TrpArg: 0.37 ± 0.023	0.592TrpSer: 0.592 ± 0.03	0.588TrpThr: 0.588 ± 0.036	0.411TrpVal: 0.411 ± 0.023	0.135TrpTrp: 0.135 ± 0.014	0.444TrpTyr: 0.444 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.872TyrAla: 2.872 ± 0.079	0.546TyrCys: 0.546 ± 0.025	2.284TyrAsp: 2.284 ± 0.06	2.413TyrGlu: 2.413 ± 0.057	1.97TyrPhe: 1.97 ± 0.06	2.521TyrGly: 2.521 ± 0.064	0.56TyrHis: 0.56 ± 0.029	2.619TyrIle: 2.619 ± 0.063	2.495TyrLys: 2.495 ± 0.063	3.071TyrLeu: 3.071 ± 0.058	0.866TyrMet: 0.866 ± 0.033	1.949TyrAsn: 1.949 ± 0.052	1.369TyrPro: 1.369 ± 0.042	0.972TyrGln: 0.972 ± 0.045	1.685TyrArg: 1.685 ± 0.048	2.886TyrSer: 2.886 ± 0.066	2.3TyrThr: 2.3 ± 0.058	2.161TyrVal: 2.161 ± 0.052	0.378TyrTrp: 0.378 ± 0.023	1.508TyrTyr: 1.508 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2189 proteins (754806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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