Amino acid dipepetide frequency for Aeromicrobium sp. PE09-221

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.689AlaAla: 17.689 ± 0.193	0.908AlaCys: 0.908 ± 0.03	8.061AlaAsp: 8.061 ± 0.105	8.7AlaGlu: 8.7 ± 0.104	3.635AlaPhe: 3.635 ± 0.056	11.449AlaGly: 11.449 ± 0.095	2.446AlaHis: 2.446 ± 0.052	5.592AlaIle: 5.592 ± 0.074	2.282AlaLys: 2.282 ± 0.052	13.026AlaLeu: 13.026 ± 0.129	2.849AlaMet: 2.849 ± 0.048	1.925AlaAsn: 1.925 ± 0.041	5.516AlaPro: 5.516 ± 0.08	3.822AlaGln: 3.822 ± 0.065	9.309AlaArg: 9.309 ± 0.111	6.595AlaSer: 6.595 ± 0.078	7.116AlaThr: 7.116 ± 0.097	11.15AlaVal: 11.15 ± 0.115	1.844AlaTrp: 1.844 ± 0.04	2.357AlaTyr: 2.357 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.031	0.071CysCys: 0.071 ± 0.008	0.432CysAsp: 0.432 ± 0.02	0.392CysGlu: 0.392 ± 0.017	0.222CysPhe: 0.222 ± 0.015	0.814CysGly: 0.814 ± 0.026	0.187CysHis: 0.187 ± 0.014	0.217CysIle: 0.217 ± 0.015	0.071CysLys: 0.071 ± 0.008	0.586CysLeu: 0.586 ± 0.023	0.081CysMet: 0.081 ± 0.009	0.098CysAsn: 0.098 ± 0.009	0.381CysPro: 0.381 ± 0.02	0.142CysGln: 0.142 ± 0.01	0.518CysArg: 0.518 ± 0.025	0.406CysSer: 0.406 ± 0.019	0.367CysThr: 0.367 ± 0.019	0.53CysVal: 0.53 ± 0.021	0.101CysTrp: 0.101 ± 0.01	0.133CysTyr: 0.133 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.994AspAla: 7.994 ± 0.109	0.32AspCys: 0.32 ± 0.019	4.829AspAsp: 4.829 ± 0.073	4.921AspGlu: 4.921 ± 0.073	1.76AspPhe: 1.76 ± 0.045	6.106AspGly: 6.106 ± 0.082	1.563AspHis: 1.563 ± 0.04	2.728AspIle: 2.728 ± 0.052	1.007AspLys: 1.007 ± 0.032	7.093AspLeu: 7.093 ± 0.089	0.896AspMet: 0.896 ± 0.03	0.942AspAsn: 0.942 ± 0.036	4.551AspPro: 4.551 ± 0.066	1.776AspGln: 1.776 ± 0.043	5.014AspArg: 5.014 ± 0.074	2.709AspSer: 2.709 ± 0.052	3.055AspThr: 3.055 ± 0.051	5.464AspVal: 5.464 ± 0.071	0.898AspTrp: 0.898 ± 0.026	1.277AspTyr: 1.277 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.312GluAla: 7.312 ± 0.089	0.321GluCys: 0.321 ± 0.017	3.589GluAsp: 3.589 ± 0.062	3.763GluGlu: 3.763 ± 0.054	1.747GluPhe: 1.747 ± 0.042	4.684GluGly: 4.684 ± 0.071	1.824GluHis: 1.824 ± 0.042	3.194GluIle: 3.194 ± 0.061	1.282GluLys: 1.282 ± 0.037	6.974GluLeu: 6.974 ± 0.083	1.111GluMet: 1.111 ± 0.032	1.29GluAsn: 1.29 ± 0.033	3.42GluPro: 3.42 ± 0.064	2.525GluGln: 2.525 ± 0.053	5.918GluArg: 5.918 ± 0.077	3.278GluSer: 3.278 ± 0.054	3.2GluThr: 3.2 ± 0.055	5.402GluVal: 5.402 ± 0.071	0.838GluTrp: 0.838 ± 0.032	1.114GluTyr: 1.114 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.948PheAla: 3.948 ± 0.063	0.265PheCys: 0.265 ± 0.016	2.265PheAsp: 2.265 ± 0.05	1.719PheGlu: 1.719 ± 0.043	0.925PhePhe: 0.925 ± 0.03	3.316PheGly: 3.316 ± 0.055	0.565PheHis: 0.565 ± 0.021	1.11PheIle: 1.11 ± 0.033	0.422PheLys: 0.422 ± 0.02	2.606PheLeu: 2.606 ± 0.054	0.449PheMet: 0.449 ± 0.019	0.594PheAsn: 0.594 ± 0.026	1.27PhePro: 1.27 ± 0.033	0.638PheGln: 0.638 ± 0.022	1.676PheArg: 1.676 ± 0.039	1.748PheSer: 1.748 ± 0.037	2.046PheThr: 2.046 ± 0.048	2.663PheVal: 2.663 ± 0.045	0.439PheTrp: 0.439 ± 0.02	0.616PheTyr: 0.616 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.955GlyAla: 9.955 ± 0.094	0.666GlyCys: 0.666 ± 0.024	5.595GlyAsp: 5.595 ± 0.074	5.616GlyGlu: 5.616 ± 0.081	3.006GlyPhe: 3.006 ± 0.051	7.867GlyGly: 7.867 ± 0.121	2.033GlyHis: 2.033 ± 0.05	4.304GlyIle: 4.304 ± 0.063	1.965GlyLys: 1.965 ± 0.043	9.187GlyLeu: 9.187 ± 0.101	1.843GlyMet: 1.843 ± 0.039	1.584GlyAsn: 1.584 ± 0.051	4.132GlyPro: 4.132 ± 0.068	2.748GlyGln: 2.748 ± 0.052	6.738GlyArg: 6.738 ± 0.079	5.214GlySer: 5.214 ± 0.067	5.533GlyThr: 5.533 ± 0.079	7.955GlyVal: 7.955 ± 0.089	1.636GlyTrp: 1.636 ± 0.041	2.112GlyTyr: 2.112 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.561HisAla: 2.561 ± 0.052	0.156HisCys: 0.156 ± 0.011	1.513HisAsp: 1.513 ± 0.038	1.39HisGlu: 1.39 ± 0.038	0.59HisPhe: 0.59 ± 0.021	2.217HisGly: 2.217 ± 0.046	0.7HisHis: 0.7 ± 0.027	0.716HisIle: 0.716 ± 0.028	0.271HisLys: 0.271 ± 0.014	2.321HisLeu: 2.321 ± 0.048	0.337HisMet: 0.337 ± 0.019	0.313HisAsn: 0.313 ± 0.014	1.558HisPro: 1.558 ± 0.037	0.654HisGln: 0.654 ± 0.024	1.896HisArg: 1.896 ± 0.042	0.867HisSer: 0.867 ± 0.026	1.086HisThr: 1.086 ± 0.029	1.803HisVal: 1.803 ± 0.042	0.297HisTrp: 0.297 ± 0.016	0.442HisTyr: 0.442 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.074IleAla: 7.074 ± 0.085	0.31IleCys: 0.31 ± 0.016	3.605IleAsp: 3.605 ± 0.059	3.22IleGlu: 3.22 ± 0.051	0.991IlePhe: 0.991 ± 0.028	5.004IleGly: 5.004 ± 0.076	0.716IleHis: 0.716 ± 0.025	1.701IleIle: 1.701 ± 0.043	0.735IleLys: 0.735 ± 0.026	3.313IleLeu: 3.313 ± 0.059	0.653IleMet: 0.653 ± 0.024	0.857IleAsn: 0.857 ± 0.029	2.116IlePro: 2.116 ± 0.045	0.823IleGln: 0.823 ± 0.025	2.532IleArg: 2.532 ± 0.047	2.252IleSer: 2.252 ± 0.042	2.744IleThr: 2.744 ± 0.044	4.689IleVal: 4.689 ± 0.066	0.516IleTrp: 0.516 ± 0.024	0.701IleTyr: 0.701 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.27LysAla: 2.27 ± 0.057	0.07LysCys: 0.07 ± 0.009	0.985LysAsp: 0.985 ± 0.029	0.981LysGlu: 0.981 ± 0.031	0.43LysPhe: 0.43 ± 0.022	1.447LysGly: 1.447 ± 0.045	0.405LysHis: 0.405 ± 0.018	0.921LysIle: 0.921 ± 0.031	0.673LysLys: 0.673 ± 0.03	1.675LysLeu: 1.675 ± 0.04	0.344LysMet: 0.344 ± 0.018	0.476LysAsn: 0.476 ± 0.021	1.029LysPro: 1.029 ± 0.033	0.605LysGln: 0.605 ± 0.023	1.416LysArg: 1.416 ± 0.034	1.061LysSer: 1.061 ± 0.03	1.195LysThr: 1.195 ± 0.036	1.59LysVal: 1.59 ± 0.042	0.209LysTrp: 0.209 ± 0.014	0.346LysTyr: 0.346 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.073LeuAla: 14.073 ± 0.124	0.68LeuCys: 0.68 ± 0.023	7.286LeuAsp: 7.286 ± 0.089	5.4LeuGlu: 5.4 ± 0.069	2.55LeuPhe: 2.55 ± 0.057	9.43LeuGly: 9.43 ± 0.102	2.012LeuHis: 2.012 ± 0.041	4.175LeuIle: 4.175 ± 0.07	1.646LeuLys: 1.646 ± 0.041	10.256LeuLeu: 10.256 ± 0.125	1.863LeuMet: 1.863 ± 0.043	1.764LeuAsn: 1.764 ± 0.043	5.415LeuPro: 5.415 ± 0.079	2.331LeuGln: 2.331 ± 0.049	7.944LeuArg: 7.944 ± 0.077	5.91LeuSer: 5.91 ± 0.075	6.468LeuThr: 6.468 ± 0.083	9.54LeuVal: 9.54 ± 0.116	1.135LeuTrp: 1.135 ± 0.033	1.586LeuTyr: 1.586 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.326MetAla: 2.326 ± 0.05	0.123MetCys: 0.123 ± 0.01	0.908MetAsp: 0.908 ± 0.031	0.804MetGlu: 0.804 ± 0.028	0.553MetPhe: 0.553 ± 0.024	1.456MetGly: 1.456 ± 0.035	0.339MetHis: 0.339 ± 0.018	0.903MetIle: 0.903 ± 0.032	0.444MetLys: 0.444 ± 0.02	2.009MetLeu: 2.009 ± 0.044	0.426MetMet: 0.426 ± 0.022	0.489MetAsn: 0.489 ± 0.021	1.093MetPro: 1.093 ± 0.033	0.476MetGln: 0.476 ± 0.021	1.584MetArg: 1.584 ± 0.035	1.658MetSer: 1.658 ± 0.038	1.818MetThr: 1.818 ± 0.036	1.477MetVal: 1.477 ± 0.034	0.224MetTrp: 0.224 ± 0.015	0.315MetTyr: 0.315 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.255AsnAla: 2.255 ± 0.046	0.113AsnCys: 0.113 ± 0.01	1.11AsnAsp: 1.11 ± 0.031	1.002AsnGlu: 1.002 ± 0.027	0.504AsnPhe: 0.504 ± 0.022	1.675AsnGly: 1.675 ± 0.04	0.375AsnHis: 0.375 ± 0.017	0.814AsnIle: 0.814 ± 0.026	0.328AsnLys: 0.328 ± 0.017	1.739AsnLeu: 1.739 ± 0.039	0.315AsnMet: 0.315 ± 0.014	0.399AsnAsn: 0.399 ± 0.021	1.346AsnPro: 1.346 ± 0.029	0.498AsnGln: 0.498 ± 0.021	1.291AsnArg: 1.291 ± 0.034	0.905AsnSer: 0.905 ± 0.044	1.049AsnThr: 1.049 ± 0.038	1.485AsnVal: 1.485 ± 0.042	0.26AsnTrp: 0.26 ± 0.015	0.381AsnTyr: 0.381 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.473ProAla: 6.473 ± 0.088	0.27ProCys: 0.27 ± 0.015	3.931ProAsp: 3.931 ± 0.055	4.076ProGlu: 4.076 ± 0.069	1.552ProPhe: 1.552 ± 0.036	5.246ProGly: 5.246 ± 0.076	1.184ProHis: 1.184 ± 0.029	2.022ProIle: 2.022 ± 0.043	0.993ProLys: 0.993 ± 0.029	4.66ProLeu: 4.66 ± 0.061	1.086ProMet: 1.086 ± 0.031	0.813ProAsn: 0.813 ± 0.024	2.553ProPro: 2.553 ± 0.059	1.495ProGln: 1.495 ± 0.034	3.583ProArg: 3.583 ± 0.058	3.127ProSer: 3.127 ± 0.05	3.097ProThr: 3.097 ± 0.053	4.752ProVal: 4.752 ± 0.072	0.886ProTrp: 0.886 ± 0.029	1.02ProTyr: 1.02 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.424GlnAla: 3.424 ± 0.058	0.148GlnCys: 0.148 ± 0.011	1.246GlnAsp: 1.246 ± 0.037	1.411GlnGlu: 1.411 ± 0.036	0.777GlnPhe: 0.777 ± 0.029	1.953GlnGly: 1.953 ± 0.046	0.724GlnHis: 0.724 ± 0.028	1.552GlnIle: 1.552 ± 0.033	0.58GlnLys: 0.58 ± 0.025	3.179GlnLeu: 3.179 ± 0.061	0.607GlnMet: 0.607 ± 0.027	0.548GlnAsn: 0.548 ± 0.023	1.4GlnPro: 1.4 ± 0.035	1.217GlnGln: 1.217 ± 0.037	2.758GlnArg: 2.758 ± 0.055	1.414GlnSer: 1.414 ± 0.038	1.554GlnThr: 1.554 ± 0.038	2.672GlnVal: 2.672 ± 0.045	0.488GlnTrp: 0.488 ± 0.019	0.571GlnTyr: 0.571 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.512ArgAla: 8.512 ± 0.1	0.483ArgCys: 0.483 ± 0.022	4.617ArgAsp: 4.617 ± 0.064	5.148ArgGlu: 5.148 ± 0.071	2.44ArgPhe: 2.44 ± 0.051	5.541ArgGly: 5.541 ± 0.067	1.925ArgHis: 1.925 ± 0.045	3.622ArgIle: 3.622 ± 0.055	1.355ArgLys: 1.355 ± 0.036	8.199ArgLeu: 8.199 ± 0.093	1.775ArgMet: 1.775 ± 0.042	1.272ArgAsn: 1.272 ± 0.032	4.031ArgPro: 4.031 ± 0.071	2.381ArgGln: 2.381 ± 0.044	7.458ArgArg: 7.458 ± 0.112	4.312ArgSer: 4.312 ± 0.06	4.294ArgThr: 4.294 ± 0.062	6.217ArgVal: 6.217 ± 0.077	1.477ArgTrp: 1.477 ± 0.039	1.708ArgTyr: 1.708 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.729SerAla: 6.729 ± 0.082	0.36SerCys: 0.36 ± 0.018	3.123SerAsp: 3.123 ± 0.05	3.116SerGlu: 3.116 ± 0.052	1.88SerPhe: 1.88 ± 0.035	5.66SerGly: 5.66 ± 0.077	1.011SerHis: 1.011 ± 0.028	2.479SerIle: 2.479 ± 0.05	0.987SerLys: 0.987 ± 0.029	5.555SerLeu: 5.555 ± 0.074	1.384SerMet: 1.384 ± 0.031	0.995SerAsn: 0.995 ± 0.033	2.936SerPro: 2.936 ± 0.049	1.408SerGln: 1.408 ± 0.037	3.95SerArg: 3.95 ± 0.062	3.467SerSer: 3.467 ± 0.063	3.498SerThr: 3.498 ± 0.055	4.723SerVal: 4.723 ± 0.059	0.962SerTrp: 0.962 ± 0.032	1.117SerTyr: 1.117 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.47ThrAla: 7.47 ± 0.094	0.406ThrCys: 0.406 ± 0.02	3.598ThrAsp: 3.598 ± 0.058	3.356ThrGlu: 3.356 ± 0.048	1.807ThrPhe: 1.807 ± 0.04	5.765ThrGly: 5.765 ± 0.072	1.199ThrHis: 1.199 ± 0.031	2.965ThrIle: 2.965 ± 0.05	0.989ThrLys: 0.989 ± 0.032	5.825ThrLeu: 5.825 ± 0.074	1.169ThrMet: 1.169 ± 0.035	1.035ThrAsn: 1.035 ± 0.036	3.58ThrPro: 3.58 ± 0.065	1.529ThrGln: 1.529 ± 0.038	3.939ThrArg: 3.939 ± 0.066	3.533ThrSer: 3.533 ± 0.059	3.994ThrThr: 3.994 ± 0.074	5.825ThrVal: 5.825 ± 0.077	0.913ThrTrp: 0.913 ± 0.027	1.257ThrTyr: 1.257 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	11.343ValAla: 11.343 ± 0.116	0.62ValCys: 0.62 ± 0.024	6.053ValAsp: 6.053 ± 0.067	5.79ValGlu: 5.79 ± 0.072	2.705ValPhe: 2.705 ± 0.056	7.098ValGly: 7.098 ± 0.086	1.79ValHis: 1.79 ± 0.044	4.239ValIle: 4.239 ± 0.059	1.507ValLys: 1.507 ± 0.045	9.517ValLeu: 9.517 ± 0.111	1.663ValMet: 1.663 ± 0.042	1.727ValAsn: 1.727 ± 0.038	4.791ValPro: 4.791 ± 0.067	2.094ValGln: 2.094 ± 0.048	6.288ValArg: 6.288 ± 0.091	4.958ValSer: 4.958 ± 0.066	5.937ValThr: 5.937 ± 0.079	9.127ValVal: 9.127 ± 0.1	1.089ValTrp: 1.089 ± 0.028	1.543ValTyr: 1.543 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.587TrpAla: 1.587 ± 0.037	0.15TrpCys: 0.15 ± 0.01	0.785TrpAsp: 0.785 ± 0.031	0.752TrpGlu: 0.752 ± 0.025	0.566TrpPhe: 0.566 ± 0.023	1.096TrpGly: 1.096 ± 0.032	0.332TrpHis: 0.332 ± 0.016	0.71TrpIle: 0.71 ± 0.027	0.293TrpLys: 0.293 ± 0.016	1.671TrpLeu: 1.671 ± 0.039	0.32TrpMet: 0.32 ± 0.015	0.351TrpAsn: 0.351 ± 0.018	0.728TrpPro: 0.728 ± 0.03	0.53TrpGln: 0.53 ± 0.02	1.287TrpArg: 1.287 ± 0.037	1.0TrpSer: 1.0 ± 0.028	0.993TrpThr: 0.993 ± 0.033	1.115TrpVal: 1.115 ± 0.031	0.387TrpTrp: 0.387 ± 0.018	0.277TrpTyr: 0.277 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.436TyrAla: 2.436 ± 0.042	0.145TyrCys: 0.145 ± 0.013	1.373TyrAsp: 1.373 ± 0.042	1.229TyrGlu: 1.229 ± 0.037	0.639TyrPhe: 0.639 ± 0.025	1.868TyrGly: 1.868 ± 0.043	0.358TyrHis: 0.358 ± 0.019	0.594TyrIle: 0.594 ± 0.025	0.296TyrLys: 0.296 ± 0.017	2.07TyrLeu: 2.07 ± 0.043	0.253TyrMet: 0.253 ± 0.014	0.373TyrAsn: 0.373 ± 0.019	0.971TyrPro: 0.971 ± 0.027	0.532TyrGln: 0.532 ± 0.022	1.669TyrArg: 1.669 ± 0.037	0.927TyrSer: 0.927 ± 0.029	1.109TyrThr: 1.109 ± 0.034	1.701TyrVal: 1.701 ± 0.037	0.332TyrTrp: 0.332 ± 0.018	0.393TyrTyr: 0.393 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3780 proteins (1179454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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