Amino acid dipepetide frequency for Desulfovibrio sp. 6_1_46AFAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.86AlaAla: 15.86 ± 0.191	1.879AlaCys: 1.879 ± 0.047	6.062AlaAsp: 6.062 ± 0.095	6.971AlaGlu: 6.971 ± 0.105	3.862AlaPhe: 3.862 ± 0.07	9.805AlaGly: 9.805 ± 0.124	2.177AlaHis: 2.177 ± 0.046	3.865AlaIle: 3.865 ± 0.072	3.644AlaLys: 3.644 ± 0.071	13.926AlaLeu: 13.926 ± 0.15	3.041AlaMet: 3.041 ± 0.06	2.314AlaAsn: 2.314 ± 0.051	5.624AlaPro: 5.624 ± 0.105	4.261AlaGln: 4.261 ± 0.073	8.887AlaArg: 8.887 ± 0.121	5.603AlaSer: 5.603 ± 0.079	4.524AlaThr: 4.524 ± 0.084	8.804AlaVal: 8.804 ± 0.108	1.608AlaTrp: 1.608 ± 0.042	2.506AlaTyr: 2.506 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.662CysAla: 1.662 ± 0.045	0.361CysCys: 0.361 ± 0.022	0.673CysAsp: 0.673 ± 0.029	0.651CysGlu: 0.651 ± 0.028	0.602CysPhe: 0.602 ± 0.024	1.581CysGly: 1.581 ± 0.04	0.373CysHis: 0.373 ± 0.025	0.708CysIle: 0.708 ± 0.03	0.456CysLys: 0.456 ± 0.021	1.788CysLeu: 1.788 ± 0.048	0.391CysMet: 0.391 ± 0.018	0.436CysAsn: 0.436 ± 0.021	0.908CysPro: 0.908 ± 0.029	0.333CysGln: 0.333 ± 0.018	1.252CysArg: 1.252 ± 0.037	0.701CysSer: 0.701 ± 0.028	0.661CysThr: 0.661 ± 0.026	1.085CysVal: 1.085 ± 0.034	0.19CysTrp: 0.19 ± 0.014	0.366CysTyr: 0.366 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	6.376AspAla: 6.376 ± 0.102	0.716AspCys: 0.716 ± 0.026	2.464AspAsp: 2.464 ± 0.057	3.065AspGlu: 3.065 ± 0.064	2.26AspPhe: 2.26 ± 0.051	4.712AspGly: 4.712 ± 0.086	0.861AspHis: 0.861 ± 0.03	2.901AspIle: 2.901 ± 0.057	2.291AspLys: 2.291 ± 0.051	5.374AspLeu: 5.374 ± 0.067	1.781AspMet: 1.781 ± 0.043	1.678AspAsn: 1.678 ± 0.044	2.705AspPro: 2.705 ± 0.048	1.411AspGln: 1.411 ± 0.044	2.694AspArg: 2.694 ± 0.046	2.509AspSer: 2.509 ± 0.046	2.432AspThr: 2.432 ± 0.054	3.941AspVal: 3.941 ± 0.059	0.808AspTrp: 0.808 ± 0.029	1.468AspTyr: 1.468 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.594GluAla: 7.594 ± 0.118	0.651GluCys: 0.651 ± 0.028	3.214GluAsp: 3.214 ± 0.065	4.362GluGlu: 4.362 ± 0.08	1.741GluPhe: 1.741 ± 0.042	4.259GluGly: 4.259 ± 0.07	1.42GluHis: 1.42 ± 0.035	2.967GluIle: 2.967 ± 0.057	3.237GluLys: 3.237 ± 0.064	6.137GluLeu: 6.137 ± 0.088	1.598GluMet: 1.598 ± 0.038	2.313GluAsn: 2.313 ± 0.05	2.388GluPro: 2.388 ± 0.054	2.685GluGln: 2.685 ± 0.06	4.626GluArg: 4.626 ± 0.081	3.093GluSer: 3.093 ± 0.055	2.798GluThr: 2.798 ± 0.061	3.753GluVal: 3.753 ± 0.06	0.613GluTrp: 0.613 ± 0.029	1.48GluTyr: 1.48 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.7PheAla: 3.7 ± 0.061	0.829PheCys: 0.829 ± 0.032	1.957PheAsp: 1.957 ± 0.045	1.882PheGlu: 1.882 ± 0.046	1.88PhePhe: 1.88 ± 0.045	3.004PheGly: 3.004 ± 0.056	0.749PheHis: 0.749 ± 0.028	1.701PheIle: 1.701 ± 0.046	1.255PheLys: 1.255 ± 0.032	3.88PheLeu: 3.88 ± 0.067	1.032PheMet: 1.032 ± 0.034	1.129PheAsn: 1.129 ± 0.035	1.721PhePro: 1.721 ± 0.042	1.017PheGln: 1.017 ± 0.031	2.204PheArg: 2.204 ± 0.046	2.756PheSer: 2.756 ± 0.061	2.081PheThr: 2.081 ± 0.057	2.483PheVal: 2.483 ± 0.055	0.644PheTrp: 0.644 ± 0.025	1.091PheTyr: 1.091 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.937GlyAla: 7.937 ± 0.098	1.259GlyCys: 1.259 ± 0.039	4.03GlyAsp: 4.03 ± 0.058	4.674GlyGlu: 4.674 ± 0.069	3.21GlyPhe: 3.21 ± 0.059	7.118GlyGly: 7.118 ± 0.101	1.763GlyHis: 1.763 ± 0.045	4.274GlyIle: 4.274 ± 0.072	4.102GlyLys: 4.102 ± 0.066	9.35GlyLeu: 9.35 ± 0.12	2.599GlyMet: 2.599 ± 0.057	2.611GlyAsn: 2.611 ± 0.064	3.229GlyPro: 3.229 ± 0.056	3.097GlyGln: 3.097 ± 0.057	5.919GlyArg: 5.919 ± 0.083	4.242GlySer: 4.242 ± 0.073	4.113GlyThr: 4.113 ± 0.092	5.874GlyVal: 5.874 ± 0.07	1.091GlyTrp: 1.091 ± 0.034	2.269GlyTyr: 2.269 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.166HisAla: 2.166 ± 0.048	0.437HisCys: 0.437 ± 0.019	1.035HisAsp: 1.035 ± 0.04	1.161HisGlu: 1.161 ± 0.034	0.854HisPhe: 0.854 ± 0.031	1.786HisGly: 1.786 ± 0.049	0.453HisHis: 0.453 ± 0.022	1.111HisIle: 1.111 ± 0.029	0.801HisLys: 0.801 ± 0.031	2.214HisLeu: 2.214 ± 0.051	0.579HisMet: 0.579 ± 0.026	0.65HisAsn: 0.65 ± 0.025	1.231HisPro: 1.231 ± 0.036	0.566HisGln: 0.566 ± 0.026	0.992HisArg: 0.992 ± 0.029	1.045HisSer: 1.045 ± 0.03	0.952HisThr: 0.952 ± 0.032	1.329HisVal: 1.329 ± 0.037	0.331HisTrp: 0.331 ± 0.02	0.607HisTyr: 0.607 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.401IleAla: 4.401 ± 0.074	0.846IleCys: 0.846 ± 0.03	2.128IleAsp: 2.128 ± 0.046	2.293IleGlu: 2.293 ± 0.046	1.991IlePhe: 1.991 ± 0.05	3.099IleGly: 3.099 ± 0.06	0.924IleHis: 0.924 ± 0.032	2.315IleIle: 2.315 ± 0.063	1.661IleLys: 1.661 ± 0.049	4.855IleLeu: 4.855 ± 0.074	1.238IleMet: 1.238 ± 0.037	1.656IleAsn: 1.656 ± 0.047	2.426IlePro: 2.426 ± 0.049	1.345IleGln: 1.345 ± 0.034	2.971IleArg: 2.971 ± 0.057	3.133IleSer: 3.133 ± 0.057	2.519IleThr: 2.519 ± 0.06	3.105IleVal: 3.105 ± 0.065	0.594IleTrp: 0.594 ± 0.023	1.267IleTyr: 1.267 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.586LysAla: 4.586 ± 0.076	0.369LysCys: 0.369 ± 0.022	2.158LysAsp: 2.158 ± 0.046	2.606LysGlu: 2.606 ± 0.054	0.972LysPhe: 0.972 ± 0.029	3.064LysGly: 3.064 ± 0.058	0.733LysHis: 0.733 ± 0.028	1.993LysIle: 1.993 ± 0.051	2.205LysLys: 2.205 ± 0.054	3.55LysLeu: 3.55 ± 0.053	1.015LysMet: 1.015 ± 0.032	1.65LysAsn: 1.65 ± 0.045	1.837LysPro: 1.837 ± 0.048	1.222LysGln: 1.222 ± 0.036	2.248LysArg: 2.248 ± 0.048	2.197LysSer: 2.197 ± 0.052	2.222LysThr: 2.222 ± 0.049	2.393LysVal: 2.393 ± 0.055	0.317LysTrp: 0.317 ± 0.019	1.052LysTyr: 1.052 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.093LeuAla: 14.093 ± 0.153	1.919LeuCys: 1.919 ± 0.05	5.944LeuAsp: 5.944 ± 0.084	6.684LeuGlu: 6.684 ± 0.085	4.082LeuPhe: 4.082 ± 0.071	8.644LeuGly: 8.644 ± 0.113	2.315LeuHis: 2.315 ± 0.053	4.146LeuIle: 4.146 ± 0.083	3.973LeuLys: 3.973 ± 0.072	12.84LeuLeu: 12.84 ± 0.172	2.378LeuMet: 2.378 ± 0.052	3.163LeuAsn: 3.163 ± 0.065	6.896LeuPro: 6.896 ± 0.124	3.089LeuGln: 3.089 ± 0.053	8.51LeuArg: 8.51 ± 0.108	6.629LeuSer: 6.629 ± 0.096	5.87LeuThr: 5.87 ± 0.093	6.525LeuVal: 6.525 ± 0.093	1.444LeuTrp: 1.444 ± 0.042	2.519LeuTyr: 2.519 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.004MetAla: 3.004 ± 0.06	0.234MetCys: 0.234 ± 0.013	1.536MetAsp: 1.536 ± 0.033	1.557MetGlu: 1.557 ± 0.039	0.735MetPhe: 0.735 ± 0.025	2.148MetGly: 2.148 ± 0.052	0.467MetHis: 0.467 ± 0.021	1.008MetIle: 1.008 ± 0.034	0.977MetLys: 0.977 ± 0.03	3.005MetLeu: 3.005 ± 0.06	0.453MetMet: 0.453 ± 0.019	0.87MetAsn: 0.87 ± 0.03	1.719MetPro: 1.719 ± 0.04	0.949MetGln: 0.949 ± 0.031	1.996MetArg: 1.996 ± 0.046	1.686MetSer: 1.686 ± 0.04	1.342MetThr: 1.342 ± 0.034	1.582MetVal: 1.582 ± 0.037	0.165MetTrp: 0.165 ± 0.011	0.507MetTyr: 0.507 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.588AsnAla: 3.588 ± 0.071	0.445AsnCys: 0.445 ± 0.021	1.464AsnAsp: 1.464 ± 0.049	1.49AsnGlu: 1.49 ± 0.04	1.205AsnPhe: 1.205 ± 0.036	2.44AsnGly: 2.44 ± 0.057	0.531AsnHis: 0.531 ± 0.03	1.788AsnIle: 1.788 ± 0.044	1.13AsnLys: 1.13 ± 0.035	3.247AsnLeu: 3.247 ± 0.057	0.857AsnMet: 0.857 ± 0.029	0.993AsnAsn: 0.993 ± 0.038	1.87AsnPro: 1.87 ± 0.04	0.841AsnGln: 0.841 ± 0.032	1.729AsnArg: 1.729 ± 0.042	1.5AsnSer: 1.5 ± 0.04	1.515AsnThr: 1.515 ± 0.046	2.172AsnVal: 2.172 ± 0.049	0.355AsnTrp: 0.355 ± 0.019	0.893AsnTyr: 0.893 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	6.149ProAla: 6.149 ± 0.094	0.706ProCys: 0.706 ± 0.029	3.653ProAsp: 3.653 ± 0.069	4.493ProGlu: 4.493 ± 0.082	1.864ProPhe: 1.864 ± 0.043	4.774ProGly: 4.774 ± 0.08	1.036ProHis: 1.036 ± 0.033	1.508ProIle: 1.508 ± 0.044	1.479ProLys: 1.479 ± 0.033	5.63ProLeu: 5.63 ± 0.089	1.1ProMet: 1.1 ± 0.036	1.11ProAsn: 1.11 ± 0.032	2.768ProPro: 2.768 ± 0.063	2.023ProGln: 2.023 ± 0.047	3.01ProArg: 3.01 ± 0.064	2.525ProSer: 2.525 ± 0.052	2.043ProThr: 2.043 ± 0.054	4.237ProVal: 4.237 ± 0.069	0.799ProTrp: 0.799 ± 0.031	1.322ProTyr: 1.322 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.329GlnAla: 4.329 ± 0.069	0.473GlnCys: 0.473 ± 0.024	1.643GlnAsp: 1.643 ± 0.041	2.145GlnGlu: 2.145 ± 0.048	0.923GlnPhe: 0.923 ± 0.03	2.951GlnGly: 2.951 ± 0.055	0.632GlnHis: 0.632 ± 0.025	1.514GlnIle: 1.514 ± 0.041	1.566GlnLys: 1.566 ± 0.041	2.89GlnLeu: 2.89 ± 0.053	0.894GlnMet: 0.894 ± 0.029	1.2GlnAsn: 1.2 ± 0.043	1.511GlnPro: 1.511 ± 0.038	1.268GlnGln: 1.268 ± 0.043	2.472GlnArg: 2.472 ± 0.048	2.156GlnSer: 2.156 ± 0.046	1.665GlnThr: 1.665 ± 0.045	2.07GlnVal: 2.07 ± 0.041	0.523GlnTrp: 0.523 ± 0.02	0.808GlnTyr: 0.808 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.246ArgAla: 7.246 ± 0.094	0.964ArgCys: 0.964 ± 0.029	3.621ArgAsp: 3.621 ± 0.065	5.386ArgGlu: 5.386 ± 0.088	2.456ArgPhe: 2.456 ± 0.056	4.529ArgGly: 4.529 ± 0.073	1.829ArgHis: 1.829 ± 0.046	3.471ArgIle: 3.471 ± 0.052	2.978ArgLys: 2.978 ± 0.061	8.391ArgLeu: 8.391 ± 0.103	1.946ArgMet: 1.946 ± 0.037	2.114ArgAsn: 2.114 ± 0.043	3.535ArgPro: 3.535 ± 0.06	2.873ArgGln: 2.873 ± 0.056	5.672ArgArg: 5.672 ± 0.105	2.996ArgSer: 2.996 ± 0.057	2.746ArgThr: 2.746 ± 0.052	4.317ArgVal: 4.317 ± 0.06	0.896ArgTrp: 0.896 ± 0.033	1.877ArgTyr: 1.877 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.613SerAla: 5.613 ± 0.082	0.765SerCys: 0.765 ± 0.026	2.449SerAsp: 2.449 ± 0.048	2.683SerGlu: 2.683 ± 0.052	2.238SerPhe: 2.238 ± 0.054	5.716SerGly: 5.716 ± 0.088	1.047SerHis: 1.047 ± 0.03	2.593SerIle: 2.593 ± 0.061	1.743SerLys: 1.743 ± 0.043	6.641SerLeu: 6.641 ± 0.077	1.477SerMet: 1.477 ± 0.039	1.363SerAsn: 1.363 ± 0.044	3.022SerPro: 3.022 ± 0.05	1.704SerGln: 1.704 ± 0.042	3.824SerArg: 3.824 ± 0.06	3.099SerSer: 3.099 ± 0.073	2.574SerThr: 2.574 ± 0.051	3.935SerVal: 3.935 ± 0.067	0.742SerTrp: 0.742 ± 0.025	1.33SerTyr: 1.33 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.008ThrAla: 6.008 ± 0.093	0.565ThrCys: 0.565 ± 0.027	2.528ThrAsp: 2.528 ± 0.07	2.581ThrGlu: 2.581 ± 0.05	1.804ThrPhe: 1.804 ± 0.06	4.764ThrGly: 4.764 ± 0.081	0.854ThrHis: 0.854 ± 0.029	2.04ThrIle: 2.04 ± 0.059	1.242ThrLys: 1.242 ± 0.036	5.442ThrLeu: 5.442 ± 0.114	0.991ThrMet: 0.991 ± 0.028	1.214ThrAsn: 1.214 ± 0.049	3.404ThrPro: 3.404 ± 0.063	1.293ThrGln: 1.293 ± 0.034	3.001ThrArg: 3.001 ± 0.068	2.443ThrSer: 2.443 ± 0.048	2.228ThrThr: 2.228 ± 0.054	3.899ThrVal: 3.899 ± 0.089	0.576ThrTrp: 0.576 ± 0.022	1.142ThrTyr: 1.142 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.99ValAla: 6.99 ± 0.086	1.17ValCys: 1.17 ± 0.032	3.808ValAsp: 3.808 ± 0.068	4.127ValGlu: 4.127 ± 0.069	2.744ValPhe: 2.744 ± 0.055	5.058ValGly: 5.058 ± 0.082	1.319ValHis: 1.319 ± 0.037	3.168ValIle: 3.168 ± 0.056	2.201ValLys: 2.201 ± 0.052	8.008ValLeu: 8.008 ± 0.097	1.682ValMet: 1.682 ± 0.044	2.263ValAsn: 2.263 ± 0.045	3.58ValPro: 3.58 ± 0.062	2.156ValGln: 2.156 ± 0.051	5.023ValArg: 5.023 ± 0.074	4.231ValSer: 4.231 ± 0.064	3.76ValThr: 3.76 ± 0.077	4.758ValVal: 4.758 ± 0.079	0.88ValTrp: 0.88 ± 0.033	1.665ValTyr: 1.665 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.136TrpAla: 1.136 ± 0.035	0.184TrpCys: 0.184 ± 0.013	0.646TrpAsp: 0.646 ± 0.024	0.691TrpGlu: 0.691 ± 0.024	0.498TrpPhe: 0.498 ± 0.023	1.024TrpGly: 1.024 ± 0.033	0.32TrpHis: 0.32 ± 0.018	0.523TrpIle: 0.523 ± 0.024	0.497TrpLys: 0.497 ± 0.019	1.891TrpLeu: 1.891 ± 0.049	0.287TrpMet: 0.287 ± 0.015	0.461TrpAsn: 0.461 ± 0.02	0.724TrpPro: 0.724 ± 0.028	0.715TrpGln: 0.715 ± 0.03	1.167TrpArg: 1.167 ± 0.035	0.598TrpSer: 0.598 ± 0.021	0.542TrpThr: 0.542 ± 0.023	0.685TrpVal: 0.685 ± 0.026	0.238TrpTrp: 0.238 ± 0.017	0.35TrpTyr: 0.35 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.784TyrAla: 2.784 ± 0.056	0.408TyrCys: 0.408 ± 0.017	1.436TyrAsp: 1.436 ± 0.039	1.425TyrGlu: 1.425 ± 0.04	1.074TyrPhe: 1.074 ± 0.032	2.284TyrGly: 2.284 ± 0.053	0.5TyrHis: 0.5 ± 0.023	1.172TyrIle: 1.172 ± 0.034	0.95TyrLys: 0.95 ± 0.035	2.605TyrLeu: 2.605 ± 0.052	0.602TyrMet: 0.602 ± 0.025	0.863TyrAsn: 0.863 ± 0.033	1.133TyrPro: 1.133 ± 0.034	0.787TyrGln: 0.787 ± 0.028	1.645TyrArg: 1.645 ± 0.043	1.416TyrSer: 1.416 ± 0.037	1.427TyrThr: 1.427 ± 0.052	1.644TyrVal: 1.644 ± 0.04	0.363TyrTrp: 0.363 ± 0.019	0.787TyrTyr: 0.787 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3312 proteins (1086973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---