Amino acid dipepetide frequency for Flavonifractor sp. An52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.929AlaAla: 11.929 ± 0.148
1.551AlaCys: 1.551 ± 0.041
5.524AlaAsp: 5.524 ± 0.094
6.097AlaGlu: 6.097 ± 0.088
3.365AlaPhe: 3.365 ± 0.077
8.137AlaGly: 8.137 ± 0.114
1.595AlaHis: 1.595 ± 0.049
5.154AlaIle: 5.154 ± 0.089
4.043AlaLys: 4.043 ± 0.074
10.558AlaLeu: 10.558 ± 0.125
2.772AlaMet: 2.772 ± 0.059
2.485AlaAsn: 2.485 ± 0.065
3.496AlaPro: 3.496 ± 0.068
3.876AlaGln: 3.876 ± 0.077
4.919AlaArg: 4.919 ± 0.089
4.242AlaSer: 4.242 ± 0.076
4.02AlaThr: 4.02 ± 0.086
8.229AlaVal: 8.229 ± 0.11
1.056AlaTrp: 1.056 ± 0.041
2.728AlaTyr: 2.728 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.622CysAla: 1.622 ± 0.046
0.354CysCys: 0.354 ± 0.022
0.937CysAsp: 0.937 ± 0.038
0.767CysGlu: 0.767 ± 0.031
0.632CysPhe: 0.632 ± 0.025
1.778CysGly: 1.778 ± 0.054
0.342CysHis: 0.342 ± 0.021
0.818CysIle: 0.818 ± 0.038
0.679CysLys: 0.679 ± 0.027
1.468CysLeu: 1.468 ± 0.043
0.379CysMet: 0.379 ± 0.021
0.449CysAsn: 0.449 ± 0.026
0.889CysPro: 0.889 ± 0.037
0.547CysGln: 0.547 ± 0.025
0.96CysArg: 0.96 ± 0.038
0.913CysSer: 0.913 ± 0.037
0.929CysThr: 0.929 ± 0.031
1.177CysVal: 1.177 ± 0.039
0.216CysTrp: 0.216 ± 0.016
0.523CysTyr: 0.523 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.791AspAla: 4.791 ± 0.074
0.914AspCys: 0.914 ± 0.035
2.635AspAsp: 2.635 ± 0.07
3.646AspGlu: 3.646 ± 0.08
2.275AspPhe: 2.275 ± 0.052
5.377AspGly: 5.377 ± 0.109
1.137AspHis: 1.137 ± 0.037
3.172AspIle: 3.172 ± 0.076
2.762AspLys: 2.762 ± 0.076
5.627AspLeu: 5.627 ± 0.075
1.427AspMet: 1.427 ± 0.048
1.718AspAsn: 1.718 ± 0.05
2.944AspPro: 2.944 ± 0.063
2.117AspGln: 2.117 ± 0.051
3.23AspArg: 3.23 ± 0.066
2.776AspSer: 2.776 ± 0.062
3.166AspThr: 3.166 ± 0.071
3.799AspVal: 3.799 ± 0.074
0.772AspTrp: 0.772 ± 0.031
2.403AspTyr: 2.403 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.453GluAla: 6.453 ± 0.088
0.685GluCys: 0.685 ± 0.029
3.906GluAsp: 3.906 ± 0.067
6.049GluGlu: 6.049 ± 0.103
1.828GluPhe: 1.828 ± 0.056
5.214GluGly: 5.214 ± 0.091
1.434GluHis: 1.434 ± 0.048
3.577GluIle: 3.577 ± 0.071
3.799GluLys: 3.799 ± 0.082
6.972GluLeu: 6.972 ± 0.113
1.88GluMet: 1.88 ± 0.053
2.558GluAsn: 2.558 ± 0.061
2.406GluPro: 2.406 ± 0.054
3.14GluGln: 3.14 ± 0.068
3.879GluArg: 3.879 ± 0.085
2.848GluSer: 2.848 ± 0.064
3.444GluThr: 3.444 ± 0.064
4.195GluVal: 4.195 ± 0.078
0.692GluTrp: 0.692 ± 0.03
2.002GluTyr: 2.002 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.332PheAla: 3.332 ± 0.066
0.796PheCys: 0.796 ± 0.033
2.281PheAsp: 2.281 ± 0.062
1.928PheGlu: 1.928 ± 0.054
1.591PhePhe: 1.591 ± 0.053
2.969PheGly: 2.969 ± 0.076
0.821PheHis: 0.821 ± 0.037
1.698PheIle: 1.698 ± 0.049
1.201PheLys: 1.201 ± 0.037
3.812PheLeu: 3.812 ± 0.084
0.802PheMet: 0.802 ± 0.034
1.181PheAsn: 1.181 ± 0.039
1.556PhePro: 1.556 ± 0.041
1.443PheGln: 1.443 ± 0.044
1.915PheArg: 1.915 ± 0.049
2.456PheSer: 2.456 ± 0.058
2.464PheThr: 2.464 ± 0.055
2.437PheVal: 2.437 ± 0.052
0.439PheTrp: 0.439 ± 0.023
1.295PheTyr: 1.295 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.0GlyAla: 7.0 ± 0.11
1.554GlyCys: 1.554 ± 0.054
4.273GlyAsp: 4.273 ± 0.076
5.393GlyGlu: 5.393 ± 0.086
3.09GlyPhe: 3.09 ± 0.074
6.938GlyGly: 6.938 ± 0.144
1.464GlyHis: 1.464 ± 0.054
4.773GlyIle: 4.773 ± 0.081
4.656GlyLys: 4.656 ± 0.077
7.764GlyLeu: 7.764 ± 0.116
2.581GlyMet: 2.581 ± 0.066
2.581GlyAsn: 2.581 ± 0.062
2.385GlyPro: 2.385 ± 0.072
2.974GlyGln: 2.974 ± 0.063
4.28GlyArg: 4.28 ± 0.079
4.455GlySer: 4.455 ± 0.104
4.94GlyThr: 4.94 ± 0.133
6.538GlyVal: 6.538 ± 0.1
1.049GlyTrp: 1.049 ± 0.038
3.092GlyTyr: 3.092 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.411HisAla: 1.411 ± 0.04
0.398HisCys: 0.398 ± 0.022
0.97HisAsp: 0.97 ± 0.043
0.929HisGlu: 0.929 ± 0.041
0.804HisPhe: 0.804 ± 0.034
1.5HisGly: 1.5 ± 0.048
0.452HisHis: 0.452 ± 0.031
1.293HisIle: 1.293 ± 0.039
0.858HisLys: 0.858 ± 0.033
1.79HisLeu: 1.79 ± 0.053
0.532HisMet: 0.532 ± 0.028
0.662HisAsn: 0.662 ± 0.029
1.17HisPro: 1.17 ± 0.043
0.674HisGln: 0.674 ± 0.031
1.052HisArg: 1.052 ± 0.038
0.887HisSer: 0.887 ± 0.039
1.216HisThr: 1.216 ± 0.039
1.06HisVal: 1.06 ± 0.038
0.269HisTrp: 0.269 ± 0.02
0.686HisTyr: 0.686 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
4.891IleAla: 4.891 ± 0.086
0.991IleCys: 0.991 ± 0.032
3.121IleAsp: 3.121 ± 0.065
2.751IleGlu: 2.751 ± 0.061
1.965IlePhe: 1.965 ± 0.054
4.165IleGly: 4.165 ± 0.073
1.137IleHis: 1.137 ± 0.037
3.082IleIle: 3.082 ± 0.069
2.163IleLys: 2.163 ± 0.05
5.921IleLeu: 5.921 ± 0.095
1.231IleMet: 1.231 ± 0.037
1.804IleAsn: 1.804 ± 0.049
2.819IlePro: 2.819 ± 0.06
1.975IleGln: 1.975 ± 0.051
3.052IleArg: 3.052 ± 0.06
3.438IleSer: 3.438 ± 0.073
3.598IleThr: 3.598 ± 0.089
3.699IleVal: 3.699 ± 0.071
0.56IleTrp: 0.56 ± 0.025
1.804IleTyr: 1.804 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.772LysAla: 4.772 ± 0.082
0.524LysCys: 0.524 ± 0.03
2.573LysAsp: 2.573 ± 0.066
3.718LysGlu: 3.718 ± 0.078
1.251LysPhe: 1.251 ± 0.045
3.46LysGly: 3.46 ± 0.067
0.791LysHis: 0.791 ± 0.027
2.416LysIle: 2.416 ± 0.061
3.203LysLys: 3.203 ± 0.07
4.579LysLeu: 4.579 ± 0.082
1.384LysMet: 1.384 ± 0.045
1.771LysAsn: 1.771 ± 0.049
1.908LysPro: 1.908 ± 0.053
1.627LysGln: 1.627 ± 0.047
2.615LysArg: 2.615 ± 0.063
2.2LysSer: 2.2 ± 0.057
2.621LysThr: 2.621 ± 0.06
3.441LysVal: 3.441 ± 0.071
0.454LysTrp: 0.454 ± 0.025
1.675LysTyr: 1.675 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
9.92LeuAla: 9.92 ± 0.118
1.981LeuCys: 1.981 ± 0.055
6.015LeuAsp: 6.015 ± 0.084
7.123LeuGlu: 7.123 ± 0.109
3.754LeuPhe: 3.754 ± 0.083
7.52LeuGly: 7.52 ± 0.12
1.812LeuHis: 1.812 ± 0.049
4.996LeuIle: 4.996 ± 0.089
4.565LeuLys: 4.565 ± 0.075
10.555LeuLeu: 10.555 ± 0.174
2.684LeuMet: 2.684 ± 0.057
3.156LeuAsn: 3.156 ± 0.063
4.951LeuPro: 4.951 ± 0.083
2.679LeuGln: 2.679 ± 0.051
5.567LeuArg: 5.567 ± 0.103
6.605LeuSer: 6.605 ± 0.09
6.636LeuThr: 6.636 ± 0.105
6.64LeuVal: 6.64 ± 0.095
1.151LeuTrp: 1.151 ± 0.041
3.214LeuTyr: 3.214 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.746MetAla: 2.746 ± 0.063
0.29MetCys: 0.29 ± 0.023
1.913MetAsp: 1.913 ± 0.055
2.286MetGlu: 2.286 ± 0.059
0.67MetPhe: 0.67 ± 0.027
2.373MetGly: 2.373 ± 0.065
0.391MetHis: 0.391 ± 0.026
1.287MetIle: 1.287 ± 0.043
1.651MetLys: 1.651 ± 0.049
2.486MetLeu: 2.486 ± 0.06
0.702MetMet: 0.702 ± 0.036
1.046MetAsn: 1.046 ± 0.036
1.168MetPro: 1.168 ± 0.038
0.747MetGln: 0.747 ± 0.031
1.278MetArg: 1.278 ± 0.044
1.502MetSer: 1.502 ± 0.043
1.673MetThr: 1.673 ± 0.046
1.945MetVal: 1.945 ± 0.05
0.191MetTrp: 0.191 ± 0.014
0.59MetTyr: 0.59 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.91AsnAla: 2.91 ± 0.06
0.523AsnCys: 0.523 ± 0.024
1.585AsnAsp: 1.585 ± 0.046
1.704AsnGlu: 1.704 ± 0.05
1.185AsnPhe: 1.185 ± 0.041
3.036AsnGly: 3.036 ± 0.089
0.617AsnHis: 0.617 ± 0.03
1.973AsnIle: 1.973 ± 0.046
1.374AsnLys: 1.374 ± 0.039
3.223AsnLeu: 3.223 ± 0.066
0.855AsnMet: 0.855 ± 0.036
1.051AsnAsn: 1.051 ± 0.044
1.975AsnPro: 1.975 ± 0.051
1.18AsnGln: 1.18 ± 0.042
1.788AsnArg: 1.788 ± 0.049
1.6AsnSer: 1.6 ± 0.053
1.908AsnThr: 1.908 ± 0.06
2.25AsnVal: 2.25 ± 0.06
0.376AsnTrp: 0.376 ± 0.022
1.228AsnTyr: 1.228 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.525ProAla: 4.525 ± 0.083
0.595ProCys: 0.595 ± 0.028
3.021ProAsp: 3.021 ± 0.061
4.045ProGlu: 4.045 ± 0.066
1.653ProPhe: 1.653 ± 0.053
3.509ProGly: 3.509 ± 0.062
0.81ProHis: 0.81 ± 0.034
2.106ProIle: 2.106 ± 0.05
1.681ProLys: 1.681 ± 0.047
3.838ProLeu: 3.838 ± 0.078
1.125ProMet: 1.125 ± 0.04
1.407ProAsn: 1.407 ± 0.04
1.557ProPro: 1.557 ± 0.048
1.662ProGln: 1.662 ± 0.049
1.935ProArg: 1.935 ± 0.049
2.217ProSer: 2.217 ± 0.061
2.303ProThr: 2.303 ± 0.076
3.824ProVal: 3.824 ± 0.079
0.518ProTrp: 0.518 ± 0.024
1.441ProTyr: 1.441 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.918GlnAla: 3.918 ± 0.081
0.477GlnCys: 0.477 ± 0.023
1.742GlnAsp: 1.742 ± 0.047
2.626GlnGlu: 2.626 ± 0.058
1.218GlnPhe: 1.218 ± 0.043
2.63GlnGly: 2.63 ± 0.058
0.526GlnHis: 0.526 ± 0.029
2.044GlnIle: 2.044 ± 0.043
1.897GlnLys: 1.897 ± 0.052
3.541GlnLeu: 3.541 ± 0.07
1.06GlnMet: 1.06 ± 0.036
1.254GlnAsn: 1.254 ± 0.044
1.556GlnPro: 1.556 ± 0.045
1.493GlnGln: 1.493 ± 0.052
2.093GlnArg: 2.093 ± 0.052
1.778GlnSer: 1.778 ± 0.047
1.923GlnThr: 1.923 ± 0.05
2.959GlnVal: 2.959 ± 0.061
0.47GlnTrp: 0.47 ± 0.023
1.324GlnTyr: 1.324 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.442ArgAla: 4.442 ± 0.08
0.891ArgCys: 0.891 ± 0.033
2.912ArgAsp: 2.912 ± 0.071
4.012ArgGlu: 4.012 ± 0.076
2.136ArgPhe: 2.136 ± 0.056
3.493ArgGly: 3.493 ± 0.072
1.038ArgHis: 1.038 ± 0.037
2.946ArgIle: 2.946 ± 0.067
2.867ArgLys: 2.867 ± 0.072
5.774ArgLeu: 5.774 ± 0.098
1.651ArgMet: 1.651 ± 0.044
1.738ArgAsn: 1.738 ± 0.048
2.328ArgPro: 2.328 ± 0.057
2.511ArgGln: 2.511 ± 0.06
4.1ArgArg: 4.1 ± 0.09
2.677ArgSer: 2.677 ± 0.055
2.999ArgThr: 2.999 ± 0.064
3.549ArgVal: 3.549 ± 0.065
0.732ArgTrp: 0.732 ± 0.031
2.078ArgTyr: 2.078 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.013SerAla: 5.013 ± 0.084
0.88SerCys: 0.88 ± 0.031
2.81SerAsp: 2.81 ± 0.07
2.669SerGlu: 2.669 ± 0.062
2.237SerPhe: 2.237 ± 0.055
5.141SerGly: 5.141 ± 0.107
1.094SerHis: 1.094 ± 0.036
3.082SerIle: 3.082 ± 0.07
2.242SerLys: 2.242 ± 0.057
5.188SerLeu: 5.188 ± 0.089
1.487SerMet: 1.487 ± 0.042
1.697SerAsn: 1.697 ± 0.047
2.326SerPro: 2.326 ± 0.064
1.968SerGln: 1.968 ± 0.051
2.973SerArg: 2.973 ± 0.07
2.97SerSer: 2.97 ± 0.081
2.874SerThr: 2.874 ± 0.068
3.93SerVal: 3.93 ± 0.081
0.619SerTrp: 0.619 ± 0.028
1.94SerTyr: 1.94 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
5.924ThrAla: 5.924 ± 0.096
0.804ThrCys: 0.804 ± 0.034
3.157ThrAsp: 3.157 ± 0.062
3.105ThrGlu: 3.105 ± 0.062
2.152ThrPhe: 2.152 ± 0.056
5.536ThrGly: 5.536 ± 0.101
1.011ThrHis: 1.011 ± 0.039
3.398ThrIle: 3.398 ± 0.099
1.968ThrLys: 1.968 ± 0.054
5.896ThrLeu: 5.896 ± 0.097
1.483ThrMet: 1.483 ± 0.042
1.624ThrAsn: 1.624 ± 0.058
3.24ThrPro: 3.24 ± 0.073
1.85ThrGln: 1.85 ± 0.055
2.669ThrArg: 2.669 ± 0.054
2.697ThrSer: 2.697 ± 0.067
2.981ThrThr: 2.981 ± 0.084
5.41ThrVal: 5.41 ± 0.102
0.658ThrTrp: 0.658 ± 0.031
1.874ThrTyr: 1.874 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
6.358ValAla: 6.358 ± 0.096
1.425ValCys: 1.425 ± 0.043
4.376ValAsp: 4.376 ± 0.073
5.143ValGlu: 5.143 ± 0.084
2.751ValPhe: 2.751 ± 0.062
5.342ValGly: 5.342 ± 0.099
1.171ValHis: 1.171 ± 0.036
4.103ValIle: 4.103 ± 0.073
3.44ValLys: 3.44 ± 0.068
7.735ValLeu: 7.735 ± 0.113
1.88ValMet: 1.88 ± 0.049
2.475ValAsn: 2.475 ± 0.06
3.256ValPro: 3.256 ± 0.068
2.118ValGln: 2.118 ± 0.05
3.879ValArg: 3.879 ± 0.07
4.517ValSer: 4.517 ± 0.082
4.988ValThr: 4.988 ± 0.107
5.925ValVal: 5.925 ± 0.117
0.777ValTrp: 0.777 ± 0.035
2.36ValTyr: 2.36 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.989TrpAla: 0.989 ± 0.04
0.198TrpCys: 0.198 ± 0.016
0.658TrpAsp: 0.658 ± 0.031
0.753TrpGlu: 0.753 ± 0.034
0.524TrpPhe: 0.524 ± 0.024
0.834TrpGly: 0.834 ± 0.035
0.237TrpHis: 0.237 ± 0.018
0.49TrpIle: 0.49 ± 0.025
0.592TrpLys: 0.592 ± 0.024
1.247TrpLeu: 1.247 ± 0.042
0.333TrpMet: 0.333 ± 0.018
0.45TrpAsn: 0.45 ± 0.022
0.391TrpPro: 0.391 ± 0.024
0.51TrpGln: 0.51 ± 0.026
0.676TrpArg: 0.676 ± 0.025
0.66TrpSer: 0.66 ± 0.029
0.597TrpThr: 0.597 ± 0.033
0.725TrpVal: 0.725 ± 0.032
0.147TrpTrp: 0.147 ± 0.017
0.498TrpTyr: 0.498 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.064
0.549TyrCys: 0.549 ± 0.026
2.281TyrAsp: 2.281 ± 0.059
2.218TyrGlu: 2.218 ± 0.055
1.335TyrPhe: 1.335 ± 0.04
2.827TyrGly: 2.827 ± 0.062
0.733TyrHis: 0.733 ± 0.03
1.756TyrIle: 1.756 ± 0.049
1.34TyrLys: 1.34 ± 0.042
3.551TyrLeu: 3.551 ± 0.077
0.683TyrMet: 0.683 ± 0.033
1.234TyrAsn: 1.234 ± 0.042
1.452TyrPro: 1.452 ± 0.043
1.438TyrGln: 1.438 ± 0.04
2.015TyrArg: 2.015 ± 0.054
1.704TyrSer: 1.704 ± 0.05
2.157TyrThr: 2.157 ± 0.061
2.286TyrVal: 2.286 ± 0.058
0.363TyrTrp: 0.363 ± 0.023
1.404TyrTyr: 1.404 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2620 proteins (823819 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski