Amino acid dipepetide frequency for Arachidicoccus sp. B3-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.687AlaAla: 4.687 ± 0.073	0.545AlaCys: 0.545 ± 0.021	3.407AlaAsp: 3.407 ± 0.052	3.484AlaGlu: 3.484 ± 0.065	3.211AlaPhe: 3.211 ± 0.054	4.254AlaGly: 4.254 ± 0.068	1.212AlaHis: 1.212 ± 0.026	5.582AlaIle: 5.582 ± 0.077	4.541AlaLys: 4.541 ± 0.061	6.028AlaLeu: 6.028 ± 0.08	1.539AlaMet: 1.539 ± 0.039	3.905AlaAsn: 3.905 ± 0.061	2.127AlaPro: 2.127 ± 0.04	2.859AlaGln: 2.859 ± 0.047	1.968AlaArg: 1.968 ± 0.035	4.411AlaSer: 4.411 ± 0.064	3.824AlaThr: 3.824 ± 0.06	3.615AlaVal: 3.615 ± 0.061	0.681AlaTrp: 0.681 ± 0.021	2.594AlaTyr: 2.594 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.466CysAla: 0.466 ± 0.018	0.118CysCys: 0.118 ± 0.01	0.342CysAsp: 0.342 ± 0.016	0.378CysGlu: 0.378 ± 0.015	0.442CysPhe: 0.442 ± 0.018	0.606CysGly: 0.606 ± 0.022	0.175CysHis: 0.175 ± 0.012	0.676CysIle: 0.676 ± 0.022	0.553CysLys: 0.553 ± 0.02	0.724CysLeu: 0.724 ± 0.026	0.186CysMet: 0.186 ± 0.012	0.429CysAsn: 0.429 ± 0.019	0.296CysPro: 0.296 ± 0.015	0.269CysGln: 0.269 ± 0.014	0.242CysArg: 0.242 ± 0.015	0.553CysSer: 0.553 ± 0.023	0.455CysThr: 0.455 ± 0.021	0.456CysVal: 0.456 ± 0.017	0.086CysTrp: 0.086 ± 0.009	0.335CysTyr: 0.335 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.858AspAla: 3.858 ± 0.06	0.376AspCys: 0.376 ± 0.017	2.356AspAsp: 2.356 ± 0.048	2.89AspGlu: 2.89 ± 0.057	3.202AspPhe: 3.202 ± 0.052	3.617AspGly: 3.617 ± 0.065	0.946AspHis: 0.946 ± 0.025	4.355AspIle: 4.355 ± 0.049	4.015AspLys: 4.015 ± 0.06	4.875AspLeu: 4.875 ± 0.066	1.094AspMet: 1.094 ± 0.036	3.196AspAsn: 3.196 ± 0.055	1.893AspPro: 1.893 ± 0.039	1.737AspGln: 1.737 ± 0.034	1.808AspArg: 1.808 ± 0.036	3.836AspSer: 3.836 ± 0.065	2.858AspThr: 2.858 ± 0.052	3.107AspVal: 3.107 ± 0.05	0.864AspTrp: 0.864 ± 0.025	2.757AspTyr: 2.757 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	3.448GluAla: 3.448 ± 0.055	0.34GluCys: 0.34 ± 0.017	2.884GluAsp: 2.884 ± 0.048	3.536GluGlu: 3.536 ± 0.071	2.316GluPhe: 2.316 ± 0.043	2.932GluGly: 2.932 ± 0.049	0.957GluHis: 0.957 ± 0.032	4.864GluIle: 4.864 ± 0.068	5.61GluLys: 5.61 ± 0.08	5.377GluLeu: 5.377 ± 0.077	1.409GluMet: 1.409 ± 0.03	4.438GluAsn: 4.438 ± 0.062	1.324GluPro: 1.324 ± 0.037	2.053GluGln: 2.053 ± 0.044	2.095GluArg: 2.095 ± 0.042	3.037GluSer: 3.037 ± 0.052	2.847GluThr: 2.847 ± 0.048	3.15GluVal: 3.15 ± 0.051	0.652GluTrp: 0.652 ± 0.024	2.106GluTyr: 2.106 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.173PheAla: 3.173 ± 0.049	0.511PheCys: 0.511 ± 0.019	2.863PheAsp: 2.863 ± 0.041	2.794PheGlu: 2.794 ± 0.051	2.582PhePhe: 2.582 ± 0.053	3.446PheGly: 3.446 ± 0.054	0.994PheHis: 0.994 ± 0.028	3.78PheIle: 3.78 ± 0.066	3.413PheLys: 3.413 ± 0.053	4.732PheLeu: 4.732 ± 0.073	1.031PheMet: 1.031 ± 0.03	3.029PheAsn: 3.029 ± 0.047	1.953PhePro: 1.953 ± 0.035	1.869PheGln: 1.869 ± 0.032	1.647PheArg: 1.647 ± 0.034	4.029PheSer: 4.029 ± 0.05	2.993PheThr: 2.993 ± 0.053	2.908PheVal: 2.908 ± 0.052	0.649PheTrp: 0.649 ± 0.021	2.248PheTyr: 2.248 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.069GlyAla: 4.069 ± 0.068	0.557GlyCys: 0.557 ± 0.021	3.148GlyAsp: 3.148 ± 0.058	2.94GlyGlu: 2.94 ± 0.049	3.433GlyPhe: 3.433 ± 0.05	4.393GlyGly: 4.393 ± 0.072	1.145GlyHis: 1.145 ± 0.03	5.381GlyIle: 5.381 ± 0.072	5.293GlyLys: 5.293 ± 0.061	5.682GlyLeu: 5.682 ± 0.073	1.602GlyMet: 1.602 ± 0.034	4.022GlyAsn: 4.022 ± 0.063	1.359GlyPro: 1.359 ± 0.032	2.071GlyGln: 2.071 ± 0.048	2.162GlyArg: 2.162 ± 0.044	4.173GlySer: 4.173 ± 0.073	3.798GlyThr: 3.798 ± 0.07	3.925GlyVal: 3.925 ± 0.052	0.97GlyTrp: 0.97 ± 0.032	3.052GlyTyr: 3.052 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.076HisAla: 1.076 ± 0.029	0.16HisCys: 0.16 ± 0.011	0.858HisAsp: 0.858 ± 0.026	0.828HisGlu: 0.828 ± 0.02	1.329HisPhe: 1.329 ± 0.03	1.07HisGly: 1.07 ± 0.032	0.47HisHis: 0.47 ± 0.021	1.57HisIle: 1.57 ± 0.036	1.071HisLys: 1.071 ± 0.029	1.934HisLeu: 1.934 ± 0.042	0.331HisMet: 0.331 ± 0.017	1.009HisAsn: 1.009 ± 0.026	0.986HisPro: 0.986 ± 0.029	0.726HisGln: 0.726 ± 0.023	0.656HisArg: 0.656 ± 0.021	1.254HisSer: 1.254 ± 0.032	0.952HisThr: 0.952 ± 0.026	0.899HisVal: 0.899 ± 0.027	0.328HisTrp: 0.328 ± 0.016	0.932HisTyr: 0.932 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.69IleAla: 5.69 ± 0.082	0.821IleCys: 0.821 ± 0.024	4.569IleAsp: 4.569 ± 0.059	4.724IleGlu: 4.724 ± 0.064	3.901IlePhe: 3.901 ± 0.062	5.298IleGly: 5.298 ± 0.069	1.608IleHis: 1.608 ± 0.039	6.008IleIle: 6.008 ± 0.079	5.498IleLys: 5.498 ± 0.072	7.654IleLeu: 7.654 ± 0.091	1.371IleMet: 1.371 ± 0.033	4.931IleAsn: 4.931 ± 0.067	3.469IlePro: 3.469 ± 0.044	3.346IleGln: 3.346 ± 0.049	2.775IleArg: 2.775 ± 0.044	6.089IleSer: 6.089 ± 0.07	4.591IleThr: 4.591 ± 0.064	5.112IleVal: 5.112 ± 0.063	0.821IleTrp: 0.821 ± 0.027	3.153IleTyr: 3.153 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.67LysAla: 4.67 ± 0.064	0.384LysCys: 0.384 ± 0.018	4.692LysAsp: 4.692 ± 0.061	5.372LysGlu: 5.372 ± 0.076	2.864LysPhe: 2.864 ± 0.049	4.317LysGly: 4.317 ± 0.057	1.181LysHis: 1.181 ± 0.03	6.442LysIle: 6.442 ± 0.073	6.577LysLys: 6.577 ± 0.097	6.466LysLeu: 6.466 ± 0.065	2.258LysMet: 2.258 ± 0.037	5.485LysAsn: 5.485 ± 0.082	2.17LysPro: 2.17 ± 0.047	2.701LysGln: 2.701 ± 0.048	2.549LysArg: 2.549 ± 0.047	4.839LysSer: 4.839 ± 0.066	4.018LysThr: 4.018 ± 0.056	4.362LysVal: 4.362 ± 0.065	0.947LysTrp: 0.947 ± 0.023	3.666LysTyr: 3.666 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.718LeuAla: 5.718 ± 0.067	0.794LeuCys: 0.794 ± 0.025	5.106LeuAsp: 5.106 ± 0.065	5.267LeuGlu: 5.267 ± 0.075	4.958LeuPhe: 4.958 ± 0.075	5.684LeuGly: 5.684 ± 0.073	1.902LeuHis: 1.902 ± 0.045	6.65LeuIle: 6.65 ± 0.078	7.298LeuLys: 7.298 ± 0.077	8.793LeuLeu: 8.793 ± 0.115	2.106LeuMet: 2.106 ± 0.038	5.971LeuAsn: 5.971 ± 0.082	4.044LeuPro: 4.044 ± 0.054	3.925LeuGln: 3.925 ± 0.057	3.183LeuArg: 3.183 ± 0.05	7.212LeuSer: 7.212 ± 0.085	5.033LeuThr: 5.033 ± 0.07	4.924LeuVal: 4.924 ± 0.059	0.9LeuTrp: 0.9 ± 0.026	3.444LeuTyr: 3.444 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.638MetAla: 1.638 ± 0.038	0.123MetCys: 0.123 ± 0.01	1.337MetAsp: 1.337 ± 0.03	1.462MetGlu: 1.462 ± 0.035	0.83MetPhe: 0.83 ± 0.027	1.396MetGly: 1.396 ± 0.032	0.495MetHis: 0.495 ± 0.019	1.507MetIle: 1.507 ± 0.032	1.949MetLys: 1.949 ± 0.039	1.869MetLeu: 1.869 ± 0.042	0.594MetMet: 0.594 ± 0.022	1.368MetAsn: 1.368 ± 0.033	0.95MetPro: 0.95 ± 0.023	1.073MetGln: 1.073 ± 0.025	0.932MetArg: 0.932 ± 0.027	1.453MetSer: 1.453 ± 0.035	1.156MetThr: 1.156 ± 0.029	1.281MetVal: 1.281 ± 0.032	0.193MetTrp: 0.193 ± 0.013	0.826MetTyr: 0.826 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.36AsnAla: 4.36 ± 0.054	0.466AsnCys: 0.466 ± 0.019	3.102AsnAsp: 3.102 ± 0.045	3.389AsnGlu: 3.389 ± 0.053	3.057AsnPhe: 3.057 ± 0.058	4.58AsnGly: 4.58 ± 0.081	1.085AsnHis: 1.085 ± 0.034	5.684AsnIle: 5.684 ± 0.068	4.675AsnLys: 4.675 ± 0.062	5.533AsnLeu: 5.533 ± 0.087	1.332AsnMet: 1.332 ± 0.032	4.57AsnAsn: 4.57 ± 0.087	2.72AsnPro: 2.72 ± 0.047	2.383AsnGln: 2.383 ± 0.044	2.19AsnArg: 2.19 ± 0.038	4.238AsnSer: 4.238 ± 0.064	3.91AsnThr: 3.91 ± 0.068	3.678AsnVal: 3.678 ± 0.056	0.936AsnTrp: 0.936 ± 0.028	3.532AsnTyr: 3.532 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.122ProAla: 2.122 ± 0.046	0.234ProCys: 0.234 ± 0.014	2.103ProAsp: 2.103 ± 0.04	2.43ProGlu: 2.43 ± 0.045	1.921ProPhe: 1.921 ± 0.04	2.022ProGly: 2.022 ± 0.034	0.621ProHis: 0.621 ± 0.022	3.135ProIle: 3.135 ± 0.055	2.518ProLys: 2.518 ± 0.045	3.12ProLeu: 3.12 ± 0.048	0.802ProMet: 0.802 ± 0.026	2.456ProAsn: 2.456 ± 0.042	0.809ProPro: 0.809 ± 0.028	1.37ProGln: 1.37 ± 0.031	0.905ProArg: 0.905 ± 0.025	2.471ProSer: 2.471 ± 0.041	2.229ProThr: 2.229 ± 0.039	2.165ProVal: 2.165 ± 0.043	0.394ProTrp: 0.394 ± 0.015	1.677ProTyr: 1.677 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.243GlnAla: 2.243 ± 0.041	0.19GlnCys: 0.19 ± 0.012	1.788GlnAsp: 1.788 ± 0.038	2.003GlnGlu: 2.003 ± 0.042	2.018GlnPhe: 2.018 ± 0.036	1.824GlnGly: 1.824 ± 0.042	0.649GlnHis: 0.649 ± 0.022	3.11GlnIle: 3.11 ± 0.051	3.294GlnLys: 3.294 ± 0.059	4.135GlnLeu: 4.135 ± 0.067	0.965GlnMet: 0.965 ± 0.028	2.76GlnAsn: 2.76 ± 0.051	1.353GlnPro: 1.353 ± 0.028	1.761GlnGln: 1.761 ± 0.042	1.295GlnArg: 1.295 ± 0.032	2.542GlnSer: 2.542 ± 0.042	2.181GlnThr: 2.181 ± 0.043	1.901GlnVal: 1.901 ± 0.037	0.514GlnTrp: 0.514 ± 0.018	1.899GlnTyr: 1.899 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	1.965ArgAla: 1.965 ± 0.039	0.208ArgCys: 0.208 ± 0.013	1.626ArgAsp: 1.626 ± 0.035	1.677ArgGlu: 1.677 ± 0.034	1.754ArgPhe: 1.754 ± 0.039	1.825ArgGly: 1.825 ± 0.038	0.565ArgHis: 0.565 ± 0.022	2.903ArgIle: 2.903 ± 0.044	2.858ArgLys: 2.858 ± 0.045	3.252ArgLeu: 3.252 ± 0.056	0.901ArgMet: 0.901 ± 0.023	2.336ArgAsn: 2.336 ± 0.045	1.192ArgPro: 1.192 ± 0.037	1.315ArgGln: 1.315 ± 0.032	1.325ArgArg: 1.325 ± 0.037	2.032ArgSer: 2.032 ± 0.042	1.778ArgThr: 1.778 ± 0.038	1.802ArgVal: 1.802 ± 0.033	0.479ArgTrp: 0.479 ± 0.021	1.567ArgTyr: 1.567 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.151SerAla: 4.151 ± 0.057	0.622SerCys: 0.622 ± 0.02	3.798SerAsp: 3.798 ± 0.054	3.511SerGlu: 3.511 ± 0.05	4.09SerPhe: 4.09 ± 0.054	4.589SerGly: 4.589 ± 0.062	1.191SerHis: 1.191 ± 0.035	6.149SerIle: 6.149 ± 0.069	4.788SerLys: 4.788 ± 0.065	6.784SerLeu: 6.784 ± 0.076	1.461SerMet: 1.461 ± 0.033	4.422SerAsn: 4.422 ± 0.064	2.152SerPro: 2.152 ± 0.036	2.499SerGln: 2.499 ± 0.042	1.987SerArg: 1.987 ± 0.041	5.163SerSer: 5.163 ± 0.088	4.206SerThr: 4.206 ± 0.085	4.111SerVal: 4.111 ± 0.062	0.843SerTrp: 0.843 ± 0.028	3.151SerTyr: 3.151 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	3.735ThrAla: 3.735 ± 0.059	0.344ThrCys: 0.344 ± 0.018	3.16ThrAsp: 3.16 ± 0.054	2.917ThrGlu: 2.917 ± 0.051	2.756ThrPhe: 2.756 ± 0.054	3.917ThrGly: 3.917 ± 0.066	1.007ThrHis: 1.007 ± 0.025	5.397ThrIle: 5.397 ± 0.076	3.798ThrLys: 3.798 ± 0.052	5.242ThrLeu: 5.242 ± 0.059	1.042ThrMet: 1.042 ± 0.027	3.567ThrAsn: 3.567 ± 0.059	2.478ThrPro: 2.478 ± 0.046	2.068ThrGln: 2.068 ± 0.04	1.569ThrArg: 1.569 ± 0.033	4.016ThrSer: 4.016 ± 0.068	3.908ThrThr: 3.908 ± 0.074	3.259ThrVal: 3.259 ± 0.054	0.629ThrTrp: 0.629 ± 0.024	2.446ThrTyr: 2.446 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.024ValAla: 4.024 ± 0.063	0.483ValCys: 0.483 ± 0.021	3.377ValAsp: 3.377 ± 0.06	3.134ValGlu: 3.134 ± 0.052	2.818ValPhe: 2.818 ± 0.05	3.635ValGly: 3.635 ± 0.052	1.087ValHis: 1.087 ± 0.03	4.323ValIle: 4.323 ± 0.062	4.14ValLys: 4.14 ± 0.067	5.263ValLeu: 5.263 ± 0.065	1.197ValMet: 1.197 ± 0.034	3.573ValAsn: 3.573 ± 0.052	2.181ValPro: 2.181 ± 0.039	2.03ValGln: 2.03 ± 0.036	1.968ValArg: 1.968 ± 0.038	4.09ValSer: 4.09 ± 0.057	3.243ValThr: 3.243 ± 0.054	3.699ValVal: 3.699 ± 0.068	0.67ValTrp: 0.67 ± 0.024	2.336ValTyr: 2.336 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.673TrpAla: 0.673 ± 0.024	0.116TrpCys: 0.116 ± 0.009	0.718TrpAsp: 0.718 ± 0.026	0.689TrpGlu: 0.689 ± 0.021	0.561TrpPhe: 0.561 ± 0.02	0.837TrpGly: 0.837 ± 0.028	0.255TrpHis: 0.255 ± 0.014	0.885TrpIle: 0.885 ± 0.029	1.05TrpLys: 1.05 ± 0.031	1.164TrpLeu: 1.164 ± 0.032	0.378TrpMet: 0.378 ± 0.015	0.914TrpAsn: 0.914 ± 0.028	0.289TrpPro: 0.289 ± 0.016	0.541TrpGln: 0.541 ± 0.017	0.49TrpArg: 0.49 ± 0.019	0.739TrpSer: 0.739 ± 0.023	0.696TrpThr: 0.696 ± 0.026	0.656TrpVal: 0.656 ± 0.022	0.189TrpTrp: 0.189 ± 0.013	0.515TrpTyr: 0.515 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.708TyrAla: 2.708 ± 0.043	0.396TyrCys: 0.396 ± 0.019	2.408TyrAsp: 2.408 ± 0.049	1.949TyrGlu: 1.949 ± 0.043	2.601TyrPhe: 2.601 ± 0.051	2.935TyrGly: 2.935 ± 0.048	0.893TyrHis: 0.893 ± 0.025	3.03TyrIle: 3.03 ± 0.045	3.021TyrLys: 3.021 ± 0.05	4.286TyrLeu: 4.286 ± 0.061	0.829TyrMet: 0.829 ± 0.028	3.039TyrAsn: 3.039 ± 0.063	1.756TyrPro: 1.756 ± 0.039	1.83TyrGln: 1.83 ± 0.038	1.615TyrArg: 1.615 ± 0.036	3.492TyrSer: 3.492 ± 0.061	2.58TyrThr: 2.58 ± 0.048	2.258TyrVal: 2.258 ± 0.044	0.61TyrTrp: 0.61 ± 0.021	2.233TyrTyr: 2.233 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3921 proteins (1376694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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