Amino acid dipepetide frequency for SAR202 cluster bacterium AD-493-K16_JPT_193m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.556AlaAla: 7.556 ± 0.393
0.68AlaCys: 0.68 ± 0.09
3.766AlaAsp: 3.766 ± 0.218
4.573AlaGlu: 4.573 ± 0.281
3.455AlaPhe: 3.455 ± 0.2
7.026AlaGly: 7.026 ± 0.258
1.497AlaHis: 1.497 ± 0.146
6.6AlaIle: 6.6 ± 0.302
3.801AlaLys: 3.801 ± 0.237
8.339AlaLeu: 8.339 ± 0.356
2.672AlaMet: 2.672 ± 0.204
3.041AlaAsn: 3.041 ± 0.208
2.638AlaPro: 2.638 ± 0.161
2.246AlaGln: 2.246 ± 0.171
3.824AlaArg: 3.824 ± 0.198
5.759AlaSer: 5.759 ± 0.267
4.573AlaThr: 4.573 ± 0.264
6.531AlaVal: 6.531 ± 0.339
0.806AlaTrp: 0.806 ± 0.083
2.407AlaTyr: 2.407 ± 0.15
0.0AlaXaa: 0.0 ± 0.0
Cys
0.691CysAla: 0.691 ± 0.079
0.104CysCys: 0.104 ± 0.039
0.53CysAsp: 0.53 ± 0.065
0.438CysGlu: 0.438 ± 0.084
0.288CysPhe: 0.288 ± 0.059
0.887CysGly: 0.887 ± 0.124
0.23CysHis: 0.23 ± 0.048
0.438CysIle: 0.438 ± 0.076
0.346CysLys: 0.346 ± 0.071
0.875CysLeu: 0.875 ± 0.1
0.173CysMet: 0.173 ± 0.042
0.207CysAsn: 0.207 ± 0.043
0.357CysPro: 0.357 ± 0.065
0.242CysGln: 0.242 ± 0.048
0.38CysArg: 0.38 ± 0.063
0.507CysSer: 0.507 ± 0.087
0.346CysThr: 0.346 ± 0.07
0.622CysVal: 0.622 ± 0.104
0.046CysTrp: 0.046 ± 0.029
0.196CysTyr: 0.196 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
3.455AspAla: 3.455 ± 0.217
0.392AspCys: 0.392 ± 0.076
2.246AspAsp: 2.246 ± 0.196
3.64AspGlu: 3.64 ± 0.218
2.269AspPhe: 2.269 ± 0.164
4.492AspGly: 4.492 ± 0.309
1.048AspHis: 1.048 ± 0.124
4.043AspIle: 4.043 ± 0.233
2.154AspLys: 2.154 ± 0.16
6.208AspLeu: 6.208 ± 0.265
1.175AspMet: 1.175 ± 0.116
1.682AspAsn: 1.682 ± 0.135
2.741AspPro: 2.741 ± 0.176
1.797AspGln: 1.797 ± 0.147
2.684AspArg: 2.684 ± 0.172
3.214AspSer: 3.214 ± 0.193
2.707AspThr: 2.707 ± 0.187
4.124AspVal: 4.124 ± 0.241
0.507AspTrp: 0.507 ± 0.088
1.67AspTyr: 1.67 ± 0.144
0.0AspXaa: 0.0 ± 0.0
Glu
5.241GluAla: 5.241 ± 0.268
0.403GluCys: 0.403 ± 0.075
3.098GluAsp: 3.098 ± 0.243
3.951GluGlu: 3.951 ± 0.24
2.131GluPhe: 2.131 ± 0.162
4.665GluGly: 4.665 ± 0.23
1.244GluHis: 1.244 ± 0.124
5.045GluIle: 5.045 ± 0.282
3.064GluLys: 3.064 ± 0.224
5.909GluLeu: 5.909 ± 0.304
1.578GluMet: 1.578 ± 0.132
2.649GluAsn: 2.649 ± 0.208
2.211GluPro: 2.211 ± 0.153
1.912GluGln: 1.912 ± 0.141
3.352GluArg: 3.352 ± 0.242
3.893GluSer: 3.893 ± 0.206
3.363GluThr: 3.363 ± 0.198
4.446GluVal: 4.446 ± 0.198
0.76GluTrp: 0.76 ± 0.1
1.705GluTyr: 1.705 ± 0.147
0.0GluXaa: 0.0 ± 0.0
Phe
3.766PheAla: 3.766 ± 0.247
0.461PheCys: 0.461 ± 0.086
2.223PheAsp: 2.223 ± 0.143
2.131PheGlu: 2.131 ± 0.172
1.394PhePhe: 1.394 ± 0.148
3.444PheGly: 3.444 ± 0.216
0.68PheHis: 0.68 ± 0.085
2.58PheIle: 2.58 ± 0.194
1.682PheLys: 1.682 ± 0.144
4.054PheLeu: 4.054 ± 0.31
0.921PheMet: 0.921 ± 0.109
1.44PheAsn: 1.44 ± 0.136
1.774PhePro: 1.774 ± 0.172
1.428PheGln: 1.428 ± 0.12
1.751PheArg: 1.751 ± 0.149
3.052PheSer: 3.052 ± 0.201
2.085PheThr: 2.085 ± 0.171
2.891PheVal: 2.891 ± 0.219
0.53PheTrp: 0.53 ± 0.095
1.371PheTyr: 1.371 ± 0.123
0.0PheXaa: 0.0 ± 0.0
Gly
6.496GlyAla: 6.496 ± 0.361
0.691GlyCys: 0.691 ± 0.103
3.801GlyAsp: 3.801 ± 0.231
4.066GlyGlu: 4.066 ± 0.228
4.089GlyPhe: 4.089 ± 0.231
6.37GlyGly: 6.37 ± 0.376
1.659GlyHis: 1.659 ± 0.153
6.945GlyIle: 6.945 ± 0.306
4.227GlyLys: 4.227 ± 0.244
8.431GlyLeu: 8.431 ± 0.375
2.05GlyMet: 2.05 ± 0.144
3.029GlyAsn: 3.029 ± 0.165
3.283GlyPro: 3.283 ± 0.199
2.315GlyGln: 2.315 ± 0.176
4.285GlyArg: 4.285 ± 0.248
6.128GlySer: 6.128 ± 0.292
4.365GlyThr: 4.365 ± 0.228
6.865GlyVal: 6.865 ± 0.323
1.417GlyTrp: 1.417 ± 0.131
2.983GlyTyr: 2.983 ± 0.183
0.0GlyXaa: 0.0 ± 0.0
His
1.52HisAla: 1.52 ± 0.154
0.242HisCys: 0.242 ± 0.051
0.852HisAsp: 0.852 ± 0.088
0.921HisGlu: 0.921 ± 0.093
0.806HisPhe: 0.806 ± 0.09
1.877HisGly: 1.877 ± 0.161
0.346HisHis: 0.346 ± 0.074
1.371HisIle: 1.371 ± 0.133
0.737HisLys: 0.737 ± 0.09
2.027HisLeu: 2.027 ± 0.15
0.484HisMet: 0.484 ± 0.072
0.795HisAsn: 0.795 ± 0.138
1.221HisPro: 1.221 ± 0.111
0.587HisGln: 0.587 ± 0.084
1.14HisArg: 1.14 ± 0.12
1.198HisSer: 1.198 ± 0.12
1.175HisThr: 1.175 ± 0.109
1.474HisVal: 1.474 ± 0.142
0.253HisTrp: 0.253 ± 0.05
0.599HisTyr: 0.599 ± 0.073
0.0HisXaa: 0.0 ± 0.0
Ile
6.45IleAla: 6.45 ± 0.338
0.576IleCys: 0.576 ± 0.076
4.354IleAsp: 4.354 ± 0.26
4.319IleGlu: 4.319 ± 0.283
2.546IlePhe: 2.546 ± 0.177
6.439IleGly: 6.439 ± 0.303
1.486IleHis: 1.486 ± 0.141
4.504IleIle: 4.504 ± 0.251
3.594IleLys: 3.594 ± 0.19
6.83IleLeu: 6.83 ± 0.356
1.543IleMet: 1.543 ± 0.125
3.133IleAsn: 3.133 ± 0.228
3.628IlePro: 3.628 ± 0.192
2.315IleGln: 2.315 ± 0.153
3.732IleArg: 3.732 ± 0.195
5.483IleSer: 5.483 ± 0.25
4.02IleThr: 4.02 ± 0.221
6.059IleVal: 6.059 ± 0.285
0.864IleTrp: 0.864 ± 0.109
1.647IleTyr: 1.647 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
3.928LysAla: 3.928 ± 0.251
0.357LysCys: 0.357 ± 0.07
2.741LysAsp: 2.741 ± 0.216
3.582LysGlu: 3.582 ± 0.223
1.313LysPhe: 1.313 ± 0.145
3.628LysGly: 3.628 ± 0.213
0.979LysHis: 0.979 ± 0.091
3.075LysIle: 3.075 ± 0.203
2.119LysLys: 2.119 ± 0.192
4.354LysLeu: 4.354 ± 0.261
1.117LysMet: 1.117 ± 0.12
1.877LysAsn: 1.877 ± 0.191
1.901LysPro: 1.901 ± 0.136
1.209LysGln: 1.209 ± 0.144
2.235LysArg: 2.235 ± 0.197
3.674LysSer: 3.674 ± 0.243
2.235LysThr: 2.235 ± 0.164
3.686LysVal: 3.686 ± 0.221
0.61LysTrp: 0.61 ± 0.081
1.221LysTyr: 1.221 ± 0.123
0.0LysXaa: 0.0 ± 0.0
Leu
8.915LeuAla: 8.915 ± 0.32
0.703LeuCys: 0.703 ± 0.105
5.563LeuAsp: 5.563 ± 0.291
6.289LeuGlu: 6.289 ± 0.27
3.548LeuPhe: 3.548 ± 0.247
9.307LeuGly: 9.307 ± 0.371
1.716LeuHis: 1.716 ± 0.145
7.498LeuIle: 7.498 ± 0.388
4.204LeuLys: 4.204 ± 0.206
10.574LeuLeu: 10.574 ± 0.491
2.522LeuMet: 2.522 ± 0.179
3.628LeuAsn: 3.628 ± 0.219
4.239LeuPro: 4.239 ± 0.226
2.592LeuGln: 2.592 ± 0.18
4.884LeuArg: 4.884 ± 0.259
7.66LeuSer: 7.66 ± 0.314
5.356LeuThr: 5.356 ± 0.335
7.648LeuVal: 7.648 ± 0.308
1.221LeuTrp: 1.221 ± 0.154
2.361LeuTyr: 2.361 ± 0.174
0.0LeuXaa: 0.0 ± 0.0
Met
2.396MetAla: 2.396 ± 0.18
0.15MetCys: 0.15 ± 0.042
1.382MetAsp: 1.382 ± 0.122
1.497MetGlu: 1.497 ± 0.128
0.956MetPhe: 0.956 ± 0.118
2.361MetGly: 2.361 ± 0.185
0.461MetHis: 0.461 ± 0.083
1.578MetIle: 1.578 ± 0.139
1.232MetLys: 1.232 ± 0.135
2.338MetLeu: 2.338 ± 0.174
0.657MetMet: 0.657 ± 0.09
0.841MetAsn: 0.841 ± 0.09
1.52MetPro: 1.52 ± 0.119
0.691MetGln: 0.691 ± 0.089
1.336MetArg: 1.336 ± 0.109
2.016MetSer: 2.016 ± 0.148
1.509MetThr: 1.509 ± 0.149
2.062MetVal: 2.062 ± 0.173
0.288MetTrp: 0.288 ± 0.059
0.518MetTyr: 0.518 ± 0.089
0.0MetXaa: 0.0 ± 0.0
Asn
2.626AsnAla: 2.626 ± 0.181
0.369AsnCys: 0.369 ± 0.065
1.97AsnAsp: 1.97 ± 0.141
2.465AsnGlu: 2.465 ± 0.187
1.302AsnPhe: 1.302 ± 0.118
2.868AsnGly: 2.868 ± 0.176
0.795AsnHis: 0.795 ± 0.089
2.672AsnIle: 2.672 ± 0.188
1.532AsnLys: 1.532 ± 0.127
4.411AsnLeu: 4.411 ± 0.271
1.083AsnMet: 1.083 ± 0.12
1.417AsnAsn: 1.417 ± 0.122
2.35AsnPro: 2.35 ± 0.163
1.371AsnGln: 1.371 ± 0.145
1.97AsnArg: 1.97 ± 0.161
2.522AsnSer: 2.522 ± 0.16
2.142AsnThr: 2.142 ± 0.166
3.064AsnVal: 3.064 ± 0.223
0.484AsnTrp: 0.484 ± 0.078
1.267AsnTyr: 1.267 ± 0.104
0.0AsnXaa: 0.0 ± 0.0
Pro
3.11ProAla: 3.11 ± 0.207
0.23ProCys: 0.23 ± 0.051
2.73ProAsp: 2.73 ± 0.187
3.502ProGlu: 3.502 ± 0.205
1.981ProPhe: 1.981 ± 0.175
3.34ProGly: 3.34 ± 0.247
0.841ProHis: 0.841 ± 0.091
3.375ProIle: 3.375 ± 0.199
2.246ProLys: 2.246 ± 0.166
3.997ProLeu: 3.997 ± 0.201
1.083ProMet: 1.083 ± 0.109
1.97ProAsn: 1.97 ± 0.157
1.693ProPro: 1.693 ± 0.168
1.14ProGln: 1.14 ± 0.101
2.142ProArg: 2.142 ± 0.18
3.202ProSer: 3.202 ± 0.199
2.741ProThr: 2.741 ± 0.19
3.444ProVal: 3.444 ± 0.185
0.795ProTrp: 0.795 ± 0.103
1.325ProTyr: 1.325 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 0.18
0.242GlnCys: 0.242 ± 0.059
1.382GlnAsp: 1.382 ± 0.132
2.062GlnGlu: 2.062 ± 0.174
1.198GlnPhe: 1.198 ± 0.144
1.935GlnGly: 1.935 ± 0.157
0.622GlnHis: 0.622 ± 0.085
2.142GlnIle: 2.142 ± 0.141
1.359GlnLys: 1.359 ± 0.142
2.891GlnLeu: 2.891 ± 0.178
0.806GlnMet: 0.806 ± 0.109
1.083GlnAsn: 1.083 ± 0.12
1.255GlnPro: 1.255 ± 0.155
0.933GlnGln: 0.933 ± 0.198
1.624GlnArg: 1.624 ± 0.156
2.373GlnSer: 2.373 ± 0.188
1.209GlnThr: 1.209 ± 0.126
2.258GlnVal: 2.258 ± 0.182
0.323GlnTrp: 0.323 ± 0.082
0.875GlnTyr: 0.875 ± 0.103
0.0GlnXaa: 0.0 ± 0.0
Arg
3.801ArgAla: 3.801 ± 0.21
0.357ArgCys: 0.357 ± 0.057
2.626ArgAsp: 2.626 ± 0.202
3.144ArgGlu: 3.144 ± 0.19
2.096ArgPhe: 2.096 ± 0.206
3.778ArgGly: 3.778 ± 0.202
1.071ArgHis: 1.071 ± 0.101
3.962ArgIle: 3.962 ± 0.201
2.684ArgLys: 2.684 ± 0.208
4.964ArgLeu: 4.964 ± 0.293
1.255ArgMet: 1.255 ± 0.119
2.085ArgAsn: 2.085 ± 0.156
1.935ArgPro: 1.935 ± 0.166
1.543ArgGln: 1.543 ± 0.142
2.649ArgArg: 2.649 ± 0.207
3.191ArgSer: 3.191 ± 0.168
2.522ArgThr: 2.522 ± 0.187
4.25ArgVal: 4.25 ± 0.241
0.61ArgTrp: 0.61 ± 0.096
1.578ArgTyr: 1.578 ± 0.153
0.0ArgXaa: 0.0 ± 0.0
Ser
5.471SerAla: 5.471 ± 0.255
0.53SerCys: 0.53 ± 0.071
3.64SerAsp: 3.64 ± 0.226
4.446SerGlu: 4.446 ± 0.227
2.799SerPhe: 2.799 ± 0.172
6.036SerGly: 6.036 ± 0.255
1.463SerHis: 1.463 ± 0.134
5.195SerIle: 5.195 ± 0.262
3.628SerLys: 3.628 ± 0.214
6.75SerLeu: 6.75 ± 0.345
1.981SerMet: 1.981 ± 0.141
2.753SerAsn: 2.753 ± 0.198
3.075SerPro: 3.075 ± 0.207
1.981SerGln: 1.981 ± 0.129
3.755SerArg: 3.755 ± 0.251
5.563SerSer: 5.563 ± 0.303
4.112SerThr: 4.112 ± 0.234
5.333SerVal: 5.333 ± 0.272
1.106SerTrp: 1.106 ± 0.114
2.131SerTyr: 2.131 ± 0.155
0.0SerXaa: 0.0 ± 0.0
Thr
4.273ThrAla: 4.273 ± 0.236
0.323ThrCys: 0.323 ± 0.058
2.741ThrAsp: 2.741 ± 0.181
2.73ThrGlu: 2.73 ± 0.186
2.442ThrPhe: 2.442 ± 0.193
5.264ThrGly: 5.264 ± 0.296
1.325ThrHis: 1.325 ± 0.114
3.813ThrIle: 3.813 ± 0.19
2.258ThrLys: 2.258 ± 0.186
5.471ThrLeu: 5.471 ± 0.277
1.359ThrMet: 1.359 ± 0.115
2.396ThrAsn: 2.396 ± 0.178
3.237ThrPro: 3.237 ± 0.21
1.29ThrGln: 1.29 ± 0.104
2.73ThrArg: 2.73 ± 0.178
3.421ThrSer: 3.421 ± 0.208
3.363ThrThr: 3.363 ± 0.216
4.204ThrVal: 4.204 ± 0.199
0.668ThrTrp: 0.668 ± 0.082
1.566ThrTyr: 1.566 ± 0.13
0.0ThrXaa: 0.0 ± 0.0
Val
6.865ValAla: 6.865 ± 0.294
0.691ValCys: 0.691 ± 0.074
4.239ValAsp: 4.239 ± 0.166
4.423ValGlu: 4.423 ± 0.241
3.271ValPhe: 3.271 ± 0.243
6.347ValGly: 6.347 ± 0.254
1.255ValHis: 1.255 ± 0.13
6.082ValIle: 6.082 ± 0.281
3.214ValLys: 3.214 ± 0.182
7.36ValLeu: 7.36 ± 0.364
2.2ValMet: 2.2 ± 0.168
3.168ValAsn: 3.168 ± 0.21
3.594ValPro: 3.594 ± 0.214
1.958ValGln: 1.958 ± 0.179
3.605ValArg: 3.605 ± 0.227
6.082ValSer: 6.082 ± 0.227
4.688ValThr: 4.688 ± 0.224
6.692ValVal: 6.692 ± 0.307
0.875ValTrp: 0.875 ± 0.131
1.843ValTyr: 1.843 ± 0.145
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 0.097
0.104TrpCys: 0.104 ± 0.032
0.818TrpAsp: 0.818 ± 0.094
0.68TrpGlu: 0.68 ± 0.095
0.68TrpPhe: 0.68 ± 0.114
1.025TrpGly: 1.025 ± 0.115
0.276TrpHis: 0.276 ± 0.061
0.898TrpIle: 0.898 ± 0.113
0.484TrpLys: 0.484 ± 0.071
1.279TrpLeu: 1.279 ± 0.143
0.311TrpMet: 0.311 ± 0.059
0.53TrpAsn: 0.53 ± 0.071
0.587TrpPro: 0.587 ± 0.087
0.495TrpGln: 0.495 ± 0.086
0.587TrpArg: 0.587 ± 0.091
0.806TrpSer: 0.806 ± 0.094
0.703TrpThr: 0.703 ± 0.087
1.014TrpVal: 1.014 ± 0.134
0.219TrpTrp: 0.219 ± 0.057
0.323TrpTyr: 0.323 ± 0.08
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.774TyrAla: 1.774 ± 0.143
0.299TyrCys: 0.299 ± 0.057
1.543TyrAsp: 1.543 ± 0.132
1.762TyrGlu: 1.762 ± 0.135
1.094TyrPhe: 1.094 ± 0.093
2.407TyrGly: 2.407 ± 0.196
0.634TyrHis: 0.634 ± 0.088
1.705TyrIle: 1.705 ± 0.166
1.29TyrLys: 1.29 ± 0.12
3.363TyrLeu: 3.363 ± 0.219
0.806TyrMet: 0.806 ± 0.099
0.956TyrAsn: 0.956 ± 0.118
1.647TyrPro: 1.647 ± 0.152
1.014TyrGln: 1.014 ± 0.108
1.44TyrArg: 1.44 ± 0.132
2.004TyrSer: 2.004 ± 0.141
1.659TyrThr: 1.659 ± 0.158
1.785TyrVal: 1.785 ± 0.13
0.403TyrTrp: 0.403 ± 0.065
0.91TyrTyr: 0.91 ± 0.105
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 268 proteins (86820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski