Amino acid dipepetide frequency for Holospora curviuscula

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.908AlaAla: 3.908 ± 0.139
1.205AlaCys: 1.205 ± 0.063
2.02AlaAsp: 2.02 ± 0.067
3.092AlaGlu: 3.092 ± 0.113
3.255AlaPhe: 3.255 ± 0.106
3.719AlaGly: 3.719 ± 0.134
1.961AlaHis: 1.961 ± 0.079
3.624AlaIle: 3.624 ± 0.12
3.851AlaLys: 3.851 ± 0.106
9.522AlaLeu: 9.522 ± 0.184
1.557AlaMet: 1.557 ± 0.066
1.71AlaAsn: 1.71 ± 0.072
2.481AlaPro: 2.481 ± 0.101
3.789AlaGln: 3.789 ± 0.113
3.349AlaArg: 3.349 ± 0.106
4.297AlaSer: 4.297 ± 0.113
2.443AlaThr: 2.443 ± 0.092
3.772AlaVal: 3.772 ± 0.12
0.913AlaTrp: 0.913 ± 0.057
2.168AlaTyr: 2.168 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
1.063CysAla: 1.063 ± 0.056
0.281CysCys: 0.281 ± 0.033
0.673CysAsp: 0.673 ± 0.049
0.721CysGlu: 0.721 ± 0.046
1.013CysPhe: 1.013 ± 0.054
1.084CysGly: 1.084 ± 0.057
0.387CysHis: 0.387 ± 0.033
1.388CysIle: 1.388 ± 0.074
0.786CysLys: 0.786 ± 0.038
1.802CysLeu: 1.802 ± 0.078
0.307CysMet: 0.307 ± 0.027
0.529CysAsn: 0.529 ± 0.043
0.685CysPro: 0.685 ± 0.041
0.665CysGln: 0.665 ± 0.04
0.603CysArg: 0.603 ± 0.042
1.276CysSer: 1.276 ± 0.065
0.901CysThr: 0.901 ± 0.051
1.311CysVal: 1.311 ± 0.062
0.286CysTrp: 0.286 ± 0.026
0.523CysTyr: 0.523 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
3.039AspAla: 3.039 ± 0.106
0.611AspCys: 0.611 ± 0.045
1.651AspAsp: 1.651 ± 0.078
2.502AspGlu: 2.502 ± 0.094
2.431AspPhe: 2.431 ± 0.086
2.389AspGly: 2.389 ± 0.086
1.199AspHis: 1.199 ± 0.052
3.166AspIle: 3.166 ± 0.109
2.531AspLys: 2.531 ± 0.088
4.953AspLeu: 4.953 ± 0.119
1.113AspMet: 1.113 ± 0.059
1.391AspAsn: 1.391 ± 0.061
2.162AspPro: 2.162 ± 0.073
1.87AspGln: 1.87 ± 0.088
2.0AspArg: 2.0 ± 0.077
2.767AspSer: 2.767 ± 0.083
2.487AspThr: 2.487 ± 0.086
2.847AspVal: 2.847 ± 0.094
0.588AspTrp: 0.588 ± 0.042
1.373AspTyr: 1.373 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.486GluAla: 4.486 ± 0.121
0.783GluCys: 0.783 ± 0.049
3.021GluAsp: 3.021 ± 0.108
4.74GluGlu: 4.74 ± 0.156
2.401GluPhe: 2.401 ± 0.088
3.459GluGly: 3.459 ± 0.108
1.701GluHis: 1.701 ± 0.067
4.584GluIle: 4.584 ± 0.152
5.68GluLys: 5.68 ± 0.163
5.272GluLeu: 5.272 ± 0.142
1.53GluMet: 1.53 ± 0.063
3.051GluAsn: 3.051 ± 0.104
1.861GluPro: 1.861 ± 0.082
2.9GluGln: 2.9 ± 0.108
3.447GluArg: 3.447 ± 0.105
3.603GluSer: 3.603 ± 0.099
2.868GluThr: 2.868 ± 0.095
3.716GluVal: 3.716 ± 0.105
0.715GluTrp: 0.715 ± 0.053
1.893GluTyr: 1.893 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.233PheAla: 2.233 ± 0.101
0.889PheCys: 0.889 ± 0.046
2.073PheAsp: 2.073 ± 0.08
2.596PheGlu: 2.596 ± 0.09
3.521PhePhe: 3.521 ± 0.125
2.711PheGly: 2.711 ± 0.087
1.161PheHis: 1.161 ± 0.054
3.243PheIle: 3.243 ± 0.086
2.658PheLys: 2.658 ± 0.096
6.43PheLeu: 6.43 ± 0.145
1.128PheMet: 1.128 ± 0.06
1.704PheAsn: 1.704 ± 0.079
2.298PhePro: 2.298 ± 0.086
2.177PheGln: 2.177 ± 0.086
2.304PheArg: 2.304 ± 0.088
4.888PheSer: 4.888 ± 0.135
2.33PheThr: 2.33 ± 0.081
2.549PheVal: 2.549 ± 0.095
0.986PheTrp: 0.986 ± 0.059
1.873PheTyr: 1.873 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.294GlyAla: 4.294 ± 0.132
1.063GlyCys: 1.063 ± 0.058
2.298GlyAsp: 2.298 ± 0.08
2.915GlyGlu: 2.915 ± 0.098
2.939GlyPhe: 2.939 ± 0.096
3.993GlyGly: 3.993 ± 0.131
1.489GlyHis: 1.489 ± 0.07
5.21GlyIle: 5.21 ± 0.147
4.297GlyLys: 4.297 ± 0.111
6.04GlyLeu: 6.04 ± 0.147
1.811GlyMet: 1.811 ± 0.083
2.062GlyAsn: 2.062 ± 0.081
1.964GlyPro: 1.964 ± 0.078
2.18GlyGln: 2.18 ± 0.09
2.968GlyArg: 2.968 ± 0.107
4.037GlySer: 4.037 ± 0.115
3.249GlyThr: 3.249 ± 0.117
4.622GlyVal: 4.622 ± 0.14
0.922GlyTrp: 0.922 ± 0.067
2.422GlyTyr: 2.422 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
1.639HisAla: 1.639 ± 0.077
0.484HisCys: 0.484 ± 0.041
1.223HisAsp: 1.223 ± 0.064
1.06HisGlu: 1.06 ± 0.055
1.161HisPhe: 1.161 ± 0.066
1.619HisGly: 1.619 ± 0.074
1.176HisHis: 1.176 ± 0.07
1.955HisIle: 1.955 ± 0.067
1.447HisLys: 1.447 ± 0.077
2.705HisLeu: 2.705 ± 0.095
0.558HisMet: 0.558 ± 0.043
0.963HisAsn: 0.963 ± 0.053
1.651HisPro: 1.651 ± 0.079
1.435HisGln: 1.435 ± 0.077
1.633HisArg: 1.633 ± 0.075
1.864HisSer: 1.864 ± 0.08
1.456HisThr: 1.456 ± 0.071
1.542HisVal: 1.542 ± 0.071
0.49HisTrp: 0.49 ± 0.036
1.17HisTyr: 1.17 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
4.194IleAla: 4.194 ± 0.114
0.933IleCys: 0.933 ± 0.052
3.027IleAsp: 3.027 ± 0.103
4.483IleGlu: 4.483 ± 0.125
3.831IlePhe: 3.831 ± 0.114
3.76IleGly: 3.76 ± 0.118
1.887IleHis: 1.887 ± 0.078
4.519IleIle: 4.519 ± 0.137
4.693IleLys: 4.693 ± 0.127
8.397IleLeu: 8.397 ± 0.175
1.474IleMet: 1.474 ± 0.06
2.776IleAsn: 2.776 ± 0.103
3.639IlePro: 3.639 ± 0.126
3.769IleGln: 3.769 ± 0.116
3.019IleArg: 3.019 ± 0.106
5.378IleSer: 5.378 ± 0.153
3.29IleThr: 3.29 ± 0.101
3.934IleVal: 3.934 ± 0.103
0.871IleTrp: 0.871 ± 0.058
1.796IleTyr: 1.796 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.622LysAla: 4.622 ± 0.124
0.727LysCys: 0.727 ± 0.035
3.645LysAsp: 3.645 ± 0.113
5.745LysGlu: 5.745 ± 0.151
2.635LysPhe: 2.635 ± 0.102
3.964LysGly: 3.964 ± 0.12
1.474LysHis: 1.474 ± 0.062
6.114LysIle: 6.114 ± 0.138
7.21LysLys: 7.21 ± 0.217
5.192LysLeu: 5.192 ± 0.147
1.58LysMet: 1.58 ± 0.067
4.519LysAsn: 4.519 ± 0.141
2.097LysPro: 2.097 ± 0.073
2.759LysGln: 2.759 ± 0.105
3.84LysArg: 3.84 ± 0.11
4.244LysSer: 4.244 ± 0.109
3.848LysThr: 3.848 ± 0.112
3.559LysVal: 3.559 ± 0.104
0.588LysTrp: 0.588 ± 0.045
1.958LysTyr: 1.958 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.731LeuAla: 6.731 ± 0.149
2.067LeuCys: 2.067 ± 0.084
4.944LeuAsp: 4.944 ± 0.132
7.942LeuGlu: 7.942 ± 0.183
5.024LeuPhe: 5.024 ± 0.138
7.024LeuGly: 7.024 ± 0.168
2.797LeuHis: 2.797 ± 0.102
5.878LeuIle: 5.878 ± 0.148
8.58LeuLys: 8.58 ± 0.18
10.399LeuLeu: 10.399 ± 0.219
2.936LeuMet: 2.936 ± 0.106
4.912LeuAsn: 4.912 ± 0.13
4.888LeuPro: 4.888 ± 0.13
4.794LeuGln: 4.794 ± 0.128
5.449LeuArg: 5.449 ± 0.135
8.474LeuSer: 8.474 ± 0.167
5.381LeuThr: 5.381 ± 0.151
5.245LeuVal: 5.245 ± 0.116
1.716LeuTrp: 1.716 ± 0.086
3.228LeuTyr: 3.228 ± 0.097
0.0LeuXaa: 0.0 ± 0.0
Met
1.545MetAla: 1.545 ± 0.067
0.349MetCys: 0.349 ± 0.034
1.14MetAsp: 1.14 ± 0.062
1.444MetGlu: 1.444 ± 0.064
0.913MetPhe: 0.913 ± 0.05
1.722MetGly: 1.722 ± 0.078
0.697MetHis: 0.697 ± 0.047
1.805MetIle: 1.805 ± 0.068
1.843MetLys: 1.843 ± 0.07
2.369MetLeu: 2.369 ± 0.078
0.656MetMet: 0.656 ± 0.045
1.326MetAsn: 1.326 ± 0.054
0.966MetPro: 0.966 ± 0.06
0.984MetGln: 0.984 ± 0.053
1.311MetArg: 1.311 ± 0.062
1.424MetSer: 1.424 ± 0.064
1.297MetThr: 1.297 ± 0.055
1.444MetVal: 1.444 ± 0.062
0.236MetTrp: 0.236 ± 0.027
0.573MetTyr: 0.573 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.084AsnAla: 3.084 ± 0.11
0.387AsnCys: 0.387 ± 0.033
1.409AsnAsp: 1.409 ± 0.066
1.902AsnGlu: 1.902 ± 0.078
2.384AsnPhe: 2.384 ± 0.088
2.014AsnGly: 2.014 ± 0.071
1.102AsnHis: 1.102 ± 0.062
3.397AsnIle: 3.397 ± 0.111
2.596AsnLys: 2.596 ± 0.095
4.129AsnLeu: 4.129 ± 0.121
0.774AsnMet: 0.774 ± 0.049
1.819AsnAsn: 1.819 ± 0.08
2.386AsnPro: 2.386 ± 0.084
1.74AsnGln: 1.74 ± 0.093
1.985AsnArg: 1.985 ± 0.076
2.578AsnSer: 2.578 ± 0.102
2.419AsnThr: 2.419 ± 0.102
2.425AsnVal: 2.425 ± 0.081
0.408AsnTrp: 0.408 ± 0.031
1.279AsnTyr: 1.279 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.84ProAla: 1.84 ± 0.076
0.709ProCys: 0.709 ± 0.049
1.666ProAsp: 1.666 ± 0.067
3.323ProGlu: 3.323 ± 0.096
2.144ProPhe: 2.144 ± 0.078
2.549ProGly: 2.549 ± 0.086
1.332ProHis: 1.332 ± 0.071
2.395ProIle: 2.395 ± 0.075
3.107ProLys: 3.107 ± 0.107
4.885ProLeu: 4.885 ± 0.134
0.851ProMet: 0.851 ± 0.043
1.574ProAsn: 1.574 ± 0.067
1.542ProPro: 1.542 ± 0.088
2.065ProGln: 2.065 ± 0.12
1.681ProArg: 1.681 ± 0.073
3.122ProSer: 3.122 ± 0.101
1.651ProThr: 1.651 ± 0.073
2.886ProVal: 2.886 ± 0.112
0.821ProTrp: 0.821 ± 0.052
1.61ProTyr: 1.61 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
3.367GlnAla: 3.367 ± 0.126
0.806GlnCys: 0.806 ± 0.048
2.679GlnAsp: 2.679 ± 0.098
4.206GlnGlu: 4.206 ± 0.157
1.728GlnPhe: 1.728 ± 0.084
3.414GlnGly: 3.414 ± 0.119
1.235GlnHis: 1.235 ± 0.059
2.59GlnIle: 2.59 ± 0.087
4.035GlnLys: 4.035 ± 0.125
3.24GlnLeu: 3.24 ± 0.105
0.91GlnMet: 0.91 ± 0.047
2.324GlnAsn: 2.324 ± 0.092
1.066GlnPro: 1.066 ± 0.072
2.094GlnGln: 2.094 ± 0.168
2.72GlnArg: 2.72 ± 0.099
2.744GlnSer: 2.744 ± 0.105
1.799GlnThr: 1.799 ± 0.081
2.381GlnVal: 2.381 ± 0.089
0.88GlnTrp: 0.88 ± 0.058
1.583GlnTyr: 1.583 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
3.166ArgAla: 3.166 ± 0.099
1.016ArgCys: 1.016 ± 0.055
2.029ArgAsp: 2.029 ± 0.074
2.682ArgGlu: 2.682 ± 0.097
2.605ArgPhe: 2.605 ± 0.081
2.747ArgGly: 2.747 ± 0.087
1.35ArgHis: 1.35 ± 0.063
3.993ArgIle: 3.993 ± 0.106
3.385ArgLys: 3.385 ± 0.115
5.402ArgLeu: 5.402 ± 0.129
1.317ArgMet: 1.317 ± 0.065
1.961ArgAsn: 1.961 ± 0.082
1.775ArgPro: 1.775 ± 0.068
1.911ArgGln: 1.911 ± 0.082
2.788ArgArg: 2.788 ± 0.086
3.311ArgSer: 3.311 ± 0.104
2.546ArgThr: 2.546 ± 0.082
3.148ArgVal: 3.148 ± 0.096
0.827ArgTrp: 0.827 ± 0.054
1.985ArgTyr: 1.985 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
4.292SerAla: 4.292 ± 0.125
1.261SerCys: 1.261 ± 0.061
2.959SerAsp: 2.959 ± 0.102
3.825SerGlu: 3.825 ± 0.098
3.73SerPhe: 3.73 ± 0.121
4.687SerGly: 4.687 ± 0.139
1.719SerHis: 1.719 ± 0.075
5.178SerIle: 5.178 ± 0.127
4.354SerLys: 4.354 ± 0.133
8.043SerLeu: 8.043 ± 0.169
1.748SerMet: 1.748 ± 0.073
2.28SerAsn: 2.28 ± 0.093
2.726SerPro: 2.726 ± 0.092
3.027SerGln: 3.027 ± 0.108
2.877SerArg: 2.877 ± 0.089
5.718SerSer: 5.718 ± 0.148
3.361SerThr: 3.361 ± 0.101
5.313SerVal: 5.313 ± 0.134
1.072SerTrp: 1.072 ± 0.064
2.478SerTyr: 2.478 ± 0.093
0.0SerXaa: 0.0 ± 0.0
Thr
2.829ThrAla: 2.829 ± 0.108
0.676ThrCys: 0.676 ± 0.044
1.867ThrAsp: 1.867 ± 0.072
2.54ThrGlu: 2.54 ± 0.099
2.428ThrPhe: 2.428 ± 0.083
3.042ThrGly: 3.042 ± 0.106
1.548ThrHis: 1.548 ± 0.068
3.329ThrIle: 3.329 ± 0.119
2.773ThrLys: 2.773 ± 0.102
7.254ThrLeu: 7.254 ± 0.14
1.108ThrMet: 1.108 ± 0.064
1.477ThrAsn: 1.477 ± 0.07
2.909ThrPro: 2.909 ± 0.097
2.688ThrGln: 2.688 ± 0.096
2.132ThrArg: 2.132 ± 0.072
3.11ThrSer: 3.11 ± 0.105
2.277ThrThr: 2.277 ± 0.089
3.107ThrVal: 3.107 ± 0.104
0.57ThrTrp: 0.57 ± 0.047
1.492ThrTyr: 1.492 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
3.459ValAla: 3.459 ± 0.117
1.246ValCys: 1.246 ± 0.071
2.552ValAsp: 2.552 ± 0.081
3.719ValGlu: 3.719 ± 0.113
3.007ValPhe: 3.007 ± 0.101
3.5ValGly: 3.5 ± 0.121
1.775ValHis: 1.775 ± 0.074
3.695ValIle: 3.695 ± 0.124
3.456ValLys: 3.456 ± 0.121
7.848ValLeu: 7.848 ± 0.163
1.598ValMet: 1.598 ± 0.07
2.062ValAsn: 2.062 ± 0.088
2.505ValPro: 2.505 ± 0.09
2.915ValGln: 2.915 ± 0.095
2.986ValArg: 2.986 ± 0.1
4.596ValSer: 4.596 ± 0.132
2.936ValThr: 2.936 ± 0.098
3.866ValVal: 3.866 ± 0.115
0.901ValTrp: 0.901 ± 0.05
2.186ValTyr: 2.186 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.859TrpAla: 0.859 ± 0.053
0.242TrpCys: 0.242 ± 0.028
0.641TrpAsp: 0.641 ± 0.053
0.697TrpGlu: 0.697 ± 0.044
0.529TrpPhe: 0.529 ± 0.04
1.105TrpGly: 1.105 ± 0.066
0.325TrpHis: 0.325 ± 0.034
1.441TrpIle: 1.441 ± 0.079
1.105TrpLys: 1.105 ± 0.062
1.314TrpLeu: 1.314 ± 0.055
0.402TrpMet: 0.402 ± 0.034
0.697TrpAsn: 0.697 ± 0.04
0.529TrpPro: 0.529 ± 0.041
0.508TrpGln: 0.508 ± 0.039
0.833TrpArg: 0.833 ± 0.051
0.91TrpSer: 0.91 ± 0.059
0.673TrpThr: 0.673 ± 0.05
1.155TrpVal: 1.155 ± 0.066
0.195TrpTrp: 0.195 ± 0.027
0.405TrpTyr: 0.405 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.985TyrAla: 1.985 ± 0.071
0.546TyrCys: 0.546 ± 0.039
1.554TyrAsp: 1.554 ± 0.074
1.577TyrGlu: 1.577 ± 0.07
2.076TyrPhe: 2.076 ± 0.078
2.274TyrGly: 2.274 ± 0.095
0.922TyrHis: 0.922 ± 0.05
2.168TyrIle: 2.168 ± 0.074
1.932TyrLys: 1.932 ± 0.075
3.213TyrLeu: 3.213 ± 0.097
0.682TyrMet: 0.682 ± 0.045
1.078TyrAsn: 1.078 ± 0.056
1.621TyrPro: 1.621 ± 0.078
1.533TyrGln: 1.533 ± 0.072
2.02TyrArg: 2.02 ± 0.086
2.307TyrSer: 2.307 ± 0.092
1.943TyrThr: 1.943 ± 0.071
1.982TyrVal: 1.982 ± 0.08
0.579TyrTrp: 0.579 ± 0.048
1.22TyrTyr: 1.22 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1546 proteins (338577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski