Amino acid dipepetide frequency for Clostridium bornimense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.521AlaAla: 3.521 ± 0.088	0.546AlaCys: 0.546 ± 0.022	2.451AlaAsp: 2.451 ± 0.053	3.355AlaGlu: 3.355 ± 0.07	2.315AlaPhe: 2.315 ± 0.053	3.437AlaGly: 3.437 ± 0.082	0.751AlaHis: 0.751 ± 0.028	5.817AlaIle: 5.817 ± 0.084	4.445AlaLys: 4.445 ± 0.089	5.461AlaLeu: 5.461 ± 0.097	1.704AlaMet: 1.704 ± 0.047	2.446AlaAsn: 2.446 ± 0.049	1.418AlaPro: 1.418 ± 0.061	1.148AlaGln: 1.148 ± 0.038	1.711AlaArg: 1.711 ± 0.043	3.083AlaSer: 3.083 ± 0.061	2.978AlaThr: 2.978 ± 0.06	3.88AlaVal: 3.88 ± 0.066	0.332AlaTrp: 0.332 ± 0.02	2.06AlaTyr: 2.06 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.536CysAla: 0.536 ± 0.021	0.202CysCys: 0.202 ± 0.016	0.783CysAsp: 0.783 ± 0.031	0.798CysGlu: 0.798 ± 0.031	0.448CysPhe: 0.448 ± 0.02	1.073CysGly: 1.073 ± 0.036	0.224CysHis: 0.224 ± 0.016	1.026CysIle: 1.026 ± 0.036	0.986CysLys: 0.986 ± 0.036	0.77CysLeu: 0.77 ± 0.029	0.241CysMet: 0.241 ± 0.017	0.818CysAsn: 0.818 ± 0.031	0.417CysPro: 0.417 ± 0.021	0.193CysGln: 0.193 ± 0.014	0.415CysArg: 0.415 ± 0.023	0.838CysSer: 0.838 ± 0.031	0.569CysThr: 0.569 ± 0.022	0.574CysVal: 0.574 ± 0.023	0.061CysTrp: 0.061 ± 0.009	0.51CysTyr: 0.51 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.701AspAla: 2.701 ± 0.05	0.595AspCys: 0.595 ± 0.028	3.316AspAsp: 3.316 ± 0.068	5.031AspGlu: 5.031 ± 0.071	2.765AspPhe: 2.765 ± 0.061	3.959AspGly: 3.959 ± 0.086	0.561AspHis: 0.561 ± 0.024	6.841AspIle: 6.841 ± 0.093	5.714AspLys: 5.714 ± 0.087	4.785AspLeu: 4.785 ± 0.073	1.532AspMet: 1.532 ± 0.036	3.893AspAsn: 3.893 ± 0.085	1.28AspPro: 1.28 ± 0.042	0.768AspGln: 0.768 ± 0.029	1.98AspArg: 1.98 ± 0.066	3.645AspSer: 3.645 ± 0.066	2.984AspThr: 2.984 ± 0.066	3.797AspVal: 3.797 ± 0.055	0.367AspTrp: 0.367 ± 0.022	2.71AspTyr: 2.71 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.114GluAla: 4.114 ± 0.089	0.619GluCys: 0.619 ± 0.022	4.866GluAsp: 4.866 ± 0.068	7.962GluGlu: 7.962 ± 0.133	3.117GluPhe: 3.117 ± 0.066	4.417GluGly: 4.417 ± 0.071	0.851GluHis: 0.851 ± 0.034	7.481GluIle: 7.481 ± 0.085	7.975GluLys: 7.975 ± 0.106	6.241GluLeu: 6.241 ± 0.085	2.054GluMet: 2.054 ± 0.05	5.452GluAsn: 5.452 ± 0.083	1.42GluPro: 1.42 ± 0.042	1.472GluGln: 1.472 ± 0.042	2.641GluArg: 2.641 ± 0.061	3.829GluSer: 3.829 ± 0.073	3.119GluThr: 3.119 ± 0.06	5.511GluVal: 5.511 ± 0.076	0.415GluTrp: 0.415 ± 0.02	3.287GluTyr: 3.287 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.177PheAla: 2.177 ± 0.053	0.516PheCys: 0.516 ± 0.023	2.607PheAsp: 2.607 ± 0.051	2.408PheGlu: 2.408 ± 0.05	1.838PhePhe: 1.838 ± 0.048	2.651PheGly: 2.651 ± 0.053	0.53PheHis: 0.53 ± 0.023	4.701PheIle: 4.701 ± 0.089	3.584PheLys: 3.584 ± 0.071	3.75PheLeu: 3.75 ± 0.066	1.072PheMet: 1.072 ± 0.03	2.912PheAsn: 2.912 ± 0.058	1.092PhePro: 1.092 ± 0.037	0.966PheGln: 0.966 ± 0.032	1.24PheArg: 1.24 ± 0.033	3.126PheSer: 3.126 ± 0.059	2.364PheThr: 2.364 ± 0.05	2.593PheVal: 2.593 ± 0.044	0.293PheTrp: 0.293 ± 0.018	1.929PheTyr: 1.929 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	3.827GlyAla: 3.827 ± 0.078	0.876GlyCys: 0.876 ± 0.031	3.791GlyAsp: 3.791 ± 0.068	4.755GlyGlu: 4.755 ± 0.074	2.932GlyPhe: 2.932 ± 0.055	4.26GlyGly: 4.26 ± 0.086	0.922GlyHis: 0.922 ± 0.031	6.635GlyIle: 6.635 ± 0.087	5.629GlyLys: 5.629 ± 0.085	4.976GlyLeu: 4.976 ± 0.083	1.655GlyMet: 1.655 ± 0.047	3.496GlyAsn: 3.496 ± 0.073	1.18GlyPro: 1.18 ± 0.059	1.261GlyGln: 1.261 ± 0.043	2.232GlyArg: 2.232 ± 0.054	3.859GlySer: 3.859 ± 0.076	3.602GlyThr: 3.602 ± 0.072	4.484GlyVal: 4.484 ± 0.073	0.516GlyTrp: 0.516 ± 0.028	3.157GlyTyr: 3.157 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.577HisAla: 0.577 ± 0.022	0.229HisCys: 0.229 ± 0.014	0.686HisAsp: 0.686 ± 0.029	0.709HisGlu: 0.709 ± 0.026	0.597HisPhe: 0.597 ± 0.026	0.999HisGly: 0.999 ± 0.029	0.287HisHis: 0.287 ± 0.017	1.204HisIle: 1.204 ± 0.036	1.009HisLys: 1.009 ± 0.032	1.105HisLeu: 1.105 ± 0.035	0.3HisMet: 0.3 ± 0.016	0.775HisAsn: 0.775 ± 0.027	0.566HisPro: 0.566 ± 0.024	0.296HisGln: 0.296 ± 0.017	0.537HisArg: 0.537 ± 0.026	0.786HisSer: 0.786 ± 0.03	0.607HisThr: 0.607 ± 0.026	0.67HisVal: 0.67 ± 0.026	0.117HisTrp: 0.117 ± 0.01	0.602HisTyr: 0.602 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.572IleAla: 5.572 ± 0.09	1.245IleCys: 1.245 ± 0.036	6.56IleAsp: 6.56 ± 0.082	7.73IleGlu: 7.73 ± 0.106	4.168IlePhe: 4.168 ± 0.086	6.138IleGly: 6.138 ± 0.088	1.203IleHis: 1.203 ± 0.037	9.813IleIle: 9.813 ± 0.155	8.815IleLys: 8.815 ± 0.103	9.097IleLeu: 9.097 ± 0.135	2.282IleMet: 2.282 ± 0.054	6.747IleAsn: 6.747 ± 0.101	3.242IlePro: 3.242 ± 0.063	1.857IleGln: 1.857 ± 0.041	3.114IleArg: 3.114 ± 0.059	7.548IleSer: 7.548 ± 0.093	5.201IleThr: 5.201 ± 0.081	6.534IleVal: 6.534 ± 0.103	0.552IleTrp: 0.552 ± 0.025	3.933IleTyr: 3.933 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	4.534LysAla: 4.534 ± 0.082	0.925LysCys: 0.925 ± 0.031	6.023LysAsp: 6.023 ± 0.084	9.21LysGlu: 9.21 ± 0.132	3.321LysPhe: 3.321 ± 0.062	5.204LysGly: 5.204 ± 0.075	0.939LysHis: 0.939 ± 0.03	8.264LysIle: 8.264 ± 0.099	8.196LysLys: 8.196 ± 0.102	7.288LysLeu: 7.288 ± 0.095	2.2LysMet: 2.2 ± 0.051	6.453LysAsn: 6.453 ± 0.081	1.882LysPro: 1.882 ± 0.046	1.615LysGln: 1.615 ± 0.043	3.015LysArg: 3.015 ± 0.057	5.266LysSer: 5.266 ± 0.085	3.888LysThr: 3.888 ± 0.068	6.283LysVal: 6.283 ± 0.081	0.643LysTrp: 0.643 ± 0.028	4.404LysTyr: 4.404 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	4.667LeuAla: 4.667 ± 0.081	1.061LeuCys: 1.061 ± 0.033	5.208LeuAsp: 5.208 ± 0.071	6.381LeuGlu: 6.381 ± 0.083	3.445LeuPhe: 3.445 ± 0.063	5.715LeuGly: 5.715 ± 0.084	1.071LeuHis: 1.071 ± 0.029	7.989LeuIle: 7.989 ± 0.114	7.881LeuLys: 7.881 ± 0.088	7.762LeuLeu: 7.762 ± 0.113	2.157LeuMet: 2.157 ± 0.045	5.411LeuAsn: 5.411 ± 0.082	2.578LeuPro: 2.578 ± 0.054	1.999LeuGln: 1.999 ± 0.046	3.121LeuArg: 3.121 ± 0.061	6.658LeuSer: 6.658 ± 0.088	4.403LeuThr: 4.403 ± 0.076	5.345LeuVal: 5.345 ± 0.076	0.567LeuTrp: 0.567 ± 0.025	3.349LeuTyr: 3.349 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.647MetAla: 1.647 ± 0.045	0.254MetCys: 0.254 ± 0.017	1.626MetAsp: 1.626 ± 0.048	1.856MetGlu: 1.856 ± 0.04	0.938MetPhe: 0.938 ± 0.038	1.679MetGly: 1.679 ± 0.045	0.309MetHis: 0.309 ± 0.019	2.398MetIle: 2.398 ± 0.054	2.649MetLys: 2.649 ± 0.054	2.016MetLeu: 2.016 ± 0.049	0.709MetMet: 0.709 ± 0.029	1.697MetAsn: 1.697 ± 0.038	0.85MetPro: 0.85 ± 0.033	0.555MetGln: 0.555 ± 0.027	0.878MetArg: 0.878 ± 0.028	1.641MetSer: 1.641 ± 0.041	1.177MetThr: 1.177 ± 0.032	1.543MetVal: 1.543 ± 0.043	0.177MetTrp: 0.177 ± 0.013	0.835MetTyr: 0.835 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.753AsnAla: 2.753 ± 0.055	0.723AsnCys: 0.723 ± 0.027	3.547AsnAsp: 3.547 ± 0.068	4.536AsnGlu: 4.536 ± 0.076	2.6AsnPhe: 2.6 ± 0.056	4.03AsnGly: 4.03 ± 0.087	0.819AsnHis: 0.819 ± 0.03	7.318AsnIle: 7.318 ± 0.114	6.12AsnLys: 6.12 ± 0.095	5.453AsnLeu: 5.453 ± 0.086	1.53AsnMet: 1.53 ± 0.039	5.029AsnAsn: 5.029 ± 0.11	2.007AsnPro: 2.007 ± 0.045	1.192AsnGln: 1.192 ± 0.034	2.106AsnArg: 2.106 ± 0.049	4.297AsnSer: 4.297 ± 0.072	3.228AsnThr: 3.228 ± 0.062	3.748AsnVal: 3.748 ± 0.059	0.443AsnTrp: 0.443 ± 0.022	2.849AsnTyr: 2.849 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.258ProAla: 1.258 ± 0.046	0.33ProCys: 0.33 ± 0.02	1.368ProAsp: 1.368 ± 0.037	2.03ProGlu: 2.03 ± 0.055	1.283ProPhe: 1.283 ± 0.04	1.602ProGly: 1.602 ± 0.043	0.446ProHis: 0.446 ± 0.022	2.573ProIle: 2.573 ± 0.053	2.044ProLys: 2.044 ± 0.047	2.313ProLeu: 2.313 ± 0.05	0.73ProMet: 0.73 ± 0.032	1.385ProAsn: 1.385 ± 0.043	0.58ProPro: 0.58 ± 0.031	0.647ProGln: 0.647 ± 0.025	0.8ProArg: 0.8 ± 0.03	1.76ProSer: 1.76 ± 0.047	1.509ProThr: 1.509 ± 0.039	2.375ProVal: 2.375 ± 0.212	0.26ProTrp: 0.26 ± 0.017	1.297ProTyr: 1.297 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.033GlnAla: 1.033 ± 0.034	0.374GlnCys: 0.374 ± 0.02	1.021GlnAsp: 1.021 ± 0.032	1.313GlnGlu: 1.313 ± 0.036	0.839GlnPhe: 0.839 ± 0.025	1.46GlnGly: 1.46 ± 0.042	0.262GlnHis: 0.262 ± 0.018	1.681GlnIle: 1.681 ± 0.045	1.563GlnLys: 1.563 ± 0.042	1.995GlnLeu: 1.995 ± 0.044	0.557GlnMet: 0.557 ± 0.027	1.176GlnAsn: 1.176 ± 0.036	0.525GlnPro: 0.525 ± 0.025	0.619GlnGln: 0.619 ± 0.032	0.802GlnArg: 0.802 ± 0.028	1.188GlnSer: 1.188 ± 0.035	0.862GlnThr: 0.862 ± 0.032	1.245GlnVal: 1.245 ± 0.04	0.276GlnTrp: 0.276 ± 0.018	1.163GlnTyr: 1.163 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.733ArgAla: 1.733 ± 0.045	0.384ArgCys: 0.384 ± 0.019	2.008ArgAsp: 2.008 ± 0.075	3.094ArgGlu: 3.094 ± 0.069	1.385ArgPhe: 1.385 ± 0.039	2.027ArgGly: 2.027 ± 0.045	0.434ArgHis: 0.434 ± 0.021	3.128ArgIle: 3.128 ± 0.062	3.123ArgLys: 3.123 ± 0.06	2.814ArgLeu: 2.814 ± 0.06	0.879ArgMet: 0.879 ± 0.029	2.076ArgAsn: 2.076 ± 0.049	0.782ArgPro: 0.782 ± 0.031	0.751ArgGln: 0.751 ± 0.031	1.484ArgArg: 1.484 ± 0.049	1.713ArgSer: 1.713 ± 0.04	1.554ArgThr: 1.554 ± 0.044	2.228ArgVal: 2.228 ± 0.05	0.273ArgTrp: 0.273 ± 0.017	1.592ArgTyr: 1.592 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	2.998SerAla: 2.998 ± 0.056	0.669SerCys: 0.669 ± 0.027	3.624SerAsp: 3.624 ± 0.06	4.362SerGlu: 4.362 ± 0.07	2.913SerPhe: 2.913 ± 0.056	4.373SerGly: 4.373 ± 0.079	0.857SerHis: 0.857 ± 0.031	7.198SerIle: 7.198 ± 0.11	6.016SerLys: 6.016 ± 0.086	6.057SerLeu: 6.057 ± 0.088	1.737SerMet: 1.737 ± 0.043	4.353SerAsn: 4.353 ± 0.062	1.562SerPro: 1.562 ± 0.039	1.328SerGln: 1.328 ± 0.042	2.114SerArg: 2.114 ± 0.042	4.659SerSer: 4.659 ± 0.093	3.484SerThr: 3.484 ± 0.069	3.889SerVal: 3.889 ± 0.071	0.498SerTrp: 0.498 ± 0.024	2.846SerTyr: 2.846 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	2.934ThrAla: 2.934 ± 0.065	0.475ThrCys: 0.475 ± 0.023	2.55ThrAsp: 2.55 ± 0.053	3.226ThrGlu: 3.226 ± 0.066	2.335ThrPhe: 2.335 ± 0.049	3.487ThrGly: 3.487 ± 0.071	0.716ThrHis: 0.716 ± 0.024	5.483ThrIle: 5.483 ± 0.081	3.773ThrLys: 3.773 ± 0.059	4.979ThrLeu: 4.979 ± 0.072	1.188ThrMet: 1.188 ± 0.035	2.916ThrAsn: 2.916 ± 0.068	1.863ThrPro: 1.863 ± 0.081	0.849ThrGln: 0.849 ± 0.031	1.457ThrArg: 1.457 ± 0.036	3.46ThrSer: 3.46 ± 0.068	3.077ThrThr: 3.077 ± 0.074	3.551ThrVal: 3.551 ± 0.066	0.397ThrTrp: 0.397 ± 0.022	2.254ThrTyr: 2.254 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.058ValAla: 4.058 ± 0.083	0.747ValCys: 0.747 ± 0.029	4.027ValAsp: 4.027 ± 0.071	4.707ValGlu: 4.707 ± 0.069	2.785ValPhe: 2.785 ± 0.055	4.297ValGly: 4.297 ± 0.082	0.803ValHis: 0.803 ± 0.026	6.575ValIle: 6.575 ± 0.099	5.547ValLys: 5.547 ± 0.068	5.714ValLeu: 5.714 ± 0.086	1.643ValMet: 1.643 ± 0.044	3.678ValAsn: 3.678 ± 0.071	1.886ValPro: 1.886 ± 0.04	1.342ValGln: 1.342 ± 0.041	2.042ValArg: 2.042 ± 0.05	4.48ValSer: 4.48 ± 0.074	3.826ValThr: 3.826 ± 0.094	4.822ValVal: 4.822 ± 0.075	0.428ValTrp: 0.428 ± 0.024	2.51ValTyr: 2.51 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.341TrpAla: 0.341 ± 0.02	0.121TrpCys: 0.121 ± 0.01	0.431TrpAsp: 0.431 ± 0.023	0.42TrpGlu: 0.42 ± 0.021	0.329TrpPhe: 0.329 ± 0.017	0.47TrpGly: 0.47 ± 0.022	0.125TrpHis: 0.125 ± 0.011	0.73TrpIle: 0.73 ± 0.029	0.516TrpLys: 0.516 ± 0.025	0.566TrpLeu: 0.566 ± 0.024	0.215TrpMet: 0.215 ± 0.018	0.499TrpAsn: 0.499 ± 0.023	0.19TrpPro: 0.19 ± 0.016	0.245TrpGln: 0.245 ± 0.018	0.243TrpArg: 0.243 ± 0.015	0.463TrpSer: 0.463 ± 0.026	0.331TrpThr: 0.331 ± 0.019	0.408TrpVal: 0.408 ± 0.022	0.089TrpTrp: 0.089 ± 0.01	0.285TrpTyr: 0.285 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.879TyrAla: 1.879 ± 0.045	0.592TyrCys: 0.592 ± 0.026	2.734TyrAsp: 2.734 ± 0.062	2.959TyrGlu: 2.959 ± 0.06	1.996TyrPhe: 1.996 ± 0.058	2.768TyrGly: 2.768 ± 0.055	0.548TyrHis: 0.548 ± 0.024	4.494TyrIle: 4.494 ± 0.077	3.966TyrLys: 3.966 ± 0.07	3.625TyrLeu: 3.625 ± 0.052	1.046TyrMet: 1.046 ± 0.033	3.117TyrAsn: 3.117 ± 0.063	1.27TyrPro: 1.27 ± 0.038	0.851TyrGln: 0.851 ± 0.031	1.53TyrArg: 1.53 ± 0.041	3.239TyrSer: 3.239 ± 0.064	2.207TyrThr: 2.207 ± 0.054	2.441TyrVal: 2.441 ± 0.052	0.313TyrTrp: 0.313 ± 0.02	2.085TyrTyr: 2.085 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3269 proteins (1032520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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