Amino acid dipepetide frequency for Fervidicola ferrireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.186AlaAla: 7.186 ± 0.121
0.922AlaCys: 0.922 ± 0.04
3.323AlaAsp: 3.323 ± 0.068
5.621AlaGlu: 5.621 ± 0.096
3.397AlaPhe: 3.397 ± 0.068
6.356AlaGly: 6.356 ± 0.107
1.14AlaHis: 1.14 ± 0.043
5.698AlaIle: 5.698 ± 0.094
5.514AlaLys: 5.514 ± 0.1
8.559AlaLeu: 8.559 ± 0.145
2.165AlaMet: 2.165 ± 0.062
2.141AlaAsn: 2.141 ± 0.068
2.151AlaPro: 2.151 ± 0.062
2.092AlaGln: 2.092 ± 0.056
4.43AlaArg: 4.43 ± 0.088
3.769AlaSer: 3.769 ± 0.072
3.14AlaThr: 3.14 ± 0.077
7.229AlaVal: 7.229 ± 0.117
0.544AlaTrp: 0.544 ± 0.026
2.352AlaTyr: 2.352 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.789CysAla: 0.789 ± 0.036
0.158CysCys: 0.158 ± 0.016
0.582CysAsp: 0.582 ± 0.032
0.658CysGlu: 0.658 ± 0.035
0.41CysPhe: 0.41 ± 0.024
1.252CysGly: 1.252 ± 0.048
0.231CysHis: 0.231 ± 0.018
0.712CysIle: 0.712 ± 0.032
0.614CysLys: 0.614 ± 0.03
0.913CysLeu: 0.913 ± 0.04
0.28CysMet: 0.28 ± 0.02
0.385CysAsn: 0.385 ± 0.023
0.657CysPro: 0.657 ± 0.038
0.218CysGln: 0.218 ± 0.017
0.662CysArg: 0.662 ± 0.03
0.669CysSer: 0.669 ± 0.027
0.388CysThr: 0.388 ± 0.025
0.612CysVal: 0.612 ± 0.032
0.087CysTrp: 0.087 ± 0.011
0.355CysTyr: 0.355 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.481AspAla: 3.481 ± 0.069
0.492AspCys: 0.492 ± 0.027
2.311AspAsp: 2.311 ± 0.066
4.421AspGlu: 4.421 ± 0.087
2.583AspPhe: 2.583 ± 0.064
3.535AspGly: 3.535 ± 0.093
0.631AspHis: 0.631 ± 0.03
4.596AspIle: 4.596 ± 0.088
3.051AspLys: 3.051 ± 0.066
4.915AspLeu: 4.915 ± 0.103
1.309AspMet: 1.309 ± 0.039
1.374AspAsn: 1.374 ± 0.049
2.19AspPro: 2.19 ± 0.062
0.696AspGln: 0.696 ± 0.033
2.355AspArg: 2.355 ± 0.056
2.084AspSer: 2.084 ± 0.063
1.98AspThr: 1.98 ± 0.059
4.285AspVal: 4.285 ± 0.088
0.388AspTrp: 0.388 ± 0.027
1.939AspTyr: 1.939 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.962GluAla: 5.962 ± 0.11
0.589GluCys: 0.589 ± 0.028
3.9GluAsp: 3.9 ± 0.078
7.949GluGlu: 7.949 ± 0.138
2.831GluPhe: 2.831 ± 0.071
5.442GluGly: 5.442 ± 0.099
1.037GluHis: 1.037 ± 0.044
7.096GluIle: 7.096 ± 0.114
8.51GluLys: 8.51 ± 0.135
7.566GluLeu: 7.566 ± 0.104
2.252GluMet: 2.252 ± 0.066
3.739GluAsn: 3.739 ± 0.079
2.089GluPro: 2.089 ± 0.057
1.804GluGln: 1.804 ± 0.061
4.762GluArg: 4.762 ± 0.106
3.304GluSer: 3.304 ± 0.065
2.902GluThr: 2.902 ± 0.066
6.015GluVal: 6.015 ± 0.103
0.526GluTrp: 0.526 ± 0.029
2.462GluTyr: 2.462 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.087PheAla: 3.087 ± 0.087
0.568PheCys: 0.568 ± 0.026
2.29PheAsp: 2.29 ± 0.063
3.046PheGlu: 3.046 ± 0.072
2.176PhePhe: 2.176 ± 0.061
3.292PheGly: 3.292 ± 0.083
0.664PheHis: 0.664 ± 0.032
3.202PheIle: 3.202 ± 0.076
2.665PheLys: 2.665 ± 0.068
4.504PheLeu: 4.504 ± 0.116
1.113PheMet: 1.113 ± 0.043
1.502PheAsn: 1.502 ± 0.054
1.765PhePro: 1.765 ± 0.052
0.913PheGln: 0.913 ± 0.038
1.808PheArg: 1.808 ± 0.053
2.971PheSer: 2.971 ± 0.082
2.103PheThr: 2.103 ± 0.058
2.795PheVal: 2.795 ± 0.062
0.383PheTrp: 0.383 ± 0.027
1.57PheTyr: 1.57 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.639GlyAla: 5.639 ± 0.114
0.975GlyCys: 0.975 ± 0.038
3.466GlyAsp: 3.466 ± 0.077
5.36GlyGlu: 5.36 ± 0.086
3.528GlyPhe: 3.528 ± 0.085
5.698GlyGly: 5.698 ± 0.117
1.264GlyHis: 1.264 ± 0.042
7.037GlyIle: 7.037 ± 0.114
6.0GlyLys: 6.0 ± 0.095
6.895GlyLeu: 6.895 ± 0.114
2.189GlyMet: 2.189 ± 0.062
2.593GlyAsn: 2.593 ± 0.071
2.227GlyPro: 2.227 ± 0.061
1.82GlyGln: 1.82 ± 0.053
4.153GlyArg: 4.153 ± 0.08
3.728GlySer: 3.728 ± 0.077
3.794GlyThr: 3.794 ± 0.093
5.767GlyVal: 5.767 ± 0.093
0.692GlyTrp: 0.692 ± 0.032
2.862GlyTyr: 2.862 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.023HisAla: 1.023 ± 0.042
0.21HisCys: 0.21 ± 0.017
0.691HisAsp: 0.691 ± 0.033
0.957HisGlu: 0.957 ± 0.04
0.664HisPhe: 0.664 ± 0.03
1.205HisGly: 1.205 ± 0.044
0.361HisHis: 0.361 ± 0.024
1.17HisIle: 1.17 ± 0.043
0.836HisLys: 0.836 ± 0.033
1.478HisLeu: 1.478 ± 0.049
0.297HisMet: 0.297 ± 0.023
0.524HisAsn: 0.524 ± 0.027
0.93HisPro: 0.93 ± 0.035
0.419HisGln: 0.419 ± 0.026
0.816HisArg: 0.816 ± 0.034
0.76HisSer: 0.76 ± 0.032
0.654HisThr: 0.654 ± 0.031
1.085HisVal: 1.085 ± 0.042
0.118HisTrp: 0.118 ± 0.013
0.521HisTyr: 0.521 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.511IleAla: 6.511 ± 0.095
0.774IleCys: 0.774 ± 0.035
4.028IleAsp: 4.028 ± 0.077
6.169IleGlu: 6.169 ± 0.101
3.226IlePhe: 3.226 ± 0.08
5.418IleGly: 5.418 ± 0.094
1.111IleHis: 1.111 ± 0.039
5.76IleIle: 5.76 ± 0.109
6.558IleLys: 6.558 ± 0.109
7.547IleLeu: 7.547 ± 0.136
1.839IleMet: 1.839 ± 0.052
3.165IleAsn: 3.165 ± 0.066
3.877IlePro: 3.877 ± 0.071
1.649IleGln: 1.649 ± 0.053
3.594IleArg: 3.594 ± 0.069
4.8IleSer: 4.8 ± 0.101
4.065IleThr: 4.065 ± 0.087
5.563IleVal: 5.563 ± 0.097
0.507IleTrp: 0.507 ± 0.03
2.6IleTyr: 2.6 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
6.232LysAla: 6.232 ± 0.108
0.588LysCys: 0.588 ± 0.03
4.07LysAsp: 4.07 ± 0.088
7.088LysGlu: 7.088 ± 0.131
2.317LysPhe: 2.317 ± 0.066
5.53LysGly: 5.53 ± 0.093
0.898LysHis: 0.898 ± 0.034
6.372LysIle: 6.372 ± 0.104
7.141LysLys: 7.141 ± 0.12
6.596LysLeu: 6.596 ± 0.109
2.039LysMet: 2.039 ± 0.061
3.874LysAsn: 3.874 ± 0.082
2.705LysPro: 2.705 ± 0.068
1.652LysGln: 1.652 ± 0.049
3.896LysArg: 3.896 ± 0.076
3.814LysSer: 3.814 ± 0.077
3.435LysThr: 3.435 ± 0.069
6.252LysVal: 6.252 ± 0.097
0.529LysTrp: 0.529 ± 0.024
2.423LysTyr: 2.423 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
7.777LeuAla: 7.777 ± 0.114
1.047LeuCys: 1.047 ± 0.045
4.637LeuAsp: 4.637 ± 0.086
8.021LeuGlu: 8.021 ± 0.123
3.934LeuPhe: 3.934 ± 0.098
7.23LeuGly: 7.23 ± 0.127
1.267LeuHis: 1.267 ± 0.04
6.871LeuIle: 6.871 ± 0.118
8.768LeuLys: 8.768 ± 0.139
9.295LeuLeu: 9.295 ± 0.146
2.519LeuMet: 2.519 ± 0.062
3.791LeuAsn: 3.791 ± 0.077
4.166LeuPro: 4.166 ± 0.075
2.382LeuGln: 2.382 ± 0.064
4.713LeuArg: 4.713 ± 0.081
6.571LeuSer: 6.571 ± 0.105
4.304LeuThr: 4.304 ± 0.087
6.741LeuVal: 6.741 ± 0.109
0.779LeuTrp: 0.779 ± 0.04
2.913LeuTyr: 2.913 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.552MetAla: 2.552 ± 0.063
0.216MetCys: 0.216 ± 0.019
1.4MetAsp: 1.4 ± 0.048
2.237MetGlu: 2.237 ± 0.059
0.832MetPhe: 0.832 ± 0.033
2.148MetGly: 2.148 ± 0.054
0.362MetHis: 0.362 ± 0.023
1.726MetIle: 1.726 ± 0.053
2.155MetLys: 2.155 ± 0.054
2.5MetLeu: 2.5 ± 0.06
0.743MetMet: 0.743 ± 0.036
0.978MetAsn: 0.978 ± 0.037
1.188MetPro: 1.188 ± 0.045
0.63MetGln: 0.63 ± 0.031
1.333MetArg: 1.333 ± 0.046
1.202MetSer: 1.202 ± 0.047
1.212MetThr: 1.212 ± 0.046
2.149MetVal: 2.149 ± 0.057
0.163MetTrp: 0.163 ± 0.015
0.56MetTyr: 0.56 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.495AsnAla: 2.495 ± 0.06
0.434AsnCys: 0.434 ± 0.026
1.377AsnAsp: 1.377 ± 0.044
2.318AsnGlu: 2.318 ± 0.058
1.904AsnPhe: 1.904 ± 0.048
2.483AsnGly: 2.483 ± 0.057
0.529AsnHis: 0.529 ± 0.027
3.352AsnIle: 3.352 ± 0.075
2.24AsnLys: 2.24 ± 0.05
4.272AsnLeu: 4.272 ± 0.075
1.056AsnMet: 1.056 ± 0.04
1.318AsnAsn: 1.318 ± 0.045
2.255AsnPro: 2.255 ± 0.056
0.906AsnGln: 0.906 ± 0.039
1.877AsnArg: 1.877 ± 0.054
1.955AsnSer: 1.955 ± 0.053
1.721AsnThr: 1.721 ± 0.055
2.839AsnVal: 2.839 ± 0.063
0.335AsnTrp: 0.335 ± 0.025
1.367AsnTyr: 1.367 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.909ProAla: 2.909 ± 0.066
0.396ProCys: 0.396 ± 0.022
2.34ProAsp: 2.34 ± 0.065
4.004ProGlu: 4.004 ± 0.069
1.828ProPhe: 1.828 ± 0.052
3.466ProGly: 3.466 ± 0.077
0.71ProHis: 0.71 ± 0.033
2.359ProIle: 2.359 ± 0.063
2.292ProLys: 2.292 ± 0.06
3.784ProLeu: 3.784 ± 0.075
0.839ProMet: 0.839 ± 0.035
1.218ProAsn: 1.218 ± 0.046
1.622ProPro: 1.622 ± 0.051
1.071ProGln: 1.071 ± 0.041
1.797ProArg: 1.797 ± 0.052
2.007ProSer: 2.007 ± 0.051
1.68ProThr: 1.68 ± 0.054
3.903ProVal: 3.903 ± 0.072
0.373ProTrp: 0.373 ± 0.022
1.473ProTyr: 1.473 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
1.955GlnAla: 1.955 ± 0.055
0.199GlnCys: 0.199 ± 0.017
1.166GlnAsp: 1.166 ± 0.043
2.09GlnGlu: 2.09 ± 0.065
0.713GlnPhe: 0.713 ± 0.032
1.655GlnGly: 1.655 ± 0.054
0.354GlnHis: 0.354 ± 0.022
1.884GlnIle: 1.884 ± 0.049
2.259GlnLys: 2.259 ± 0.061
2.252GlnLeu: 2.252 ± 0.058
0.643GlnMet: 0.643 ± 0.033
1.109GlnAsn: 1.109 ± 0.045
0.744GlnPro: 0.744 ± 0.032
0.848GlnGln: 0.848 ± 0.054
1.236GlnArg: 1.236 ± 0.044
1.015GlnSer: 1.015 ± 0.038
0.905GlnThr: 0.905 ± 0.038
1.843GlnVal: 1.843 ± 0.056
0.189GlnTrp: 0.189 ± 0.015
0.702GlnTyr: 0.702 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
3.8ArgAla: 3.8 ± 0.082
0.61ArgCys: 0.61 ± 0.031
2.268ArgAsp: 2.268 ± 0.059
4.961ArgGlu: 4.961 ± 0.104
2.117ArgPhe: 2.117 ± 0.056
3.564ArgGly: 3.564 ± 0.069
0.77ArgHis: 0.77 ± 0.034
4.318ArgIle: 4.318 ± 0.09
4.021ArgLys: 4.021 ± 0.069
5.148ArgLeu: 5.148 ± 0.089
1.598ArgMet: 1.598 ± 0.048
1.866ArgAsn: 1.866 ± 0.052
1.884ArgPro: 1.884 ± 0.058
1.581ArgGln: 1.581 ± 0.054
2.992ArgArg: 2.992 ± 0.082
2.018ArgSer: 2.018 ± 0.058
2.18ArgThr: 2.18 ± 0.057
3.722ArgVal: 3.722 ± 0.077
0.557ArgTrp: 0.557 ± 0.026
1.811ArgTyr: 1.811 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.803SerAla: 3.803 ± 0.08
0.681SerCys: 0.681 ± 0.032
2.392SerAsp: 2.392 ± 0.065
3.783SerGlu: 3.783 ± 0.07
2.607SerPhe: 2.607 ± 0.071
4.709SerGly: 4.709 ± 0.097
0.884SerHis: 0.884 ± 0.033
4.048SerIle: 4.048 ± 0.077
3.367SerLys: 3.367 ± 0.055
5.461SerLeu: 5.461 ± 0.108
1.376SerMet: 1.376 ± 0.048
1.607SerAsn: 1.607 ± 0.05
2.395SerPro: 2.395 ± 0.062
1.366SerGln: 1.366 ± 0.044
2.939SerArg: 2.939 ± 0.071
3.326SerSer: 3.326 ± 0.092
2.468SerThr: 2.468 ± 0.062
3.653SerVal: 3.653 ± 0.074
0.413SerTrp: 0.413 ± 0.022
1.703SerTyr: 1.703 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
3.769ThrAla: 3.769 ± 0.08
0.513ThrCys: 0.513 ± 0.028
1.968ThrAsp: 1.968 ± 0.064
2.716ThrGlu: 2.716 ± 0.056
1.938ThrPhe: 1.938 ± 0.05
4.27ThrGly: 4.27 ± 0.082
0.712ThrHis: 0.712 ± 0.032
3.232ThrIle: 3.232 ± 0.082
2.597ThrLys: 2.597 ± 0.061
4.575ThrLeu: 4.575 ± 0.078
1.081ThrMet: 1.081 ± 0.042
1.433ThrAsn: 1.433 ± 0.05
2.31ThrPro: 2.31 ± 0.073
0.963ThrGln: 0.963 ± 0.041
2.163ThrArg: 2.163 ± 0.052
2.406ThrSer: 2.406 ± 0.064
2.186ThrThr: 2.186 ± 0.067
4.015ThrVal: 4.015 ± 0.081
0.358ThrTrp: 0.358 ± 0.024
1.502ThrTyr: 1.502 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.893ValAla: 5.893 ± 0.087
0.782ValCys: 0.782 ± 0.034
4.218ValAsp: 4.218 ± 0.089
6.27ValGlu: 6.27 ± 0.125
3.35ValPhe: 3.35 ± 0.076
5.194ValGly: 5.194 ± 0.085
1.054ValHis: 1.054 ± 0.036
6.296ValIle: 6.296 ± 0.097
6.232ValLys: 6.232 ± 0.085
7.525ValLeu: 7.525 ± 0.1
2.022ValMet: 2.022 ± 0.057
2.84ValAsn: 2.84 ± 0.064
3.205ValPro: 3.205 ± 0.062
1.619ValGln: 1.619 ± 0.048
3.918ValArg: 3.918 ± 0.072
4.238ValSer: 4.238 ± 0.081
3.715ValThr: 3.715 ± 0.085
6.556ValVal: 6.556 ± 0.118
0.526ValTrp: 0.526 ± 0.026
2.434ValTyr: 2.434 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.564TrpAla: 0.564 ± 0.028
0.079TrpCys: 0.079 ± 0.011
0.445TrpAsp: 0.445 ± 0.028
0.645TrpGlu: 0.645 ± 0.03
0.306TrpPhe: 0.306 ± 0.022
0.588TrpGly: 0.588 ± 0.029
0.178TrpHis: 0.178 ± 0.019
0.567TrpIle: 0.567 ± 0.032
0.537TrpLys: 0.537 ± 0.029
0.747TrpLeu: 0.747 ± 0.035
0.23TrpMet: 0.23 ± 0.021
0.328TrpAsn: 0.328 ± 0.022
0.337TrpPro: 0.337 ± 0.024
0.335TrpGln: 0.335 ± 0.023
0.383TrpArg: 0.383 ± 0.024
0.41TrpSer: 0.41 ± 0.026
0.266TrpThr: 0.266 ± 0.019
0.53TrpVal: 0.53 ± 0.029
0.114TrpTrp: 0.114 ± 0.015
0.266TrpTyr: 0.266 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.302TyrAla: 2.302 ± 0.056
0.402TyrCys: 0.402 ± 0.022
1.748TyrAsp: 1.748 ± 0.056
2.424TyrGlu: 2.424 ± 0.059
1.758TyrPhe: 1.758 ± 0.054
2.652TyrGly: 2.652 ± 0.069
0.564TyrHis: 0.564 ± 0.03
2.466TyrIle: 2.466 ± 0.064
2.093TyrLys: 2.093 ± 0.062
3.192TyrLeu: 3.192 ± 0.078
0.695TyrMet: 0.695 ± 0.029
1.244TyrAsn: 1.244 ± 0.041
1.374TyrPro: 1.374 ± 0.042
0.796TyrGln: 0.796 ± 0.035
1.959TyrArg: 1.959 ± 0.054
1.931TyrSer: 1.931 ± 0.052
1.61TyrThr: 1.61 ± 0.05
2.334TyrVal: 2.334 ± 0.051
0.273TyrTrp: 0.273 ± 0.021
1.339TyrTyr: 1.339 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2421 proteins (709530 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski