Amino acid dipepetide frequency for Rhizobacter gummiphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.021AlaAla: 19.021 ± 0.149
1.191AlaCys: 1.191 ± 0.027
7.213AlaAsp: 7.213 ± 0.071
6.887AlaGlu: 6.887 ± 0.068
4.35AlaPhe: 4.35 ± 0.05
11.447AlaGly: 11.447 ± 0.091
2.643AlaHis: 2.643 ± 0.045
4.666AlaIle: 4.666 ± 0.054
3.692AlaLys: 3.692 ± 0.064
14.695AlaLeu: 14.695 ± 0.15
3.399AlaMet: 3.399 ± 0.048
2.817AlaAsn: 2.817 ± 0.047
6.804AlaPro: 6.804 ± 0.075
4.585AlaGln: 4.585 ± 0.084
9.53AlaArg: 9.53 ± 0.089
6.841AlaSer: 6.841 ± 0.081
6.991AlaThr: 6.991 ± 0.077
10.28AlaVal: 10.28 ± 0.08
2.118AlaTrp: 2.118 ± 0.043
2.427AlaTyr: 2.427 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.054CysAla: 1.054 ± 0.024
0.083CysCys: 0.083 ± 0.007
0.48CysAsp: 0.48 ± 0.017
0.455CysGlu: 0.455 ± 0.015
0.287CysPhe: 0.287 ± 0.013
0.915CysGly: 0.915 ± 0.023
0.256CysHis: 0.256 ± 0.013
0.332CysIle: 0.332 ± 0.014
0.174CysLys: 0.174 ± 0.01
0.78CysLeu: 0.78 ± 0.022
0.155CysMet: 0.155 ± 0.01
0.186CysAsn: 0.186 ± 0.011
0.407CysPro: 0.407 ± 0.015
0.199CysGln: 0.199 ± 0.01
0.565CysArg: 0.565 ± 0.02
0.438CysSer: 0.438 ± 0.015
0.443CysThr: 0.443 ± 0.018
0.672CysVal: 0.672 ± 0.018
0.102CysTrp: 0.102 ± 0.008
0.151CysTyr: 0.151 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.328AspAla: 7.328 ± 0.064
0.394AspCys: 0.394 ± 0.015
3.204AspAsp: 3.204 ± 0.057
3.224AspGlu: 3.224 ± 0.048
1.929AspPhe: 1.929 ± 0.033
5.314AspGly: 5.314 ± 0.07
1.346AspHis: 1.346 ± 0.031
2.128AspIle: 2.128 ± 0.037
1.446AspLys: 1.446 ± 0.033
5.904AspLeu: 5.904 ± 0.067
0.987AspMet: 0.987 ± 0.026
1.16AspAsn: 1.16 ± 0.024
3.424AspPro: 3.424 ± 0.045
1.647AspGln: 1.647 ± 0.05
4.04AspArg: 4.04 ± 0.052
2.11AspSer: 2.11 ± 0.036
3.395AspThr: 3.395 ± 0.055
4.651AspVal: 4.651 ± 0.054
0.947AspTrp: 0.947 ± 0.021
1.193AspTyr: 1.193 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.146GluAla: 7.146 ± 0.072
0.336GluCys: 0.336 ± 0.014
2.109GluAsp: 2.109 ± 0.033
2.148GluGlu: 2.148 ± 0.045
1.658GluPhe: 1.658 ± 0.031
3.849GluGly: 3.849 ± 0.049
1.353GluHis: 1.353 ± 0.026
2.198GluIle: 2.198 ± 0.038
1.503GluLys: 1.503 ± 0.035
5.368GluLeu: 5.368 ± 0.057
1.157GluMet: 1.157 ± 0.026
1.13GluAsn: 1.13 ± 0.023
2.721GluPro: 2.721 ± 0.038
2.143GluGln: 2.143 ± 0.036
4.736GluArg: 4.736 ± 0.064
2.514GluSer: 2.514 ± 0.042
2.593GluThr: 2.593 ± 0.047
4.219GluVal: 4.219 ± 0.051
0.698GluTrp: 0.698 ± 0.019
0.904GluTyr: 0.904 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.372PheAla: 4.372 ± 0.055
0.342PheCys: 0.342 ± 0.016
2.684PheAsp: 2.684 ± 0.039
2.138PheGlu: 2.138 ± 0.034
1.313PhePhe: 1.313 ± 0.033
3.53PheGly: 3.53 ± 0.048
0.771PheHis: 0.771 ± 0.02
1.303PheIle: 1.303 ± 0.028
1.047PheLys: 1.047 ± 0.026
2.96PheLeu: 2.96 ± 0.044
0.678PheMet: 0.678 ± 0.018
1.01PheAsn: 1.01 ± 0.025
1.506PhePro: 1.506 ± 0.029
1.062PheGln: 1.062 ± 0.023
2.076PheArg: 2.076 ± 0.035
2.017PheSer: 2.017 ± 0.033
2.122PheThr: 2.122 ± 0.037
2.923PheVal: 2.923 ± 0.044
0.484PheTrp: 0.484 ± 0.017
0.777PheTyr: 0.777 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
9.615GlyAla: 9.615 ± 0.081
0.831GlyCys: 0.831 ± 0.023
4.495GlyAsp: 4.495 ± 0.053
4.417GlyGlu: 4.417 ± 0.061
3.32GlyPhe: 3.32 ± 0.042
7.409GlyGly: 7.409 ± 0.1
2.092GlyHis: 2.092 ± 0.035
3.633GlyIle: 3.633 ± 0.045
2.818GlyLys: 2.818 ± 0.046
9.396GlyLeu: 9.396 ± 0.081
2.018GlyMet: 2.018 ± 0.039
2.115GlyAsn: 2.115 ± 0.048
3.671GlyPro: 3.671 ± 0.051
3.142GlyGln: 3.142 ± 0.054
6.221GlyArg: 6.221 ± 0.072
4.58GlySer: 4.58 ± 0.069
5.167GlyThr: 5.167 ± 0.079
6.959GlyVal: 6.959 ± 0.076
1.608GlyTrp: 1.608 ± 0.032
2.165GlyTyr: 2.165 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
2.892HisAla: 2.892 ± 0.051
0.232HisCys: 0.232 ± 0.012
1.351HisAsp: 1.351 ± 0.029
1.2HisGlu: 1.2 ± 0.025
0.899HisPhe: 0.899 ± 0.025
2.284HisGly: 2.284 ± 0.037
0.679HisHis: 0.679 ± 0.023
0.751HisIle: 0.751 ± 0.022
0.475HisLys: 0.475 ± 0.016
2.448HisLeu: 2.448 ± 0.046
0.425HisMet: 0.425 ± 0.017
0.424HisAsn: 0.424 ± 0.015
1.557HisPro: 1.557 ± 0.031
0.716HisGln: 0.716 ± 0.021
1.675HisArg: 1.675 ± 0.034
0.869HisSer: 0.869 ± 0.024
1.145HisThr: 1.145 ± 0.025
1.832HisVal: 1.832 ± 0.029
0.378HisTrp: 0.378 ± 0.015
0.54HisTyr: 0.54 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
5.68IleAla: 5.68 ± 0.078
0.271IleCys: 0.271 ± 0.012
3.006IleAsp: 3.006 ± 0.041
2.713IleGlu: 2.713 ± 0.04
1.016IlePhe: 1.016 ± 0.029
3.856IleGly: 3.856 ± 0.054
0.785IleHis: 0.785 ± 0.024
1.074IleIle: 1.074 ± 0.031
1.083IleLys: 1.083 ± 0.031
2.651IleLeu: 2.651 ± 0.042
0.54IleMet: 0.54 ± 0.019
1.115IleAsn: 1.115 ± 0.029
1.781IlePro: 1.781 ± 0.034
1.055IleGln: 1.055 ± 0.023
2.269IleArg: 2.269 ± 0.04
1.926IleSer: 1.926 ± 0.037
2.229IleThr: 2.229 ± 0.042
3.43IleVal: 3.43 ± 0.048
0.339IleTrp: 0.339 ± 0.016
0.71IleTyr: 0.71 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.891LysAla: 3.891 ± 0.057
0.133LysCys: 0.133 ± 0.01
1.536LysAsp: 1.536 ± 0.036
1.267LysGlu: 1.267 ± 0.028
0.898LysPhe: 0.898 ± 0.023
2.315LysGly: 2.315 ± 0.039
0.582LysHis: 0.582 ± 0.021
1.09LysIle: 1.09 ± 0.031
1.101LysLys: 1.101 ± 0.035
2.986LysLeu: 2.986 ± 0.05
0.654LysMet: 0.654 ± 0.02
0.761LysAsn: 0.761 ± 0.021
1.919LysPro: 1.919 ± 0.037
1.044LysGln: 1.044 ± 0.025
1.973LysArg: 1.973 ± 0.035
1.562LysSer: 1.562 ± 0.03
1.62LysThr: 1.62 ± 0.035
2.636LysVal: 2.636 ± 0.045
0.307LysTrp: 0.307 ± 0.014
0.606LysTyr: 0.606 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.203LeuAla: 15.203 ± 0.126
0.933LeuCys: 0.933 ± 0.024
6.285LeuAsp: 6.285 ± 0.06
4.831LeuGlu: 4.831 ± 0.058
3.437LeuPhe: 3.437 ± 0.042
8.835LeuGly: 8.835 ± 0.074
2.327LeuHis: 2.327 ± 0.04
3.617LeuIle: 3.617 ± 0.052
3.444LeuLys: 3.444 ± 0.046
10.906LeuLeu: 10.906 ± 0.109
2.387LeuMet: 2.387 ± 0.039
2.54LeuAsn: 2.54 ± 0.038
6.17LeuPro: 6.17 ± 0.071
3.737LeuGln: 3.737 ± 0.044
7.884LeuArg: 7.884 ± 0.096
6.32LeuSer: 6.32 ± 0.082
5.605LeuThr: 5.605 ± 0.14
8.847LeuVal: 8.847 ± 0.08
1.364LeuTrp: 1.364 ± 0.025
1.934LeuTyr: 1.934 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.843MetAla: 2.843 ± 0.041
0.15MetCys: 0.15 ± 0.01
1.079MetAsp: 1.079 ± 0.026
0.809MetGlu: 0.809 ± 0.02
0.687MetPhe: 0.687 ± 0.018
1.715MetGly: 1.715 ± 0.035
0.492MetHis: 0.492 ± 0.017
0.826MetIle: 0.826 ± 0.023
0.932MetLys: 0.932 ± 0.024
2.319MetLeu: 2.319 ± 0.039
0.496MetMet: 0.496 ± 0.018
0.846MetAsn: 0.846 ± 0.021
1.422MetPro: 1.422 ± 0.027
0.846MetGln: 0.846 ± 0.023
1.588MetArg: 1.588 ± 0.031
1.571MetSer: 1.571 ± 0.029
1.553MetThr: 1.553 ± 0.031
1.644MetVal: 1.644 ± 0.036
0.191MetTrp: 0.191 ± 0.011
0.349MetTyr: 0.349 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.092AsnAla: 3.092 ± 0.052
0.198AsnCys: 0.198 ± 0.01
1.398AsnAsp: 1.398 ± 0.031
1.165AsnGlu: 1.165 ± 0.026
0.851AsnPhe: 0.851 ± 0.027
2.254AsnGly: 2.254 ± 0.043
0.519AsnHis: 0.519 ± 0.017
0.96AsnIle: 0.96 ± 0.025
0.662AsnLys: 0.662 ± 0.019
2.541AsnLeu: 2.541 ± 0.038
0.474AsnMet: 0.474 ± 0.016
0.687AsnAsn: 0.687 ± 0.023
1.733AsnPro: 1.733 ± 0.028
0.81AsnGln: 0.81 ± 0.021
1.573AsnArg: 1.573 ± 0.029
0.996AsnSer: 0.996 ± 0.024
1.449AsnThr: 1.449 ± 0.031
1.966AsnVal: 1.966 ± 0.039
0.351AsnTrp: 0.351 ± 0.014
0.579AsnTyr: 0.579 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.034ProAla: 8.034 ± 0.091
0.32ProCys: 0.32 ± 0.012
3.49ProAsp: 3.49 ± 0.047
3.323ProGlu: 3.323 ± 0.048
1.913ProPhe: 1.913 ± 0.031
4.951ProGly: 4.951 ± 0.051
1.148ProHis: 1.148 ± 0.027
1.702ProIle: 1.702 ± 0.03
1.572ProLys: 1.572 ± 0.035
5.494ProLeu: 5.494 ± 0.066
1.309ProMet: 1.309 ± 0.024
1.279ProAsn: 1.279 ± 0.029
3.178ProPro: 3.178 ± 0.059
1.765ProGln: 1.765 ± 0.033
3.234ProArg: 3.234 ± 0.048
3.041ProSer: 3.041 ± 0.047
2.755ProThr: 2.755 ± 0.045
5.141ProVal: 5.141 ± 0.067
0.919ProTrp: 0.919 ± 0.025
1.078ProTyr: 1.078 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
4.933GlnAla: 4.933 ± 0.055
0.232GlnCys: 0.232 ± 0.013
1.358GlnAsp: 1.358 ± 0.031
1.301GlnGlu: 1.301 ± 0.03
1.157GlnPhe: 1.157 ± 0.034
2.653GlnGly: 2.653 ± 0.042
0.822GlnHis: 0.822 ± 0.019
1.371GlnIle: 1.371 ± 0.058
0.911GlnLys: 0.911 ± 0.025
3.874GlnLeu: 3.874 ± 0.054
0.809GlnMet: 0.809 ± 0.022
0.722GlnAsn: 0.722 ± 0.021
1.973GlnPro: 1.973 ± 0.035
1.607GlnGln: 1.607 ± 0.034
3.111GlnArg: 3.111 ± 0.047
1.783GlnSer: 1.783 ± 0.032
1.629GlnThr: 1.629 ± 0.042
3.127GlnVal: 3.127 ± 0.06
0.559GlnTrp: 0.559 ± 0.017
0.675GlnTyr: 0.675 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.37ArgAla: 8.37 ± 0.085
0.589ArgCys: 0.589 ± 0.022
4.046ArgAsp: 4.046 ± 0.049
4.112ArgGlu: 4.112 ± 0.051
2.92ArgPhe: 2.92 ± 0.043
5.008ArgGly: 5.008 ± 0.057
2.133ArgHis: 2.133 ± 0.04
3.234ArgIle: 3.234 ± 0.042
1.879ArgLys: 1.879 ± 0.038
8.448ArgLeu: 8.448 ± 0.095
1.799ArgMet: 1.799 ± 0.033
1.68ArgAsn: 1.68 ± 0.032
3.695ArgPro: 3.695 ± 0.054
2.867ArgGln: 2.867 ± 0.039
5.745ArgArg: 5.745 ± 0.072
3.67ArgSer: 3.67 ± 0.05
3.689ArgThr: 3.689 ± 0.051
5.803ArgVal: 5.803 ± 0.052
1.347ArgTrp: 1.347 ± 0.03
1.767ArgTyr: 1.767 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.419SerAla: 6.419 ± 0.082
0.412SerCys: 0.412 ± 0.016
2.598SerAsp: 2.598 ± 0.044
2.304SerGlu: 2.304 ± 0.039
1.985SerPhe: 1.985 ± 0.032
5.135SerGly: 5.135 ± 0.069
1.142SerHis: 1.142 ± 0.025
2.136SerIle: 2.136 ± 0.035
1.383SerLys: 1.383 ± 0.029
5.811SerLeu: 5.811 ± 0.069
1.293SerMet: 1.293 ± 0.027
1.342SerAsn: 1.342 ± 0.039
3.277SerPro: 3.277 ± 0.04
1.653SerGln: 1.653 ± 0.031
3.792SerArg: 3.792 ± 0.049
3.021SerSer: 3.021 ± 0.059
3.06SerThr: 3.06 ± 0.051
4.217SerVal: 4.217 ± 0.057
0.734SerTrp: 0.734 ± 0.021
1.096SerTyr: 1.096 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.85ThrAla: 6.85 ± 0.096
0.436ThrCys: 0.436 ± 0.017
2.911ThrAsp: 2.911 ± 0.076
2.42ThrGlu: 2.42 ± 0.035
2.056ThrPhe: 2.056 ± 0.034
5.232ThrGly: 5.232 ± 0.082
1.177ThrHis: 1.177 ± 0.027
1.928ThrIle: 1.928 ± 0.062
1.311ThrLys: 1.311 ± 0.027
6.635ThrLeu: 6.635 ± 0.078
1.11ThrMet: 1.11 ± 0.026
1.282ThrAsn: 1.282 ± 0.032
3.822ThrPro: 3.822 ± 0.042
1.728ThrGln: 1.728 ± 0.029
3.687ThrArg: 3.687 ± 0.053
3.044ThrSer: 3.044 ± 0.064
3.409ThrThr: 3.409 ± 0.114
4.905ThrVal: 4.905 ± 0.098
0.845ThrTrp: 0.845 ± 0.021
1.189ThrTyr: 1.189 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
10.844ValAla: 10.844 ± 0.087
0.698ValCys: 0.698 ± 0.02
4.693ValAsp: 4.693 ± 0.053
4.208ValGlu: 4.208 ± 0.05
3.003ValPhe: 3.003 ± 0.043
6.042ValGly: 6.042 ± 0.057
1.708ValHis: 1.708 ± 0.033
3.296ValIle: 3.296 ± 0.049
2.464ValLys: 2.464 ± 0.042
9.17ValLeu: 9.17 ± 0.089
1.919ValMet: 1.919 ± 0.031
2.152ValAsn: 2.152 ± 0.032
4.786ValPro: 4.786 ± 0.056
2.628ValGln: 2.628 ± 0.037
6.04ValArg: 6.04 ± 0.068
4.664ValSer: 4.664 ± 0.052
5.002ValThr: 5.002 ± 0.112
7.382ValVal: 7.382 ± 0.081
1.151ValTrp: 1.151 ± 0.032
1.571ValTyr: 1.571 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.541TrpAla: 1.541 ± 0.031
0.161TrpCys: 0.161 ± 0.009
0.644TrpAsp: 0.644 ± 0.019
0.516TrpGlu: 0.516 ± 0.017
0.634TrpPhe: 0.634 ± 0.02
1.005TrpGly: 1.005 ± 0.027
0.388TrpHis: 0.388 ± 0.013
0.626TrpIle: 0.626 ± 0.019
0.429TrpLys: 0.429 ± 0.017
2.059TrpLeu: 2.059 ± 0.041
0.384TrpMet: 0.384 ± 0.013
0.457TrpAsn: 0.457 ± 0.02
0.763TrpPro: 0.763 ± 0.021
0.65TrpGln: 0.65 ± 0.019
1.33TrpArg: 1.33 ± 0.031
0.876TrpSer: 0.876 ± 0.021
0.868TrpThr: 0.868 ± 0.022
1.158TrpVal: 1.158 ± 0.028
0.314TrpTrp: 0.314 ± 0.011
0.291TrpTyr: 0.291 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.467TyrAla: 2.467 ± 0.038
0.195TyrCys: 0.195 ± 0.011
1.189TyrAsp: 1.189 ± 0.049
1.045TyrGlu: 1.045 ± 0.024
0.802TyrPhe: 0.802 ± 0.02
1.922TyrGly: 1.922 ± 0.035
0.408TyrHis: 0.408 ± 0.015
0.661TyrIle: 0.661 ± 0.018
0.555TyrLys: 0.555 ± 0.019
2.159TyrLeu: 2.159 ± 0.036
0.365TyrMet: 0.365 ± 0.014
0.555TyrAsn: 0.555 ± 0.02
1.036TyrPro: 1.036 ± 0.024
0.726TyrGln: 0.726 ± 0.019
1.727TyrArg: 1.727 ± 0.032
0.968TyrSer: 0.968 ± 0.026
1.252TyrThr: 1.252 ± 0.038
1.63TyrVal: 1.63 ± 0.03
0.34TyrTrp: 0.34 ± 0.013
0.472TyrTyr: 0.472 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5678 proteins (1907566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski