Amino acid dipepetide frequency for Streptococcus satellite phage Javan504

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.558AlaAla: 0.558 ± 0.469
0.279AlaCys: 0.279 ± 0.268
3.069AlaAsp: 3.069 ± 1.122
5.859AlaGlu: 5.859 ± 1.889
2.511AlaPhe: 2.511 ± 0.919
1.395AlaGly: 1.395 ± 0.653
0.0AlaHis: 0.0 ± 0.0
4.743AlaIle: 4.743 ± 1.116
4.185AlaLys: 4.185 ± 1.285
5.022AlaLeu: 5.022 ± 1.157
1.395AlaMet: 1.395 ± 0.454
4.185AlaAsn: 4.185 ± 0.724
0.837AlaPro: 0.837 ± 0.507
2.232AlaGln: 2.232 ± 0.785
3.069AlaArg: 3.069 ± 1.002
2.511AlaSer: 2.511 ± 1.037
3.906AlaThr: 3.906 ± 0.756
3.348AlaVal: 3.348 ± 0.992
0.558AlaTrp: 0.558 ± 0.635
1.395AlaTyr: 1.395 ± 0.622
0.0AlaXaa: 0.0 ± 0.0
Cys
0.837CysAla: 0.837 ± 0.406
0.0CysCys: 0.0 ± 0.0
0.558CysAsp: 0.558 ± 0.367
0.558CysGlu: 0.558 ± 0.38
0.0CysPhe: 0.0 ± 0.0
0.279CysGly: 0.279 ± 0.313
0.0CysHis: 0.0 ± 0.0
0.279CysIle: 0.279 ± 0.244
0.837CysLys: 0.837 ± 0.497
1.116CysLeu: 1.116 ± 0.39
0.0CysMet: 0.0 ± 0.0
1.116CysAsn: 1.116 ± 0.565
0.0CysPro: 0.0 ± 0.0
0.558CysGln: 0.558 ± 0.477
0.279CysArg: 0.279 ± 0.318
0.837CysSer: 0.837 ± 0.475
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.558CysTyr: 0.558 ± 0.317
0.0CysXaa: 0.0 ± 0.0
Asp
2.511AspAla: 2.511 ± 0.749
0.279AspCys: 0.279 ± 0.243
2.232AspAsp: 2.232 ± 0.744
3.906AspGlu: 3.906 ± 1.142
2.511AspPhe: 2.511 ± 0.831
3.627AspGly: 3.627 ± 1.184
0.558AspHis: 0.558 ± 0.495
7.533AspIle: 7.533 ± 1.127
6.975AspLys: 6.975 ± 1.069
7.254AspLeu: 7.254 ± 0.99
1.116AspMet: 1.116 ± 0.586
1.953AspAsn: 1.953 ± 0.582
1.674AspPro: 1.674 ± 0.537
1.674AspGln: 1.674 ± 0.544
2.511AspArg: 2.511 ± 0.749
2.79AspSer: 2.79 ± 0.864
3.906AspThr: 3.906 ± 0.953
1.116AspVal: 1.116 ± 0.629
0.837AspTrp: 0.837 ± 0.555
4.743AspTyr: 4.743 ± 1.093
0.0AspXaa: 0.0 ± 0.0
Glu
7.533GluAla: 7.533 ± 1.256
0.837GluCys: 0.837 ± 0.53
5.58GluAsp: 5.58 ± 1.158
6.696GluGlu: 6.696 ± 1.842
2.79GluPhe: 2.79 ± 1.58
3.627GluGly: 3.627 ± 1.038
1.674GluHis: 1.674 ± 0.718
4.464GluIle: 4.464 ± 1.119
5.301GluLys: 5.301 ± 0.906
8.929GluLeu: 8.929 ± 1.414
1.674GluMet: 1.674 ± 0.597
3.348GluAsn: 3.348 ± 0.695
1.953GluPro: 1.953 ± 0.792
5.301GluGln: 5.301 ± 1.768
5.301GluArg: 5.301 ± 1.549
3.627GluSer: 3.627 ± 0.865
5.301GluThr: 5.301 ± 1.025
6.417GluVal: 6.417 ± 1.635
1.674GluTrp: 1.674 ± 0.58
4.185GluTyr: 4.185 ± 1.011
0.0GluXaa: 0.0 ± 0.0
Phe
1.674PheAla: 1.674 ± 0.509
0.279PheCys: 0.279 ± 0.288
3.348PheAsp: 3.348 ± 1.251
2.79PheGlu: 2.79 ± 1.173
1.116PhePhe: 1.116 ± 0.638
1.395PheGly: 1.395 ± 0.59
0.558PheHis: 0.558 ± 0.347
2.232PheIle: 2.232 ± 0.836
4.185PheLys: 4.185 ± 1.302
2.79PheLeu: 2.79 ± 1.102
1.116PheMet: 1.116 ± 0.567
3.906PheAsn: 3.906 ± 0.774
0.558PhePro: 0.558 ± 0.482
1.953PheGln: 1.953 ± 0.708
2.79PheArg: 2.79 ± 0.851
3.348PheSer: 3.348 ± 0.971
2.511PheThr: 2.511 ± 0.77
2.79PheVal: 2.79 ± 0.544
0.0PheTrp: 0.0 ± 0.0
1.116PheTyr: 1.116 ± 0.483
0.0PheXaa: 0.0 ± 0.0
Gly
2.232GlyAla: 2.232 ± 1.107
0.0GlyCys: 0.0 ± 0.0
3.348GlyAsp: 3.348 ± 1.128
3.627GlyGlu: 3.627 ± 1.04
2.511GlyPhe: 2.511 ± 0.678
2.79GlyGly: 2.79 ± 0.975
1.116GlyHis: 1.116 ± 0.65
3.348GlyIle: 3.348 ± 0.942
4.464GlyLys: 4.464 ± 1.221
5.859GlyLeu: 5.859 ± 1.4
0.558GlyMet: 0.558 ± 0.406
3.348GlyAsn: 3.348 ± 1.283
0.279GlyPro: 0.279 ± 0.243
1.116GlyGln: 1.116 ± 0.614
1.674GlyArg: 1.674 ± 0.584
1.116GlySer: 1.116 ± 0.386
2.511GlyThr: 2.511 ± 0.792
3.627GlyVal: 3.627 ± 1.03
1.116GlyTrp: 1.116 ± 0.799
2.511GlyTyr: 2.511 ± 0.777
0.0GlyXaa: 0.0 ± 0.0
His
1.116HisAla: 1.116 ± 1.072
0.558HisCys: 0.558 ± 0.352
0.837HisAsp: 0.837 ± 0.661
1.116HisGlu: 1.116 ± 0.751
0.279HisPhe: 0.279 ± 0.292
0.279HisGly: 0.279 ± 0.304
0.279HisHis: 0.279 ± 0.289
0.837HisIle: 0.837 ± 0.467
1.116HisLys: 1.116 ± 0.587
3.069HisLeu: 3.069 ± 1.199
0.0HisMet: 0.0 ± 0.0
0.558HisAsn: 0.558 ± 0.38
0.279HisPro: 0.279 ± 0.233
1.674HisGln: 1.674 ± 0.848
0.558HisArg: 0.558 ± 0.387
0.0HisSer: 0.0 ± 0.0
1.395HisThr: 1.395 ± 0.44
0.279HisVal: 0.279 ± 0.244
0.0HisTrp: 0.0 ± 0.0
0.837HisTyr: 0.837 ± 0.55
0.0HisXaa: 0.0 ± 0.0
Ile
4.185IleAla: 4.185 ± 1.006
0.558IleCys: 0.558 ± 0.395
3.906IleAsp: 3.906 ± 1.08
7.254IleGlu: 7.254 ± 1.553
1.953IlePhe: 1.953 ± 0.608
2.79IleGly: 2.79 ± 0.796
1.116IleHis: 1.116 ± 0.457
2.79IleIle: 2.79 ± 0.915
8.092IleLys: 8.092 ± 1.65
5.022IleLeu: 5.022 ± 1.079
1.116IleMet: 1.116 ± 0.44
3.627IleAsn: 3.627 ± 0.653
2.511IlePro: 2.511 ± 1.03
2.511IleGln: 2.511 ± 0.631
2.79IleArg: 2.79 ± 0.754
5.859IleSer: 5.859 ± 1.163
5.58IleThr: 5.58 ± 1.284
2.79IleVal: 2.79 ± 0.683
0.279IleTrp: 0.279 ± 0.244
2.232IleTyr: 2.232 ± 0.82
0.0IleXaa: 0.0 ± 0.0
Lys
4.464LysAla: 4.464 ± 0.841
0.558LysCys: 0.558 ± 0.456
7.254LysAsp: 7.254 ± 1.638
8.929LysGlu: 8.929 ± 2.024
3.069LysPhe: 3.069 ± 0.819
3.069LysGly: 3.069 ± 1.036
2.232LysHis: 2.232 ± 1.0
5.859LysIle: 5.859 ± 1.645
10.045LysLys: 10.045 ± 2.618
6.975LysLeu: 6.975 ± 1.253
2.511LysMet: 2.511 ± 0.97
6.417LysAsn: 6.417 ± 1.06
3.906LysPro: 3.906 ± 0.897
5.022LysGln: 5.022 ± 1.119
5.022LysArg: 5.022 ± 1.437
3.906LysSer: 3.906 ± 1.091
5.859LysThr: 5.859 ± 1.641
5.301LysVal: 5.301 ± 1.122
1.116LysTrp: 1.116 ± 0.58
2.232LysTyr: 2.232 ± 0.722
0.0LysXaa: 0.0 ± 0.0
Leu
3.627LeuAla: 3.627 ± 1.203
1.116LeuCys: 1.116 ± 0.562
8.929LeuAsp: 8.929 ± 0.956
11.998LeuGlu: 11.998 ± 1.6
3.906LeuPhe: 3.906 ± 0.856
6.138LeuGly: 6.138 ± 1.482
0.837LeuHis: 0.837 ± 0.545
7.254LeuIle: 7.254 ± 1.494
7.812LeuLys: 7.812 ± 1.295
8.929LeuLeu: 8.929 ± 1.633
2.511LeuMet: 2.511 ± 0.895
5.301LeuAsn: 5.301 ± 0.984
3.906LeuPro: 3.906 ± 0.903
3.627LeuGln: 3.627 ± 0.854
3.069LeuArg: 3.069 ± 0.852
7.812LeuSer: 7.812 ± 1.289
3.906LeuThr: 3.906 ± 0.87
3.906LeuVal: 3.906 ± 1.378
0.837LeuTrp: 0.837 ± 0.494
5.301LeuTyr: 5.301 ± 0.935
0.0LeuXaa: 0.0 ± 0.0
Met
0.558MetAla: 0.558 ± 0.486
0.279MetCys: 0.279 ± 0.244
0.558MetAsp: 0.558 ± 0.44
1.953MetGlu: 1.953 ± 0.623
1.395MetPhe: 1.395 ± 0.574
0.279MetGly: 0.279 ± 0.244
0.0MetHis: 0.0 ± 0.0
1.116MetIle: 1.116 ± 0.732
3.348MetLys: 3.348 ± 0.905
2.511MetLeu: 2.511 ± 0.765
0.279MetMet: 0.279 ± 0.303
1.953MetAsn: 1.953 ± 0.627
0.279MetPro: 0.279 ± 0.268
0.558MetGln: 0.558 ± 0.438
1.116MetArg: 1.116 ± 0.456
1.674MetSer: 1.674 ± 0.624
2.232MetThr: 2.232 ± 0.685
1.116MetVal: 1.116 ± 0.461
0.0MetTrp: 0.0 ± 0.0
0.558MetTyr: 0.558 ± 0.372
0.0MetXaa: 0.0 ± 0.0
Asn
4.464AsnAla: 4.464 ± 1.07
0.558AsnCys: 0.558 ± 0.388
2.79AsnAsp: 2.79 ± 0.951
5.301AsnGlu: 5.301 ± 1.059
1.953AsnPhe: 1.953 ± 0.602
5.022AsnGly: 5.022 ± 1.12
1.116AsnHis: 1.116 ± 0.542
2.511AsnIle: 2.511 ± 0.854
5.58AsnLys: 5.58 ± 1.072
5.301AsnLeu: 5.301 ± 0.83
1.674AsnMet: 1.674 ± 0.514
2.511AsnAsn: 2.511 ± 0.681
1.395AsnPro: 1.395 ± 0.504
4.464AsnGln: 4.464 ± 1.293
3.906AsnArg: 3.906 ± 0.678
1.116AsnSer: 1.116 ± 0.492
3.069AsnThr: 3.069 ± 0.933
2.511AsnVal: 2.511 ± 0.673
0.558AsnTrp: 0.558 ± 0.385
2.232AsnTyr: 2.232 ± 0.83
0.0AsnXaa: 0.0 ± 0.0
Pro
0.837ProAla: 0.837 ± 0.42
0.558ProCys: 0.558 ± 0.409
0.837ProAsp: 0.837 ± 0.453
2.79ProGlu: 2.79 ± 0.914
2.232ProPhe: 2.232 ± 0.685
0.279ProGly: 0.279 ± 0.303
0.0ProHis: 0.0 ± 0.0
1.395ProIle: 1.395 ± 0.698
3.348ProLys: 3.348 ± 1.184
3.069ProLeu: 3.069 ± 0.857
0.279ProMet: 0.279 ± 0.244
2.511ProAsn: 2.511 ± 0.639
0.837ProPro: 0.837 ± 0.402
0.558ProGln: 0.558 ± 0.411
1.395ProArg: 1.395 ± 0.763
1.395ProSer: 1.395 ± 0.518
2.232ProThr: 2.232 ± 0.647
1.674ProVal: 1.674 ± 0.84
0.0ProTrp: 0.0 ± 0.0
1.395ProTyr: 1.395 ± 0.635
0.0ProXaa: 0.0 ± 0.0
Gln
1.674GlnAla: 1.674 ± 0.582
0.279GlnCys: 0.279 ± 0.298
3.069GlnAsp: 3.069 ± 1.6
4.185GlnGlu: 4.185 ± 1.302
2.232GlnPhe: 2.232 ± 0.655
1.674GlnGly: 1.674 ± 0.748
0.837GlnHis: 0.837 ± 0.482
1.953GlnIle: 1.953 ± 0.801
3.348GlnLys: 3.348 ± 0.843
5.859GlnLeu: 5.859 ± 0.814
1.953GlnMet: 1.953 ± 0.924
2.232GlnAsn: 2.232 ± 0.89
1.953GlnPro: 1.953 ± 0.716
1.674GlnGln: 1.674 ± 0.746
2.79GlnArg: 2.79 ± 0.723
2.232GlnSer: 2.232 ± 0.719
1.395GlnThr: 1.395 ± 0.595
3.069GlnVal: 3.069 ± 0.687
0.279GlnTrp: 0.279 ± 0.303
2.511GlnTyr: 2.511 ± 0.937
0.0GlnXaa: 0.0 ± 0.0
Arg
3.069ArgAla: 3.069 ± 0.893
0.279ArgCys: 0.279 ± 0.268
2.232ArgAsp: 2.232 ± 0.561
2.79ArgGlu: 2.79 ± 0.696
1.395ArgPhe: 1.395 ± 0.569
2.232ArgGly: 2.232 ± 0.842
1.116ArgHis: 1.116 ± 0.648
1.674ArgIle: 1.674 ± 0.5
6.975ArgLys: 6.975 ± 1.211
6.138ArgLeu: 6.138 ± 0.916
0.837ArgMet: 0.837 ± 0.476
1.674ArgAsn: 1.674 ± 0.661
1.395ArgPro: 1.395 ± 0.705
3.069ArgGln: 3.069 ± 0.982
2.511ArgArg: 2.511 ± 0.999
2.511ArgSer: 2.511 ± 0.805
3.627ArgThr: 3.627 ± 0.687
3.627ArgVal: 3.627 ± 1.241
0.837ArgTrp: 0.837 ± 0.419
2.79ArgTyr: 2.79 ± 0.757
0.0ArgXaa: 0.0 ± 0.0
Ser
2.79SerAla: 2.79 ± 1.067
0.279SerCys: 0.279 ± 0.313
4.185SerAsp: 4.185 ± 0.633
3.627SerGlu: 3.627 ± 0.91
1.953SerPhe: 1.953 ± 0.787
3.069SerGly: 3.069 ± 0.653
0.558SerHis: 0.558 ± 0.34
5.58SerIle: 5.58 ± 1.305
6.696SerLys: 6.696 ± 1.134
4.743SerLeu: 4.743 ± 1.084
0.558SerMet: 0.558 ± 0.42
1.395SerAsn: 1.395 ± 0.511
0.558SerPro: 0.558 ± 0.356
2.511SerGln: 2.511 ± 0.91
2.79SerArg: 2.79 ± 0.689
2.79SerSer: 2.79 ± 1.027
2.511SerThr: 2.511 ± 0.906
3.348SerVal: 3.348 ± 0.932
0.558SerTrp: 0.558 ± 0.387
2.511SerTyr: 2.511 ± 0.732
0.0SerXaa: 0.0 ± 0.0
Thr
3.627ThrAla: 3.627 ± 1.107
0.0ThrCys: 0.0 ± 0.0
1.395ThrAsp: 1.395 ± 0.703
5.58ThrGlu: 5.58 ± 0.991
2.79ThrPhe: 2.79 ± 0.888
3.906ThrGly: 3.906 ± 0.86
0.837ThrHis: 0.837 ± 0.414
4.743ThrIle: 4.743 ± 1.489
3.348ThrLys: 3.348 ± 0.869
6.417ThrLeu: 6.417 ± 1.472
0.837ThrMet: 0.837 ± 0.437
2.232ThrAsn: 2.232 ± 0.778
2.79ThrPro: 2.79 ± 0.851
1.953ThrGln: 1.953 ± 0.699
2.79ThrArg: 2.79 ± 1.125
3.906ThrSer: 3.906 ± 1.032
4.743ThrThr: 4.743 ± 1.114
3.348ThrVal: 3.348 ± 1.006
1.116ThrTrp: 1.116 ± 0.469
5.022ThrTyr: 5.022 ± 1.217
0.0ThrXaa: 0.0 ± 0.0
Val
3.906ValAla: 3.906 ± 0.989
0.558ValCys: 0.558 ± 0.363
2.79ValAsp: 2.79 ± 0.971
2.511ValGlu: 2.511 ± 0.837
3.627ValPhe: 3.627 ± 0.871
1.395ValGly: 1.395 ± 0.487
0.279ValHis: 0.279 ± 0.272
3.906ValIle: 3.906 ± 0.96
3.348ValLys: 3.348 ± 0.975
6.975ValLeu: 6.975 ± 1.244
1.953ValMet: 1.953 ± 0.612
5.022ValAsn: 5.022 ± 0.96
1.395ValPro: 1.395 ± 0.598
1.395ValGln: 1.395 ± 0.706
1.953ValArg: 1.953 ± 0.612
3.906ValSer: 3.906 ± 0.916
4.464ValThr: 4.464 ± 1.073
1.953ValVal: 1.953 ± 0.612
0.558ValTrp: 0.558 ± 0.386
1.953ValTyr: 1.953 ± 0.511
0.0ValXaa: 0.0 ± 0.0
Trp
0.558TrpAla: 0.558 ± 0.339
0.0TrpCys: 0.0 ± 0.0
0.837TrpAsp: 0.837 ± 0.534
0.558TrpGlu: 0.558 ± 0.409
0.279TrpPhe: 0.279 ± 0.244
0.837TrpGly: 0.837 ± 0.411
0.837TrpHis: 0.837 ± 0.536
0.558TrpIle: 0.558 ± 0.409
0.279TrpLys: 0.279 ± 0.287
1.674TrpLeu: 1.674 ± 0.594
0.0TrpMet: 0.0 ± 0.0
0.558TrpAsn: 0.558 ± 0.388
0.0TrpPro: 0.0 ± 0.0
0.558TrpGln: 0.558 ± 0.317
0.0TrpArg: 0.0 ± 0.0
0.279TrpSer: 0.279 ± 0.243
0.279TrpThr: 0.279 ± 0.303
1.395TrpVal: 1.395 ± 0.569
0.558TrpTrp: 0.558 ± 0.388
0.837TrpTyr: 0.837 ± 0.4
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.837TyrAla: 0.837 ± 0.537
0.558TyrCys: 0.558 ± 0.367
1.953TyrAsp: 1.953 ± 0.602
4.185TyrGlu: 4.185 ± 0.854
2.232TyrPhe: 2.232 ± 0.631
3.069TyrGly: 3.069 ± 0.992
1.116TyrHis: 1.116 ± 0.435
4.185TyrIle: 4.185 ± 1.602
4.464TyrLys: 4.464 ± 1.06
3.069TyrLeu: 3.069 ± 0.705
1.116TyrMet: 1.116 ± 0.493
4.185TyrAsn: 4.185 ± 1.082
1.116TyrPro: 1.116 ± 0.772
2.79TyrGln: 2.79 ± 0.896
4.464TyrArg: 4.464 ± 0.951
1.395TyrSer: 1.395 ± 0.681
1.953TyrThr: 1.953 ± 0.477
2.232TyrVal: 2.232 ± 0.559
0.0TyrTrp: 0.0 ± 0.0
3.627TyrTyr: 3.627 ± 0.921
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (3585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski