Amino acid dipepetide frequency for Candidatus Thiomargarita nelsonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.775AlaAla: 5.775 ± 0.075	0.904AlaCys: 0.904 ± 0.03	3.705AlaAsp: 3.705 ± 0.049	4.588AlaGlu: 4.588 ± 0.055	3.226AlaPhe: 3.226 ± 0.044	4.753AlaGly: 4.753 ± 0.067	1.647AlaHis: 1.647 ± 0.034	5.327AlaIle: 5.327 ± 0.072	4.422AlaLys: 4.422 ± 0.067	8.674AlaLeu: 8.674 ± 0.088	1.746AlaMet: 1.746 ± 0.042	3.076AlaAsn: 3.076 ± 0.046	2.707AlaPro: 2.707 ± 0.044	3.753AlaGln: 3.753 ± 0.052	3.506AlaArg: 3.506 ± 0.052	3.857AlaSer: 3.857 ± 0.054	3.911AlaThr: 3.911 ± 0.062	4.467AlaVal: 4.467 ± 0.055	1.075AlaTrp: 1.075 ± 0.025	2.498AlaTyr: 2.498 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.717CysAla: 0.717 ± 0.024	0.149CysCys: 0.149 ± 0.009	0.558CysAsp: 0.558 ± 0.021	0.616CysGlu: 0.616 ± 0.021	0.469CysPhe: 0.469 ± 0.017	0.852CysGly: 0.852 ± 0.025	0.457CysHis: 0.457 ± 0.021	0.603CysIle: 0.603 ± 0.019	0.435CysLys: 0.435 ± 0.019	1.108CysLeu: 1.108 ± 0.024	0.208CysMet: 0.208 ± 0.011	0.357CysAsn: 0.357 ± 0.016	0.59CysPro: 0.59 ± 0.024	0.613CysGln: 0.613 ± 0.018	0.577CysArg: 0.577 ± 0.02	0.659CysSer: 0.659 ± 0.023	0.519CysThr: 0.519 ± 0.018	0.672CysVal: 0.672 ± 0.021	0.154CysTrp: 0.154 ± 0.011	0.391CysTyr: 0.391 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.626AspAla: 3.626 ± 0.055	0.644AspCys: 0.644 ± 0.024	3.043AspAsp: 3.043 ± 0.054	3.983AspGlu: 3.983 ± 0.049	2.788AspPhe: 2.788 ± 0.047	3.517AspGly: 3.517 ± 0.065	0.806AspHis: 0.806 ± 0.026	4.018AspIle: 4.018 ± 0.058	3.732AspLys: 3.732 ± 0.052	5.128AspLeu: 5.128 ± 0.066	1.136AspMet: 1.136 ± 0.027	2.708AspAsn: 2.708 ± 0.048	1.787AspPro: 1.787 ± 0.039	1.52AspGln: 1.52 ± 0.028	2.156AspArg: 2.156 ± 0.035	3.101AspSer: 3.101 ± 0.056	2.593AspThr: 2.593 ± 0.041	3.138AspVal: 3.138 ± 0.044	0.961AspTrp: 0.961 ± 0.029	2.333AspTyr: 2.333 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.515GluAla: 4.515 ± 0.06	0.521GluCys: 0.521 ± 0.019	2.765GluAsp: 2.765 ± 0.045	4.161GluGlu: 4.161 ± 0.069	2.502GluPhe: 2.502 ± 0.041	3.364GluGly: 3.364 ± 0.045	1.391GluHis: 1.391 ± 0.029	5.218GluIle: 5.218 ± 0.068	5.034GluLys: 5.034 ± 0.081	6.414GluLeu: 6.414 ± 0.072	1.711GluMet: 1.711 ± 0.032	3.516GluAsn: 3.516 ± 0.049	2.333GluPro: 2.333 ± 0.039	3.699GluGln: 3.699 ± 0.06	3.473GluArg: 3.473 ± 0.047	3.522GluSer: 3.522 ± 0.055	3.798GluThr: 3.798 ± 0.051	3.708GluVal: 3.708 ± 0.06	0.923GluTrp: 0.923 ± 0.025	2.17GluTyr: 2.17 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	2.967PheAla: 2.967 ± 0.046	0.573PheCys: 0.573 ± 0.018	2.685PheAsp: 2.685 ± 0.043	2.971PheGlu: 2.971 ± 0.056	2.167PhePhe: 2.167 ± 0.049	2.864PheGly: 2.864 ± 0.052	0.875PheHis: 0.875 ± 0.021	3.044PheIle: 3.044 ± 0.045	2.567PheLys: 2.567 ± 0.04	4.336PheLeu: 4.336 ± 0.068	0.992PheMet: 0.992 ± 0.028	2.004PheAsn: 2.004 ± 0.037	1.65PhePro: 1.65 ± 0.036	1.648PheGln: 1.648 ± 0.033	1.929PheArg: 1.929 ± 0.033	3.252PheSer: 3.252 ± 0.054	2.126PheThr: 2.126 ± 0.041	2.696PheVal: 2.696 ± 0.048	0.648PheTrp: 0.648 ± 0.021	1.671PheTyr: 1.671 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.158GlyAla: 4.158 ± 0.064	0.81GlyCys: 0.81 ± 0.025	3.267GlyAsp: 3.267 ± 0.057	4.151GlyGlu: 4.151 ± 0.067	2.912GlyPhe: 2.912 ± 0.048	4.414GlyGly: 4.414 ± 0.081	1.427GlyHis: 1.427 ± 0.032	4.866GlyIle: 4.866 ± 0.054	4.373GlyLys: 4.373 ± 0.062	6.296GlyLeu: 6.296 ± 0.082	1.511GlyMet: 1.511 ± 0.033	2.824GlyAsn: 2.824 ± 0.054	1.399GlyPro: 1.399 ± 0.035	2.699GlyGln: 2.699 ± 0.048	2.97GlyArg: 2.97 ± 0.046	3.544GlySer: 3.544 ± 0.066	3.665GlyThr: 3.665 ± 0.068	4.051GlyVal: 4.051 ± 0.063	1.015GlyTrp: 1.015 ± 0.029	2.371GlyTyr: 2.371 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.396HisAla: 1.396 ± 0.033	0.345HisCys: 0.345 ± 0.016	1.056HisAsp: 1.056 ± 0.025	1.135HisGlu: 1.135 ± 0.029	1.299HisPhe: 1.299 ± 0.027	1.32HisGly: 1.32 ± 0.029	0.714HisHis: 0.714 ± 0.024	1.565HisIle: 1.565 ± 0.03	1.228HisLys: 1.228 ± 0.029	2.723HisLeu: 2.723 ± 0.045	0.292HisMet: 0.292 ± 0.014	0.993HisAsn: 0.993 ± 0.024	1.32HisPro: 1.32 ± 0.031	1.158HisGln: 1.158 ± 0.031	1.142HisArg: 1.142 ± 0.028	1.385HisSer: 1.385 ± 0.03	1.016HisThr: 1.016 ± 0.026	1.004HisVal: 1.004 ± 0.024	0.419HisTrp: 0.419 ± 0.015	1.058HisTyr: 1.058 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.503IleAla: 5.503 ± 0.066	0.684IleCys: 0.684 ± 0.02	4.383IleAsp: 4.383 ± 0.066	5.197IleGlu: 5.197 ± 0.062	2.822IlePhe: 2.822 ± 0.045	4.295IleGly: 4.295 ± 0.058	1.441IleHis: 1.441 ± 0.032	4.762IleIle: 4.762 ± 0.064	4.541IleLys: 4.541 ± 0.062	6.739IleLeu: 6.739 ± 0.075	1.245IleMet: 1.245 ± 0.027	3.418IleAsn: 3.418 ± 0.046	3.174IlePro: 3.174 ± 0.054	2.795IleGln: 2.795 ± 0.045	3.129IleArg: 3.129 ± 0.043	4.604IleSer: 4.604 ± 0.059	3.706IleThr: 3.706 ± 0.05	4.325IleVal: 4.325 ± 0.052	0.916IleTrp: 0.916 ± 0.029	2.291IleTyr: 2.291 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.902LysAla: 4.902 ± 0.075	0.506LysCys: 0.506 ± 0.016	2.743LysAsp: 2.743 ± 0.04	3.895LysGlu: 3.895 ± 0.066	1.924LysPhe: 1.924 ± 0.038	3.605LysGly: 3.605 ± 0.055	1.38LysHis: 1.38 ± 0.026	4.566LysIle: 4.566 ± 0.057	4.832LysLys: 4.832 ± 0.081	6.118LysLeu: 6.118 ± 0.075	1.566LysMet: 1.566 ± 0.033	3.304LysAsn: 3.304 ± 0.049	2.738LysPro: 2.738 ± 0.042	3.174LysGln: 3.174 ± 0.052	3.464LysArg: 3.464 ± 0.055	3.444LysSer: 3.444 ± 0.047	3.855LysThr: 3.855 ± 0.054	3.572LysVal: 3.572 ± 0.047	0.805LysTrp: 0.805 ± 0.024	2.023LysTyr: 2.023 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	8.227LeuAla: 8.227 ± 0.086	1.128LeuCys: 1.128 ± 0.03	5.64LeuAsp: 5.64 ± 0.068	7.001LeuGlu: 7.001 ± 0.07	4.648LeuPhe: 4.648 ± 0.074	6.332LeuGly: 6.332 ± 0.075	2.291LeuHis: 2.291 ± 0.041	6.921LeuIle: 6.921 ± 0.073	6.99LeuLys: 6.99 ± 0.087	10.942LeuLeu: 10.942 ± 0.135	2.408LeuMet: 2.408 ± 0.042	4.898LeuAsn: 4.898 ± 0.059	5.12LeuPro: 5.12 ± 0.072	4.392LeuGln: 4.392 ± 0.064	5.28LeuArg: 5.28 ± 0.075	8.06LeuSer: 8.06 ± 0.086	5.81LeuThr: 5.81 ± 0.06	6.071LeuVal: 6.071 ± 0.065	1.442LeuTrp: 1.442 ± 0.033	3.174LeuTyr: 3.174 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.001MetAla: 2.001 ± 0.034	0.153MetCys: 0.153 ± 0.01	1.1MetAsp: 1.1 ± 0.031	1.225MetGlu: 1.225 ± 0.035	0.637MetPhe: 0.637 ± 0.02	1.533MetGly: 1.533 ± 0.038	0.379MetHis: 0.379 ± 0.016	1.417MetIle: 1.417 ± 0.03	1.356MetLys: 1.356 ± 0.033	2.254MetLeu: 2.254 ± 0.039	0.567MetMet: 0.567 ± 0.021	1.07MetAsn: 1.07 ± 0.028	1.217MetPro: 1.217 ± 0.025	1.034MetGln: 1.034 ± 0.022	1.171MetArg: 1.171 ± 0.026	1.475MetSer: 1.475 ± 0.029	1.356MetThr: 1.356 ± 0.03	1.378MetVal: 1.378 ± 0.028	0.183MetTrp: 0.183 ± 0.011	0.474MetTyr: 0.474 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.215AsnAla: 3.215 ± 0.051	0.514AsnCys: 0.514 ± 0.02	2.305AsnAsp: 2.305 ± 0.044	2.634AsnGlu: 2.634 ± 0.042	1.945AsnPhe: 1.945 ± 0.038	3.04AsnGly: 3.04 ± 0.048	1.056AsnHis: 1.056 ± 0.023	3.272AsnIle: 3.272 ± 0.053	2.74AsnLys: 2.74 ± 0.048	4.703AsnLeu: 4.703 ± 0.068	0.896AsnMet: 0.896 ± 0.024	2.464AsnAsn: 2.464 ± 0.056	2.434AsnPro: 2.434 ± 0.037	2.231AsnGln: 2.231 ± 0.043	2.26AsnArg: 2.26 ± 0.037	2.683AsnSer: 2.683 ± 0.056	2.375AsnThr: 2.375 ± 0.044	2.421AsnVal: 2.421 ± 0.044	0.782AsnTrp: 0.782 ± 0.026	1.665AsnTyr: 1.665 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.765ProAla: 2.765 ± 0.041	0.401ProCys: 0.401 ± 0.018	2.68ProAsp: 2.68 ± 0.045	3.255ProGlu: 3.255 ± 0.056	1.914ProPhe: 1.914 ± 0.035	2.088ProGly: 2.088 ± 0.046	0.918ProHis: 0.918 ± 0.024	2.861ProIle: 2.861 ± 0.047	2.526ProLys: 2.526 ± 0.042	4.485ProLeu: 4.485 ± 0.057	0.878ProMet: 0.878 ± 0.025	2.035ProAsn: 2.035 ± 0.034	1.927ProPro: 1.927 ± 0.049	1.945ProGln: 1.945 ± 0.038	1.673ProArg: 1.673 ± 0.034	2.614ProSer: 2.614 ± 0.043	2.411ProThr: 2.411 ± 0.038	2.718ProVal: 2.718 ± 0.041	0.508ProTrp: 0.508 ± 0.019	1.39ProTyr: 1.39 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.326GlnAla: 4.326 ± 0.055	0.423GlnCys: 0.423 ± 0.017	2.049GlnAsp: 2.049 ± 0.039	2.728GlnGlu: 2.728 ± 0.045	1.843GlnPhe: 1.843 ± 0.038	2.757GlnGly: 2.757 ± 0.047	1.101GlnHis: 1.101 ± 0.027	3.359GlnIle: 3.359 ± 0.051	2.935GlnLys: 2.935 ± 0.048	5.021GlnLeu: 5.021 ± 0.073	0.991GlnMet: 0.991 ± 0.026	2.038GlnAsn: 2.038 ± 0.037	1.743GlnPro: 1.743 ± 0.037	2.682GlnGln: 2.682 ± 0.054	2.645GlnArg: 2.645 ± 0.044	2.628GlnSer: 2.628 ± 0.046	2.746GlnThr: 2.746 ± 0.042	2.91GlnVal: 2.91 ± 0.044	0.715GlnTrp: 0.715 ± 0.02	1.373GlnTyr: 1.373 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.274ArgAla: 3.274 ± 0.055	0.57ArgCys: 0.57 ± 0.021	2.479ArgAsp: 2.479 ± 0.043	3.32ArgGlu: 3.32 ± 0.051	2.55ArgPhe: 2.55 ± 0.045	2.793ArgGly: 2.793 ± 0.041	1.315ArgHis: 1.315 ± 0.029	3.224ArgIle: 3.224 ± 0.05	2.602ArgLys: 2.602 ± 0.049	6.301ArgLeu: 6.301 ± 0.065	1.12ArgMet: 1.12 ± 0.031	1.788ArgAsn: 1.788 ± 0.032	1.677ArgPro: 1.677 ± 0.031	2.766ArgGln: 2.766 ± 0.044	2.749ArgArg: 2.749 ± 0.045	2.419ArgSer: 2.419 ± 0.04	2.263ArgThr: 2.263 ± 0.035	2.993ArgVal: 2.993 ± 0.044	0.805ArgTrp: 0.805 ± 0.032	1.973ArgTyr: 1.973 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.138SerAla: 4.138 ± 0.055	0.628SerCys: 0.628 ± 0.02	3.374SerAsp: 3.374 ± 0.052	3.81SerGlu: 3.81 ± 0.058	2.75SerPhe: 2.75 ± 0.046	4.352SerGly: 4.352 ± 0.083	1.513SerHis: 1.513 ± 0.032	3.878SerIle: 3.878 ± 0.046	3.336SerLys: 3.336 ± 0.04	6.925SerLeu: 6.925 ± 0.07	1.311SerMet: 1.311 ± 0.033	2.484SerAsn: 2.484 ± 0.041	2.831SerPro: 2.831 ± 0.048	2.928SerGln: 2.928 ± 0.048	2.778SerArg: 2.778 ± 0.041	3.821SerSer: 3.821 ± 0.064	3.09SerThr: 3.09 ± 0.046	3.748SerVal: 3.748 ± 0.048	0.903SerTrp: 0.903 ± 0.029	2.056SerTyr: 2.056 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.037ThrAla: 4.037 ± 0.064	0.515ThrCys: 0.515 ± 0.021	2.934ThrAsp: 2.934 ± 0.06	3.232ThrGlu: 3.232 ± 0.04	2.272ThrPhe: 2.272 ± 0.04	3.998ThrGly: 3.998 ± 0.072	1.32ThrHis: 1.32 ± 0.027	3.747ThrIle: 3.747 ± 0.053	2.625ThrLys: 2.625 ± 0.045	6.479ThrLeu: 6.479 ± 0.071	0.971ThrMet: 0.971 ± 0.028	2.022ThrAsn: 2.022 ± 0.04	2.888ThrPro: 2.888 ± 0.042	2.701ThrGln: 2.701 ± 0.043	2.312ThrArg: 2.312 ± 0.041	2.867ThrSer: 2.867 ± 0.042	3.06ThrThr: 3.06 ± 0.056	3.728ThrVal: 3.728 ± 0.061	0.73ThrTrp: 0.73 ± 0.023	1.727ThrTyr: 1.727 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.7ValAla: 4.7 ± 0.057	0.656ValCys: 0.656 ± 0.019	3.198ValAsp: 3.198 ± 0.047	3.974ValGlu: 3.974 ± 0.057	2.636ValPhe: 2.636 ± 0.039	3.773ValGly: 3.773 ± 0.054	1.162ValHis: 1.162 ± 0.028	4.376ValIle: 4.376 ± 0.055	3.59ValLys: 3.59 ± 0.048	6.359ValLeu: 6.359 ± 0.069	1.422ValMet: 1.422 ± 0.032	2.621ValAsn: 2.621 ± 0.039	2.507ValPro: 2.507 ± 0.045	2.313ValGln: 2.313 ± 0.041	2.887ValArg: 2.887 ± 0.045	3.897ValSer: 3.897 ± 0.05	3.541ValThr: 3.541 ± 0.057	4.112ValVal: 4.112 ± 0.062	0.906ValTrp: 0.906 ± 0.026	1.887ValTyr: 1.887 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.966TrpAla: 0.966 ± 0.023	0.164TrpCys: 0.164 ± 0.01	0.764TrpAsp: 0.764 ± 0.025	0.912TrpGlu: 0.912 ± 0.027	0.648TrpPhe: 0.648 ± 0.021	0.873TrpGly: 0.873 ± 0.027	0.435TrpHis: 0.435 ± 0.016	0.977TrpIle: 0.977 ± 0.029	0.76TrpLys: 0.76 ± 0.025	1.911TrpLeu: 1.911 ± 0.038	0.371TrpMet: 0.371 ± 0.016	0.57TrpAsn: 0.57 ± 0.021	0.392TrpPro: 0.392 ± 0.019	0.968TrpGln: 0.968 ± 0.031	0.829TrpArg: 0.829 ± 0.026	0.736TrpSer: 0.736 ± 0.023	0.73TrpThr: 0.73 ± 0.027	0.965TrpVal: 0.965 ± 0.031	0.243TrpTrp: 0.243 ± 0.013	0.496TrpTyr: 0.496 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.044	0.413TyrCys: 0.413 ± 0.017	1.99TyrAsp: 1.99 ± 0.055	1.953TyrGlu: 1.953 ± 0.038	1.713TyrPhe: 1.713 ± 0.033	2.201TyrGly: 2.201 ± 0.045	0.937TyrHis: 0.937 ± 0.028	1.966TyrIle: 1.966 ± 0.035	1.792TyrLys: 1.792 ± 0.043	3.861TyrLeu: 3.861 ± 0.062	0.638TyrMet: 0.638 ± 0.02	1.446TyrAsn: 1.446 ± 0.033	1.557TyrPro: 1.557 ± 0.036	1.995TyrGln: 1.995 ± 0.038	2.051TyrArg: 2.051 ± 0.047	2.087TyrSer: 2.087 ± 0.042	1.596TyrThr: 1.596 ± 0.036	1.838TyrVal: 1.838 ± 0.037	0.574TyrTrp: 0.574 ± 0.02	1.447TyrTyr: 1.447 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5897 proteins (1621432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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