Amino acid dipepetide frequency for Cycad leaf necrosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.566AlaAla: 8.566 ± 0.975
0.902AlaCys: 0.902 ± 0.437
1.353AlaAsp: 1.353 ± 0.655
6.312AlaGlu: 6.312 ± 2.602
2.254AlaPhe: 2.254 ± 1.091
2.705AlaGly: 2.705 ± 1.351
1.353AlaHis: 1.353 ± 0.655
6.312AlaIle: 6.312 ± 1.807
2.254AlaLys: 2.254 ± 1.03
6.763AlaLeu: 6.763 ± 2.015
1.803AlaMet: 1.803 ± 0.873
1.353AlaAsn: 1.353 ± 1.672
2.705AlaPro: 2.705 ± 1.31
3.156AlaGln: 3.156 ± 1.301
4.509AlaArg: 4.509 ± 1.366
4.058AlaSer: 4.058 ± 1.317
4.959AlaThr: 4.959 ± 3.034
3.607AlaVal: 3.607 ± 0.969
0.902AlaTrp: 0.902 ± 1.819
2.254AlaTyr: 2.254 ± 1.433
0.0AlaXaa: 0.0 ± 0.0
Cys
0.902CysAla: 0.902 ± 0.437
1.353CysCys: 1.353 ± 0.655
0.451CysAsp: 0.451 ± 0.218
1.803CysGlu: 1.803 ± 1.137
0.902CysPhe: 0.902 ± 0.437
0.451CysGly: 0.451 ± 0.218
0.902CysHis: 0.902 ± 1.429
1.353CysIle: 1.353 ± 0.655
3.156CysLys: 3.156 ± 1.528
0.451CysLeu: 0.451 ± 1.6
1.353CysMet: 1.353 ± 0.655
1.353CysAsn: 1.353 ± 0.655
0.451CysPro: 0.451 ± 0.218
0.902CysGln: 0.902 ± 0.437
0.451CysArg: 0.451 ± 0.218
1.353CysSer: 1.353 ± 0.655
0.902CysThr: 0.902 ± 0.437
0.451CysVal: 0.451 ± 0.218
0.0CysTrp: 0.0 ± 0.0
0.902CysTyr: 0.902 ± 0.437
0.0CysXaa: 0.0 ± 0.0
Asp
1.803AspAla: 1.803 ± 1.542
0.902AspCys: 0.902 ± 0.437
5.41AspAsp: 5.41 ± 1.568
4.509AspGlu: 4.509 ± 1.155
1.803AspPhe: 1.803 ± 0.873
3.156AspGly: 3.156 ± 1.528
0.902AspHis: 0.902 ± 1.429
3.156AspIle: 3.156 ± 0.94
4.058AspLys: 4.058 ± 1.309
7.665AspLeu: 7.665 ± 6.537
2.254AspMet: 2.254 ± 1.091
1.803AspAsn: 1.803 ± 0.873
3.156AspPro: 3.156 ± 1.528
2.254AspGln: 2.254 ± 1.091
3.156AspArg: 3.156 ± 1.301
4.509AspSer: 4.509 ± 2.866
3.156AspThr: 3.156 ± 1.528
0.902AspVal: 0.902 ± 0.437
0.451AspTrp: 0.451 ± 0.218
3.156AspTyr: 3.156 ± 1.528
0.0AspXaa: 0.0 ± 0.0
Glu
5.861GluAla: 5.861 ± 1.625
0.451GluCys: 0.451 ± 0.218
5.41GluAsp: 5.41 ± 2.619
9.919GluGlu: 9.919 ± 3.421
2.254GluPhe: 2.254 ± 1.091
6.312GluGly: 6.312 ± 1.852
3.156GluHis: 3.156 ± 0.94
2.254GluIle: 2.254 ± 1.091
7.214GluLys: 7.214 ± 3.008
9.017GluLeu: 9.017 ± 4.211
1.803GluMet: 1.803 ± 0.873
4.058GluAsn: 4.058 ± 1.043
0.902GluPro: 0.902 ± 0.437
5.41GluGln: 5.41 ± 0.707
4.959GluArg: 4.959 ± 2.401
2.705GluSer: 2.705 ± 0.962
2.705GluThr: 2.705 ± 1.351
4.959GluVal: 4.959 ± 1.454
1.803GluTrp: 1.803 ± 0.873
2.254GluTyr: 2.254 ± 1.03
0.0GluXaa: 0.0 ± 0.0
Phe
1.803PheAla: 1.803 ± 0.873
1.353PheCys: 1.353 ± 0.655
1.803PheAsp: 1.803 ± 1.137
1.803PheGlu: 1.803 ± 1.542
1.803PhePhe: 1.803 ± 0.873
1.353PheGly: 1.353 ± 0.655
0.902PheHis: 0.902 ± 0.437
1.803PheIle: 1.803 ± 0.873
0.902PheLys: 0.902 ± 0.437
3.156PheLeu: 3.156 ± 1.301
0.902PheMet: 0.902 ± 0.437
1.803PheAsn: 1.803 ± 0.873
0.902PhePro: 0.902 ± 0.437
1.803PheGln: 1.803 ± 0.873
0.902PheArg: 0.902 ± 0.437
4.058PheSer: 4.058 ± 1.309
1.353PheThr: 1.353 ± 0.655
0.451PheVal: 0.451 ± 0.218
1.353PheTrp: 1.353 ± 1.273
1.353PheTyr: 1.353 ± 0.655
0.0PheXaa: 0.0 ± 0.0
Gly
3.607GlyAla: 3.607 ± 1.746
1.353GlyCys: 1.353 ± 0.655
2.254GlyAsp: 2.254 ± 1.03
5.41GlyGlu: 5.41 ± 2.619
1.353GlyPhe: 1.353 ± 1.672
1.803GlyGly: 1.803 ± 0.873
1.353GlyHis: 1.353 ± 1.273
3.156GlyIle: 3.156 ± 1.528
4.058GlyLys: 4.058 ± 1.964
4.959GlyLeu: 4.959 ± 0.903
0.902GlyMet: 0.902 ± 1.015
1.803GlyAsn: 1.803 ± 1.137
0.902GlyPro: 0.902 ± 0.437
1.353GlyGln: 1.353 ± 0.655
3.607GlyArg: 3.607 ± 1.746
2.254GlySer: 2.254 ± 1.03
5.41GlyThr: 5.41 ± 4.625
2.705GlyVal: 2.705 ± 1.31
1.353GlyTrp: 1.353 ± 0.655
0.902GlyTyr: 0.902 ± 0.437
0.0GlyXaa: 0.0 ± 0.0
His
1.353HisAla: 1.353 ± 0.655
0.451HisCys: 0.451 ± 0.218
1.803HisAsp: 1.803 ± 0.873
0.451HisGlu: 0.451 ± 0.218
0.902HisPhe: 0.902 ± 0.437
0.0HisGly: 0.0 ± 0.0
0.451HisHis: 0.451 ± 0.218
3.156HisIle: 3.156 ± 1.528
0.902HisLys: 0.902 ± 0.437
2.254HisLeu: 2.254 ± 1.03
0.902HisMet: 0.902 ± 0.437
1.353HisAsn: 1.353 ± 3.025
0.451HisPro: 0.451 ± 0.218
1.353HisGln: 1.353 ± 0.655
3.156HisArg: 3.156 ± 3.274
1.803HisSer: 1.803 ± 1.137
0.902HisThr: 0.902 ± 0.437
1.803HisVal: 1.803 ± 1.137
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.254IleAla: 2.254 ± 1.433
1.803IleCys: 1.803 ± 0.873
4.509IleAsp: 4.509 ± 2.866
6.763IleGlu: 6.763 ± 3.09
2.254IlePhe: 2.254 ± 1.091
4.959IleGly: 4.959 ± 2.401
1.803IleHis: 1.803 ± 1.137
4.058IleIle: 4.058 ± 1.964
3.156IleLys: 3.156 ± 1.301
4.058IleLeu: 4.058 ± 2.846
0.451IleMet: 0.451 ± 0.386
2.254IleAsn: 2.254 ± 2.172
3.156IlePro: 3.156 ± 1.528
4.058IleGln: 4.058 ± 1.964
4.058IleArg: 4.058 ± 1.309
3.156IleSer: 3.156 ± 2.403
4.058IleThr: 4.058 ± 1.964
2.254IleVal: 2.254 ± 1.091
0.451IleTrp: 0.451 ± 0.218
1.353IleTyr: 1.353 ± 0.655
0.0IleXaa: 0.0 ± 0.0
Lys
3.607LysAla: 3.607 ± 1.529
2.705LysCys: 2.705 ± 1.31
5.861LysAsp: 5.861 ± 1.625
5.41LysGlu: 5.41 ± 2.619
5.41LysPhe: 5.41 ± 1.452
3.607LysGly: 3.607 ± 0.969
1.353LysHis: 1.353 ± 0.655
5.861LysIle: 5.861 ± 1.625
4.058LysLys: 4.058 ± 1.964
4.058LysLeu: 4.058 ± 1.043
1.353LysMet: 1.353 ± 0.655
3.156LysAsn: 3.156 ± 0.94
1.353LysPro: 1.353 ± 0.655
1.353LysGln: 1.353 ± 0.655
2.705LysArg: 2.705 ± 1.31
5.861LysSer: 5.861 ± 3.75
5.41LysThr: 5.41 ± 0.707
5.861LysVal: 5.861 ± 5.52
0.902LysTrp: 0.902 ± 0.437
0.451LysTyr: 0.451 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
5.861LeuAla: 5.861 ± 7.795
0.902LeuCys: 0.902 ± 1.429
7.214LeuAsp: 7.214 ± 0.431
7.214LeuGlu: 7.214 ± 3.008
1.803LeuPhe: 1.803 ± 1.542
6.312LeuGly: 6.312 ± 4.807
2.254LeuHis: 2.254 ± 1.091
3.607LeuIle: 3.607 ± 0.969
9.017LeuLys: 9.017 ± 2.438
6.763LeuLeu: 6.763 ± 2.015
2.254LeuMet: 2.254 ± 1.091
3.156LeuAsn: 3.156 ± 1.301
3.607LeuPro: 3.607 ± 1.746
8.115LeuGln: 8.115 ± 4.061
5.861LeuArg: 5.861 ± 5.151
5.41LeuSer: 5.41 ± 2.702
7.665LeuThr: 7.665 ± 4.756
6.312LeuVal: 6.312 ± 3.552
0.0LeuTrp: 0.0 ± 0.0
3.156LeuTyr: 3.156 ± 1.528
0.0LeuXaa: 0.0 ± 0.0
Met
1.353MetAla: 1.353 ± 0.655
0.902MetCys: 0.902 ± 0.437
2.254MetAsp: 2.254 ± 1.091
4.058MetGlu: 4.058 ± 1.964
0.451MetPhe: 0.451 ± 0.218
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.902MetIle: 0.902 ± 0.437
2.254MetLys: 2.254 ± 1.091
1.353MetLeu: 1.353 ± 0.655
0.451MetMet: 0.451 ± 0.218
0.451MetAsn: 0.451 ± 0.218
0.902MetPro: 0.902 ± 0.437
1.353MetGln: 1.353 ± 0.655
0.902MetArg: 0.902 ± 0.437
1.803MetSer: 1.803 ± 2.387
0.902MetThr: 0.902 ± 0.437
1.803MetVal: 1.803 ± 0.873
0.451MetTrp: 0.451 ± 0.218
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.156AsnAla: 3.156 ± 1.301
0.0AsnCys: 0.0 ± 0.0
0.902AsnAsp: 0.902 ± 0.437
0.902AsnGlu: 0.902 ± 0.437
1.353AsnPhe: 1.353 ± 0.655
1.803AsnGly: 1.803 ± 0.873
0.902AsnHis: 0.902 ± 0.437
1.803AsnIle: 1.803 ± 0.873
3.156AsnLys: 3.156 ± 0.94
7.214AsnLeu: 7.214 ± 1.389
0.451AsnMet: 0.451 ± 0.218
0.0AsnAsn: 0.0 ± 0.0
2.254AsnPro: 2.254 ± 3.487
0.451AsnGln: 0.451 ± 1.6
2.254AsnArg: 2.254 ± 2.172
1.803AsnSer: 1.803 ± 2.387
4.058AsnThr: 4.058 ± 1.317
1.353AsnVal: 1.353 ± 0.655
0.0AsnTrp: 0.0 ± 0.0
2.254AsnTyr: 2.254 ± 1.091
0.0AsnXaa: 0.0 ± 0.0
Pro
4.058ProAla: 4.058 ± 1.964
0.451ProCys: 0.451 ± 0.218
3.156ProAsp: 3.156 ± 1.528
0.902ProGlu: 0.902 ± 0.437
0.902ProPhe: 0.902 ± 1.819
1.353ProGly: 1.353 ± 0.655
0.902ProHis: 0.902 ± 0.437
0.902ProIle: 0.902 ± 0.437
3.156ProLys: 3.156 ± 0.94
2.254ProLeu: 2.254 ± 1.03
0.451ProMet: 0.451 ± 0.218
1.803ProAsn: 1.803 ± 0.873
2.254ProPro: 2.254 ± 1.091
1.803ProGln: 1.803 ± 0.873
2.254ProArg: 2.254 ± 1.091
3.156ProSer: 3.156 ± 1.301
2.254ProThr: 2.254 ± 1.433
1.803ProVal: 1.803 ± 0.873
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
6.312GlnAla: 6.312 ± 1.852
0.451GlnCys: 0.451 ± 0.218
1.803GlnAsp: 1.803 ± 1.542
3.156GlnGlu: 3.156 ± 1.528
0.451GlnPhe: 0.451 ± 0.218
2.254GlnGly: 2.254 ± 1.091
0.451GlnHis: 0.451 ± 0.218
3.607GlnIle: 3.607 ± 4.774
3.607GlnLys: 3.607 ± 5.715
4.959GlnLeu: 4.959 ± 2.777
1.803GlnMet: 1.803 ± 0.873
4.959GlnAsn: 4.959 ± 3.034
2.705GlnPro: 2.705 ± 0.962
4.959GlnGln: 4.959 ± 6.981
4.058GlnArg: 4.058 ± 1.964
1.803GlnSer: 1.803 ± 1.137
3.607GlnThr: 3.607 ± 0.969
5.41GlnVal: 5.41 ± 0.707
0.0GlnTrp: 0.0 ± 0.0
0.902GlnTyr: 0.902 ± 0.437
0.0GlnXaa: 0.0 ± 0.0
Arg
3.607ArgAla: 3.607 ± 1.529
0.902ArgCys: 0.902 ± 0.437
2.254ArgAsp: 2.254 ± 1.03
2.705ArgGlu: 2.705 ± 1.351
0.902ArgPhe: 0.902 ± 0.437
1.353ArgGly: 1.353 ± 0.655
1.803ArgHis: 1.803 ± 0.873
4.959ArgIle: 4.959 ± 3.034
4.058ArgLys: 4.058 ± 1.964
5.41ArgLeu: 5.41 ± 0.707
1.803ArgMet: 1.803 ± 1.012
3.156ArgAsn: 3.156 ± 1.301
2.705ArgPro: 2.705 ± 0.962
3.607ArgGln: 3.607 ± 1.287
4.058ArgArg: 4.058 ± 1.309
6.312ArgSer: 6.312 ± 1.881
3.156ArgThr: 3.156 ± 1.528
4.959ArgVal: 4.959 ± 2.777
1.353ArgTrp: 1.353 ± 0.655
1.803ArgTyr: 1.803 ± 0.873
0.0ArgXaa: 0.0 ± 0.0
Ser
2.705SerAla: 2.705 ± 1.31
1.803SerCys: 1.803 ± 1.137
4.058SerAsp: 4.058 ± 4.559
4.509SerGlu: 4.509 ± 1.155
2.254SerPhe: 2.254 ± 1.03
4.058SerGly: 4.058 ± 1.317
1.803SerHis: 1.803 ± 1.137
3.607SerIle: 3.607 ± 1.287
7.665SerLys: 7.665 ± 0.588
9.017SerLeu: 9.017 ± 6.853
0.902SerMet: 0.902 ± 0.437
0.902SerAsn: 0.902 ± 1.819
2.254SerPro: 2.254 ± 1.091
4.058SerGln: 4.058 ± 4.561
4.058SerArg: 4.058 ± 1.309
4.959SerSer: 4.959 ± 3.034
1.803SerThr: 1.803 ± 0.873
4.058SerVal: 4.058 ± 2.159
0.451SerTrp: 0.451 ± 0.218
3.607SerTyr: 3.607 ± 1.746
0.0SerXaa: 0.0 ± 0.0
Thr
5.41ThrAla: 5.41 ± 2.702
0.902ThrCys: 0.902 ± 0.437
2.705ThrAsp: 2.705 ± 1.31
7.214ThrGlu: 7.214 ± 2.192
2.254ThrPhe: 2.254 ± 1.091
3.607ThrGly: 3.607 ± 1.287
1.803ThrHis: 1.803 ± 1.137
4.058ThrIle: 4.058 ± 1.317
2.254ThrLys: 2.254 ± 1.091
5.41ThrLeu: 5.41 ± 2.852
0.0ThrMet: 0.0 ± 0.0
0.451ThrAsn: 0.451 ± 0.218
1.803ThrPro: 1.803 ± 1.542
4.058ThrGln: 4.058 ± 1.043
3.156ThrArg: 3.156 ± 1.301
4.959ThrSer: 4.959 ± 0.903
3.607ThrThr: 3.607 ± 3.083
3.607ThrVal: 3.607 ± 1.529
1.803ThrTrp: 1.803 ± 0.873
1.803ThrTyr: 1.803 ± 1.137
0.0ThrXaa: 0.0 ± 0.0
Val
2.705ValAla: 2.705 ± 1.31
2.254ValCys: 2.254 ± 1.03
1.803ValAsp: 1.803 ± 1.137
5.41ValGlu: 5.41 ± 1.924
1.803ValPhe: 1.803 ± 0.873
4.509ValGly: 4.509 ± 2.183
0.451ValHis: 0.451 ± 1.979
4.509ValIle: 4.509 ± 1.108
2.254ValLys: 2.254 ± 1.091
7.214ValLeu: 7.214 ± 3.164
1.353ValMet: 1.353 ± 0.655
0.902ValAsn: 0.902 ± 0.437
0.902ValPro: 0.902 ± 0.437
4.959ValGln: 4.959 ± 4.128
3.607ValArg: 3.607 ± 1.529
5.41ValSer: 5.41 ± 1.924
2.254ValThr: 2.254 ± 1.091
2.254ValVal: 2.254 ± 2.697
0.0ValTrp: 0.0 ± 0.0
1.803ValTyr: 1.803 ± 1.542
0.0ValXaa: 0.0 ± 0.0
Trp
1.353TrpAla: 1.353 ± 0.655
0.0TrpCys: 0.0 ± 0.0
0.902TrpAsp: 0.902 ± 0.437
1.803TrpGlu: 1.803 ± 2.387
0.0TrpPhe: 0.0 ± 0.0
0.451TrpGly: 0.451 ± 0.218
0.451TrpHis: 0.451 ± 0.218
0.0TrpIle: 0.0 ± 0.0
0.902TrpLys: 0.902 ± 0.437
1.353TrpLeu: 1.353 ± 0.655
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.353TrpArg: 1.353 ± 0.655
0.451TrpSer: 0.451 ± 0.218
1.803TrpThr: 1.803 ± 0.873
0.451TrpVal: 0.451 ± 0.218
0.451TrpTrp: 0.451 ± 0.218
0.451TrpTyr: 0.451 ± 0.218
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.803TyrAla: 1.803 ± 0.873
0.0TyrCys: 0.0 ± 0.0
2.254TyrAsp: 2.254 ± 1.091
3.156TyrGlu: 3.156 ± 1.528
0.451TyrPhe: 0.451 ± 0.218
0.451TyrGly: 0.451 ± 1.979
0.451TyrHis: 0.451 ± 0.218
2.254TyrIle: 2.254 ± 1.091
2.254TyrLys: 2.254 ± 1.03
3.156TyrLeu: 3.156 ± 0.94
0.902TyrMet: 0.902 ± 0.437
1.353TyrAsn: 1.353 ± 0.655
0.451TyrPro: 0.451 ± 0.218
2.254TyrGln: 2.254 ± 1.433
1.803TyrArg: 1.803 ± 0.873
2.705TyrSer: 2.705 ± 1.31
0.902TyrThr: 0.902 ± 0.437
1.353TyrVal: 1.353 ± 0.655
0.451TyrTrp: 0.451 ± 0.218
0.451TyrTyr: 0.451 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski