Amino acid dipepetide frequency for Circovirus-like genome RW-E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.559AlaAla: 4.559 ± 1.727
0.0AlaCys: 0.0 ± 0.0
6.079AlaAsp: 6.079 ± 0.853
4.559AlaGlu: 4.559 ± 3.902
1.52AlaPhe: 1.52 ± 0.874
7.599AlaGly: 7.599 ± 0.021
0.0AlaHis: 0.0 ± 0.0
3.04AlaIle: 3.04 ± 0.426
1.52AlaLys: 1.52 ± 1.301
3.04AlaLeu: 3.04 ± 0.426
1.52AlaMet: 1.52 ± 1.301
1.52AlaAsn: 1.52 ± 0.874
1.52AlaPro: 1.52 ± 0.874
1.52AlaGln: 1.52 ± 0.874
3.04AlaArg: 3.04 ± 1.749
3.04AlaSer: 3.04 ± 0.426
7.599AlaThr: 7.599 ± 0.021
4.559AlaVal: 4.559 ± 0.448
3.04AlaTrp: 3.04 ± 0.426
3.04AlaTyr: 3.04 ± 2.601
0.0AlaXaa: 0.0 ± 0.0
Cys
1.52CysAla: 1.52 ± 1.301
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.52CysPhe: 1.52 ± 1.301
1.52CysGly: 1.52 ± 1.301
1.52CysHis: 1.52 ± 1.301
1.52CysIle: 1.52 ± 0.874
1.52CysLys: 1.52 ± 0.874
1.52CysLeu: 1.52 ± 1.301
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.52CysPro: 1.52 ± 0.874
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.52CysSer: 1.52 ± 0.874
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.52CysTyr: 1.52 ± 1.301
0.0CysXaa: 0.0 ± 0.0
Asp
3.04AspAla: 3.04 ± 2.601
1.52AspCys: 1.52 ± 1.301
0.0AspAsp: 0.0 ± 0.0
4.559AspGlu: 4.559 ± 1.727
3.04AspPhe: 3.04 ± 0.426
1.52AspGly: 1.52 ± 1.301
0.0AspHis: 0.0 ± 0.0
6.079AspIle: 6.079 ± 0.853
3.04AspLys: 3.04 ± 1.749
1.52AspLeu: 1.52 ± 0.874
0.0AspMet: 0.0 ± 0.0
0.0AspAsn: 0.0 ± 0.0
4.559AspPro: 4.559 ± 1.727
3.04AspGln: 3.04 ± 2.601
1.52AspArg: 1.52 ± 1.301
4.559AspSer: 4.559 ± 0.448
6.079AspThr: 6.079 ± 1.322
4.559AspVal: 4.559 ± 0.448
1.52AspTrp: 1.52 ± 1.301
1.52AspTyr: 1.52 ± 0.874
0.0AspXaa: 0.0 ± 0.0
Glu
3.04GluAla: 3.04 ± 2.601
0.0GluCys: 0.0 ± 0.0
4.559GluAsp: 4.559 ± 1.727
0.0GluGlu: 0.0 ± 0.0
4.559GluPhe: 4.559 ± 3.902
1.52GluGly: 1.52 ± 0.874
1.52GluHis: 1.52 ± 1.301
1.52GluIle: 1.52 ± 1.301
3.04GluLys: 3.04 ± 0.426
1.52GluLeu: 1.52 ± 1.301
1.52GluMet: 1.52 ± 0.83
3.04GluAsn: 3.04 ± 1.749
3.04GluPro: 3.04 ± 0.426
3.04GluGln: 3.04 ± 0.426
4.559GluArg: 4.559 ± 1.727
1.52GluSer: 1.52 ± 0.874
4.559GluThr: 4.559 ± 2.623
1.52GluVal: 1.52 ± 0.874
1.52GluTrp: 1.52 ± 1.301
4.559GluTyr: 4.559 ± 0.448
0.0GluXaa: 0.0 ± 0.0
Phe
1.52PheAla: 1.52 ± 1.301
1.52PheCys: 1.52 ± 0.874
0.0PheAsp: 0.0 ± 0.0
6.079PheGlu: 6.079 ± 3.028
1.52PhePhe: 1.52 ± 0.874
6.079PheGly: 6.079 ± 0.853
1.52PheHis: 1.52 ± 0.874
0.0PheIle: 0.0 ± 0.0
3.04PheLys: 3.04 ± 0.426
0.0PheLeu: 0.0 ± 0.0
1.52PheMet: 1.52 ± 0.874
1.52PheAsn: 1.52 ± 0.874
0.0PhePro: 0.0 ± 0.0
3.04PheGln: 3.04 ± 1.749
4.559PheArg: 4.559 ± 0.448
1.52PheSer: 1.52 ± 0.874
1.52PheThr: 1.52 ± 0.874
1.52PheVal: 1.52 ± 1.301
1.52PheTrp: 1.52 ± 1.301
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.559GlyAla: 4.559 ± 0.448
0.0GlyCys: 0.0 ± 0.0
3.04GlyAsp: 3.04 ± 2.601
1.52GlyGlu: 1.52 ± 1.301
1.52GlyPhe: 1.52 ± 0.874
1.52GlyGly: 1.52 ± 0.874
0.0GlyHis: 0.0 ± 0.0
1.52GlyIle: 1.52 ± 1.301
4.559GlyLys: 4.559 ± 0.448
0.0GlyLeu: 0.0 ± 0.0
4.559GlyMet: 4.559 ± 1.727
4.559GlyAsn: 4.559 ± 2.623
4.559GlyPro: 4.559 ± 0.448
3.04GlyGln: 3.04 ± 0.426
4.559GlyArg: 4.559 ± 2.623
7.599GlySer: 7.599 ± 0.021
12.158GlyThr: 12.158 ± 2.644
4.559GlyVal: 4.559 ± 1.727
1.52GlyTrp: 1.52 ± 0.874
3.04GlyTyr: 3.04 ± 2.601
0.0GlyXaa: 0.0 ± 0.0
His
1.52HisAla: 1.52 ± 1.301
0.0HisCys: 0.0 ± 0.0
1.52HisAsp: 1.52 ± 0.874
0.0HisGlu: 0.0 ± 0.0
1.52HisPhe: 1.52 ± 0.874
1.52HisGly: 1.52 ± 0.874
0.0HisHis: 0.0 ± 0.0
1.52HisIle: 1.52 ± 1.301
1.52HisLys: 1.52 ± 0.874
3.04HisLeu: 3.04 ± 0.426
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
3.04HisPro: 3.04 ± 0.426
0.0HisGln: 0.0 ± 0.0
1.52HisArg: 1.52 ± 0.874
0.0HisSer: 0.0 ± 0.0
1.52HisThr: 1.52 ± 1.301
3.04HisVal: 3.04 ± 0.426
1.52HisTrp: 1.52 ± 1.301
1.52HisTyr: 1.52 ± 0.874
0.0HisXaa: 0.0 ± 0.0
Ile
1.52IleAla: 1.52 ± 0.874
0.0IleCys: 0.0 ± 0.0
4.559IleAsp: 4.559 ± 0.448
6.079IleGlu: 6.079 ± 3.497
0.0IlePhe: 0.0 ± 0.0
3.04IleGly: 3.04 ± 1.749
0.0IleHis: 0.0 ± 0.0
1.52IleIle: 1.52 ± 0.874
6.079IleLys: 6.079 ± 0.853
1.52IleLeu: 1.52 ± 1.301
0.0IleMet: 0.0 ± 0.0
1.52IleAsn: 1.52 ± 1.301
6.079IlePro: 6.079 ± 0.853
4.559IleGln: 4.559 ± 0.448
4.559IleArg: 4.559 ± 1.727
1.52IleSer: 1.52 ± 1.301
7.599IleThr: 7.599 ± 2.154
1.52IleVal: 1.52 ± 0.874
1.52IleTrp: 1.52 ± 1.301
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.04LysAla: 3.04 ± 0.426
1.52LysCys: 1.52 ± 0.874
4.559LysAsp: 4.559 ± 1.727
6.079LysGlu: 6.079 ± 0.853
4.559LysPhe: 4.559 ± 0.448
7.599LysGly: 7.599 ± 2.154
1.52LysHis: 1.52 ± 1.301
3.04LysIle: 3.04 ± 1.749
4.559LysLys: 4.559 ± 2.623
7.599LysLeu: 7.599 ± 2.197
0.0LysMet: 0.0 ± 0.0
1.52LysAsn: 1.52 ± 0.874
0.0LysPro: 0.0 ± 0.0
1.52LysGln: 1.52 ± 0.874
7.599LysArg: 7.599 ± 2.197
6.079LysSer: 6.079 ± 1.322
0.0LysThr: 0.0 ± 0.0
6.079LysVal: 6.079 ± 3.497
0.0LysTrp: 0.0 ± 0.0
1.52LysTyr: 1.52 ± 0.874
0.0LysXaa: 0.0 ± 0.0
Leu
3.04LeuAla: 3.04 ± 1.749
0.0LeuCys: 0.0 ± 0.0
4.559LeuAsp: 4.559 ± 1.727
3.04LeuGlu: 3.04 ± 1.749
1.52LeuPhe: 1.52 ± 0.874
1.52LeuGly: 1.52 ± 0.874
1.52LeuHis: 1.52 ± 1.301
0.0LeuIle: 0.0 ± 0.0
3.04LeuLys: 3.04 ± 1.749
3.04LeuLeu: 3.04 ± 2.601
0.0LeuMet: 0.0 ± 0.0
1.52LeuAsn: 1.52 ± 0.874
3.04LeuPro: 3.04 ± 2.601
1.52LeuGln: 1.52 ± 1.301
7.599LeuArg: 7.599 ± 4.329
6.079LeuSer: 6.079 ± 0.853
4.559LeuThr: 4.559 ± 0.448
9.119LeuVal: 9.119 ± 1.279
1.52LeuTrp: 1.52 ± 1.301
3.04LeuTyr: 3.04 ± 1.749
0.0LeuXaa: 0.0 ± 0.0
Met
1.52MetAla: 1.52 ± 0.874
1.52MetCys: 1.52 ± 0.874
3.04MetAsp: 3.04 ± 0.426
0.0MetGlu: 0.0 ± 0.0
1.52MetPhe: 1.52 ± 1.301
1.52MetGly: 1.52 ± 0.874
0.0MetHis: 0.0 ± 0.0
3.04MetIle: 3.04 ± 0.426
1.52MetLys: 1.52 ± 0.874
1.52MetLeu: 1.52 ± 1.301
1.52MetMet: 1.52 ± 0.874
0.0MetAsn: 0.0 ± 0.0
1.52MetPro: 1.52 ± 0.874
0.0MetGln: 0.0 ± 0.0
1.52MetArg: 1.52 ± 0.874
0.0MetSer: 0.0 ± 0.0
1.52MetThr: 1.52 ± 0.874
1.52MetVal: 1.52 ± 1.301
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.04AsnAla: 3.04 ± 1.749
1.52AsnCys: 1.52 ± 0.874
3.04AsnAsp: 3.04 ± 0.426
1.52AsnGlu: 1.52 ± 1.301
3.04AsnPhe: 3.04 ± 1.749
4.559AsnGly: 4.559 ± 0.448
1.52AsnHis: 1.52 ± 0.874
0.0AsnIle: 0.0 ± 0.0
3.04AsnLys: 3.04 ± 1.749
3.04AsnLeu: 3.04 ± 1.749
1.52AsnMet: 1.52 ± 0.874
3.04AsnAsn: 3.04 ± 1.749
1.52AsnPro: 1.52 ± 0.874
0.0AsnGln: 0.0 ± 0.0
0.0AsnArg: 0.0 ± 0.0
3.04AsnSer: 3.04 ± 1.749
1.52AsnThr: 1.52 ± 0.874
9.119AsnVal: 9.119 ± 3.071
0.0AsnTrp: 0.0 ± 0.0
1.52AsnTyr: 1.52 ± 0.874
0.0AsnXaa: 0.0 ± 0.0
Pro
1.52ProAla: 1.52 ± 1.301
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
4.559ProGlu: 4.559 ± 1.727
3.04ProPhe: 3.04 ± 0.426
6.079ProGly: 6.079 ± 3.497
1.52ProHis: 1.52 ± 1.301
3.04ProIle: 3.04 ± 1.749
7.599ProLys: 7.599 ± 0.021
3.04ProLeu: 3.04 ± 1.749
1.52ProMet: 1.52 ± 1.301
4.559ProAsn: 4.559 ± 0.448
1.52ProPro: 1.52 ± 0.874
3.04ProGln: 3.04 ± 0.426
4.559ProArg: 4.559 ± 0.448
1.52ProSer: 1.52 ± 0.874
7.599ProThr: 7.599 ± 0.021
1.52ProVal: 1.52 ± 0.874
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
4.559GlnAla: 4.559 ± 2.623
3.04GlnCys: 3.04 ± 2.601
3.04GlnAsp: 3.04 ± 0.426
1.52GlnGlu: 1.52 ± 0.874
1.52GlnPhe: 1.52 ± 1.301
3.04GlnGly: 3.04 ± 0.426
0.0GlnHis: 0.0 ± 0.0
4.559GlnIle: 4.559 ± 1.727
4.559GlnLys: 4.559 ± 1.727
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
4.559GlnAsn: 4.559 ± 2.623
1.52GlnPro: 1.52 ± 0.874
3.04GlnGln: 3.04 ± 1.749
1.52GlnArg: 1.52 ± 0.874
3.04GlnSer: 3.04 ± 1.749
0.0GlnThr: 0.0 ± 0.0
3.04GlnVal: 3.04 ± 0.426
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.079ArgAla: 6.079 ± 3.028
0.0ArgCys: 0.0 ± 0.0
1.52ArgAsp: 1.52 ± 1.301
3.04ArgGlu: 3.04 ± 1.749
0.0ArgPhe: 0.0 ± 0.0
6.079ArgGly: 6.079 ± 0.853
1.52ArgHis: 1.52 ± 0.874
3.04ArgIle: 3.04 ± 0.426
4.559ArgLys: 4.559 ± 0.448
3.04ArgLeu: 3.04 ± 0.426
0.0ArgMet: 0.0 ± 0.0
3.04ArgAsn: 3.04 ± 0.426
0.0ArgPro: 0.0 ± 0.0
7.599ArgGln: 7.599 ± 0.021
7.599ArgArg: 7.599 ± 4.329
4.559ArgSer: 4.559 ± 0.448
6.079ArgThr: 6.079 ± 3.028
6.079ArgVal: 6.079 ± 1.322
1.52ArgTrp: 1.52 ± 1.301
4.559ArgTyr: 4.559 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
7.599SerAla: 7.599 ± 2.154
1.52SerCys: 1.52 ± 1.301
1.52SerAsp: 1.52 ± 0.874
1.52SerGlu: 1.52 ± 1.301
1.52SerPhe: 1.52 ± 0.874
1.52SerGly: 1.52 ± 0.874
3.04SerHis: 3.04 ± 0.426
6.079SerIle: 6.079 ± 3.497
1.52SerLys: 1.52 ± 0.874
4.559SerLeu: 4.559 ± 0.448
1.52SerMet: 1.52 ± 0.874
6.079SerAsn: 6.079 ± 1.322
6.079SerPro: 6.079 ± 3.497
4.559SerGln: 4.559 ± 2.623
6.079SerArg: 6.079 ± 0.853
0.0SerSer: 0.0 ± 0.0
4.559SerThr: 4.559 ± 0.448
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
3.04ThrAla: 3.04 ± 1.749
1.52ThrCys: 1.52 ± 1.301
1.52ThrAsp: 1.52 ± 0.874
0.0ThrGlu: 0.0 ± 0.0
1.52ThrPhe: 1.52 ± 0.874
9.119ThrGly: 9.119 ± 3.454
4.559ThrHis: 4.559 ± 2.623
6.079ThrIle: 6.079 ± 3.028
4.559ThrLys: 4.559 ± 0.448
10.638ThrLeu: 10.638 ± 0.405
1.52ThrMet: 1.52 ± 0.874
3.04ThrAsn: 3.04 ± 1.749
4.559ThrPro: 4.559 ± 2.623
1.52ThrGln: 1.52 ± 0.874
1.52ThrArg: 1.52 ± 1.301
6.079ThrSer: 6.079 ± 1.322
3.04ThrThr: 3.04 ± 1.749
7.599ThrVal: 7.599 ± 0.021
1.52ThrTrp: 1.52 ± 0.874
4.559ThrTyr: 4.559 ± 2.623
0.0ThrXaa: 0.0 ± 0.0
Val
6.079ValAla: 6.079 ± 1.322
0.0ValCys: 0.0 ± 0.0
4.559ValAsp: 4.559 ± 1.727
3.04ValGlu: 3.04 ± 0.426
1.52ValPhe: 1.52 ± 1.301
3.04ValGly: 3.04 ± 0.426
3.04ValHis: 3.04 ± 0.426
3.04ValIle: 3.04 ± 1.749
7.599ValLys: 7.599 ± 4.372
6.079ValLeu: 6.079 ± 0.853
4.559ValMet: 4.559 ± 3.103
4.559ValAsn: 4.559 ± 2.623
4.559ValPro: 4.559 ± 0.448
0.0ValGln: 0.0 ± 0.0
3.04ValArg: 3.04 ± 2.601
3.04ValSer: 3.04 ± 0.426
4.559ValThr: 4.559 ± 2.623
7.599ValVal: 7.599 ± 2.154
1.52ValTrp: 1.52 ± 1.301
4.559ValTyr: 4.559 ± 1.727
0.0ValXaa: 0.0 ± 0.0
Trp
1.52TrpAla: 1.52 ± 1.301
0.0TrpCys: 0.0 ± 0.0
1.52TrpAsp: 1.52 ± 1.301
3.04TrpGlu: 3.04 ± 2.601
1.52TrpPhe: 1.52 ± 0.874
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.52TrpIle: 1.52 ± 1.301
1.52TrpLys: 1.52 ± 1.301
3.04TrpLeu: 3.04 ± 2.601
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.52TrpGln: 1.52 ± 1.301
0.0TrpArg: 0.0 ± 0.0
1.52TrpSer: 1.52 ± 0.874
1.52TrpThr: 1.52 ± 0.874
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.52TrpTyr: 1.52 ± 1.301
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.52TyrCys: 1.52 ± 1.301
3.04TyrAsp: 3.04 ± 1.749
0.0TyrGlu: 0.0 ± 0.0
1.52TyrPhe: 1.52 ± 0.874
0.0TyrGly: 0.0 ± 0.0
1.52TyrHis: 1.52 ± 0.874
3.04TyrIle: 3.04 ± 0.426
0.0TyrLys: 0.0 ± 0.0
1.52TyrLeu: 1.52 ± 1.301
0.0TyrMet: 0.0 ± 0.0
1.52TyrAsn: 1.52 ± 0.874
7.599TyrPro: 7.599 ± 2.154
0.0TyrGln: 0.0 ± 0.0
4.559TyrArg: 4.559 ± 1.727
3.04TyrSer: 3.04 ± 1.749
1.52TyrThr: 1.52 ± 0.874
4.559TyrVal: 4.559 ± 0.448
1.52TyrTrp: 1.52 ± 1.301
3.04TyrTyr: 3.04 ± 1.749
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski