Amino acid dipepetide frequency for bacterium HR11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.072AlaAla: 10.072 ± 0.154	1.197AlaCys: 1.197 ± 0.046	5.119AlaAsp: 5.119 ± 0.09	6.518AlaGlu: 6.518 ± 0.106	4.224AlaPhe: 4.224 ± 0.074	8.04AlaGly: 8.04 ± 0.112	2.063AlaHis: 2.063 ± 0.051	3.961AlaIle: 3.961 ± 0.081	1.613AlaLys: 1.613 ± 0.056	12.31AlaLeu: 12.31 ± 0.165	1.965AlaMet: 1.965 ± 0.048	1.349AlaAsn: 1.349 ± 0.048	4.888AlaPro: 4.888 ± 0.097	3.658AlaGln: 3.658 ± 0.07	9.283AlaArg: 9.283 ± 0.12	3.964AlaSer: 3.964 ± 0.07	4.244AlaThr: 4.244 ± 0.08	9.744AlaVal: 9.744 ± 0.127	2.858AlaTrp: 2.858 ± 0.078	3.373AlaTyr: 3.373 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.758CysAla: 0.758 ± 0.031	0.097CysCys: 0.097 ± 0.013	0.453CysAsp: 0.453 ± 0.025	0.5CysGlu: 0.5 ± 0.028	0.298CysPhe: 0.298 ± 0.021	0.899CysGly: 0.899 ± 0.037	0.389CysHis: 0.389 ± 0.047	0.418CysIle: 0.418 ± 0.023	0.151CysLys: 0.151 ± 0.014	0.947CysLeu: 0.947 ± 0.04	0.187CysMet: 0.187 ± 0.015	0.177CysAsn: 0.177 ± 0.017	0.759CysPro: 0.759 ± 0.036	0.329CysGln: 0.329 ± 0.019	0.857CysArg: 0.857 ± 0.035	0.418CysSer: 0.418 ± 0.023	0.489CysThr: 0.489 ± 0.033	0.675CysVal: 0.675 ± 0.028	0.123CysTrp: 0.123 ± 0.011	0.309CysTyr: 0.309 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.481AspAla: 4.481 ± 0.08	0.431AspCys: 0.431 ± 0.023	2.236AspAsp: 2.236 ± 0.057	3.218AspGlu: 3.218 ± 0.061	2.125AspPhe: 2.125 ± 0.049	4.143AspGly: 4.143 ± 0.094	0.964AspHis: 0.964 ± 0.034	2.12AspIle: 2.12 ± 0.051	0.834AspLys: 0.834 ± 0.034	6.113AspLeu: 6.113 ± 0.081	0.797AspMet: 0.797 ± 0.031	0.571AspAsn: 0.571 ± 0.028	4.072AspPro: 4.072 ± 0.089	1.343AspGln: 1.343 ± 0.044	5.239AspArg: 5.239 ± 0.088	1.316AspSer: 1.316 ± 0.037	2.033AspThr: 2.033 ± 0.047	5.118AspVal: 5.118 ± 0.087	1.21AspTrp: 1.21 ± 0.042	1.563AspTyr: 1.563 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.648GluAla: 8.648 ± 0.12	0.398GluCys: 0.398 ± 0.022	3.035GluAsp: 3.035 ± 0.062	3.76GluGlu: 3.76 ± 0.096	1.974GluPhe: 1.974 ± 0.054	4.469GluGly: 4.469 ± 0.082	1.006GluHis: 1.006 ± 0.036	2.669GluIle: 2.669 ± 0.07	1.976GluLys: 1.976 ± 0.054	5.269GluLeu: 5.269 ± 0.095	1.42GluMet: 1.42 ± 0.052	1.154GluAsn: 1.154 ± 0.037	3.142GluPro: 3.142 ± 0.074	1.955GluGln: 1.955 ± 0.055	6.237GluArg: 6.237 ± 0.092	2.432GluSer: 2.432 ± 0.062	3.57GluThr: 3.57 ± 0.068	5.928GluVal: 5.928 ± 0.09	1.307GluTrp: 1.307 ± 0.047	1.382GluTyr: 1.382 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	2.507PheAla: 2.507 ± 0.058	0.399PheCys: 0.399 ± 0.022	1.638PheAsp: 1.638 ± 0.05	2.144PheGlu: 2.144 ± 0.052	1.482PhePhe: 1.482 ± 0.05	2.811PheGly: 2.811 ± 0.058	0.942PheHis: 0.942 ± 0.039	1.777PheIle: 1.777 ± 0.05	0.637PheLys: 0.637 ± 0.031	4.402PheLeu: 4.402 ± 0.091	0.628PheMet: 0.628 ± 0.03	0.685PheAsn: 0.685 ± 0.028	2.137PhePro: 2.137 ± 0.054	1.815PheGln: 1.815 ± 0.048	3.667PheArg: 3.667 ± 0.079	1.62PheSer: 1.62 ± 0.053	1.679PheThr: 1.679 ± 0.047	2.927PheVal: 2.927 ± 0.056	0.917PheTrp: 0.917 ± 0.028	1.363PheTyr: 1.363 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.521GlyAla: 6.521 ± 0.101	0.83GlyCys: 0.83 ± 0.035	3.524GlyAsp: 3.524 ± 0.077	3.886GlyGlu: 3.886 ± 0.067	3.214GlyPhe: 3.214 ± 0.063	6.058GlyGly: 6.058 ± 0.121	1.788GlyHis: 1.788 ± 0.048	3.824GlyIle: 3.824 ± 0.081	1.937GlyLys: 1.937 ± 0.056	9.884GlyLeu: 9.884 ± 0.149	1.733GlyMet: 1.733 ± 0.045	1.283GlyAsn: 1.283 ± 0.05	4.682GlyPro: 4.682 ± 0.077	2.71GlyGln: 2.71 ± 0.055	7.903GlyArg: 7.903 ± 0.119	3.771GlySer: 3.771 ± 0.092	4.542GlyThr: 4.542 ± 0.09	6.733GlyVal: 6.733 ± 0.099	2.058GlyTrp: 2.058 ± 0.055	2.389GlyTyr: 2.389 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.835HisAla: 1.835 ± 0.05	0.208HisCys: 0.208 ± 0.018	0.905HisAsp: 0.905 ± 0.033	1.161HisGlu: 1.161 ± 0.04	0.78HisPhe: 0.78 ± 0.033	1.813HisGly: 1.813 ± 0.049	0.553HisHis: 0.553 ± 0.027	0.835HisIle: 0.835 ± 0.032	0.338HisLys: 0.338 ± 0.022	2.265HisLeu: 2.265 ± 0.056	0.403HisMet: 0.403 ± 0.022	0.327HisAsn: 0.327 ± 0.021	1.949HisPro: 1.949 ± 0.054	0.689HisGln: 0.689 ± 0.032	2.355HisArg: 2.355 ± 0.063	0.663HisSer: 0.663 ± 0.028	0.938HisThr: 0.938 ± 0.037	1.906HisVal: 1.906 ± 0.044	0.458HisTrp: 0.458 ± 0.024	0.66HisTyr: 0.66 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.19IleAla: 4.19 ± 0.09	0.375IleCys: 0.375 ± 0.023	2.277IleAsp: 2.277 ± 0.054	3.095IleGlu: 3.095 ± 0.074	1.331IlePhe: 1.331 ± 0.042	3.552IleGly: 3.552 ± 0.078	1.024IleHis: 1.024 ± 0.035	1.466IleIle: 1.466 ± 0.05	0.68IleLys: 0.68 ± 0.034	4.338IleLeu: 4.338 ± 0.087	0.554IleMet: 0.554 ± 0.028	0.668IleAsn: 0.668 ± 0.029	2.876IlePro: 2.876 ± 0.053	1.9IleGln: 1.9 ± 0.056	4.387IleArg: 4.387 ± 0.075	1.478IleSer: 1.478 ± 0.035	1.841IleThr: 1.841 ± 0.046	3.98IleVal: 3.98 ± 0.074	0.478IleTrp: 0.478 ± 0.025	1.224IleTyr: 1.224 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	2.606LysAla: 2.606 ± 0.068	0.166LysCys: 0.166 ± 0.015	1.168LysAsp: 1.168 ± 0.041	1.335LysGlu: 1.335 ± 0.059	0.646LysPhe: 0.646 ± 0.031	1.717LysGly: 1.717 ± 0.053	0.37LysHis: 0.37 ± 0.022	1.001LysIle: 1.001 ± 0.04	0.905LysLys: 0.905 ± 0.04	1.924LysLeu: 1.924 ± 0.05	0.53LysMet: 0.53 ± 0.024	0.512LysAsn: 0.512 ± 0.028	1.569LysPro: 1.569 ± 0.048	0.65LysGln: 0.65 ± 0.031	1.696LysArg: 1.696 ± 0.051	0.886LysSer: 0.886 ± 0.036	1.317LysThr: 1.317 ± 0.043	2.06LysVal: 2.06 ± 0.056	0.282LysTrp: 0.282 ± 0.022	0.733LysTyr: 0.733 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.142LeuAla: 11.142 ± 0.157	0.883LeuCys: 0.883 ± 0.041	5.346LeuAsp: 5.346 ± 0.08	7.138LeuGlu: 7.138 ± 0.107	3.46LeuPhe: 3.46 ± 0.068	8.756LeuGly: 8.756 ± 0.132	2.251LeuHis: 2.251 ± 0.057	4.611LeuIle: 4.611 ± 0.093	2.782LeuLys: 2.782 ± 0.061	10.943LeuLeu: 10.943 ± 0.148	2.167LeuMet: 2.167 ± 0.057	2.081LeuAsn: 2.081 ± 0.046	6.229LeuPro: 6.229 ± 0.099	5.045LeuGln: 5.045 ± 0.085	11.386LeuArg: 11.386 ± 0.136	4.658LeuSer: 4.658 ± 0.077	6.076LeuThr: 6.076 ± 0.102	7.852LeuVal: 7.852 ± 0.102	2.585LeuTrp: 2.585 ± 0.069	3.243LeuTyr: 3.243 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.781MetAla: 2.781 ± 0.065	0.129MetCys: 0.129 ± 0.012	1.192MetAsp: 1.192 ± 0.036	1.425MetGlu: 1.425 ± 0.045	0.514MetPhe: 0.514 ± 0.027	1.875MetGly: 1.875 ± 0.051	0.321MetHis: 0.321 ± 0.023	0.689MetIle: 0.689 ± 0.038	0.761MetLys: 0.761 ± 0.031	1.363MetLeu: 1.363 ± 0.045	0.353MetMet: 0.353 ± 0.022	0.537MetAsn: 0.537 ± 0.026	1.02MetPro: 1.02 ± 0.035	0.552MetGln: 0.552 ± 0.028	1.46MetArg: 1.46 ± 0.04	0.91MetSer: 0.91 ± 0.038	1.436MetThr: 1.436 ± 0.049	1.632MetVal: 1.632 ± 0.045	0.236MetTrp: 0.236 ± 0.017	0.419MetTyr: 0.419 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	1.643AsnAla: 1.643 ± 0.047	0.231AsnCys: 0.231 ± 0.019	0.714AsnAsp: 0.714 ± 0.03	0.782AsnGlu: 0.782 ± 0.029	0.684AsnPhe: 0.684 ± 0.032	1.347AsnGly: 1.347 ± 0.049	0.323AsnHis: 0.323 ± 0.023	0.783AsnIle: 0.783 ± 0.03	0.317AsnLys: 0.317 ± 0.022	2.054AsnLeu: 2.054 ± 0.051	0.299AsnMet: 0.299 ± 0.021	0.346AsnAsn: 0.346 ± 0.026	1.733AsnPro: 1.733 ± 0.06	0.524AsnGln: 0.524 ± 0.026	1.508AsnArg: 1.508 ± 0.051	0.589AsnSer: 0.589 ± 0.034	0.791AsnThr: 0.791 ± 0.038	1.742AsnVal: 1.742 ± 0.046	0.292AsnTrp: 0.292 ± 0.021	0.513AsnTyr: 0.513 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.606ProAla: 6.606 ± 0.09	0.478ProCys: 0.478 ± 0.027	4.519ProAsp: 4.519 ± 0.079	5.145ProGlu: 5.145 ± 0.081	2.108ProPhe: 2.108 ± 0.046	5.139ProGly: 5.139 ± 0.079	1.246ProHis: 1.246 ± 0.04	2.367ProIle: 2.367 ± 0.052	1.435ProLys: 1.435 ± 0.048	5.494ProLeu: 5.494 ± 0.079	1.343ProMet: 1.343 ± 0.037	1.188ProAsn: 1.188 ± 0.042	5.148ProPro: 5.148 ± 0.114	1.771ProGln: 1.771 ± 0.039	4.415ProArg: 4.415 ± 0.083	3.176ProSer: 3.176 ± 0.07	3.736ProThr: 3.736 ± 0.071	5.976ProVal: 5.976 ± 0.093	1.549ProTrp: 1.549 ± 0.045	1.833ProTyr: 1.833 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	5.427GlnAla: 5.427 ± 0.108	0.274GlnCys: 0.274 ± 0.018	1.783GlnAsp: 1.783 ± 0.044	2.237GlnGlu: 2.237 ± 0.068	1.083GlnPhe: 1.083 ± 0.041	2.825GlnGly: 2.825 ± 0.056	0.525GlnHis: 0.525 ± 0.03	1.449GlnIle: 1.449 ± 0.047	1.217GlnLys: 1.217 ± 0.047	2.71GlnLeu: 2.71 ± 0.081	0.919GlnMet: 0.919 ± 0.038	0.721GlnAsn: 0.721 ± 0.032	1.69GlnPro: 1.69 ± 0.049	1.341GlnGln: 1.341 ± 0.054	3.17GlnArg: 3.17 ± 0.068	1.285GlnSer: 1.285 ± 0.047	2.225GlnThr: 2.225 ± 0.051	3.927GlnVal: 3.927 ± 0.086	0.886GlnTrp: 0.886 ± 0.038	0.905GlnTyr: 0.905 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	8.428ArgAla: 8.428 ± 0.111	0.829ArgCys: 0.829 ± 0.04	4.263ArgAsp: 4.263 ± 0.069	4.936ArgGlu: 4.936 ± 0.09	3.529ArgPhe: 3.529 ± 0.078	5.796ArgGly: 5.796 ± 0.09	2.107ArgHis: 2.107 ± 0.057	4.325ArgIle: 4.325 ± 0.072	2.133ArgLys: 2.133 ± 0.06	11.304ArgLeu: 11.304 ± 0.127	2.105ArgMet: 2.105 ± 0.055	1.515ArgAsn: 1.515 ± 0.04	6.723ArgPro: 6.723 ± 0.106	3.986ArgGln: 3.986 ± 0.084	9.959ArgArg: 9.959 ± 0.138	4.005ArgSer: 4.005 ± 0.078	4.375ArgThr: 4.375 ± 0.07	8.074ArgVal: 8.074 ± 0.107	3.378ArgTrp: 3.378 ± 0.091	2.989ArgTyr: 2.989 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	4.008SerAla: 4.008 ± 0.072	0.383SerCys: 0.383 ± 0.026	2.072SerAsp: 2.072 ± 0.051	2.15SerGlu: 2.15 ± 0.05	1.561SerPhe: 1.561 ± 0.049	3.564SerGly: 3.564 ± 0.075	0.868SerHis: 0.868 ± 0.03	1.854SerIle: 1.854 ± 0.051	0.815SerLys: 0.815 ± 0.03	4.649SerLeu: 4.649 ± 0.081	0.996SerMet: 0.996 ± 0.037	0.677SerAsn: 0.677 ± 0.029	3.228SerPro: 3.228 ± 0.075	1.204SerGln: 1.204 ± 0.033	3.18SerArg: 3.18 ± 0.058	1.848SerSer: 1.848 ± 0.053	2.019SerThr: 2.019 ± 0.058	3.767SerVal: 3.767 ± 0.069	0.769SerTrp: 0.769 ± 0.032	1.074SerTyr: 1.074 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.49ThrAla: 5.49 ± 0.085	0.589ThrCys: 0.589 ± 0.034	2.692ThrAsp: 2.692 ± 0.054	2.644ThrGlu: 2.644 ± 0.058	1.911ThrPhe: 1.911 ± 0.05	4.914ThrGly: 4.914 ± 0.087	1.13ThrHis: 1.13 ± 0.035	1.775ThrIle: 1.775 ± 0.055	0.926ThrLys: 0.926 ± 0.039	5.73ThrLeu: 5.73 ± 0.094	0.871ThrMet: 0.871 ± 0.032	0.87ThrAsn: 0.87 ± 0.034	4.032ThrPro: 4.032 ± 0.071	1.495ThrGln: 1.495 ± 0.051	3.573ThrArg: 3.573 ± 0.072	1.959ThrSer: 1.959 ± 0.066	2.638ThrThr: 2.638 ± 0.063	5.352ThrVal: 5.352 ± 0.095	1.239ThrTrp: 1.239 ± 0.037	1.592ThrTyr: 1.592 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	8.211ValAla: 8.211 ± 0.108	0.88ValCys: 0.88 ± 0.035	4.083ValAsp: 4.083 ± 0.068	6.446ValGlu: 6.446 ± 0.106	3.442ValPhe: 3.442 ± 0.063	7.286ValGly: 7.286 ± 0.096	2.027ValHis: 2.027 ± 0.048	3.651ValIle: 3.651 ± 0.073	1.489ValLys: 1.489 ± 0.045	10.982ValLeu: 10.982 ± 0.115	1.306ValMet: 1.306 ± 0.041	1.453ValAsn: 1.453 ± 0.042	5.644ValPro: 5.644 ± 0.1	3.63ValGln: 3.63 ± 0.071	9.401ValArg: 9.401 ± 0.125	3.555ValSer: 3.555 ± 0.066	4.45ValThr: 4.45 ± 0.081	8.591ValVal: 8.591 ± 0.124	2.0ValTrp: 2.0 ± 0.06	2.677ValTyr: 2.677 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	2.426TrpAla: 2.426 ± 0.06	0.166TrpCys: 0.166 ± 0.016	1.287TrpAsp: 1.287 ± 0.041	1.205TrpGlu: 1.205 ± 0.038	0.693TrpPhe: 0.693 ± 0.032	1.645TrpGly: 1.645 ± 0.054	0.453TrpHis: 0.453 ± 0.027	0.943TrpIle: 0.943 ± 0.033	0.585TrpLys: 0.585 ± 0.027	2.832TrpLeu: 2.832 ± 0.079	0.502TrpMet: 0.502 ± 0.024	0.555TrpAsn: 0.555 ± 0.028	1.358TrpPro: 1.358 ± 0.049	0.917TrpGln: 0.917 ± 0.044	1.78TrpArg: 1.78 ± 0.055	1.149TrpSer: 1.149 ± 0.041	1.591TrpThr: 1.591 ± 0.059	2.7TrpVal: 2.7 ± 0.069	0.524TrpTrp: 0.524 ± 0.026	0.495TrpTyr: 0.495 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.06	0.292TyrCys: 0.292 ± 0.022	1.62TyrAsp: 1.62 ± 0.05	2.006TyrGlu: 2.006 ± 0.049	1.116TyrPhe: 1.116 ± 0.035	2.623TyrGly: 2.623 ± 0.059	0.691TyrHis: 0.691 ± 0.03	1.198TyrIle: 1.198 ± 0.041	0.543TyrLys: 0.543 ± 0.03	3.121TyrLeu: 3.121 ± 0.068	0.522TyrMet: 0.522 ± 0.027	0.546TyrAsn: 0.546 ± 0.026	1.794TyrPro: 1.794 ± 0.041	1.086TyrGln: 1.086 ± 0.04	3.306TyrArg: 3.306 ± 0.068	1.005TyrSer: 1.005 ± 0.039	1.429TyrThr: 1.429 ± 0.045	2.517TyrVal: 2.517 ± 0.054	0.66TyrTrp: 0.66 ± 0.028	1.059TyrTyr: 1.059 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2436 proteins (832185 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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