Amino acid dipepetide frequency for Streptococcus phage Javan478

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.553AlaAla: 3.553 ± 1.262
0.496AlaCys: 0.496 ± 0.225
4.709AlaAsp: 4.709 ± 0.65
4.792AlaGlu: 4.792 ± 0.981
1.9AlaPhe: 1.9 ± 0.399
3.8AlaGly: 3.8 ± 0.887
0.661AlaHis: 0.661 ± 0.187
4.296AlaIle: 4.296 ± 0.65
6.609AlaLys: 6.609 ± 0.658
7.022AlaLeu: 7.022 ± 1.378
1.818AlaMet: 1.818 ± 0.474
4.131AlaAsn: 4.131 ± 0.579
1.735AlaPro: 1.735 ± 0.442
3.305AlaGln: 3.305 ± 0.876
2.313AlaArg: 2.313 ± 0.45
4.627AlaSer: 4.627 ± 0.864
3.883AlaThr: 3.883 ± 0.959
4.544AlaVal: 4.544 ± 0.933
0.578AlaTrp: 0.578 ± 0.218
2.148AlaTyr: 2.148 ± 0.389
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.083CysCys: 0.083 ± 0.079
0.413CysAsp: 0.413 ± 0.166
0.413CysGlu: 0.413 ± 0.172
0.413CysPhe: 0.413 ± 0.192
0.578CysGly: 0.578 ± 0.242
0.0CysHis: 0.0 ± 0.0
0.248CysIle: 0.248 ± 0.148
0.413CysLys: 0.413 ± 0.209
0.496CysLeu: 0.496 ± 0.219
0.083CysMet: 0.083 ± 0.079
0.248CysAsn: 0.248 ± 0.148
0.165CysPro: 0.165 ± 0.113
0.165CysGln: 0.165 ± 0.109
0.496CysArg: 0.496 ± 0.206
0.0CysSer: 0.0 ± 0.0
0.248CysThr: 0.248 ± 0.147
0.248CysVal: 0.248 ± 0.167
0.083CysTrp: 0.083 ± 0.102
0.33CysTyr: 0.33 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
3.305AspAla: 3.305 ± 0.482
0.33AspCys: 0.33 ± 0.166
4.131AspAsp: 4.131 ± 0.667
4.461AspGlu: 4.461 ± 0.576
3.305AspPhe: 3.305 ± 0.542
6.031AspGly: 6.031 ± 1.073
0.661AspHis: 0.661 ± 0.267
5.04AspIle: 5.04 ± 0.679
6.609AspLys: 6.609 ± 0.59
6.444AspLeu: 6.444 ± 0.686
1.487AspMet: 1.487 ± 0.338
3.387AspAsn: 3.387 ± 0.453
1.487AspPro: 1.487 ± 0.273
0.991AspGln: 0.991 ± 0.302
2.231AspArg: 2.231 ± 0.363
3.8AspSer: 3.8 ± 0.483
3.553AspThr: 3.553 ± 0.53
4.709AspVal: 4.709 ± 0.623
0.578AspTrp: 0.578 ± 0.207
3.057AspTyr: 3.057 ± 0.654
0.0AspXaa: 0.0 ± 0.0
Glu
4.627GluAla: 4.627 ± 0.871
0.33GluCys: 0.33 ± 0.166
2.974GluAsp: 2.974 ± 0.564
5.948GluGlu: 5.948 ± 0.743
2.974GluPhe: 2.974 ± 0.449
2.644GluGly: 2.644 ± 0.579
0.909GluHis: 0.909 ± 0.297
7.353GluIle: 7.353 ± 0.938
7.353GluLys: 7.353 ± 0.828
8.179GluLeu: 8.179 ± 0.838
1.652GluMet: 1.652 ± 0.335
3.387GluAsn: 3.387 ± 0.522
1.735GluPro: 1.735 ± 0.501
2.231GluGln: 2.231 ± 0.385
3.057GluArg: 3.057 ± 0.498
4.792GluSer: 4.792 ± 0.672
4.544GluThr: 4.544 ± 0.613
4.957GluVal: 4.957 ± 0.743
1.404GluTrp: 1.404 ± 0.299
2.892GluTyr: 2.892 ± 0.594
0.0GluXaa: 0.0 ± 0.0
Phe
2.726PheAla: 2.726 ± 0.507
0.33PheCys: 0.33 ± 0.163
3.387PheAsp: 3.387 ± 0.491
3.057PheGlu: 3.057 ± 0.526
1.487PhePhe: 1.487 ± 0.49
3.057PheGly: 3.057 ± 0.462
0.413PheHis: 0.413 ± 0.153
2.726PheIle: 2.726 ± 0.528
3.8PheLys: 3.8 ± 0.762
2.561PheLeu: 2.561 ± 0.554
1.074PheMet: 1.074 ± 0.258
1.983PheAsn: 1.983 ± 0.417
0.661PhePro: 0.661 ± 0.211
1.157PheGln: 1.157 ± 0.342
1.983PheArg: 1.983 ± 0.4
2.313PheSer: 2.313 ± 0.472
2.396PheThr: 2.396 ± 0.388
2.479PheVal: 2.479 ± 0.449
0.33PheTrp: 0.33 ± 0.163
1.322PheTyr: 1.322 ± 0.377
0.0PheXaa: 0.0 ± 0.0
Gly
3.139GlyAla: 3.139 ± 0.664
0.413GlyCys: 0.413 ± 0.215
4.627GlyAsp: 4.627 ± 0.878
3.635GlyGlu: 3.635 ± 0.597
2.479GlyPhe: 2.479 ± 0.531
3.883GlyGly: 3.883 ± 0.669
1.239GlyHis: 1.239 ± 0.264
4.461GlyIle: 4.461 ± 0.619
6.031GlyLys: 6.031 ± 0.769
5.783GlyLeu: 5.783 ± 0.976
1.983GlyMet: 1.983 ± 0.419
3.883GlyAsn: 3.883 ± 0.704
0.991GlyPro: 0.991 ± 0.349
2.396GlyGln: 2.396 ± 0.46
2.396GlyArg: 2.396 ± 0.409
2.231GlySer: 2.231 ± 0.56
3.635GlyThr: 3.635 ± 0.652
4.709GlyVal: 4.709 ± 0.596
1.074GlyTrp: 1.074 ± 0.322
2.809GlyTyr: 2.809 ± 0.636
0.0GlyXaa: 0.0 ± 0.0
His
0.33HisAla: 0.33 ± 0.149
0.0HisCys: 0.0 ± 0.0
0.661HisAsp: 0.661 ± 0.342
0.909HisGlu: 0.909 ± 0.213
0.578HisPhe: 0.578 ± 0.22
0.991HisGly: 0.991 ± 0.277
0.165HisHis: 0.165 ± 0.102
0.826HisIle: 0.826 ± 0.251
0.909HisLys: 0.909 ± 0.29
1.157HisLeu: 1.157 ± 0.354
0.33HisMet: 0.33 ± 0.172
0.909HisAsn: 0.909 ± 0.267
0.578HisPro: 0.578 ± 0.204
0.413HisGln: 0.413 ± 0.183
0.744HisArg: 0.744 ± 0.261
0.661HisSer: 0.661 ± 0.273
0.661HisThr: 0.661 ± 0.231
1.157HisVal: 1.157 ± 0.241
0.165HisTrp: 0.165 ± 0.115
0.578HisTyr: 0.578 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
4.874IleAla: 4.874 ± 0.68
0.496IleCys: 0.496 ± 0.23
6.114IleAsp: 6.114 ± 0.923
5.618IleGlu: 5.618 ± 0.651
1.983IlePhe: 1.983 ± 0.402
4.131IleGly: 4.131 ± 0.906
1.487IleHis: 1.487 ± 0.27
4.792IleIle: 4.792 ± 0.77
7.601IleLys: 7.601 ± 0.855
5.535IleLeu: 5.535 ± 0.813
0.909IleMet: 0.909 ± 0.238
5.04IleAsn: 5.04 ± 0.743
2.561IlePro: 2.561 ± 0.489
1.404IleGln: 1.404 ± 0.414
1.818IleArg: 1.818 ± 0.461
4.131IleSer: 4.131 ± 0.674
4.379IleThr: 4.379 ± 0.661
3.966IleVal: 3.966 ± 0.513
0.744IleTrp: 0.744 ± 0.218
3.222IleTyr: 3.222 ± 0.608
0.0IleXaa: 0.0 ± 0.0
Lys
6.527LysAla: 6.527 ± 0.917
0.496LysCys: 0.496 ± 0.199
4.957LysAsp: 4.957 ± 0.81
7.27LysGlu: 7.27 ± 0.89
2.726LysPhe: 2.726 ± 0.526
5.122LysGly: 5.122 ± 0.786
1.239LysHis: 1.239 ± 0.3
7.188LysIle: 7.188 ± 0.994
7.931LysLys: 7.931 ± 0.939
7.518LysLeu: 7.518 ± 0.802
2.313LysMet: 2.313 ± 0.427
6.114LysAsn: 6.114 ± 0.674
3.47LysPro: 3.47 ± 0.669
5.205LysGln: 5.205 ± 0.66
3.305LysArg: 3.305 ± 0.621
5.866LysSer: 5.866 ± 0.708
5.948LysThr: 5.948 ± 0.775
5.866LysVal: 5.866 ± 0.791
0.744LysTrp: 0.744 ± 0.221
2.892LysTyr: 2.892 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
6.114LeuAla: 6.114 ± 1.109
0.33LeuCys: 0.33 ± 0.164
7.022LeuAsp: 7.022 ± 0.655
7.353LeuGlu: 7.353 ± 0.943
3.387LeuPhe: 3.387 ± 0.623
4.957LeuGly: 4.957 ± 0.927
0.661LeuHis: 0.661 ± 0.284
5.37LeuIle: 5.37 ± 0.772
9.418LeuLys: 9.418 ± 0.951
7.022LeuLeu: 7.022 ± 0.738
1.652LeuMet: 1.652 ± 0.371
6.114LeuAsn: 6.114 ± 0.608
3.139LeuPro: 3.139 ± 0.436
3.305LeuGln: 3.305 ± 0.562
4.131LeuArg: 4.131 ± 0.571
5.618LeuSer: 5.618 ± 0.804
4.957LeuThr: 4.957 ± 0.727
5.122LeuVal: 5.122 ± 0.693
0.413LeuTrp: 0.413 ± 0.284
1.983LeuTyr: 1.983 ± 0.428
0.0LeuXaa: 0.0 ± 0.0
Met
2.148MetAla: 2.148 ± 0.448
0.083MetCys: 0.083 ± 0.086
1.239MetAsp: 1.239 ± 0.456
1.322MetGlu: 1.322 ± 0.336
1.322MetPhe: 1.322 ± 0.364
0.909MetGly: 0.909 ± 0.286
0.33MetHis: 0.33 ± 0.172
1.983MetIle: 1.983 ± 0.387
1.818MetLys: 1.818 ± 0.473
2.148MetLeu: 2.148 ± 0.502
0.413MetMet: 0.413 ± 0.184
0.991MetAsn: 0.991 ± 0.26
0.991MetPro: 0.991 ± 0.266
0.661MetGln: 0.661 ± 0.251
1.57MetArg: 1.57 ± 0.278
1.57MetSer: 1.57 ± 0.525
2.065MetThr: 2.065 ± 0.45
1.322MetVal: 1.322 ± 0.338
0.165MetTrp: 0.165 ± 0.116
0.661MetTyr: 0.661 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
3.718AsnAla: 3.718 ± 0.792
0.165AsnCys: 0.165 ± 0.113
3.8AsnAsp: 3.8 ± 0.42
4.296AsnGlu: 4.296 ± 0.688
2.313AsnPhe: 2.313 ± 0.464
5.205AsnGly: 5.205 ± 0.728
0.826AsnHis: 0.826 ± 0.245
3.222AsnIle: 3.222 ± 0.541
3.883AsnLys: 3.883 ± 0.558
5.205AsnLeu: 5.205 ± 0.586
1.404AsnMet: 1.404 ± 0.396
3.966AsnAsn: 3.966 ± 0.7
2.644AsnPro: 2.644 ± 0.451
2.644AsnGln: 2.644 ± 0.553
2.479AsnArg: 2.479 ± 0.55
3.8AsnSer: 3.8 ± 0.653
2.644AsnThr: 2.644 ± 0.479
3.966AsnVal: 3.966 ± 0.48
0.909AsnTrp: 0.909 ± 0.24
2.065AsnTyr: 2.065 ± 0.422
0.0AsnXaa: 0.0 ± 0.0
Pro
1.57ProAla: 1.57 ± 0.487
0.0ProCys: 0.0 ± 0.0
2.396ProAsp: 2.396 ± 0.483
1.983ProGlu: 1.983 ± 0.356
1.818ProPhe: 1.818 ± 0.423
1.239ProGly: 1.239 ± 0.355
0.496ProHis: 0.496 ± 0.203
1.487ProIle: 1.487 ± 0.349
3.222ProLys: 3.222 ± 0.594
3.057ProLeu: 3.057 ± 0.569
0.413ProMet: 0.413 ± 0.252
1.818ProAsn: 1.818 ± 0.418
0.578ProPro: 0.578 ± 0.255
0.991ProGln: 0.991 ± 0.261
1.239ProArg: 1.239 ± 0.484
1.735ProSer: 1.735 ± 0.401
2.313ProThr: 2.313 ± 0.429
1.9ProVal: 1.9 ± 0.471
0.083ProTrp: 0.083 ± 0.078
0.991ProTyr: 0.991 ± 0.414
0.0ProXaa: 0.0 ± 0.0
Gln
3.305GlnAla: 3.305 ± 0.553
0.165GlnCys: 0.165 ± 0.122
2.065GlnAsp: 2.065 ± 0.344
2.892GlnGlu: 2.892 ± 0.505
1.652GlnPhe: 1.652 ± 0.31
1.818GlnGly: 1.818 ± 0.451
0.496GlnHis: 0.496 ± 0.199
2.231GlnIle: 2.231 ± 0.509
3.8GlnLys: 3.8 ± 0.685
3.305GlnLeu: 3.305 ± 0.471
1.487GlnMet: 1.487 ± 0.417
1.735GlnAsn: 1.735 ± 0.418
0.744GlnPro: 0.744 ± 0.205
1.57GlnGln: 1.57 ± 0.448
1.818GlnArg: 1.818 ± 0.447
3.305GlnSer: 3.305 ± 0.751
2.065GlnThr: 2.065 ± 0.404
1.57GlnVal: 1.57 ± 0.363
0.744GlnTrp: 0.744 ± 0.319
0.909GlnTyr: 0.909 ± 0.258
0.0GlnXaa: 0.0 ± 0.0
Arg
2.809ArgAla: 2.809 ± 0.548
0.083ArgCys: 0.083 ± 0.077
1.818ArgAsp: 1.818 ± 0.444
3.553ArgGlu: 3.553 ± 0.474
1.157ArgPhe: 1.157 ± 0.314
2.231ArgGly: 2.231 ± 0.412
0.661ArgHis: 0.661 ± 0.265
3.8ArgIle: 3.8 ± 0.742
3.966ArgLys: 3.966 ± 0.564
3.883ArgLeu: 3.883 ± 0.532
0.909ArgMet: 0.909 ± 0.252
2.313ArgAsn: 2.313 ± 0.555
0.496ArgPro: 0.496 ± 0.228
1.735ArgGln: 1.735 ± 0.42
2.726ArgArg: 2.726 ± 0.552
1.818ArgSer: 1.818 ± 0.345
1.818ArgThr: 1.818 ± 0.449
2.644ArgVal: 2.644 ± 0.559
0.33ArgTrp: 0.33 ± 0.151
1.9ArgTyr: 1.9 ± 0.528
0.0ArgXaa: 0.0 ± 0.0
Ser
5.288SerAla: 5.288 ± 1.072
0.165SerCys: 0.165 ± 0.121
4.627SerAsp: 4.627 ± 0.512
4.296SerGlu: 4.296 ± 0.446
3.139SerPhe: 3.139 ± 0.395
3.966SerGly: 3.966 ± 0.771
0.991SerHis: 0.991 ± 0.316
4.379SerIle: 4.379 ± 0.677
4.379SerLys: 4.379 ± 0.566
4.379SerLeu: 4.379 ± 0.626
2.148SerMet: 2.148 ± 0.358
3.635SerAsn: 3.635 ± 0.584
1.652SerPro: 1.652 ± 0.347
2.644SerGln: 2.644 ± 0.452
1.818SerArg: 1.818 ± 0.422
3.47SerSer: 3.47 ± 0.688
2.892SerThr: 2.892 ± 0.603
4.544SerVal: 4.544 ± 0.666
0.826SerTrp: 0.826 ± 0.343
2.561SerTyr: 2.561 ± 0.559
0.0SerXaa: 0.0 ± 0.0
Thr
4.874ThrAla: 4.874 ± 1.038
0.165ThrCys: 0.165 ± 0.117
2.974ThrAsp: 2.974 ± 0.458
2.892ThrGlu: 2.892 ± 0.705
2.396ThrPhe: 2.396 ± 0.484
4.461ThrGly: 4.461 ± 0.562
0.578ThrHis: 0.578 ± 0.22
5.04ThrIle: 5.04 ± 0.709
5.288ThrLys: 5.288 ± 0.628
4.461ThrLeu: 4.461 ± 0.606
1.239ThrMet: 1.239 ± 0.389
2.974ThrAsn: 2.974 ± 0.458
2.231ThrPro: 2.231 ± 0.412
2.396ThrGln: 2.396 ± 0.53
1.652ThrArg: 1.652 ± 0.364
4.544ThrSer: 4.544 ± 0.656
4.379ThrThr: 4.379 ± 0.718
3.883ThrVal: 3.883 ± 0.595
0.661ThrTrp: 0.661 ± 0.207
1.9ThrTyr: 1.9 ± 0.556
0.0ThrXaa: 0.0 ± 0.0
Val
5.288ValAla: 5.288 ± 0.961
0.496ValCys: 0.496 ± 0.232
4.213ValAsp: 4.213 ± 0.669
5.37ValGlu: 5.37 ± 0.695
2.396ValPhe: 2.396 ± 0.54
4.131ValGly: 4.131 ± 0.433
0.496ValHis: 0.496 ± 0.222
3.47ValIle: 3.47 ± 0.5
5.866ValLys: 5.866 ± 0.801
6.031ValLeu: 6.031 ± 0.786
1.239ValMet: 1.239 ± 0.402
4.131ValAsn: 4.131 ± 0.669
1.818ValPro: 1.818 ± 0.35
1.735ValGln: 1.735 ± 0.382
2.396ValArg: 2.396 ± 0.489
4.792ValSer: 4.792 ± 0.772
3.8ValThr: 3.8 ± 0.683
3.305ValVal: 3.305 ± 0.444
0.413ValTrp: 0.413 ± 0.198
2.396ValTyr: 2.396 ± 0.507
0.0ValXaa: 0.0 ± 0.0
Trp
0.413TrpAla: 0.413 ± 0.19
0.248TrpCys: 0.248 ± 0.15
1.239TrpAsp: 1.239 ± 0.381
0.991TrpGlu: 0.991 ± 0.313
0.578TrpPhe: 0.578 ± 0.22
0.578TrpGly: 0.578 ± 0.28
0.083TrpHis: 0.083 ± 0.081
0.991TrpIle: 0.991 ± 0.346
0.909TrpLys: 0.909 ± 0.27
0.909TrpLeu: 0.909 ± 0.267
0.248TrpMet: 0.248 ± 0.158
0.33TrpAsn: 0.33 ± 0.133
0.165TrpPro: 0.165 ± 0.11
0.661TrpGln: 0.661 ± 0.211
0.578TrpArg: 0.578 ± 0.248
0.661TrpSer: 0.661 ± 0.192
0.33TrpThr: 0.33 ± 0.158
0.413TrpVal: 0.413 ± 0.187
0.083TrpTrp: 0.083 ± 0.082
0.496TrpTyr: 0.496 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.313TyrAla: 2.313 ± 0.31
0.248TyrCys: 0.248 ± 0.146
2.231TyrAsp: 2.231 ± 0.463
2.892TyrGlu: 2.892 ± 0.489
1.239TyrPhe: 1.239 ± 0.343
2.065TyrGly: 2.065 ± 0.52
0.33TyrHis: 0.33 ± 0.171
1.9TyrIle: 1.9 ± 0.557
2.892TyrLys: 2.892 ± 0.472
2.974TyrLeu: 2.974 ± 0.523
0.826TyrMet: 0.826 ± 0.289
2.065TyrAsn: 2.065 ± 0.49
1.487TyrPro: 1.487 ± 0.465
2.065TyrGln: 2.065 ± 0.505
1.9TyrArg: 1.9 ± 0.448
2.065TyrSer: 2.065 ± 0.577
2.479TyrThr: 2.479 ± 0.483
2.479TyrVal: 2.479 ± 0.676
0.578TyrTrp: 0.578 ± 0.204
2.065TyrTyr: 2.065 ± 0.321
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (12105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski