Amino acid dipepetide frequency for Legionella fallonii LLAP-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.175AlaAla: 6.175 ± 0.1
0.952AlaCys: 0.952 ± 0.033
3.317AlaAsp: 3.317 ± 0.063
4.397AlaGlu: 4.397 ± 0.069
3.082AlaPhe: 3.082 ± 0.05
4.453AlaGly: 4.453 ± 0.083
1.827AlaHis: 1.827 ± 0.038
6.047AlaIle: 6.047 ± 0.074
4.589AlaLys: 4.589 ± 0.065
9.09AlaLeu: 9.09 ± 0.096
2.007AlaMet: 2.007 ± 0.04
3.466AlaAsn: 3.466 ± 0.056
2.637AlaPro: 2.637 ± 0.048
3.718AlaGln: 3.718 ± 0.057
3.291AlaArg: 3.291 ± 0.061
4.622AlaSer: 4.622 ± 0.069
4.117AlaThr: 4.117 ± 0.063
4.722AlaVal: 4.722 ± 0.069
0.752AlaTrp: 0.752 ± 0.029
2.557AlaTyr: 2.557 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.788CysAla: 0.788 ± 0.027
0.198CysCys: 0.198 ± 0.012
0.599CysAsp: 0.599 ± 0.022
0.56CysGlu: 0.56 ± 0.02
0.679CysPhe: 0.679 ± 0.028
0.807CysGly: 0.807 ± 0.03
0.367CysHis: 0.367 ± 0.017
0.845CysIle: 0.845 ± 0.026
0.601CysLys: 0.601 ± 0.023
1.255CysLeu: 1.255 ± 0.035
0.281CysMet: 0.281 ± 0.015
0.47CysAsn: 0.47 ± 0.018
0.479CysPro: 0.479 ± 0.022
0.488CysGln: 0.488 ± 0.021
0.47CysArg: 0.47 ± 0.02
0.877CysSer: 0.877 ± 0.028
0.615CysThr: 0.615 ± 0.024
0.653CysVal: 0.653 ± 0.027
0.138CysTrp: 0.138 ± 0.01
0.487CysTyr: 0.487 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.596AspAla: 3.596 ± 0.068
0.56AspCys: 0.56 ± 0.022
2.433AspAsp: 2.433 ± 0.052
3.583AspGlu: 3.583 ± 0.067
2.371AspPhe: 2.371 ± 0.044
2.735AspGly: 2.735 ± 0.056
0.976AspHis: 0.976 ± 0.031
3.626AspIle: 3.626 ± 0.059
3.476AspLys: 3.476 ± 0.062
5.22AspLeu: 5.22 ± 0.066
1.075AspMet: 1.075 ± 0.037
2.428AspAsn: 2.428 ± 0.045
1.893AspPro: 1.893 ± 0.038
1.604AspGln: 1.604 ± 0.041
1.867AspArg: 1.867 ± 0.043
3.13AspSer: 3.13 ± 0.061
2.383AspThr: 2.383 ± 0.04
3.086AspVal: 3.086 ± 0.051
0.664AspTrp: 0.664 ± 0.024
2.01AspTyr: 2.01 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.274GluAla: 4.274 ± 0.08
0.584GluCys: 0.584 ± 0.022
2.488GluAsp: 2.488 ± 0.058
4.398GluGlu: 4.398 ± 0.08
2.392GluPhe: 2.392 ± 0.045
2.989GluGly: 2.989 ± 0.059
1.947GluHis: 1.947 ± 0.039
4.309GluIle: 4.309 ± 0.061
4.462GluLys: 4.462 ± 0.083
6.976GluLeu: 6.976 ± 0.099
1.47GluMet: 1.47 ± 0.035
2.701GluAsn: 2.701 ± 0.053
1.877GluPro: 1.877 ± 0.038
4.183GluGln: 4.183 ± 0.081
3.024GluArg: 3.024 ± 0.064
3.373GluSer: 3.373 ± 0.055
2.85GluThr: 2.85 ± 0.058
3.405GluVal: 3.405 ± 0.061
0.607GluTrp: 0.607 ± 0.023
1.921GluTyr: 1.921 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.357PheAla: 3.357 ± 0.064
0.642PheCys: 0.642 ± 0.025
2.398PheAsp: 2.398 ± 0.047
2.112PheGlu: 2.112 ± 0.042
2.423PhePhe: 2.423 ± 0.057
2.503PheGly: 2.503 ± 0.06
1.037PheHis: 1.037 ± 0.028
3.759PheIle: 3.759 ± 0.068
2.517PheLys: 2.517 ± 0.048
4.439PheLeu: 4.439 ± 0.083
0.953PheMet: 0.953 ± 0.027
2.455PheAsn: 2.455 ± 0.045
1.646PhePro: 1.646 ± 0.039
1.425PheGln: 1.425 ± 0.035
1.439PheArg: 1.439 ± 0.038
3.576PheSer: 3.576 ± 0.055
2.481PheThr: 2.481 ± 0.052
2.37PheVal: 2.37 ± 0.044
0.539PheTrp: 0.539 ± 0.022
1.727PheTyr: 1.727 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
4.338GlyAla: 4.338 ± 0.076
0.784GlyCys: 0.784 ± 0.026
2.662GlyAsp: 2.662 ± 0.046
3.106GlyGlu: 3.106 ± 0.058
3.046GlyPhe: 3.046 ± 0.063
3.94GlyGly: 3.94 ± 0.087
1.533GlyHis: 1.533 ± 0.038
4.822GlyIle: 4.822 ± 0.075
3.559GlyLys: 3.559 ± 0.055
6.349GlyLeu: 6.349 ± 0.076
1.623GlyMet: 1.623 ± 0.045
2.487GlyAsn: 2.487 ± 0.047
1.523GlyPro: 1.523 ± 0.036
2.401GlyGln: 2.401 ± 0.056
2.426GlyArg: 2.426 ± 0.053
3.684GlySer: 3.684 ± 0.061
3.149GlyThr: 3.149 ± 0.056
4.14GlyVal: 4.14 ± 0.065
0.817GlyTrp: 0.817 ± 0.031
2.432GlyTyr: 2.432 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.833HisAla: 1.833 ± 0.043
0.407HisCys: 0.407 ± 0.017
1.191HisAsp: 1.191 ± 0.034
1.418HisGlu: 1.418 ± 0.041
1.297HisPhe: 1.297 ± 0.032
1.56HisGly: 1.56 ± 0.037
0.959HisHis: 0.959 ± 0.037
1.611HisIle: 1.611 ± 0.039
1.152HisLys: 1.152 ± 0.032
2.899HisLeu: 2.899 ± 0.044
0.497HisMet: 0.497 ± 0.02
1.014HisAsn: 1.014 ± 0.034
1.273HisPro: 1.273 ± 0.033
1.451HisGln: 1.451 ± 0.04
1.102HisArg: 1.102 ± 0.03
1.7HisSer: 1.7 ± 0.042
1.172HisThr: 1.172 ± 0.032
1.369HisVal: 1.369 ± 0.033
0.376HisTrp: 0.376 ± 0.018
1.24HisTyr: 1.24 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.481IleAla: 6.481 ± 0.075
0.818IleCys: 0.818 ± 0.024
4.391IleAsp: 4.391 ± 0.063
4.768IleGlu: 4.768 ± 0.067
2.742IlePhe: 2.742 ± 0.057
4.594IleGly: 4.594 ± 0.075
1.796IleHis: 1.796 ± 0.039
5.5IleIle: 5.5 ± 0.081
4.979IleLys: 4.979 ± 0.064
6.877IleLeu: 6.877 ± 0.083
1.502IleMet: 1.502 ± 0.036
4.516IleAsn: 4.516 ± 0.066
3.328IlePro: 3.328 ± 0.056
2.946IleGln: 2.946 ± 0.054
2.983IleArg: 2.983 ± 0.044
5.27IleSer: 5.27 ± 0.074
4.331IleThr: 4.331 ± 0.067
4.044IleVal: 4.044 ± 0.064
0.641IleTrp: 0.641 ± 0.027
2.289IleTyr: 2.289 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.633LysAla: 4.633 ± 0.074
0.401LysCys: 0.401 ± 0.018
3.042LysAsp: 3.042 ± 0.054
5.025LysGlu: 5.025 ± 0.094
1.628LysPhe: 1.628 ± 0.036
3.179LysGly: 3.179 ± 0.056
1.458LysHis: 1.458 ± 0.03
4.719LysIle: 4.719 ± 0.066
4.996LysLys: 4.996 ± 0.078
5.95LysLeu: 5.95 ± 0.08
1.555LysMet: 1.555 ± 0.041
3.741LysAsn: 3.741 ± 0.061
2.607LysPro: 2.607 ± 0.049
3.505LysGln: 3.505 ± 0.062
2.821LysArg: 2.821 ± 0.045
3.75LysSer: 3.75 ± 0.055
3.679LysThr: 3.679 ± 0.068
3.245LysVal: 3.245 ± 0.059
0.497LysTrp: 0.497 ± 0.021
1.726LysTyr: 1.726 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
8.834LeuAla: 8.834 ± 0.091
1.369LeuCys: 1.369 ± 0.036
5.279LeuAsp: 5.279 ± 0.08
5.802LeuGlu: 5.802 ± 0.089
5.184LeuPhe: 5.184 ± 0.09
6.379LeuGly: 6.379 ± 0.089
2.628LeuHis: 2.628 ± 0.047
8.226LeuIle: 8.226 ± 0.092
6.561LeuLys: 6.561 ± 0.089
11.81LeuLeu: 11.81 ± 0.134
2.636LeuMet: 2.636 ± 0.051
5.655LeuAsn: 5.655 ± 0.073
4.728LeuPro: 4.728 ± 0.067
4.543LeuGln: 4.543 ± 0.071
4.384LeuArg: 4.384 ± 0.067
8.515LeuSer: 8.515 ± 0.1
6.047LeuThr: 6.047 ± 0.074
6.211LeuVal: 6.211 ± 0.082
1.077LeuTrp: 1.077 ± 0.032
3.284LeuTyr: 3.284 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.946MetAla: 1.946 ± 0.046
0.176MetCys: 0.176 ± 0.013
1.223MetAsp: 1.223 ± 0.036
1.276MetGlu: 1.276 ± 0.037
0.764MetPhe: 0.764 ± 0.026
1.449MetGly: 1.449 ± 0.041
0.63MetHis: 0.63 ± 0.026
1.589MetIle: 1.589 ± 0.033
1.603MetLys: 1.603 ± 0.056
2.512MetLeu: 2.512 ± 0.046
0.739MetMet: 0.739 ± 0.027
1.292MetAsn: 1.292 ± 0.033
1.086MetPro: 1.086 ± 0.032
1.18MetGln: 1.18 ± 0.028
1.088MetArg: 1.088 ± 0.031
1.722MetSer: 1.722 ± 0.042
1.383MetThr: 1.383 ± 0.033
1.377MetVal: 1.377 ± 0.038
0.162MetTrp: 0.162 ± 0.01
0.544MetTyr: 0.544 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.597AsnAla: 3.597 ± 0.054
0.529AsnCys: 0.529 ± 0.021
2.353AsnAsp: 2.353 ± 0.046
3.163AsnGlu: 3.163 ± 0.053
1.92AsnPhe: 1.92 ± 0.036
2.729AsnGly: 2.729 ± 0.06
1.294AsnHis: 1.294 ± 0.031
3.495AsnIle: 3.495 ± 0.05
3.654AsnLys: 3.654 ± 0.066
4.773AsnLeu: 4.773 ± 0.069
0.97AsnMet: 0.97 ± 0.031
2.911AsnAsn: 2.911 ± 0.063
2.635AsnPro: 2.635 ± 0.052
2.746AsnGln: 2.746 ± 0.057
1.963AsnArg: 1.963 ± 0.037
3.287AsnSer: 3.287 ± 0.07
2.716AsnThr: 2.716 ± 0.045
2.525AsnVal: 2.525 ± 0.05
0.601AsnTrp: 0.601 ± 0.025
1.963AsnTyr: 1.963 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
2.664ProAla: 2.664 ± 0.05
0.411ProCys: 0.411 ± 0.017
2.118ProAsp: 2.118 ± 0.05
3.051ProGlu: 3.051 ± 0.051
1.815ProPhe: 1.815 ± 0.036
2.462ProGly: 2.462 ± 0.051
0.985ProHis: 0.985 ± 0.03
3.073ProIle: 3.073 ± 0.053
2.254ProLys: 2.254 ± 0.042
4.331ProLeu: 4.331 ± 0.062
0.935ProMet: 0.935 ± 0.03
1.884ProAsn: 1.884 ± 0.042
1.574ProPro: 1.574 ± 0.049
2.04ProGln: 2.04 ± 0.042
1.335ProArg: 1.335 ± 0.034
2.66ProSer: 2.66 ± 0.047
2.243ProThr: 2.243 ± 0.045
2.84ProVal: 2.84 ± 0.057
0.473ProTrp: 0.473 ± 0.019
1.428ProTyr: 1.428 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.722GlnAla: 3.722 ± 0.061
0.55GlnCys: 0.55 ± 0.023
1.89GlnAsp: 1.89 ± 0.044
2.967GlnGlu: 2.967 ± 0.087
2.138GlnPhe: 2.138 ± 0.036
2.681GlnGly: 2.681 ± 0.05
1.262GlnHis: 1.262 ± 0.03
3.279GlnIle: 3.279 ± 0.053
3.011GlnLys: 3.011 ± 0.052
5.751GlnLeu: 5.751 ± 0.088
1.06GlnMet: 1.06 ± 0.028
2.157GlnAsn: 2.157 ± 0.046
1.673GlnPro: 1.673 ± 0.04
3.102GlnGln: 3.102 ± 0.076
2.211GlnArg: 2.211 ± 0.068
2.987GlnSer: 2.987 ± 0.057
2.348GlnThr: 2.348 ± 0.055
2.65GlnVal: 2.65 ± 0.053
0.67GlnTrp: 0.67 ± 0.027
1.646GlnTyr: 1.646 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.928ArgAla: 2.928 ± 0.05
0.474ArgCys: 0.474 ± 0.021
2.093ArgAsp: 2.093 ± 0.04
2.654ArgGlu: 2.654 ± 0.051
2.055ArgPhe: 2.055 ± 0.041
2.209ArgGly: 2.209 ± 0.041
1.084ArgHis: 1.084 ± 0.03
3.091ArgIle: 3.091 ± 0.048
2.472ArgLys: 2.472 ± 0.055
4.878ArgLeu: 4.878 ± 0.077
1.081ArgMet: 1.081 ± 0.029
1.852ArgAsn: 1.852 ± 0.039
1.433ArgPro: 1.433 ± 0.033
1.997ArgGln: 1.997 ± 0.051
1.851ArgArg: 1.851 ± 0.048
2.334ArgSer: 2.334 ± 0.049
2.018ArgThr: 2.018 ± 0.039
2.592ArgVal: 2.592 ± 0.05
0.504ArgTrp: 0.504 ± 0.022
1.682ArgTyr: 1.682 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.651SerAla: 4.651 ± 0.063
0.844SerCys: 0.844 ± 0.026
3.212SerAsp: 3.212 ± 0.055
3.636SerGlu: 3.636 ± 0.063
3.178SerPhe: 3.178 ± 0.053
4.368SerGly: 4.368 ± 0.063
1.711SerHis: 1.711 ± 0.036
5.073SerIle: 5.073 ± 0.062
3.646SerLys: 3.646 ± 0.059
8.015SerLeu: 8.015 ± 0.088
1.7SerMet: 1.7 ± 0.042
3.156SerAsn: 3.156 ± 0.057
2.912SerPro: 2.912 ± 0.055
2.996SerGln: 2.996 ± 0.045
2.601SerArg: 2.601 ± 0.049
5.121SerSer: 5.121 ± 0.09
3.6SerThr: 3.6 ± 0.059
3.764SerVal: 3.764 ± 0.055
0.827SerTrp: 0.827 ± 0.03
2.362SerTyr: 2.362 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.162ThrAla: 4.162 ± 0.064
0.569ThrCys: 0.569 ± 0.022
2.459ThrAsp: 2.459 ± 0.05
2.94ThrGlu: 2.94 ± 0.055
2.047ThrPhe: 2.047 ± 0.042
3.466ThrGly: 3.466 ± 0.055
1.411ThrHis: 1.411 ± 0.034
4.149ThrIle: 4.149 ± 0.061
2.828ThrLys: 2.828 ± 0.05
6.293ThrLeu: 6.293 ± 0.082
1.162ThrMet: 1.162 ± 0.027
2.501ThrAsn: 2.501 ± 0.047
2.964ThrPro: 2.964 ± 0.051
2.643ThrGln: 2.643 ± 0.055
2.062ThrArg: 2.062 ± 0.043
3.432ThrSer: 3.432 ± 0.057
3.16ThrThr: 3.16 ± 0.064
3.492ThrVal: 3.492 ± 0.054
0.493ThrTrp: 0.493 ± 0.02
1.743ThrTyr: 1.743 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.761ValAla: 4.761 ± 0.066
0.704ValCys: 0.704 ± 0.022
3.23ValAsp: 3.23 ± 0.052
3.145ValGlu: 3.145 ± 0.05
2.655ValPhe: 2.655 ± 0.057
3.49ValGly: 3.49 ± 0.06
1.32ValHis: 1.32 ± 0.038
4.633ValIle: 4.633 ± 0.07
3.386ValLys: 3.386 ± 0.053
6.314ValLeu: 6.314 ± 0.071
1.52ValMet: 1.52 ± 0.044
3.052ValAsn: 3.052 ± 0.052
2.332ValPro: 2.332 ± 0.054
2.095ValGln: 2.095 ± 0.049
2.262ValArg: 2.262 ± 0.053
4.151ValSer: 4.151 ± 0.058
3.494ValThr: 3.494 ± 0.058
4.048ValVal: 4.048 ± 0.073
0.566ValTrp: 0.566 ± 0.019
1.853ValTyr: 1.853 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.665TrpAla: 0.665 ± 0.025
0.142TrpCys: 0.142 ± 0.011
0.524TrpAsp: 0.524 ± 0.018
0.501TrpGlu: 0.501 ± 0.024
0.586TrpPhe: 0.586 ± 0.023
0.697TrpGly: 0.697 ± 0.026
0.368TrpHis: 0.368 ± 0.018
0.849TrpIle: 0.849 ± 0.03
0.496TrpLys: 0.496 ± 0.019
1.385TrpLeu: 1.385 ± 0.039
0.297TrpMet: 0.297 ± 0.014
0.507TrpAsn: 0.507 ± 0.023
0.434TrpPro: 0.434 ± 0.017
0.688TrpGln: 0.688 ± 0.023
0.538TrpArg: 0.538 ± 0.024
0.732TrpSer: 0.732 ± 0.028
0.466TrpThr: 0.466 ± 0.02
0.661TrpVal: 0.661 ± 0.024
0.168TrpTrp: 0.168 ± 0.013
0.395TrpTyr: 0.395 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.413TyrAla: 2.413 ± 0.043
0.544TyrCys: 0.544 ± 0.022
1.813TyrAsp: 1.813 ± 0.086
1.728TyrGlu: 1.728 ± 0.041
1.798TyrPhe: 1.798 ± 0.043
2.134TyrGly: 2.134 ± 0.047
0.929TyrHis: 0.929 ± 0.03
2.102TyrIle: 2.102 ± 0.051
1.915TyrLys: 1.915 ± 0.04
4.035TyrLeu: 4.035 ± 0.064
0.675TyrMet: 0.675 ± 0.025
1.577TyrAsn: 1.577 ± 0.044
1.541TyrPro: 1.541 ± 0.036
2.002TyrGln: 2.002 ± 0.04
1.565TyrArg: 1.565 ± 0.035
2.447TyrSer: 2.447 ± 0.046
1.725TyrThr: 1.725 ± 0.038
1.817TyrVal: 1.817 ± 0.039
0.528TyrTrp: 0.528 ± 0.025
1.413TyrTyr: 1.413 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3840 proteins (1280907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski