Amino acid dipepetide frequency for Providencia phage vB_PreS-PibeRecoleta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.392AlaAla: 9.392 ± 1.38
0.475AlaCys: 0.475 ± 0.167
5.013AlaAsp: 5.013 ± 0.436
6.754AlaGlu: 6.754 ± 0.55
3.694AlaPhe: 3.694 ± 0.41
6.754AlaGly: 6.754 ± 0.909
1.477AlaHis: 1.477 ± 0.268
5.646AlaIle: 5.646 ± 0.701
5.804AlaLys: 5.804 ± 0.841
7.545AlaLeu: 7.545 ± 0.786
2.849AlaMet: 2.849 ± 0.392
3.166AlaAsn: 3.166 ± 0.371
3.694AlaPro: 3.694 ± 0.417
4.327AlaGln: 4.327 ± 0.737
4.538AlaArg: 4.538 ± 0.638
5.171AlaSer: 5.171 ± 0.623
5.646AlaThr: 5.646 ± 0.554
5.91AlaVal: 5.91 ± 0.645
1.161AlaTrp: 1.161 ± 0.235
3.166AlaTyr: 3.166 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.209
0.317CysCys: 0.317 ± 0.129
0.791CysAsp: 0.791 ± 0.254
0.528CysGlu: 0.528 ± 0.13
0.475CysPhe: 0.475 ± 0.133
0.633CysGly: 0.633 ± 0.18
0.264CysHis: 0.264 ± 0.116
0.317CysIle: 0.317 ± 0.128
0.317CysLys: 0.317 ± 0.132
0.58CysLeu: 0.58 ± 0.146
0.264CysMet: 0.264 ± 0.112
0.475CysAsn: 0.475 ± 0.138
0.686CysPro: 0.686 ± 0.234
0.317CysGln: 0.317 ± 0.151
0.686CysArg: 0.686 ± 0.184
0.633CysSer: 0.633 ± 0.157
0.528CysThr: 0.528 ± 0.163
0.369CysVal: 0.369 ± 0.151
0.106CysTrp: 0.106 ± 0.073
0.369CysTyr: 0.369 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
5.593AspAla: 5.593 ± 0.52
0.475AspCys: 0.475 ± 0.172
4.907AspAsp: 4.907 ± 0.701
4.591AspGlu: 4.591 ± 0.627
2.427AspPhe: 2.427 ± 0.27
5.593AspGly: 5.593 ± 0.65
1.003AspHis: 1.003 ± 0.236
3.588AspIle: 3.588 ± 0.456
3.43AspLys: 3.43 ± 0.427
4.802AspLeu: 4.802 ± 0.489
1.794AspMet: 1.794 ± 0.24
2.005AspAsn: 2.005 ± 0.317
3.482AspPro: 3.482 ± 0.543
1.794AspGln: 1.794 ± 0.276
3.588AspArg: 3.588 ± 0.415
2.797AspSer: 2.797 ± 0.453
3.641AspThr: 3.641 ± 0.472
4.749AspVal: 4.749 ± 0.513
1.53AspTrp: 1.53 ± 0.323
2.638AspTyr: 2.638 ± 0.267
0.0AspXaa: 0.0 ± 0.0
Glu
6.332GluAla: 6.332 ± 0.7
1.214GluCys: 1.214 ± 0.241
4.327GluAsp: 4.327 ± 0.454
4.96GluGlu: 4.96 ± 0.537
2.216GluPhe: 2.216 ± 0.314
3.324GluGly: 3.324 ± 0.405
1.161GluHis: 1.161 ± 0.37
4.168GluIle: 4.168 ± 0.469
3.324GluLys: 3.324 ± 0.463
5.171GluLeu: 5.171 ± 0.587
2.322GluMet: 2.322 ± 0.37
3.324GluAsn: 3.324 ± 0.484
2.269GluPro: 2.269 ± 0.389
2.111GluGln: 2.111 ± 0.288
3.482GluArg: 3.482 ± 0.396
4.379GluSer: 4.379 ± 0.296
3.588GluThr: 3.588 ± 0.385
5.382GluVal: 5.382 ± 0.629
1.53GluTrp: 1.53 ± 0.265
2.005GluTyr: 2.005 ± 0.257
0.0GluXaa: 0.0 ± 0.0
Phe
3.271PheAla: 3.271 ± 0.417
0.528PheCys: 0.528 ± 0.171
3.641PheAsp: 3.641 ± 0.415
2.955PheGlu: 2.955 ± 0.398
1.319PhePhe: 1.319 ± 0.289
2.849PheGly: 2.849 ± 0.457
0.739PheHis: 0.739 ± 0.183
1.741PheIle: 1.741 ± 0.306
2.955PheLys: 2.955 ± 0.386
1.794PheLeu: 1.794 ± 0.337
1.319PheMet: 1.319 ± 0.266
1.847PheAsn: 1.847 ± 0.294
1.372PhePro: 1.372 ± 0.297
0.844PheGln: 0.844 ± 0.206
2.058PheArg: 2.058 ± 0.3
1.952PheSer: 1.952 ± 0.22
2.269PheThr: 2.269 ± 0.389
2.322PheVal: 2.322 ± 0.318
0.475PheTrp: 0.475 ± 0.174
0.844PheTyr: 0.844 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
6.015GlyAla: 6.015 ± 0.574
0.791GlyCys: 0.791 ± 0.208
4.274GlyAsp: 4.274 ± 0.525
4.485GlyGlu: 4.485 ± 0.534
3.06GlyPhe: 3.06 ± 0.505
6.279GlyGly: 6.279 ± 1.03
1.372GlyHis: 1.372 ± 0.3
3.746GlyIle: 3.746 ± 0.522
4.379GlyLys: 4.379 ± 0.358
4.802GlyLeu: 4.802 ± 0.623
2.585GlyMet: 2.585 ± 0.39
2.797GlyAsn: 2.797 ± 0.447
1.53GlyPro: 1.53 ± 0.352
2.48GlyGln: 2.48 ± 0.484
4.116GlyArg: 4.116 ± 0.533
3.166GlySer: 3.166 ± 0.376
4.696GlyThr: 4.696 ± 0.649
4.802GlyVal: 4.802 ± 0.448
1.741GlyTrp: 1.741 ± 0.278
2.797GlyTyr: 2.797 ± 0.399
0.0GlyXaa: 0.0 ± 0.0
His
1.214HisAla: 1.214 ± 0.292
0.106HisCys: 0.106 ± 0.077
1.372HisAsp: 1.372 ± 0.308
0.791HisGlu: 0.791 ± 0.202
0.528HisPhe: 0.528 ± 0.149
1.266HisGly: 1.266 ± 0.224
0.422HisHis: 0.422 ± 0.17
1.161HisIle: 1.161 ± 0.239
1.266HisLys: 1.266 ± 0.292
1.53HisLeu: 1.53 ± 0.207
0.369HisMet: 0.369 ± 0.133
0.633HisAsn: 0.633 ± 0.167
0.791HisPro: 0.791 ± 0.22
0.58HisGln: 0.58 ± 0.206
1.161HisArg: 1.161 ± 0.268
0.897HisSer: 0.897 ± 0.213
1.055HisThr: 1.055 ± 0.326
1.688HisVal: 1.688 ± 0.34
0.211HisTrp: 0.211 ± 0.118
1.108HisTyr: 1.108 ± 0.233
0.0HisXaa: 0.0 ± 0.0
Ile
5.435IleAla: 5.435 ± 0.469
0.528IleCys: 0.528 ± 0.175
4.221IleAsp: 4.221 ± 0.422
4.643IleGlu: 4.643 ± 0.455
1.741IlePhe: 1.741 ± 0.275
3.957IleGly: 3.957 ± 0.432
1.003IleHis: 1.003 ± 0.258
3.377IleIle: 3.377 ± 0.418
3.482IleLys: 3.482 ± 0.424
2.955IleLeu: 2.955 ± 0.309
1.161IleMet: 1.161 ± 0.27
3.166IleAsn: 3.166 ± 0.433
2.533IlePro: 2.533 ± 0.327
1.952IleGln: 1.952 ± 0.288
3.219IleArg: 3.219 ± 0.38
2.955IleSer: 2.955 ± 0.456
3.271IleThr: 3.271 ± 0.366
4.327IleVal: 4.327 ± 0.531
0.422IleTrp: 0.422 ± 0.151
1.794IleTyr: 1.794 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
5.118LysAla: 5.118 ± 0.536
0.422LysCys: 0.422 ± 0.13
3.06LysAsp: 3.06 ± 0.351
4.802LysGlu: 4.802 ± 0.648
1.583LysPhe: 1.583 ± 0.298
3.43LysGly: 3.43 ± 0.367
1.53LysHis: 1.53 ± 0.275
3.535LysIle: 3.535 ± 0.506
3.641LysLys: 3.641 ± 0.522
3.957LysLeu: 3.957 ± 0.645
2.374LysMet: 2.374 ± 0.355
2.427LysAsn: 2.427 ± 0.357
2.533LysPro: 2.533 ± 0.377
1.952LysGln: 1.952 ± 0.322
4.116LysArg: 4.116 ± 0.503
3.535LysSer: 3.535 ± 0.496
3.43LysThr: 3.43 ± 0.451
2.638LysVal: 2.638 ± 0.321
1.003LysTrp: 1.003 ± 0.297
2.111LysTyr: 2.111 ± 0.332
0.0LysXaa: 0.0 ± 0.0
Leu
8.126LeuAla: 8.126 ± 1.116
0.633LeuCys: 0.633 ± 0.168
5.488LeuAsp: 5.488 ± 0.504
4.591LeuGlu: 4.591 ± 0.551
3.06LeuPhe: 3.06 ± 0.447
4.749LeuGly: 4.749 ± 0.658
1.161LeuHis: 1.161 ± 0.346
3.43LeuIle: 3.43 ± 0.448
4.591LeuLys: 4.591 ± 0.496
5.118LeuLeu: 5.118 ± 0.483
1.847LeuMet: 1.847 ± 0.357
3.271LeuAsn: 3.271 ± 0.451
3.905LeuPro: 3.905 ± 0.528
2.955LeuGln: 2.955 ± 0.399
4.432LeuArg: 4.432 ± 0.545
4.485LeuSer: 4.485 ± 0.423
5.065LeuThr: 5.065 ± 0.552
4.432LeuVal: 4.432 ± 0.428
1.108LeuTrp: 1.108 ± 0.244
2.269LeuTyr: 2.269 ± 0.386
0.0LeuXaa: 0.0 ± 0.0
Met
3.166MetAla: 3.166 ± 0.329
0.211MetCys: 0.211 ± 0.102
1.477MetAsp: 1.477 ± 0.255
1.477MetGlu: 1.477 ± 0.393
0.791MetPhe: 0.791 ± 0.152
2.005MetGly: 2.005 ± 0.337
0.739MetHis: 0.739 ± 0.167
1.53MetIle: 1.53 ± 0.338
1.636MetLys: 1.636 ± 0.323
2.163MetLeu: 2.163 ± 0.308
0.844MetMet: 0.844 ± 0.168
1.266MetAsn: 1.266 ± 0.362
2.111MetPro: 2.111 ± 0.382
1.372MetGln: 1.372 ± 0.284
2.216MetArg: 2.216 ± 0.328
2.849MetSer: 2.849 ± 0.4
2.005MetThr: 2.005 ± 0.313
1.741MetVal: 1.741 ± 0.258
0.475MetTrp: 0.475 ± 0.134
1.319MetTyr: 1.319 ± 0.251
0.0MetXaa: 0.0 ± 0.0
Asn
4.485AsnAla: 4.485 ± 0.47
0.264AsnCys: 0.264 ± 0.129
2.111AsnAsp: 2.111 ± 0.341
2.638AsnGlu: 2.638 ± 0.326
1.161AsnPhe: 1.161 ± 0.194
4.116AsnGly: 4.116 ± 0.406
0.528AsnHis: 0.528 ± 0.193
2.322AsnIle: 2.322 ± 0.286
1.794AsnLys: 1.794 ± 0.362
3.271AsnLeu: 3.271 ± 0.352
1.214AsnMet: 1.214 ± 0.288
1.741AsnAsn: 1.741 ± 0.388
2.849AsnPro: 2.849 ± 0.451
1.636AsnGln: 1.636 ± 0.312
2.322AsnArg: 2.322 ± 0.365
2.374AsnSer: 2.374 ± 0.336
3.43AsnThr: 3.43 ± 0.449
2.163AsnVal: 2.163 ± 0.288
0.739AsnTrp: 0.739 ± 0.19
1.794AsnTyr: 1.794 ± 0.403
0.0AsnXaa: 0.0 ± 0.0
Pro
3.746ProAla: 3.746 ± 0.351
0.422ProCys: 0.422 ± 0.2
3.377ProAsp: 3.377 ± 0.564
2.744ProGlu: 2.744 ± 0.413
1.741ProPhe: 1.741 ± 0.334
3.008ProGly: 3.008 ± 0.436
1.161ProHis: 1.161 ± 0.241
2.797ProIle: 2.797 ± 0.423
2.48ProLys: 2.48 ± 0.356
3.377ProLeu: 3.377 ± 0.439
1.266ProMet: 1.266 ± 0.359
2.48ProAsn: 2.48 ± 0.377
1.794ProPro: 1.794 ± 0.501
1.53ProGln: 1.53 ± 0.368
1.583ProArg: 1.583 ± 0.361
2.638ProSer: 2.638 ± 0.409
3.008ProThr: 3.008 ± 0.449
2.902ProVal: 2.902 ± 0.496
0.791ProTrp: 0.791 ± 0.195
2.163ProTyr: 2.163 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
3.641GlnAla: 3.641 ± 0.504
0.211GlnCys: 0.211 ± 0.103
1.9GlnAsp: 1.9 ± 0.308
1.688GlnGlu: 1.688 ± 0.352
1.741GlnPhe: 1.741 ± 0.318
2.48GlnGly: 2.48 ± 0.314
0.686GlnHis: 0.686 ± 0.173
1.9GlnIle: 1.9 ± 0.32
2.163GlnLys: 2.163 ± 0.558
3.166GlnLeu: 3.166 ± 0.408
1.688GlnMet: 1.688 ± 0.345
1.372GlnAsn: 1.372 ± 0.206
1.847GlnPro: 1.847 ± 0.378
1.583GlnGln: 1.583 ± 0.364
2.163GlnArg: 2.163 ± 0.353
2.48GlnSer: 2.48 ± 0.409
2.216GlnThr: 2.216 ± 0.387
2.955GlnVal: 2.955 ± 0.638
0.528GlnTrp: 0.528 ± 0.188
1.53GlnTyr: 1.53 ± 0.225
0.0GlnXaa: 0.0 ± 0.0
Arg
4.749ArgAla: 4.749 ± 0.492
0.528ArgCys: 0.528 ± 0.167
3.746ArgAsp: 3.746 ± 0.439
2.797ArgGlu: 2.797 ± 0.395
2.638ArgPhe: 2.638 ± 0.327
3.113ArgGly: 3.113 ± 0.464
0.95ArgHis: 0.95 ± 0.223
3.008ArgIle: 3.008 ± 0.28
3.324ArgLys: 3.324 ± 0.399
5.013ArgLeu: 5.013 ± 0.439
1.9ArgMet: 1.9 ± 0.307
1.741ArgAsn: 1.741 ± 0.312
2.374ArgPro: 2.374 ± 0.347
2.058ArgGln: 2.058 ± 0.37
2.955ArgArg: 2.955 ± 0.399
3.06ArgSer: 3.06 ± 0.344
3.324ArgThr: 3.324 ± 0.387
5.118ArgVal: 5.118 ± 0.507
0.95ArgTrp: 0.95 ± 0.185
1.688ArgTyr: 1.688 ± 0.257
0.0ArgXaa: 0.0 ± 0.0
Ser
4.907SerAla: 4.907 ± 0.567
0.739SerCys: 0.739 ± 0.174
3.377SerAsp: 3.377 ± 0.475
3.113SerGlu: 3.113 ± 0.387
2.269SerPhe: 2.269 ± 0.41
4.643SerGly: 4.643 ± 0.358
1.266SerHis: 1.266 ± 0.264
3.482SerIle: 3.482 ± 0.433
3.694SerLys: 3.694 ± 0.526
4.327SerLeu: 4.327 ± 0.471
2.585SerMet: 2.585 ± 0.328
2.849SerAsn: 2.849 ± 0.395
2.744SerPro: 2.744 ± 0.431
2.48SerGln: 2.48 ± 0.492
2.744SerArg: 2.744 ± 0.424
2.902SerSer: 2.902 ± 0.36
2.797SerThr: 2.797 ± 0.412
4.168SerVal: 4.168 ± 0.527
1.003SerTrp: 1.003 ± 0.214
2.111SerTyr: 2.111 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
5.488ThrAla: 5.488 ± 0.575
0.211ThrCys: 0.211 ± 0.108
3.852ThrAsp: 3.852 ± 0.375
3.641ThrGlu: 3.641 ± 0.484
2.427ThrPhe: 2.427 ± 0.353
4.168ThrGly: 4.168 ± 0.574
0.739ThrHis: 0.739 ± 0.216
3.905ThrIle: 3.905 ± 0.556
3.271ThrLys: 3.271 ± 0.446
4.96ThrLeu: 4.96 ± 0.456
1.688ThrMet: 1.688 ± 0.273
2.533ThrAsn: 2.533 ± 0.344
3.324ThrPro: 3.324 ± 0.396
2.585ThrGln: 2.585 ± 0.374
2.955ThrArg: 2.955 ± 0.317
3.43ThrSer: 3.43 ± 0.468
4.327ThrThr: 4.327 ± 0.528
5.593ThrVal: 5.593 ± 0.707
1.161ThrTrp: 1.161 ± 0.253
1.794ThrTyr: 1.794 ± 0.277
0.0ThrXaa: 0.0 ± 0.0
Val
6.49ValAla: 6.49 ± 0.762
0.686ValCys: 0.686 ± 0.164
3.588ValAsp: 3.588 ± 0.362
5.646ValGlu: 5.646 ± 0.464
2.005ValPhe: 2.005 ± 0.246
4.591ValGly: 4.591 ± 0.588
0.897ValHis: 0.897 ± 0.22
3.905ValIle: 3.905 ± 0.386
3.377ValLys: 3.377 ± 0.44
6.279ValLeu: 6.279 ± 0.55
1.847ValMet: 1.847 ± 0.356
3.43ValAsn: 3.43 ± 0.448
2.585ValPro: 2.585 ± 0.333
2.849ValGln: 2.849 ± 0.333
3.957ValArg: 3.957 ± 0.508
4.485ValSer: 4.485 ± 0.461
4.591ValThr: 4.591 ± 0.482
4.696ValVal: 4.696 ± 0.541
0.897ValTrp: 0.897 ± 0.198
2.374ValTyr: 2.374 ± 0.477
0.0ValXaa: 0.0 ± 0.0
Trp
1.847TrpAla: 1.847 ± 0.367
0.158TrpCys: 0.158 ± 0.098
1.425TrpAsp: 1.425 ± 0.272
1.372TrpGlu: 1.372 ± 0.322
0.897TrpPhe: 0.897 ± 0.22
0.844TrpGly: 0.844 ± 0.199
0.369TrpHis: 0.369 ± 0.147
0.686TrpIle: 0.686 ± 0.147
0.844TrpLys: 0.844 ± 0.189
1.583TrpLeu: 1.583 ± 0.311
0.211TrpMet: 0.211 ± 0.104
0.739TrpAsn: 0.739 ± 0.181
0.686TrpPro: 0.686 ± 0.204
1.003TrpGln: 1.003 ± 0.226
0.633TrpArg: 0.633 ± 0.177
1.214TrpSer: 1.214 ± 0.239
0.686TrpThr: 0.686 ± 0.19
0.791TrpVal: 0.791 ± 0.244
0.369TrpTrp: 0.369 ± 0.133
0.475TrpTyr: 0.475 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.316
0.528TyrCys: 0.528 ± 0.164
2.48TyrAsp: 2.48 ± 0.422
2.374TyrGlu: 2.374 ± 0.332
1.319TyrPhe: 1.319 ± 0.282
2.163TyrGly: 2.163 ± 0.31
0.686TyrHis: 0.686 ± 0.197
1.9TyrIle: 1.9 ± 0.336
1.425TyrLys: 1.425 ± 0.308
2.322TyrLeu: 2.322 ± 0.375
1.214TyrMet: 1.214 ± 0.196
1.688TyrAsn: 1.688 ± 0.282
1.9TyrPro: 1.9 ± 0.37
1.53TyrGln: 1.53 ± 0.291
2.111TyrArg: 2.111 ± 0.273
2.797TyrSer: 2.797 ± 0.378
2.48TyrThr: 2.48 ± 0.355
2.427TyrVal: 2.427 ± 0.361
0.633TyrTrp: 0.633 ± 0.184
1.214TyrTyr: 1.214 ± 0.258
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (18953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski