Amino acid dipepetide frequency for Deinococcus geothermalis (strain DSM 11300 / AG-3a)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.412AlaAla: 17.412 ± 0.188	0.912AlaCys: 0.912 ± 0.031	5.735AlaAsp: 5.735 ± 0.077	7.211AlaGlu: 7.211 ± 0.103	4.23AlaPhe: 4.23 ± 0.076	11.142AlaGly: 11.142 ± 0.138	2.717AlaHis: 2.717 ± 0.054	3.634AlaIle: 3.634 ± 0.071	2.418AlaLys: 2.418 ± 0.061	16.952AlaLeu: 16.952 ± 0.171	2.086AlaMet: 2.086 ± 0.052	2.404AlaAsn: 2.404 ± 0.058	6.421AlaPro: 6.421 ± 0.103	5.899AlaGln: 5.899 ± 0.102	11.169AlaArg: 11.169 ± 0.137	5.604AlaSer: 5.604 ± 0.081	5.867AlaThr: 5.867 ± 0.096	8.987AlaVal: 8.987 ± 0.109	1.898AlaTrp: 1.898 ± 0.051	3.0AlaTyr: 3.0 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.685CysAla: 0.685 ± 0.028	0.075CysCys: 0.075 ± 0.01	0.298CysAsp: 0.298 ± 0.016	0.282CysGlu: 0.282 ± 0.016	0.152CysPhe: 0.152 ± 0.012	0.721CysGly: 0.721 ± 0.028	0.135CysHis: 0.135 ± 0.012	0.197CysIle: 0.197 ± 0.014	0.113CysLys: 0.113 ± 0.011	0.586CysLeu: 0.586 ± 0.025	0.102CysMet: 0.102 ± 0.011	0.128CysAsn: 0.128 ± 0.012	0.454CysPro: 0.454 ± 0.025	0.184CysGln: 0.184 ± 0.015	0.423CysArg: 0.423 ± 0.02	0.337CysSer: 0.337 ± 0.02	0.374CysThr: 0.374 ± 0.022	0.47CysVal: 0.47 ± 0.022	0.073CysTrp: 0.073 ± 0.008	0.122CysTyr: 0.122 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.042AspAla: 6.042 ± 0.095	0.238AspCys: 0.238 ± 0.015	2.06AspAsp: 2.06 ± 0.052	2.985AspGlu: 2.985 ± 0.062	1.709AspPhe: 1.709 ± 0.046	4.072AspGly: 4.072 ± 0.077	1.102AspHis: 1.102 ± 0.036	1.571AspIle: 1.571 ± 0.044	0.954AspLys: 0.954 ± 0.041	6.839AspLeu: 6.839 ± 0.093	0.728AspMet: 0.728 ± 0.026	0.915AspAsn: 0.915 ± 0.036	3.756AspPro: 3.756 ± 0.069	1.387AspGln: 1.387 ± 0.041	3.377AspArg: 3.377 ± 0.059	1.708AspSer: 1.708 ± 0.037	2.6AspThr: 2.6 ± 0.053	4.294AspVal: 4.294 ± 0.069	0.738AspTrp: 0.738 ± 0.033	1.094AspTyr: 1.094 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.168GluAla: 8.168 ± 0.112	0.234GluCys: 0.234 ± 0.015	2.646GluAsp: 2.646 ± 0.06	3.665GluGlu: 3.665 ± 0.08	1.528GluPhe: 1.528 ± 0.04	4.958GluGly: 4.958 ± 0.086	1.379GluHis: 1.379 ± 0.042	2.085GluIle: 2.085 ± 0.052	1.508GluLys: 1.508 ± 0.043	6.364GluLeu: 6.364 ± 0.1	0.969GluMet: 0.969 ± 0.037	1.352GluAsn: 1.352 ± 0.038	2.271GluPro: 2.271 ± 0.053	2.476GluGln: 2.476 ± 0.052	5.901GluArg: 5.901 ± 0.086	1.97GluSer: 1.97 ± 0.047	2.948GluThr: 2.948 ± 0.058	5.128GluVal: 5.128 ± 0.079	0.789GluTrp: 0.789 ± 0.031	1.283GluTyr: 1.283 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.594PheAla: 3.594 ± 0.078	0.229PheCys: 0.229 ± 0.015	1.736PheAsp: 1.736 ± 0.046	1.81PheGlu: 1.81 ± 0.05	1.063PhePhe: 1.063 ± 0.036	3.139PheGly: 3.139 ± 0.069	0.586PheHis: 0.586 ± 0.023	1.096PheIle: 1.096 ± 0.037	0.76PheLys: 0.76 ± 0.031	3.436PheLeu: 3.436 ± 0.081	0.524PheMet: 0.524 ± 0.024	0.778PheAsn: 0.778 ± 0.027	1.829PhePro: 1.829 ± 0.05	1.083PheGln: 1.083 ± 0.034	2.074PheArg: 2.074 ± 0.049	1.703PheSer: 1.703 ± 0.048	2.131PheThr: 2.131 ± 0.05	2.409PheVal: 2.409 ± 0.052	0.489PheTrp: 0.489 ± 0.021	0.771PheTyr: 0.771 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.485GlyAla: 9.485 ± 0.121	0.547GlyCys: 0.547 ± 0.027	3.988GlyAsp: 3.988 ± 0.077	5.58GlyGlu: 5.58 ± 0.097	2.974GlyPhe: 2.974 ± 0.066	8.25GlyGly: 8.25 ± 0.113	2.001GlyHis: 2.001 ± 0.052	3.252GlyIle: 3.252 ± 0.071	2.82GlyLys: 2.82 ± 0.056	10.504GlyLeu: 10.504 ± 0.125	1.929GlyMet: 1.929 ± 0.056	2.249GlyAsn: 2.249 ± 0.063	3.764GlyPro: 3.764 ± 0.069	4.097GlyGln: 4.097 ± 0.081	6.639GlyArg: 6.639 ± 0.097	4.323GlySer: 4.323 ± 0.083	5.632GlyThr: 5.632 ± 0.11	7.818GlyVal: 7.818 ± 0.096	1.473GlyTrp: 1.473 ± 0.046	2.324GlyTyr: 2.324 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.853HisAla: 2.853 ± 0.06	0.157HisCys: 0.157 ± 0.013	1.038HisAsp: 1.038 ± 0.037	1.02HisGlu: 1.02 ± 0.031	0.719HisPhe: 0.719 ± 0.027	1.907HisGly: 1.907 ± 0.051	0.638HisHis: 0.638 ± 0.031	0.68HisIle: 0.68 ± 0.025	0.395HisLys: 0.395 ± 0.022	2.845HisLeu: 2.845 ± 0.049	0.291HisMet: 0.291 ± 0.016	0.442HisAsn: 0.442 ± 0.024	1.876HisPro: 1.876 ± 0.048	0.566HisGln: 0.566 ± 0.025	1.498HisArg: 1.498 ± 0.042	0.867HisSer: 0.867 ± 0.032	1.206HisThr: 1.206 ± 0.034	1.654HisVal: 1.654 ± 0.046	0.322HisTrp: 0.322 ± 0.017	0.565HisTyr: 0.565 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.044IleAla: 4.044 ± 0.07	0.222IleCys: 0.222 ± 0.015	1.662IleAsp: 1.662 ± 0.047	2.176IleGlu: 2.176 ± 0.054	1.061IlePhe: 1.061 ± 0.036	3.223IleGly: 3.223 ± 0.067	0.77IleHis: 0.77 ± 0.029	1.301IleIle: 1.301 ± 0.042	0.858IleLys: 0.858 ± 0.033	3.611IleLeu: 3.611 ± 0.063	0.521IleMet: 0.521 ± 0.025	0.877IleAsn: 0.877 ± 0.03	2.103IlePro: 2.103 ± 0.046	1.122IleGln: 1.122 ± 0.036	2.493IleArg: 2.493 ± 0.054	1.834IleSer: 1.834 ± 0.046	2.221IleThr: 2.221 ± 0.057	2.776IleVal: 2.776 ± 0.065	0.359IleTrp: 0.359 ± 0.018	0.803IleTyr: 0.803 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.954LysAla: 2.954 ± 0.064	0.113LysCys: 0.113 ± 0.012	1.167LysAsp: 1.167 ± 0.042	1.131LysGlu: 1.131 ± 0.04	0.706LysPhe: 0.706 ± 0.029	1.991LysGly: 1.991 ± 0.051	0.474LysHis: 0.474 ± 0.021	0.923LysIle: 0.923 ± 0.032	0.973LysLys: 0.973 ± 0.044	2.577LysLeu: 2.577 ± 0.057	0.496LysMet: 0.496 ± 0.027	0.783LysAsn: 0.783 ± 0.033	1.506LysPro: 1.506 ± 0.047	0.861LysGln: 0.861 ± 0.032	1.78LysArg: 1.78 ± 0.051	1.128LysSer: 1.128 ± 0.036	1.64LysThr: 1.64 ± 0.051	2.084LysVal: 2.084 ± 0.048	0.275LysTrp: 0.275 ± 0.018	0.635LysTyr: 0.635 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	16.263LeuAla: 16.263 ± 0.159	0.673LeuCys: 0.673 ± 0.028	6.17LeuAsp: 6.17 ± 0.094	6.548LeuGlu: 6.548 ± 0.1	2.951LeuPhe: 2.951 ± 0.066	10.807LeuGly: 10.807 ± 0.14	2.657LeuHis: 2.657 ± 0.059	4.334LeuIle: 4.334 ± 0.075	3.165LeuLys: 3.165 ± 0.062	14.015LeuLeu: 14.015 ± 0.191	1.855LeuMet: 1.855 ± 0.05	3.124LeuAsn: 3.124 ± 0.057	7.908LeuPro: 7.908 ± 0.096	3.635LeuGln: 3.635 ± 0.074	9.602LeuArg: 9.602 ± 0.127	6.663LeuSer: 6.663 ± 0.091	8.296LeuThr: 8.296 ± 0.112	7.85LeuVal: 7.85 ± 0.112	1.386LeuTrp: 1.386 ± 0.046	2.481LeuTyr: 2.481 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.613MetAla: 1.613 ± 0.041	0.065MetCys: 0.065 ± 0.008	0.695MetAsp: 0.695 ± 0.028	0.702MetGlu: 0.702 ± 0.031	0.465MetPhe: 0.465 ± 0.024	1.288MetGly: 1.288 ± 0.045	0.337MetHis: 0.337 ± 0.021	0.738MetIle: 0.738 ± 0.029	0.657MetLys: 0.657 ± 0.027	2.019MetLeu: 2.019 ± 0.046	0.317MetMet: 0.317 ± 0.021	0.673MetAsn: 0.673 ± 0.026	1.145MetPro: 1.145 ± 0.035	0.699MetGln: 0.699 ± 0.024	1.315MetArg: 1.315 ± 0.038	1.082MetSer: 1.082 ± 0.034	1.737MetThr: 1.737 ± 0.044	1.019MetVal: 1.019 ± 0.036	0.16MetTrp: 0.16 ± 0.012	0.357MetTyr: 0.357 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.17AsnAla: 3.17 ± 0.057	0.142AsnCys: 0.142 ± 0.012	0.963AsnAsp: 0.963 ± 0.031	1.016AsnGlu: 1.016 ± 0.033	0.86AsnPhe: 0.86 ± 0.035	2.105AsnGly: 2.105 ± 0.058	0.424AsnHis: 0.424 ± 0.023	1.02AsnIle: 1.02 ± 0.035	0.554AsnLys: 0.554 ± 0.024	3.052AsnLeu: 3.052 ± 0.062	0.43AsnMet: 0.43 ± 0.021	0.623AsnAsn: 0.623 ± 0.031	2.039AsnPro: 2.039 ± 0.053	0.673AsnGln: 0.673 ± 0.027	1.536AsnArg: 1.536 ± 0.041	0.992AsnSer: 0.992 ± 0.031	1.442AsnThr: 1.442 ± 0.044	2.27AsnVal: 2.27 ± 0.061	0.378AsnTrp: 0.378 ± 0.022	0.631AsnTyr: 0.631 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.614ProAla: 7.614 ± 0.107	0.294ProCys: 0.294 ± 0.018	3.988ProAsp: 3.988 ± 0.069	4.836ProGlu: 4.836 ± 0.076	1.849ProPhe: 1.849 ± 0.047	5.841ProGly: 5.841 ± 0.087	1.366ProHis: 1.366 ± 0.04	1.675ProIle: 1.675 ± 0.043	1.341ProLys: 1.341 ± 0.039	6.633ProLeu: 6.633 ± 0.09	0.967ProMet: 0.967 ± 0.03	1.421ProAsn: 1.421 ± 0.04	3.478ProPro: 3.478 ± 0.072	2.507ProGln: 2.507 ± 0.056	3.636ProArg: 3.636 ± 0.059	2.839ProSer: 2.839 ± 0.063	3.195ProThr: 3.195 ± 0.066	4.728ProVal: 4.728 ± 0.065	0.739ProTrp: 0.739 ± 0.028	1.355ProTyr: 1.355 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.81GlnAla: 5.81 ± 0.088	0.145GlnCys: 0.145 ± 0.01	1.846GlnAsp: 1.846 ± 0.044	2.15GlnGlu: 2.15 ± 0.052	0.964GlnPhe: 0.964 ± 0.038	3.508GlnGly: 3.508 ± 0.07	0.834GlnHis: 0.834 ± 0.03	1.289GlnIle: 1.289 ± 0.039	1.074GlnLys: 1.074 ± 0.043	3.911GlnLeu: 3.911 ± 0.078	0.646GlnMet: 0.646 ± 0.027	1.095GlnAsn: 1.095 ± 0.037	2.459GlnPro: 2.459 ± 0.067	1.67GlnGln: 1.67 ± 0.054	2.671GlnArg: 2.671 ± 0.063	1.539GlnSer: 1.539 ± 0.042	2.248GlnThr: 2.248 ± 0.048	3.356GlnVal: 3.356 ± 0.058	0.322GlnTrp: 0.322 ± 0.019	0.705GlnTyr: 0.705 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	10.215ArgAla: 10.215 ± 0.126	0.419ArgCys: 0.419 ± 0.023	4.023ArgAsp: 4.023 ± 0.073	5.847ArgGlu: 5.847 ± 0.09	2.545ArgPhe: 2.545 ± 0.052	5.994ArgGly: 5.994 ± 0.086	1.632ArgHis: 1.632 ± 0.037	2.543ArgIle: 2.543 ± 0.054	1.684ArgLys: 1.684 ± 0.049	9.241ArgLeu: 9.241 ± 0.109	1.571ArgMet: 1.571 ± 0.045	1.658ArgAsn: 1.658 ± 0.044	4.234ArgPro: 4.234 ± 0.066	2.967ArgGln: 2.967 ± 0.065	6.221ArgArg: 6.221 ± 0.089	3.28ArgSer: 3.28 ± 0.06	4.104ArgThr: 4.104 ± 0.065	7.008ArgVal: 7.008 ± 0.093	1.161ArgTrp: 1.161 ± 0.037	1.945ArgTyr: 1.945 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.567SerAla: 5.567 ± 0.095	0.316SerCys: 0.316 ± 0.019	2.081SerAsp: 2.081 ± 0.05	2.353SerGlu: 2.353 ± 0.053	1.611SerPhe: 1.611 ± 0.043	5.492SerGly: 5.492 ± 0.088	0.871SerHis: 0.871 ± 0.032	1.614SerIle: 1.614 ± 0.041	1.062SerLys: 1.062 ± 0.039	5.259SerLeu: 5.259 ± 0.084	0.817SerMet: 0.817 ± 0.03	1.153SerAsn: 1.153 ± 0.044	2.952SerPro: 2.952 ± 0.056	1.498SerGln: 1.498 ± 0.041	3.417SerArg: 3.417 ± 0.062	2.583SerSer: 2.583 ± 0.054	2.596SerThr: 2.596 ± 0.05	3.9SerVal: 3.9 ± 0.068	0.62SerTrp: 0.62 ± 0.024	1.024SerTyr: 1.024 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.766ThrAla: 6.766 ± 0.107	0.373ThrCys: 0.373 ± 0.019	2.684ThrAsp: 2.684 ± 0.058	2.526ThrGlu: 2.526 ± 0.053	2.255ThrPhe: 2.255 ± 0.049	5.376ThrGly: 5.376 ± 0.091	1.304ThrHis: 1.304 ± 0.04	1.697ThrIle: 1.697 ± 0.039	0.966ThrLys: 0.966 ± 0.039	8.642ThrLeu: 8.642 ± 0.123	0.705ThrMet: 0.705 ± 0.025	1.25ThrAsn: 1.25 ± 0.04	5.087ThrPro: 5.087 ± 0.084	1.949ThrGln: 1.949 ± 0.049	4.529ThrArg: 4.529 ± 0.078	2.726ThrSer: 2.726 ± 0.055	3.216ThrThr: 3.216 ± 0.066	5.234ThrVal: 5.234 ± 0.081	0.804ThrTrp: 0.804 ± 0.031	1.555ThrTyr: 1.555 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	8.846ValAla: 8.846 ± 0.111	0.535ValCys: 0.535 ± 0.027	3.461ValAsp: 3.461 ± 0.064	4.1ValGlu: 4.1 ± 0.069	2.405ValPhe: 2.405 ± 0.059	6.451ValGly: 6.451 ± 0.088	1.461ValHis: 1.461 ± 0.04	3.379ValIle: 3.379 ± 0.066	2.103ValLys: 2.103 ± 0.054	9.486ValLeu: 9.486 ± 0.111	1.592ValMet: 1.592 ± 0.038	2.315ValAsn: 2.315 ± 0.054	4.899ValPro: 4.899 ± 0.068	3.423ValGln: 3.423 ± 0.054	6.578ValArg: 6.578 ± 0.089	3.915ValSer: 3.915 ± 0.066	5.786ValThr: 5.786 ± 0.094	6.085ValVal: 6.085 ± 0.1	1.096ValTrp: 1.096 ± 0.034	1.9ValTyr: 1.9 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.511TrpAla: 1.511 ± 0.04	0.086TrpCys: 0.086 ± 0.009	0.666TrpAsp: 0.666 ± 0.031	0.634TrpGlu: 0.634 ± 0.029	0.396TrpPhe: 0.396 ± 0.02	1.084TrpGly: 1.084 ± 0.035	0.316TrpHis: 0.316 ± 0.018	0.382TrpIle: 0.382 ± 0.022	0.328TrpLys: 0.328 ± 0.02	1.728TrpLeu: 1.728 ± 0.051	0.273TrpMet: 0.273 ± 0.018	0.526TrpAsn: 0.526 ± 0.03	0.749TrpPro: 0.749 ± 0.03	0.712TrpGln: 0.712 ± 0.03	1.217TrpArg: 1.217 ± 0.033	0.588TrpSer: 0.588 ± 0.028	0.895TrpThr: 0.895 ± 0.026	1.06TrpVal: 1.06 ± 0.033	0.248TrpTrp: 0.248 ± 0.016	0.263TrpTyr: 0.263 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.081TyrAla: 3.081 ± 0.061	0.135TyrCys: 0.135 ± 0.013	1.261TyrAsp: 1.261 ± 0.041	1.053TyrGlu: 1.053 ± 0.036	0.799TyrPhe: 0.799 ± 0.032	2.298TyrGly: 2.298 ± 0.048	0.533TyrHis: 0.533 ± 0.025	0.627TyrIle: 0.627 ± 0.031	0.468TyrLys: 0.468 ± 0.024	2.682TyrLeu: 2.682 ± 0.057	0.263TyrMet: 0.263 ± 0.018	0.556TyrAsn: 0.556 ± 0.026	1.373TyrPro: 1.373 ± 0.039	0.835TyrGln: 0.835 ± 0.029	2.216TyrArg: 2.216 ± 0.049	1.107TyrSer: 1.107 ± 0.038	1.507TyrThr: 1.507 ± 0.043	1.685TyrVal: 1.685 ± 0.042	0.334TyrTrp: 0.334 ± 0.024	0.589TyrTyr: 0.589 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3006 proteins (955421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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