Amino acid dipepetide frequency for Streptococcus phage Javan599

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.755AlaAla: 3.755 ± 1.246
0.501AlaCys: 0.501 ± 0.194
3.838AlaAsp: 3.838 ± 0.441
4.506AlaGlu: 4.506 ± 0.643
2.503AlaPhe: 2.503 ± 0.379
4.589AlaGly: 4.589 ± 0.656
0.584AlaHis: 0.584 ± 0.21
6.008AlaIle: 6.008 ± 0.818
6.508AlaLys: 6.508 ± 0.62
6.258AlaLeu: 6.258 ± 0.899
1.502AlaMet: 1.502 ± 0.322
3.588AlaAsn: 3.588 ± 0.546
1.585AlaPro: 1.585 ± 0.359
3.421AlaGln: 3.421 ± 0.757
3.254AlaArg: 3.254 ± 0.52
4.839AlaSer: 4.839 ± 0.87
4.172AlaThr: 4.172 ± 0.552
3.922AlaVal: 3.922 ± 0.703
0.834AlaTrp: 0.834 ± 0.275
3.338AlaTyr: 3.338 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
0.501CysAla: 0.501 ± 0.216
0.167CysCys: 0.167 ± 0.105
0.25CysAsp: 0.25 ± 0.157
0.584CysGlu: 0.584 ± 0.177
0.334CysPhe: 0.334 ± 0.164
0.751CysGly: 0.751 ± 0.198
0.25CysHis: 0.25 ± 0.148
0.501CysIle: 0.501 ± 0.231
0.501CysLys: 0.501 ± 0.276
0.584CysLeu: 0.584 ± 0.22
0.083CysMet: 0.083 ± 0.086
0.334CysAsn: 0.334 ± 0.182
0.417CysPro: 0.417 ± 0.193
0.668CysGln: 0.668 ± 0.212
0.417CysArg: 0.417 ± 0.182
0.25CysSer: 0.25 ± 0.137
0.167CysThr: 0.167 ± 0.129
0.668CysVal: 0.668 ± 0.264
0.0CysTrp: 0.0 ± 0.0
0.501CysTyr: 0.501 ± 0.226
0.0CysXaa: 0.0 ± 0.0
Asp
3.421AspAla: 3.421 ± 0.405
0.417AspCys: 0.417 ± 0.165
3.421AspAsp: 3.421 ± 0.674
4.172AspGlu: 4.172 ± 0.837
3.254AspPhe: 3.254 ± 0.384
4.923AspGly: 4.923 ± 0.577
1.168AspHis: 1.168 ± 0.288
4.255AspIle: 4.255 ± 0.524
3.838AspLys: 3.838 ± 0.406
5.674AspLeu: 5.674 ± 0.942
1.919AspMet: 1.919 ± 0.381
2.253AspAsn: 2.253 ± 0.386
1.752AspPro: 1.752 ± 0.446
2.086AspGln: 2.086 ± 0.374
2.67AspArg: 2.67 ± 0.657
3.838AspSer: 3.838 ± 0.619
2.837AspThr: 2.837 ± 0.383
3.254AspVal: 3.254 ± 0.582
0.918AspTrp: 0.918 ± 0.231
2.587AspTyr: 2.587 ± 0.511
0.0AspXaa: 0.0 ± 0.0
Glu
5.34GluAla: 5.34 ± 0.582
0.417GluCys: 0.417 ± 0.221
4.172GluAsp: 4.172 ± 0.525
6.341GluGlu: 6.341 ± 1.033
1.836GluPhe: 1.836 ± 0.38
4.422GluGly: 4.422 ± 0.463
1.502GluHis: 1.502 ± 0.392
4.673GluIle: 4.673 ± 0.422
6.008GluLys: 6.008 ± 1.089
8.177GluLeu: 8.177 ± 0.972
2.336GluMet: 2.336 ± 0.667
3.504GluAsn: 3.504 ± 0.613
1.669GluPro: 1.669 ± 0.461
4.005GluGln: 4.005 ± 0.464
3.254GluArg: 3.254 ± 0.456
3.504GluSer: 3.504 ± 0.515
5.173GluThr: 5.173 ± 0.651
3.755GluVal: 3.755 ± 0.529
0.834GluTrp: 0.834 ± 0.279
1.502GluTyr: 1.502 ± 0.312
0.0GluXaa: 0.0 ± 0.0
Phe
2.169PheAla: 2.169 ± 0.474
0.417PheCys: 0.417 ± 0.162
2.837PheAsp: 2.837 ± 0.427
3.004PheGlu: 3.004 ± 0.555
1.585PhePhe: 1.585 ± 0.411
2.753PheGly: 2.753 ± 0.424
0.918PheHis: 0.918 ± 0.256
1.669PheIle: 1.669 ± 0.432
3.338PheLys: 3.338 ± 0.559
2.67PheLeu: 2.67 ± 0.585
0.668PheMet: 0.668 ± 0.241
2.003PheAsn: 2.003 ± 0.283
0.668PhePro: 0.668 ± 0.272
1.502PheGln: 1.502 ± 0.4
1.669PheArg: 1.669 ± 0.25
2.169PheSer: 2.169 ± 0.428
2.003PheThr: 2.003 ± 0.442
1.585PheVal: 1.585 ± 0.422
0.668PheTrp: 0.668 ± 0.278
2.003PheTyr: 2.003 ± 0.361
0.0PheXaa: 0.0 ± 0.0
Gly
3.087GlyAla: 3.087 ± 0.504
0.25GlyCys: 0.25 ± 0.133
4.088GlyAsp: 4.088 ± 0.628
4.255GlyGlu: 4.255 ± 0.526
2.67GlyPhe: 2.67 ± 0.436
4.422GlyGly: 4.422 ± 0.704
2.003GlyHis: 2.003 ± 0.433
6.091GlyIle: 6.091 ± 0.809
4.589GlyLys: 4.589 ± 0.475
5.59GlyLeu: 5.59 ± 0.976
1.919GlyMet: 1.919 ± 0.424
3.671GlyAsn: 3.671 ± 0.628
0.751GlyPro: 0.751 ± 0.194
2.92GlyGln: 2.92 ± 0.505
4.339GlyArg: 4.339 ± 0.476
4.005GlySer: 4.005 ± 0.502
4.255GlyThr: 4.255 ± 0.542
4.088GlyVal: 4.088 ± 0.633
0.751GlyTrp: 0.751 ± 0.219
2.92GlyTyr: 2.92 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
0.751HisAla: 0.751 ± 0.209
0.167HisCys: 0.167 ± 0.113
1.168HisAsp: 1.168 ± 0.261
1.168HisGlu: 1.168 ± 0.316
0.834HisPhe: 0.834 ± 0.292
1.585HisGly: 1.585 ± 0.339
0.751HisHis: 0.751 ± 0.235
1.418HisIle: 1.418 ± 0.336
0.834HisLys: 0.834 ± 0.228
1.919HisLeu: 1.919 ± 0.331
0.334HisMet: 0.334 ± 0.186
0.751HisAsn: 0.751 ± 0.204
1.335HisPro: 1.335 ± 0.309
1.001HisGln: 1.001 ± 0.302
1.001HisArg: 1.001 ± 0.218
0.834HisSer: 0.834 ± 0.288
1.001HisThr: 1.001 ± 0.294
1.252HisVal: 1.252 ± 0.286
0.25HisTrp: 0.25 ± 0.14
0.668HisTyr: 0.668 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
4.923IleAla: 4.923 ± 0.437
0.501IleCys: 0.501 ± 0.204
5.09IleAsp: 5.09 ± 0.54
3.755IleGlu: 3.755 ± 0.524
1.252IlePhe: 1.252 ± 0.338
4.839IleGly: 4.839 ± 0.588
1.085IleHis: 1.085 ± 0.329
3.421IleIle: 3.421 ± 0.515
4.756IleLys: 4.756 ± 0.549
5.423IleLeu: 5.423 ± 0.608
0.834IleMet: 0.834 ± 0.269
2.753IleAsn: 2.753 ± 0.405
2.336IlePro: 2.336 ± 0.361
3.087IleGln: 3.087 ± 0.397
2.753IleArg: 2.753 ± 0.379
5.59IleSer: 5.59 ± 1.336
5.173IleThr: 5.173 ± 0.953
4.756IleVal: 4.756 ± 0.855
1.085IleTrp: 1.085 ± 0.343
2.503IleTyr: 2.503 ± 0.348
0.0IleXaa: 0.0 ± 0.0
Lys
6.258LysAla: 6.258 ± 0.489
0.417LysCys: 0.417 ± 0.165
3.588LysAsp: 3.588 ± 0.688
5.257LysGlu: 5.257 ± 0.5
1.836LysPhe: 1.836 ± 0.244
4.923LysGly: 4.923 ± 0.649
1.669LysHis: 1.669 ± 0.328
4.756LysIle: 4.756 ± 0.437
3.755LysLys: 3.755 ± 0.603
6.174LysLeu: 6.174 ± 0.655
1.752LysMet: 1.752 ± 0.442
2.92LysAsn: 2.92 ± 0.474
2.587LysPro: 2.587 ± 0.35
3.254LysGln: 3.254 ± 0.613
4.673LysArg: 4.673 ± 0.863
4.589LysSer: 4.589 ± 0.636
4.255LysThr: 4.255 ± 0.542
4.923LysVal: 4.923 ± 0.664
1.085LysTrp: 1.085 ± 0.278
2.086LysTyr: 2.086 ± 0.426
0.0LysXaa: 0.0 ± 0.0
Leu
6.508LeuAla: 6.508 ± 0.713
0.417LeuCys: 0.417 ± 0.208
5.257LeuAsp: 5.257 ± 0.568
7.843LeuGlu: 7.843 ± 0.975
3.004LeuPhe: 3.004 ± 0.49
5.173LeuGly: 5.173 ± 0.521
1.502LeuHis: 1.502 ± 0.298
4.255LeuIle: 4.255 ± 0.369
7.092LeuLys: 7.092 ± 0.692
7.843LeuLeu: 7.843 ± 0.933
1.836LeuMet: 1.836 ± 0.282
4.005LeuAsn: 4.005 ± 0.633
3.254LeuPro: 3.254 ± 0.706
3.755LeuGln: 3.755 ± 0.524
3.588LeuArg: 3.588 ± 0.521
7.259LeuSer: 7.259 ± 0.641
7.176LeuThr: 7.176 ± 0.74
6.174LeuVal: 6.174 ± 0.765
0.668LeuTrp: 0.668 ± 0.188
3.755LeuTyr: 3.755 ± 0.749
0.0LeuXaa: 0.0 ± 0.0
Met
2.169MetAla: 2.169 ± 0.434
0.083MetCys: 0.083 ± 0.082
1.752MetAsp: 1.752 ± 0.451
1.502MetGlu: 1.502 ± 0.383
0.918MetPhe: 0.918 ± 0.24
1.585MetGly: 1.585 ± 0.486
0.083MetHis: 0.083 ± 0.082
1.585MetIle: 1.585 ± 0.346
1.919MetLys: 1.919 ± 0.34
1.252MetLeu: 1.252 ± 0.323
0.834MetMet: 0.834 ± 0.328
0.668MetAsn: 0.668 ± 0.21
0.417MetPro: 0.417 ± 0.143
0.751MetGln: 0.751 ± 0.279
1.335MetArg: 1.335 ± 0.319
1.836MetSer: 1.836 ± 0.393
1.919MetThr: 1.919 ± 0.436
1.335MetVal: 1.335 ± 0.348
0.167MetTrp: 0.167 ± 0.143
0.417MetTyr: 0.417 ± 0.167
0.0MetXaa: 0.0 ± 0.0
Asn
4.923AsnAla: 4.923 ± 0.694
0.334AsnCys: 0.334 ± 0.21
2.42AsnAsp: 2.42 ± 0.326
2.753AsnGlu: 2.753 ± 0.483
1.836AsnPhe: 1.836 ± 0.379
4.923AsnGly: 4.923 ± 0.535
0.918AsnHis: 0.918 ± 0.204
2.253AsnIle: 2.253 ± 0.349
2.336AsnLys: 2.336 ± 0.451
4.506AsnLeu: 4.506 ± 0.763
1.085AsnMet: 1.085 ± 0.253
1.669AsnAsn: 1.669 ± 0.413
2.003AsnPro: 2.003 ± 0.426
2.086AsnGln: 2.086 ± 0.368
2.086AsnArg: 2.086 ± 0.421
2.503AsnSer: 2.503 ± 0.484
1.919AsnThr: 1.919 ± 0.529
2.503AsnVal: 2.503 ± 0.51
0.918AsnTrp: 0.918 ± 0.264
1.085AsnTyr: 1.085 ± 0.281
0.0AsnXaa: 0.0 ± 0.0
Pro
1.335ProAla: 1.335 ± 0.263
0.334ProCys: 0.334 ± 0.132
1.669ProAsp: 1.669 ± 0.39
2.336ProGlu: 2.336 ± 0.431
1.085ProPhe: 1.085 ± 0.313
0.751ProGly: 0.751 ± 0.335
0.918ProHis: 0.918 ± 0.211
2.003ProIle: 2.003 ± 0.471
2.169ProLys: 2.169 ± 0.458
3.087ProLeu: 3.087 ± 0.428
0.584ProMet: 0.584 ± 0.179
1.502ProAsn: 1.502 ± 0.365
0.751ProPro: 0.751 ± 0.309
1.085ProGln: 1.085 ± 0.31
1.502ProArg: 1.502 ± 0.274
2.587ProSer: 2.587 ± 0.533
2.503ProThr: 2.503 ± 0.461
2.253ProVal: 2.253 ± 0.403
0.417ProTrp: 0.417 ± 0.181
1.252ProTyr: 1.252 ± 0.324
0.0ProXaa: 0.0 ± 0.0
Gln
4.756GlnAla: 4.756 ± 0.582
0.417GlnCys: 0.417 ± 0.16
2.086GlnAsp: 2.086 ± 0.38
4.172GlnGlu: 4.172 ± 0.616
1.752GlnPhe: 1.752 ± 0.283
2.336GlnGly: 2.336 ± 0.392
0.501GlnHis: 0.501 ± 0.156
2.67GlnIle: 2.67 ± 0.414
2.753GlnLys: 2.753 ± 0.525
4.673GlnLeu: 4.673 ± 0.634
1.252GlnMet: 1.252 ± 0.369
1.919GlnAsn: 1.919 ± 0.406
1.585GlnPro: 1.585 ± 0.4
2.336GlnGln: 2.336 ± 0.397
1.669GlnArg: 1.669 ± 0.509
2.92GlnSer: 2.92 ± 0.511
3.254GlnThr: 3.254 ± 0.907
4.339GlnVal: 4.339 ± 0.606
0.834GlnTrp: 0.834 ± 0.265
0.668GlnTyr: 0.668 ± 0.263
0.0GlnXaa: 0.0 ± 0.0
Arg
2.336ArgAla: 2.336 ± 0.474
0.918ArgCys: 0.918 ± 0.263
2.336ArgAsp: 2.336 ± 0.478
3.254ArgGlu: 3.254 ± 0.396
1.836ArgPhe: 1.836 ± 0.439
2.503ArgGly: 2.503 ± 0.446
0.668ArgHis: 0.668 ± 0.25
3.338ArgIle: 3.338 ± 0.722
3.671ArgLys: 3.671 ± 0.603
5.423ArgLeu: 5.423 ± 0.643
0.668ArgMet: 0.668 ± 0.226
2.42ArgAsn: 2.42 ± 0.312
1.085ArgPro: 1.085 ± 0.262
3.004ArgGln: 3.004 ± 0.49
2.086ArgArg: 2.086 ± 0.508
2.587ArgSer: 2.587 ± 0.394
3.504ArgThr: 3.504 ± 0.801
3.671ArgVal: 3.671 ± 0.535
1.168ArgTrp: 1.168 ± 0.3
1.585ArgTyr: 1.585 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
4.339SerAla: 4.339 ± 0.766
0.584SerCys: 0.584 ± 0.247
4.506SerAsp: 4.506 ± 0.478
3.755SerGlu: 3.755 ± 0.446
2.67SerPhe: 2.67 ± 0.591
4.756SerGly: 4.756 ± 0.601
1.502SerHis: 1.502 ± 0.32
4.756SerIle: 4.756 ± 0.903
4.005SerLys: 4.005 ± 0.433
5.507SerLeu: 5.507 ± 0.681
1.335SerMet: 1.335 ± 0.29
3.171SerAsn: 3.171 ± 0.567
2.42SerPro: 2.42 ± 0.337
4.005SerGln: 4.005 ± 0.959
3.171SerArg: 3.171 ± 0.462
5.423SerSer: 5.423 ± 1.012
4.589SerThr: 4.589 ± 0.684
4.255SerVal: 4.255 ± 0.605
1.001SerTrp: 1.001 ± 0.214
2.587SerTyr: 2.587 ± 0.474
0.0SerXaa: 0.0 ± 0.0
Thr
5.674ThrAla: 5.674 ± 0.527
0.167ThrCys: 0.167 ± 0.122
3.087ThrAsp: 3.087 ± 0.542
4.756ThrGlu: 4.756 ± 0.614
2.92ThrPhe: 2.92 ± 0.705
4.339ThrGly: 4.339 ± 0.757
0.751ThrHis: 0.751 ± 0.204
5.34ThrIle: 5.34 ± 0.887
5.674ThrLys: 5.674 ± 0.605
5.423ThrLeu: 5.423 ± 0.566
1.085ThrMet: 1.085 ± 0.299
2.587ThrAsn: 2.587 ± 0.72
2.086ThrPro: 2.086 ± 0.443
2.503ThrGln: 2.503 ± 0.66
2.253ThrArg: 2.253 ± 0.557
5.423ThrSer: 5.423 ± 1.166
5.423ThrThr: 5.423 ± 0.999
5.507ThrVal: 5.507 ± 0.767
1.001ThrTrp: 1.001 ± 0.26
2.086ThrTyr: 2.086 ± 0.453
0.0ThrXaa: 0.0 ± 0.0
Val
4.005ValAla: 4.005 ± 0.577
0.417ValCys: 0.417 ± 0.222
3.588ValAsp: 3.588 ± 0.611
5.173ValGlu: 5.173 ± 0.687
2.169ValPhe: 2.169 ± 0.491
3.922ValGly: 3.922 ± 0.596
1.252ValHis: 1.252 ± 0.287
4.255ValIle: 4.255 ± 0.693
4.589ValLys: 4.589 ± 0.671
6.091ValLeu: 6.091 ± 0.622
1.252ValMet: 1.252 ± 0.336
2.086ValAsn: 2.086 ± 0.413
2.086ValPro: 2.086 ± 0.316
2.503ValGln: 2.503 ± 0.442
3.922ValArg: 3.922 ± 0.66
4.756ValSer: 4.756 ± 0.935
5.34ValThr: 5.34 ± 0.598
3.087ValVal: 3.087 ± 0.487
1.085ValTrp: 1.085 ± 0.244
2.336ValTyr: 2.336 ± 0.516
0.0ValXaa: 0.0 ± 0.0
Trp
1.001TrpAla: 1.001 ± 0.277
0.25TrpCys: 0.25 ± 0.158
0.417TrpAsp: 0.417 ± 0.137
1.168TrpGlu: 1.168 ± 0.277
0.918TrpPhe: 0.918 ± 0.281
0.751TrpGly: 0.751 ± 0.23
0.25TrpHis: 0.25 ± 0.124
0.668TrpIle: 0.668 ± 0.231
0.417TrpLys: 0.417 ± 0.248
1.168TrpLeu: 1.168 ± 0.263
0.417TrpMet: 0.417 ± 0.155
1.418TrpAsn: 1.418 ± 0.291
0.083TrpPro: 0.083 ± 0.07
0.834TrpGln: 0.834 ± 0.262
0.751TrpArg: 0.751 ± 0.291
1.252TrpSer: 1.252 ± 0.33
1.085TrpThr: 1.085 ± 0.303
0.834TrpVal: 0.834 ± 0.31
0.167TrpTrp: 0.167 ± 0.094
0.334TrpTyr: 0.334 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.253TyrAla: 2.253 ± 0.422
0.751TyrCys: 0.751 ± 0.231
3.087TyrAsp: 3.087 ± 0.661
2.67TyrGlu: 2.67 ± 0.532
1.085TyrPhe: 1.085 ± 0.306
2.42TyrGly: 2.42 ± 0.541
0.751TyrHis: 0.751 ± 0.248
2.003TyrIle: 2.003 ± 0.461
2.086TyrLys: 2.086 ± 0.414
2.92TyrLeu: 2.92 ± 0.554
0.751TyrMet: 0.751 ± 0.278
1.836TyrAsn: 1.836 ± 0.412
1.252TyrPro: 1.252 ± 0.27
2.086TyrGln: 2.086 ± 0.363
1.669TyrArg: 1.669 ± 0.309
2.169TyrSer: 2.169 ± 0.385
2.336TyrThr: 2.336 ± 0.493
1.752TyrVal: 1.752 ± 0.332
0.334TyrTrp: 0.334 ± 0.131
1.085TyrTyr: 1.085 ± 0.303
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (11986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski