Amino acid dipepetide frequency for Massilia lurida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.011AlaAla: 20.011 ± 0.187	1.184AlaCys: 1.184 ± 0.027	7.042AlaAsp: 7.042 ± 0.067	6.424AlaGlu: 6.424 ± 0.071	4.119AlaPhe: 4.119 ± 0.045	11.851AlaGly: 11.851 ± 0.103	2.552AlaHis: 2.552 ± 0.04	5.658AlaIle: 5.658 ± 0.057	3.75AlaLys: 3.75 ± 0.068	14.493AlaLeu: 14.493 ± 0.122	3.224AlaMet: 3.224 ± 0.047	3.353AlaAsn: 3.353 ± 0.045	6.701AlaPro: 6.701 ± 0.082	5.608AlaGln: 5.608 ± 0.076	8.84AlaArg: 8.84 ± 0.078	6.724AlaSer: 6.724 ± 0.071	7.018AlaThr: 7.018 ± 0.069	9.139AlaVal: 9.139 ± 0.085	1.879AlaTrp: 1.879 ± 0.038	2.698AlaTyr: 2.698 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.157CysAla: 1.157 ± 0.024	0.11CysCys: 0.11 ± 0.008	0.482CysAsp: 0.482 ± 0.018	0.4CysGlu: 0.4 ± 0.014	0.263CysPhe: 0.263 ± 0.012	0.856CysGly: 0.856 ± 0.022	0.251CysHis: 0.251 ± 0.014	0.385CysIle: 0.385 ± 0.015	0.179CysLys: 0.179 ± 0.01	0.765CysLeu: 0.765 ± 0.021	0.167CysMet: 0.167 ± 0.009	0.217CysAsn: 0.217 ± 0.011	0.388CysPro: 0.388 ± 0.015	0.232CysGln: 0.232 ± 0.012	0.553CysArg: 0.553 ± 0.019	0.434CysSer: 0.434 ± 0.017	0.478CysThr: 0.478 ± 0.017	0.627CysVal: 0.627 ± 0.022	0.12CysTrp: 0.12 ± 0.009	0.208CysTyr: 0.208 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.205AspAla: 7.205 ± 0.068	0.459AspCys: 0.459 ± 0.019	3.182AspAsp: 3.182 ± 0.052	3.139AspGlu: 3.139 ± 0.047	2.127AspPhe: 2.127 ± 0.035	5.378AspGly: 5.378 ± 0.069	1.097AspHis: 1.097 ± 0.027	2.644AspIle: 2.644 ± 0.039	1.812AspLys: 1.812 ± 0.037	5.301AspLeu: 5.301 ± 0.058	1.268AspMet: 1.268 ± 0.026	1.528AspAsn: 1.528 ± 0.03	3.034AspPro: 3.034 ± 0.042	1.769AspGln: 1.769 ± 0.037	3.544AspArg: 3.544 ± 0.055	2.469AspSer: 2.469 ± 0.035	2.905AspThr: 2.905 ± 0.038	4.247AspVal: 4.247 ± 0.053	0.944AspTrp: 0.944 ± 0.023	1.657AspTyr: 1.657 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.391GluAla: 6.391 ± 0.07	0.321GluCys: 0.321 ± 0.015	2.189GluAsp: 2.189 ± 0.037	2.721GluGlu: 2.721 ± 0.051	1.702GluPhe: 1.702 ± 0.036	3.705GluGly: 3.705 ± 0.052	1.294GluHis: 1.294 ± 0.03	2.496GluIle: 2.496 ± 0.045	1.943GluLys: 1.943 ± 0.038	5.612GluLeu: 5.612 ± 0.072	1.234GluMet: 1.234 ± 0.03	1.358GluAsn: 1.358 ± 0.03	2.298GluPro: 2.298 ± 0.042	2.469GluGln: 2.469 ± 0.036	4.418GluArg: 4.418 ± 0.063	2.187GluSer: 2.187 ± 0.039	2.599GluThr: 2.599 ± 0.036	3.5GluVal: 3.5 ± 0.047	0.66GluTrp: 0.66 ± 0.019	1.14GluTyr: 1.14 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.198PheAla: 4.198 ± 0.048	0.351PheCys: 0.351 ± 0.017	2.607PheAsp: 2.607 ± 0.038	1.789PheGlu: 1.789 ± 0.034	1.253PhePhe: 1.253 ± 0.035	3.406PheGly: 3.406 ± 0.046	0.775PheHis: 0.775 ± 0.022	1.522PheIle: 1.522 ± 0.028	1.041PheLys: 1.041 ± 0.024	3.035PheLeu: 3.035 ± 0.042	0.753PheMet: 0.753 ± 0.02	1.219PheAsn: 1.219 ± 0.028	1.501PhePro: 1.501 ± 0.034	1.057PheGln: 1.057 ± 0.022	2.113PheArg: 2.113 ± 0.033	2.042PheSer: 2.042 ± 0.034	2.195PheThr: 2.195 ± 0.037	2.588PheVal: 2.588 ± 0.041	0.478PheTrp: 0.478 ± 0.019	0.982PheTyr: 0.982 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.897GlyAla: 9.897 ± 0.106	0.749GlyCys: 0.749 ± 0.024	4.344GlyAsp: 4.344 ± 0.049	4.173GlyGlu: 4.173 ± 0.054	3.215GlyPhe: 3.215 ± 0.045	7.23GlyGly: 7.23 ± 0.096	1.879GlyHis: 1.879 ± 0.032	4.311GlyIle: 4.311 ± 0.053	3.414GlyLys: 3.414 ± 0.05	8.063GlyLeu: 8.063 ± 0.078	2.301GlyMet: 2.301 ± 0.038	2.518GlyAsn: 2.518 ± 0.045	3.044GlyPro: 3.044 ± 0.044	3.165GlyGln: 3.165 ± 0.047	5.758GlyArg: 5.758 ± 0.059	4.644GlySer: 4.644 ± 0.064	5.395GlyThr: 5.395 ± 0.067	6.171GlyVal: 6.171 ± 0.059	1.414GlyTrp: 1.414 ± 0.029	2.483GlyTyr: 2.483 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.929HisAla: 2.929 ± 0.045	0.246HisCys: 0.246 ± 0.014	1.312HisAsp: 1.312 ± 0.032	1.13HisGlu: 1.13 ± 0.029	0.884HisPhe: 0.884 ± 0.022	2.208HisGly: 2.208 ± 0.04	0.627HisHis: 0.627 ± 0.019	0.879HisIle: 0.879 ± 0.019	0.538HisLys: 0.538 ± 0.019	2.158HisLeu: 2.158 ± 0.039	0.504HisMet: 0.504 ± 0.016	0.537HisAsn: 0.537 ± 0.019	1.388HisPro: 1.388 ± 0.029	0.706HisGln: 0.706 ± 0.021	1.462HisArg: 1.462 ± 0.027	0.957HisSer: 0.957 ± 0.026	1.059HisThr: 1.059 ± 0.027	1.6HisVal: 1.6 ± 0.031	0.369HisTrp: 0.369 ± 0.018	0.675HisTyr: 0.675 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.458IleAla: 6.458 ± 0.064	0.383IleCys: 0.383 ± 0.015	3.272IleAsp: 3.272 ± 0.041	2.82IleGlu: 2.82 ± 0.047	1.261IlePhe: 1.261 ± 0.03	4.305IleGly: 4.305 ± 0.059	0.856IleHis: 0.856 ± 0.024	1.653IleIle: 1.653 ± 0.035	1.306IleLys: 1.306 ± 0.031	3.53IleLeu: 3.53 ± 0.053	0.775IleMet: 0.775 ± 0.022	1.427IleAsn: 1.427 ± 0.03	2.064IlePro: 2.064 ± 0.035	1.06IleGln: 1.06 ± 0.027	2.73IleArg: 2.73 ± 0.042	2.229IleSer: 2.229 ± 0.04	2.602IleThr: 2.602 ± 0.04	3.853IleVal: 3.853 ± 0.051	0.434IleTrp: 0.434 ± 0.018	0.888IleTyr: 0.888 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.875LysAla: 3.875 ± 0.057	0.163LysCys: 0.163 ± 0.01	1.733LysAsp: 1.733 ± 0.037	1.644LysGlu: 1.644 ± 0.033	0.989LysPhe: 0.989 ± 0.029	2.43LysGly: 2.43 ± 0.046	0.66LysHis: 0.66 ± 0.022	1.481LysIle: 1.481 ± 0.035	1.428LysLys: 1.428 ± 0.034	3.546LysLeu: 3.546 ± 0.051	0.868LysMet: 0.868 ± 0.024	1.115LysAsn: 1.115 ± 0.025	2.026LysPro: 2.026 ± 0.037	1.18LysGln: 1.18 ± 0.029	2.033LysArg: 2.033 ± 0.036	1.695LysSer: 1.695 ± 0.036	1.815LysThr: 1.815 ± 0.037	2.496LysVal: 2.496 ± 0.045	0.361LysTrp: 0.361 ± 0.015	0.775LysTyr: 0.775 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.412LeuAla: 15.412 ± 0.128	0.974LeuCys: 0.974 ± 0.027	6.066LeuAsp: 6.066 ± 0.06	4.916LeuGlu: 4.916 ± 0.069	3.489LeuPhe: 3.489 ± 0.053	7.925LeuGly: 7.925 ± 0.076	2.37LeuHis: 2.37 ± 0.042	3.735LeuIle: 3.735 ± 0.043	3.471LeuLys: 3.471 ± 0.044	11.129LeuLeu: 11.129 ± 0.115	2.179LeuMet: 2.179 ± 0.036	2.824LeuAsn: 2.824 ± 0.039	6.238LeuPro: 6.238 ± 0.062	4.171LeuGln: 4.171 ± 0.056	7.62LeuArg: 7.62 ± 0.076	5.536LeuSer: 5.536 ± 0.061	5.449LeuThr: 5.449 ± 0.052	7.568LeuVal: 7.568 ± 0.078	1.155LeuTrp: 1.155 ± 0.03	2.282LeuTyr: 2.282 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.965MetAla: 2.965 ± 0.045	0.148MetCys: 0.148 ± 0.008	1.121MetAsp: 1.121 ± 0.023	1.011MetGlu: 1.011 ± 0.025	0.679MetPhe: 0.679 ± 0.022	1.601MetGly: 1.601 ± 0.033	0.53MetHis: 0.53 ± 0.016	0.979MetIle: 0.979 ± 0.028	1.02MetLys: 1.02 ± 0.023	2.643MetLeu: 2.643 ± 0.04	0.599MetMet: 0.599 ± 0.022	0.927MetAsn: 0.927 ± 0.021	1.425MetPro: 1.425 ± 0.028	0.994MetGln: 0.994 ± 0.028	1.555MetArg: 1.555 ± 0.033	1.458MetSer: 1.458 ± 0.032	1.586MetThr: 1.586 ± 0.028	1.535MetVal: 1.535 ± 0.032	0.203MetTrp: 0.203 ± 0.012	0.43MetTyr: 0.43 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.641AsnAla: 3.641 ± 0.044	0.255AsnCys: 0.255 ± 0.013	1.565AsnAsp: 1.565 ± 0.03	1.368AsnGlu: 1.368 ± 0.027	1.007AsnPhe: 1.007 ± 0.025	2.811AsnGly: 2.811 ± 0.044	0.576AsnHis: 0.576 ± 0.018	1.327AsnIle: 1.327 ± 0.027	0.865AsnLys: 0.865 ± 0.024	2.968AsnLeu: 2.968 ± 0.045	0.597AsnMet: 0.597 ± 0.018	0.966AsnAsn: 0.966 ± 0.027	1.814AsnPro: 1.814 ± 0.036	0.968AsnGln: 0.968 ± 0.025	1.804AsnArg: 1.804 ± 0.035	1.35AsnSer: 1.35 ± 0.03	1.674AsnThr: 1.674 ± 0.035	2.371AsnVal: 2.371 ± 0.043	0.418AsnTrp: 0.418 ± 0.018	0.814AsnTyr: 0.814 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.188ProAla: 8.188 ± 0.097	0.33ProCys: 0.33 ± 0.014	3.412ProAsp: 3.412 ± 0.045	2.974ProGlu: 2.974 ± 0.042	1.846ProPhe: 1.846 ± 0.03	4.541ProGly: 4.541 ± 0.045	1.162ProHis: 1.162 ± 0.025	1.76ProIle: 1.76 ± 0.037	1.51ProLys: 1.51 ± 0.032	5.241ProLeu: 5.241 ± 0.059	1.13ProMet: 1.13 ± 0.025	1.394ProAsn: 1.394 ± 0.03	2.66ProPro: 2.66 ± 0.052	2.067ProGln: 2.067 ± 0.036	2.883ProArg: 2.883 ± 0.043	2.476ProSer: 2.476 ± 0.038	2.305ProThr: 2.305 ± 0.038	4.547ProVal: 4.547 ± 0.058	0.664ProTrp: 0.664 ± 0.02	1.188ProTyr: 1.188 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.186GlnAla: 5.186 ± 0.066	0.256GlnCys: 0.256 ± 0.012	1.725GlnAsp: 1.725 ± 0.031	1.685GlnGlu: 1.685 ± 0.036	1.337GlnPhe: 1.337 ± 0.025	2.908GlnGly: 2.908 ± 0.04	0.962GlnHis: 0.962 ± 0.025	1.648GlnIle: 1.648 ± 0.03	1.225GlnLys: 1.225 ± 0.029	4.239GlnLeu: 4.239 ± 0.057	0.974GlnMet: 0.974 ± 0.022	1.02GlnAsn: 1.02 ± 0.026	2.326GlnPro: 2.326 ± 0.04	1.958GlnGln: 1.958 ± 0.042	3.02GlnArg: 3.02 ± 0.046	1.884GlnSer: 1.884 ± 0.037	1.76GlnThr: 1.76 ± 0.031	2.941GlnVal: 2.941 ± 0.043	0.554GlnTrp: 0.554 ± 0.018	0.981GlnTyr: 0.981 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.856ArgAla: 7.856 ± 0.084	0.507ArgCys: 0.507 ± 0.018	3.906ArgAsp: 3.906 ± 0.051	3.805ArgGlu: 3.805 ± 0.053	2.699ArgPhe: 2.699 ± 0.033	4.613ArgGly: 4.613 ± 0.054	1.886ArgHis: 1.886 ± 0.036	3.597ArgIle: 3.597 ± 0.044	2.125ArgLys: 2.125 ± 0.036	7.555ArgLeu: 7.555 ± 0.071	1.851ArgMet: 1.851 ± 0.035	2.072ArgAsn: 2.072 ± 0.035	3.187ArgPro: 3.187 ± 0.046	2.961ArgGln: 2.961 ± 0.042	4.992ArgArg: 4.992 ± 0.059	3.273ArgSer: 3.273 ± 0.042	3.642ArgThr: 3.642 ± 0.051	4.575ArgVal: 4.575 ± 0.053	1.066ArgTrp: 1.066 ± 0.025	2.073ArgTyr: 2.073 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.481SerAla: 6.481 ± 0.064	0.417SerCys: 0.417 ± 0.017	2.576SerAsp: 2.576 ± 0.043	2.192SerGlu: 2.192 ± 0.036	1.937SerPhe: 1.937 ± 0.033	5.05SerGly: 5.05 ± 0.073	1.119SerHis: 1.119 ± 0.021	2.41SerIle: 2.41 ± 0.04	1.582SerLys: 1.582 ± 0.035	5.242SerLeu: 5.242 ± 0.053	1.258SerMet: 1.258 ± 0.026	1.538SerAsn: 1.538 ± 0.03	2.592SerPro: 2.592 ± 0.042	1.737SerGln: 1.737 ± 0.033	3.249SerArg: 3.249 ± 0.046	2.968SerSer: 2.968 ± 0.052	3.01SerThr: 3.01 ± 0.051	3.683SerVal: 3.683 ± 0.051	0.723SerTrp: 0.723 ± 0.021	1.444SerTyr: 1.444 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.829ThrAla: 6.829 ± 0.082	0.381ThrCys: 0.381 ± 0.015	2.85ThrAsp: 2.85 ± 0.04	2.408ThrGlu: 2.408 ± 0.036	1.956ThrPhe: 1.956 ± 0.036	5.182ThrGly: 5.182 ± 0.07	1.105ThrHis: 1.105 ± 0.026	2.56ThrIle: 2.56 ± 0.041	1.474ThrLys: 1.474 ± 0.027	6.419ThrLeu: 6.419 ± 0.059	1.224ThrMet: 1.224 ± 0.03	1.521ThrAsn: 1.521 ± 0.033	3.619ThrPro: 3.619 ± 0.045	1.876ThrGln: 1.876 ± 0.034	3.323ThrArg: 3.323 ± 0.046	2.946ThrSer: 2.946 ± 0.044	3.18ThrThr: 3.18 ± 0.058	4.737ThrVal: 4.737 ± 0.064	0.772ThrTrp: 0.772 ± 0.022	1.34ThrTyr: 1.34 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.633ValAla: 9.633 ± 0.089	0.636ValCys: 0.636 ± 0.02	4.223ValAsp: 4.223 ± 0.052	3.827ValGlu: 3.827 ± 0.052	2.588ValPhe: 2.588 ± 0.038	5.08ValGly: 5.08 ± 0.063	1.536ValHis: 1.536 ± 0.03	3.384ValIle: 3.384 ± 0.048	2.476ValLys: 2.476 ± 0.041	8.095ValLeu: 8.095 ± 0.081	1.693ValMet: 1.693 ± 0.035	2.38ValAsn: 2.38 ± 0.034	4.071ValPro: 4.071 ± 0.046	2.79ValGln: 2.79 ± 0.04	5.114ValArg: 5.114 ± 0.055	3.84ValSer: 3.84 ± 0.05	4.79ValThr: 4.79 ± 0.05	5.595ValVal: 5.595 ± 0.062	0.867ValTrp: 0.867 ± 0.023	1.698ValTyr: 1.698 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.11TrpAla: 1.11 ± 0.027	0.15TrpCys: 0.15 ± 0.01	0.633TrpAsp: 0.633 ± 0.02	0.565TrpGlu: 0.565 ± 0.017	0.537TrpPhe: 0.537 ± 0.022	0.871TrpGly: 0.871 ± 0.019	0.415TrpHis: 0.415 ± 0.016	0.638TrpIle: 0.638 ± 0.02	0.434TrpLys: 0.434 ± 0.016	1.861TrpLeu: 1.861 ± 0.037	0.352TrpMet: 0.352 ± 0.012	0.496TrpAsn: 0.496 ± 0.018	0.639TrpPro: 0.639 ± 0.021	0.83TrpGln: 0.83 ± 0.024	1.207TrpArg: 1.207 ± 0.025	0.78TrpSer: 0.78 ± 0.025	0.76TrpThr: 0.76 ± 0.024	0.817TrpVal: 0.817 ± 0.025	0.262TrpTrp: 0.262 ± 0.014	0.382TrpTyr: 0.382 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.845TyrAla: 2.845 ± 0.04	0.251TyrCys: 0.251 ± 0.013	1.469TyrAsp: 1.469 ± 0.028	1.243TyrGlu: 1.243 ± 0.029	1.016TyrPhe: 1.016 ± 0.027	2.213TyrGly: 2.213 ± 0.039	0.518TyrHis: 0.518 ± 0.017	0.843TyrIle: 0.843 ± 0.021	0.722TyrLys: 0.722 ± 0.021	2.613TyrLeu: 2.613 ± 0.044	0.455TyrMet: 0.455 ± 0.015	0.748TyrAsn: 0.748 ± 0.022	1.265TyrPro: 1.265 ± 0.029	0.991TyrGln: 0.991 ± 0.022	2.026TyrArg: 2.026 ± 0.033	1.315TyrSer: 1.315 ± 0.032	1.481TyrThr: 1.481 ± 0.034	1.726TyrVal: 1.726 ± 0.03	0.398TyrTrp: 0.398 ± 0.018	0.759TyrTyr: 0.759 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5075 proteins (1795910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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